M Channels Containing KCNQ2 Subunits Modulate Norepinephrine, Aspartate, and GABA Release from Hippocampal Nerve Terminals

Journal of Neuroscience

Volumn 24, Issue 3, 2004, Pages 592-597

  Martire, Maria ^a   Castaldo, Pasqualina ^b   D'Amico, Monia ^a   Preziosi, Paolo ^a   Annunziato, Lucio ^b   Taglialatela, Maurizio ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Epilepsy; Hippocampus; KCNQ2 subunits; Norepinephrine release; Potassium channels; Retigabine

Indexed keywords

10,10 BIS(4 PYRIDINYLMETHYL) 9(10H) ANTHRACENONE; 4 AMINOBUTYRIC ACID; ANTHRACENE DERIVATIVE; ASPARTIC ACID; FLUPIRTINE; NORADRENALIN; PEPTIDE; POLYCLONAL ANTIBODY; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3; PROTEIN SUBUNIT; TETRYLAMMONIUM; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL CELL; ARTICLE; BRAIN SYNAPTOSOME; CHANNEL GATING; CHO CELL; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXTRACELLULAR SPACE; GENETIC CODE; GENETIC TRANSFECTION; HIPPOCAMPUS; HYPERPOLARIZATION; M CHANNEL; MALE; NERVE CELL EXCITABILITY; NERVE ENDING; NEUROTRANSMITTER RELEASE; NONHUMAN; NORADRENALIN RELEASE; POTASSIUM CURRENT; PRESYNAPTIC NERVE; PRIORITY JOURNAL; RAT;

AMINOPYRIDINES; ANIMALS; ANTHRACENES; ANTICONVULSANTS; ASPARTIC ACID; CARBAMATES; CHO CELLS; CRICETINAE; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; KCNQ2 POTASSIUM CHANNEL; KCNQ3 POTASSIUM CHANNEL; MALE; NOREPINEPHRINE; PATCH-CLAMP TECHNIQUES; PHENYLENEDIAMINES; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PRESYNAPTIC TERMINALS; PROTEIN SUBUNITS; RATS; SYNAPTOSOMES;

EID: 0842305796     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3143-03.2004     Document Type: Article

References (28)

1. 2+ channels present in synaptosomes from rat and chicken central nervous system. J Neurochem 64:2544-2551.
2. Brown BS, Yu SP (2000) Modulation and genetic identification of the M channel. Prog Biophys Mol Biol 73:135-166.
3. + current in a vertebrate neurone. Nature 283:673-676.
4. Cooper EC, Aldape KD, Abosch A, Barbaro NM, Berger MS, Peacock WS, Jan YN, Jan LY (2000) Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy. Proc Natl Acad Sci USA 97:4914-4919.
5. Cooper EC, Harrington E, Jan YN, Jan LY (2001) M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J Neurosci 21:9529-9540.
6. Davies LP, Johnston GAR (1976) Uptake and release of D- and L-aspartate by rat brain slices. J Neurochem 26:1007-1014.
7. Fieles WE, Smith J, Christian EP, Cross A, Mrzljak L (2002) Subcellular localization of KCNQ2 potassium channel subunit in the macaque monkey cerebral cortex and hippocampus. Soc Neurosci Abstr 28:438.8.
8. Friedel HA, Fitton A (1993) Flupirtine. A review of its pharmacological properties, and therapeutic efficacy in pain states. Drugs 45:548-569.
9. Gundersen V, Shupliakov O, Brodin L, Ottersen OP, Storm-Mathisen J (1995) Quantification of excitatory amino acid uptake at intact glutamatergic synapses by immunocytochemistry of exogenous D-aspartate. J Neurosci 15:4417-4428.
10. Hetka R, Rundfeldt C, Heinemann U, Schmitz D (1999) Retigabine strongly reduces repetitive firing in rat entorhinal cortex. Eur J Pharmacol 386:165-171.
11. Jentsch TJ (2000) Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev Neurosci 1:21-30.
12. Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA (2000) Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine. Mol Pharmacol 58:253-262.
13. Marrion NV (1997) Control of M-current. Annu Rev Physiol 59:483-504.
14. 3H]D-aspartate release in rat spinal cord synaptosomes: modulation by neuropeptide Y and calcium channel antagonists. J Neurosci Res 62:722-729.
15. O'Shea RD (2002) Roles and regulation of glutamate transporters in the central nervous system. Clin Exp Pharmacol Physiol 29:1018-1029.
16. Otto JF, Kimball MM, Wilcox KS (2002) Effects of the anticonvulsant retigabine on cultured cortical neurons: changes in electroresponsive properties and synaptic transmission. Mol Pharmacol 61:921-927.
17. +]: involvement of transporter reversal and mitochondrial calcium. J Neurochem 80:706-714.
18. Raiteri M, Sala R, Fassio A, Rossetto O, Bonanno G (2000) Entrapping of impermeant probes of different size into nonpermeabilized synaptosomes as a method to study presynaptic mechanisms. J Neurochem 74:423-431.
19. Robbins J, Trouslard J, Marsh SJ, Brown DA (1992) Kinetic and pharmacological properties of the M-current in rodent neuroblastoma X glioma hybrid cells. J Physiol (Lond) 451:159-185.
20. + channels and the molecular pathogenesis of epilepsy: implications for therapy. Trends Neurosci 23:393-398.
21. Rundfeldt C, Netzer R (2000a) The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells transfected with human KCNQ2/3 subunits. Neurosci Lett 282:73-76.
22. Rundfeldt C, Netzer R (2000b) Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels. Arzneimittelforschung 50:1063-1070.
23. Shah MM, Mistry M, Marsh SJ, Brown DA, Delmas P (2002) Molecular correlates of the M-current in cultured rat hippocampal neurons. J Physiol (Lond) 544:29-37.
24. Tatulian L, Delmas P, Abogadie FC, Brown DA (2001) Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine. J Neurosci 21:5535-5545.
25. Vickroy TW (1993) Presynaptic cholinergic actions by the putative cognitive enhancing agent DuP 996. J Pharmacol Exp Ther 264:910-917.
26. Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D (1998) KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282:1890-1893.
27. Wickenden AD, Yu W, Zou A, Jegla T, Wagoner PK (2000) Retigabine, a novel anticonvulsant, enhances activation of KCNQ2/3 potassium channels. Mol Pharmacol 58:591-600.
28. Zaczek R, Chorvat RJ, Saye JA, Pierdomenico ME, Maciag CM, Logue AR, Fisher BN, Rominger DH, Earl RA (1998) Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther 285:724-730.