Presynaptic NMDA autoreceptors facilitate axon excitability: A new molecular target for the anticonvulsant gabapentin

European Journal of Neuroscience

Volumn 21, Issue 1, 2005, Pages 197-209

  Suárez, Luz M ^a   Suárez, Francisco ^a   Del Olmo, Nuria ^b   Ruiz, Manuel ^c   González Escalada, José R ^a   Solís, José M ^a  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

^b UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA   (Spain)

^c PFIZER INC   (United States)

Author keywords

Action potential; Axon; Gabapentin; NMDA receptor; Rat hippocampal slice; Sodium

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ANTICONVULSIVE AGENT; AUTORECEPTOR; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; DIZOCILPINE; GABAPENTIN; GLUTAMIC ACID; MAGNESIUM; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PRESYNAPTIC RECEPTOR; SODIUM;

ANALGESIC ACTIVITY; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG EFFECT; DRUG TARGETING; HIPPOCAMPUS; MALE; NERVE EXCITABILITY; NEUROTRANSMITTER RELEASE; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; RAT; SODIUM TRANSPORT;

AMINES; ANALYSIS OF VARIANCE; ANIMALS; ANTICONVULSANTS; AXONS; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; MALE; N-METHYLASPARTATE; NEURAL INHIBITION; PHOSPHINIC ACIDS; PICROTOXIN; POTASSIUM CHLORIDE; PROPANOLAMINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, PRESYNAPTIC;

EID: 13244255647     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2004.03832.x     Document Type: Article

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