R67, the other dihydrofolate reductase: Rational design of an alternate active site configuration

Biochemistry

Volumn 47, Issue 2, 2008, Pages 555-565

  Feng, Jian ^a   Goswami, Sumit ^a   Howell, Elizabeth E ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE CONFIGURATION; DIHYDROFOLATE REDUCTASE (DHFR);

AMINO ACIDS; CATALYST ACTIVITY; GENES; MONOMERS; PROTEINS;

ENZYME ACTIVITY;

AMINO ACID; DIHYDROFOLATE REDUCTASE; DIHYDROFOLIC ACID; MONOMER; R67 DIHYDROFOLATE REDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE; GENE DUPLICATION; GENE MUTATION; PRIORITY JOURNAL; WILD TYPE;

APOPROTEINS; BINDING SITES; CALORIMETRY; FLUORESCENCE; HYDROGEN-ION CONCENTRATION; KINETICS; LIGANDS; MUTANT PROTEINS; OSMOLAR CONCENTRATION; PROTEIN STRUCTURE, SECONDARY; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS;

EID: 38849168343     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701455x     Document Type: Article

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