NMR studies of the interaction of a type II dihydrofolate reductase with pyridine nucleotides reveal unexpected phosphatase and reductase activity

Biochemistry

Volumn 42, Issue 38, 2003, Pages 11150-11160

  Pitcher III, Wayne H ^a   DeRose, Eugene F ^a   Mueller, Geoffrey A ^a   Howell, Elizabeth E ^b   London, Robert E ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; AROMATIC COMPOUNDS; CATALYST ACTIVITY; CHEMICAL BONDS; COMPLEXATION; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

NUCLEOTIDES;

ENZYME KINETICS;

ACETYLPYRIDINE ADENOSINE DINUCLEOTIDE PHOSPHATE; AMINO ACID; AMMONIUM CHLORIDE; CHYMOTRYPSIN; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE 2; FOLIC ACID; GLUCOSE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXIDOREDUCTASE; PHOSPHATASE; PYRIDINE NUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIUM CULTURE; BINDING SITE; CULTURE MEDIUM; ENZYME ACTIVITY; ESCHERICHIA COLI; MASS SPECTROMETRY; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN TERTIARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE;

AMIDES; CATALYSIS; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; NAD; NADP; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXIDOREDUCTASES; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; RECOMBINANT PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0141456387     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0349874     Document Type: Article

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