Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP + complex reveals a novel cofactor binding mode

Protein Science

Volumn 16, Issue 6, 2007, Pages 1063-1068

  Divya, N ^a   Grifith, E ^a   Narayana, Narendra ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Crystal structure; Folate metabolism; NADP+; R67 DHFR; Symmetric binding; Trimethoprim resistance

Indexed keywords

DIHYDROFOLATE REDUCTASE; GENE PRODUCT; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PYROPHOSPHATE; Q67H PROTEIN; RIBOSE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CATALYSIS; CHROMOSOME; COENZYME; CONTROLLED STUDY; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DYNAMICS; MUTANT; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; STOICHIOMETRY;

AMINO ACID SUBSTITUTION; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; NADP; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETHOPRIM;

BACTERIA (MICROORGANISMS);

EID: 34249794278     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.062740907     Document Type: Article

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