Calorimetric studies of ligand binding in R67 dihydrofolate reductase

Biochemistry

Volumn 44, Issue 37, 2005, Pages 12420-12433

  Jackson, Michael ^a   Chopra, Shaileja ^a   Smiley, R Derike ^a,e   Maynord, Patrick O'Neal ^a   Rosowsky, Andre ^c   London, Robert E ^b   Levy, Louis ^b   Kalman, Thomas I ^d   Howell, Elizabeth E ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY AT BUFFALO   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CALORIMETRY; CATALYSIS; ENTHALPY; ENZYME INHIBITION; MOLECULAR STRUCTURE;

BACTERIAL PROTEINS; COFACTORS; LIGAND BINDING; TERNARY COMPLEX;

ENZYMES;

4 AMINOBENZOYLGLUTAMATE; AMIDE; AMINOPTERIN; BACTERIAL PROTEIN; BIOPTERIN; DIHYDROFOLATE REDUCTASE; FOLIC ACID; GLUTAMIC ACID DERIVATIVE; METHOTREXATE; NICOTINAMIDE CARBOXAMIDE; NOVOBIOCIN; PTERIDINE DERIVATIVE; PTEROIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CALORIMETRY; ENTHALPY; ENZYME ACTIVE SITE; ENZYME BINDING; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT;

CALORIMETRY; ESCHERICHIA COLI; FOLIC ACID; FOLIC ACID ANTAGONISTS; KINETICS; LIGANDS; MODELS, MOLECULAR; NADP; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS;

BACTERIA (MICROORGANISMS);

EID: 24944534426     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi050881s     Document Type: Article

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