Redesigning the quaternary structure of R67 dihydrofolate reductase: Creation of an active monomer from a tetrameric protein by quadruplication of the gene

Journal of Biological Chemistry

Volumn 271, Issue 45, 1996, Pages 28031-28037

  Bradrick, Thomas D ^a   Shattuck, Chris ^a   Strader, Michael B ^a   Wicker, Carol ^b   Eisenstein, Edward ^c,d   Howell, Elizabeth E ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b Mycogen Corporation   (United States)

^c UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^d UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE;

ARTICLE; ENZYME ANALYSIS; ENZYME STRUCTURE; GENE EXPRESSION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; STRUCTURE ANALYSIS;

CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; GENE AMPLIFICATION; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; PLASMIDS; PROTEIN CONFORMATION; SPECTROMETRY, FLUORESCENCE; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0029911187     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.45.28031     Document Type: Article

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