Role of ionic interactions in ligand binding and catalysis of R67 dihydrofolate reductase

Biochemistry

Volumn 42, Issue 36, 2003, Pages 10569-10578

  Hicks, Stephanie N ^a   Smiley, R Derike ^a   Hamilton, J Bradley ^a,b   Howell, Elizabeth E ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b Upstate Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DIMERS; GROUND STATE; SUBSTRATES; TITRATION;

IONIC INTERACTIONS;

BIOCHEMISTRY;

DIHYDROFOLATE REDUCTASE; DIHYDROFOLIC ACID; DIMER; FOLIC ACID; MONOMER; PYROPHOSPHORIC ACID DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TETRAHYDROFOLIC ACID; TETRAMER; TRIMETHOPRIM;

ARTICLE; CRYSTAL STRUCTURE; ENTHALPY; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; IONIC STRENGTH; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR MODEL; MUTANT; PRIORITY JOURNAL; R PLASMID; REDUCTION; SITE DIRECTED MUTAGENESIS; WILD TYPE;

CALORIMETRY; CATALYSIS; DIMERIZATION; ESCHERICHIA COLI PROTEINS; FOLIC ACID; HYDROGEN-ION CONCENTRATION; KINETICS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NADP; OSMOLAR CONCENTRATION; PROTEIN BINDING; R FACTORS; SODIUM; SPECTROMETRY, FLUORESCENCE; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS;

FELIS CATUS;

EID: 0042318979     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034643d     Document Type: Article

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