Interligand overhauser effects in type II dihydrofolate reductase

Biochemistry

Volumn 40, Issue 14, 2001, Pages 4242-4252

  Li, D ^a   Levy, L A ^a   Gabel, S A ^a   Lebetkin, M S ^a   DeRose, E F ^a   Wall, M J ^b   Howell, E E ^c   London, R E ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMAL ENZYMES;

BACTERIA; CONCENTRATION (PROCESS); CRYSTAL STRUCTURE; ENZYMES; NUCLEAR MAGNETIC RESONANCE; PROTONS;

BIOCHEMISTRY;

2 DEAMINO 2 METHYL 5,8 DIDEAZAFOLATE; ADENOSINE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE TYPE 2; FOLIC ACID; FOLIC ACID DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NICOTINAMIDE DERIVATIVE; PROTON; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING SITE; CALCULATION; CHEMICAL BOND; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBUNIT; HIGH TEMPERATURE; MOLECULAR INTERACTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN CONFORMATION;

BINDING SITES; CATALYSIS; ESCHERICHIA COLI; FOLIC ACID; KINETICS; LIGANDS; MACROMOLECULAR SUBSTANCES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0035836454     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0026425     Document Type: Article

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