Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemia

Infection and Immunity

Volumn 70, Issue 12, 2002, Pages 6896-6903

  Joshi, Vishwas D ^a   Kalvakolanu, Dhananjaya V ^a   Hebel, John R ^a   Hasday, Jeffrey D ^a   Cross, Alan S ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE INHIBITOR; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; MESSENGER RNA;

ADOLESCENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GRAM NEGATIVE BACTERIUM; HOST RESISTANCE; IMMUNE RESPONSE; INFECTION SENSITIVITY; LETHALITY; MOUSE; NONHUMAN; PRECURSOR; PRIORITY JOURNAL; SEPTIC SHOCK; SPLEEN;

ANIMALS; CASPASE 1; CYTOKINES; DISEASE SUSCEPTIBILITY; ENDOTOXEMIA; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FEMALE; IMMUNITY, NATURAL; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C3H; SEPSIS; UP-REGULATION;

EID: 0036893361     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.12.6896-6903.2002     Document Type: Article

References (43)

1. Akita, K., T. Ohtsuki, Y. Nukada, T. Tanimoto, M. Namba, T. Okura, R. Takakura-Yamamoto, K. Torigoe, Y. Gu, M. S. Su, M. Fujii, M. Satoh-ltoh, K. Yamamoto, K. Kohno, M. Ikeda, and M. Kurimoto. 1997. Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells. J. Biol. Chem. 272:26595-26603.
2. + T cells. J. Immunol. 156:1458-1468.
3. Bohn, E., A. Sing, R. Zumbihl, C. Bielfeldt, H. Okamura, M. Kurimoto, J. Heesemann, and I. B. Autenrieth. 1998. IL-18 (IFN-γ-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice. J. Immunol. 160:299-307.
4. Cross, A., L. Asher, M. Seguin, L. Yuan, N. Kelly, C. Hammack, J. Sadoff, and P. Gemski, Jr. 1995. The importance of a lipopolysaccharide-initiated, cytokine-mediated host defense mechanism in mice against extraintestinally invasive Escherichia coli. J. Clin. Investig. 96:676-686.
5. Cross, A. S., J. C. Sadoff, N. Kelly, E. Bernton, and P. Gemski. 1989. Pretreatment with recombinant murine tumor necrosis factor alpha/cachectin and murine interleukin la protects mice from lethal bacterial infection. J. Exp. Med. 169:2021-2027.
6. De Boer, M. L., J. Hu, D. V. Kalvakolanu, J. D. Hasday, and A. S. Cross. 2001. IFN-γ inhibits lipopolysaccharide-induced interleukin-1β in primary murine macrophages via a Stat1-dependent pathway. J. Interferon Cytokine Res. 21:485-494.
7. Dinarello, C. A. 1999. Interleukin-18. Methods 19:121-132.
8. Dybing, J. K., N. Walters, and D. W. Pascual. 1999. Role of endogenous interleukin-18 in resolving wild-type and attenuated Salmonella typhimurium infections. Infect. Immun. 67:6242-6248.
9. Eckmann, L., and M. F. Kagnoff. 2001. Cytokines in host defense against Salmonella. Microbes Infect. 3:1191-1200.
10. Fantuzzi, G., and C. A. Dinarello. 1999. Interleukin-18 and interleukin-1β: Two cytokine substrates for ICE (caspase-1). J. Clin. Immunol. 19:1-11.
11. Fantuzzi, G., A. J. Puren, M. W. Harding, D. J. Livingston, and C. A. Dinarello. 1998. Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1β-converting enzyme (caspase-1)-deficient mice. Blood 91:2118-2125.
12. Foss, D. L., M. J. Zilliox, and M. P. Murtaugh. 2001. Bacterially induced activation of interleukin-18.in porcine intestinal mucosa. Vet. Immunol. Immunopathol. 78:263-277.
13. Ghayur, T., S. Banerjee, M. Hugunin, D. Butler, L. Herzog, A. Carter, L. Quintal, L. Sekut, R. Talanian, M. Paskind, W. Wong, R. Kamen, D. Tracey, and H. Allen. 1997. Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production. Nature 386:619-623.
14. Gu, Y., K. Kuida, H. Tsutsui, G. Ku, K. Hsiao, M. A. Fleming, N. Hayashi, K. Higashino, H. Okamura, K. Nakanishi, M. Kurimoto, T. Tanimoto, R. A. Flavell, V. Sato, M. W. Harding, D. J. Livingston, and M. S. Su. 1997. Activation of interferon-gamma inducing factor mediated by interleukin-1β converting enzyme. Science 275:206-209.
15. Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis: Evidence for expansion of distinct helper T-cell subsets. J. Exp. Med. 169:59-72.
16. + lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc. Natl. Acad. Sci. USA 88:7011-7015.
17. Hochholzer, P., G. B. Lipford, H. Wagner, K. Pfefrer, and K. Heeg. 2000. Role of interleukin-18 (IL-18) during lethal shock: Decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice. Infect. Immun. 68:3502-3508.
18. Joshi, V. D., J. D. Hasday, R. J. Hebel, and D. V. Kalvakolanu. 2002. Serum IL-18 levels determine outcome of innate immune response to LPS through an positive regulatory feedback loop with caspase-1. J. Immunol. 169:2536-2544.
19. Kamens, J., M. Paskind, M. Hugunin, R. V. Talanian, H. Allen, D. Banach, N. Bump, M. Hackett, C. G. Johnston, P. Li, et al. 1995. Identification and characterization of ICH-2, a novel member of the interleukin-1β-converting enzyme family of cysteine proteases. J. Biol. Chem. 270:15250-15256.
20. Kim, Y. M., R. V. Talanian, J. Li, and T. R. Billiar. 1998. Nitric oxide prevents 1L-1β and IFN-γ-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1β-converting enzyme). J. Immunol. 161:4122-4128.
21. Labow, M., D. Shuster, M. Zetterstrom, P. Nunes, R. Terry, E. B. Cullinan, T. Bartfai, C. Solorzano, L. L. Moldawer, R. Chizzonite, and K. W. Mclntyre. 1997. Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. J. Immunol. 159:2452-2461.
22. Li, P., H. Allen, S. Banerjee, S. Franklin, L. Herzog, C. Johnston, J. McDowell, M. Paskind, L. Rodman, J. Salfeld, et al. 1995. Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock. Cell 80:401-411.
23. Li, P., H. Allen, S. Banerjee, and T. Seshadri. 1997. Characterization of mice deficient in interleukin-1β converting enzyme. J. Cell Biochem. 64:27-32.
24. Livingston, D. J. 1997. In vitro and in vivo studies of ICE inhibitors. J. Cell. Biochem. 64:19-26.
25. Mancilla, J., P. Garcia, and C. A. Dinarello. 1993. The interleukin-1 receptor antagonist can either reduce or enhance the lethality of Klebsiella pneumoniae sepsis in newborn rats. Infect. Immun. 61:926-932.
26. Mastroeni, P., S. Clare, S. Khan, J. A. Harrison, C. E. Hormaeche, H. Okamura, M. Kurimoto, and G. Dougan. 1999. Interleukin-18 contributes to host resistance and gamma interferon production in mice infected with virulent Salmonella typhimurium. Infect. Immun. 67:478-483.
27. Mencacci, A., A. Bacei, E. Cenci, C. Montagnoli, S. Fiorucei, A. Casagrande, R. A. Flavell, F. Bistoni, and L. Romani. 2000. Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice. Infect. Immun. 68:5126-5131.
28. Neighbors, M., X. Xu, F. J. Barrat, S. R. Ruuls, T. Churakova, R. Debets, J. F. Bazan, R. A. Kastelein, J. S. Abrams, and A. O'Garra. 2001. A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on interferon gamma production. J. Exp. Med. 194:343-354.
29. Netea, M. G., G. Fantuzzi, B. J. Kullberg, R. J. Stuyt, E. J. Pulido, R. C. McIntyre, Jr., L. A. Joosten, J. W. van der Meer, and C. A. Dinarello. 2000. Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia. J. Immunol. 164:2644-2649.
30. Ohlsson, K., P. Bjork, M. Bergenfeldt, R. Hageman, and R. C. Thompson. 1990. Interleukin-1 receptor antagonist reduces mortality from endotoxin shock. Nature 348:550-552.
31. Okamura, H., H. Tsutsi, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori, et al. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378:88-91.
32. Pasquali, P., R. Adone, L. C. Gasbarre, C. Pistoia, and F. Ciuchini. 2002. Effect of exogenous interleukin-18 (IL-18) and IL-12 in the course of Brucella abortus 2308 infection in mice. Clin. Diagn. Lab. Immunol. 9:491-492.
33. Rangel-Frausto, M. S. 1999. The epidemiology of bacterial sepsis. Infect. Dis. Clin. N. Am. 13:299-312.
34. Sakao, Y., K. Takeda, H. Tsutsui, T. Kaisho, F. Nomura, H. Okamura, K. Nakanishi, and S. Akira. 1999. IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock. Int. Immunol. 11:471-480.
35. Sansonetti, P. J., A. Phalipon, J. Arondel, K. Thirumalai, S. Banerjee, S. Akira, K. Takeda, and A. Zychlinsky. 2000. Caspase-1 activation of IL-1β and IL-18 are essential for Shigella flexneri-induced inflammation. Immunity 12:581-590.
36. Thornberry, N. A. 1994. Interleukin-1β converting enzyme. Methods Enzymol. 244:615-631.
37. Wakabayashi, G., J. A. Gelfand, J. F. Burke, R. C. Thompson, and C. A. Dinarello. 1991. A specific receptor antagonist for interleukin 1 prevents Escherichia coli-induced shock in rabbits. FASEB J. 5:338-343.
38. Wang, S., M. Miura, Y. K. Jung, H. Zhu, E. Li, and J. Yuan. 1998. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92:501-509.
39. Watson, R. W., O. D. Rotstein, J. Parodo, R. Bitar, J. C. Marshall, R. William, and G. Watson. 1998. The IL-1β-converting enzyme (caspase-1) inhibits apoptosis of inflammatory neutrophils through activation of IL-1β. J. Immunol. 161:957-962.
40. Wei, X. Q., B. P. Leung, W. Niedbala, D. Piedrafita, G. J. Feng, M. Sweet, L. Dobbie, A. J. Smith, and F. Y. Liew. 1999. Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice. J. Immunol. 163:2821-2828.
41. Yamada, H., S. Mizumo, R. Horai, Y. Iwakura, and I. Sugawara. 2000. Protective role of interleukin-1 in mycobacterial infection in IL-1 alpha/beta double-knockout mice. Lab. Investig. 80:759-767.
42. Yamanaka, K., M. Tanaka, H. Tsutsui, T. S. Kupper, K. Asahi, H. Okamura, K. Nakanishi, M. Suzuki, N. Kayagaki, R. A. Black, D. K. Miller, K. Nakashima, M. Shimizu, and H. Mizutani. 2000. Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18. J. Immunol. 165:997-1003.
43. Young, J. L., G. K. Sukhova, D. Foster, W. Kisiel, P. Libby, and U. Schonbeck. 2000. The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1β-converting enzyme (caspase-1) activity in human vascular smooth muscle cells. J. Exp. Med. 191:1535-1544.