-
1
-
-
37549040906
-
-
Mouscadet JF, Tchertanov L, Deprez E. Structure de l'intégrase et rôle dans le cycle viral. Virologie 2007; 11(spécial): S143-52.
-
Mouscadet JF, Tchertanov L, Deprez E. Structure de l'intégrase et rôle dans le cycle viral. Virologie 2007; 11(spécial): S143-52.
-
-
-
-
2
-
-
37549037452
-
-
Cribier A, Emiliani S. Les partenaires cellulaires de l'intégrase du VIH1 : vers de nouvelles cibles thérapeutiques. Virologie 2007 ; 11 (spécial) : S153-62.
-
Cribier A, Emiliani S. Les partenaires cellulaires de l'intégrase du VIH1 : vers de nouvelles cibles thérapeutiques. Virologie 2007 ; 11 (spécial) : S153-62.
-
-
-
-
3
-
-
33750532296
-
A platform for designing HIV integrase inhibitors. Part 2 : A two-metal binding models as a potential mechanism of HIV integrase inhibitors
-
Kawasuji T, Fuji M, Yoshinaga T, Sato A, Fujiwara T, Kiyama R. A platform for designing HIV integrase inhibitors. Part 2 : a two-metal binding models as a potential mechanism of HIV integrase inhibitors. Bioorg Med Chem 2006 ; 14 : 8420-9.
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 8420-8429
-
-
Kawasuji, T.1
Fuji, M.2
Yoshinaga, T.3
Sato, A.4
Fujiwara, T.5
Kiyama, R.6
-
4
-
-
3042843657
-
HIV-1 integrase inhibitors : A decade of research and two drugs in clinical trial
-
Johnson AA, Marchand C, Pommier Y. HIV-1 integrase inhibitors : a decade of research and two drugs in clinical trial. Curr Top Med Chem 2004 ; 4 : 1059-77.
-
(2004)
Curr Top Med Chem
, vol.4
, pp. 1059-1077
-
-
Johnson, A.A.1
Marchand, C.2
Pommier, Y.3
-
6
-
-
0042423356
-
Structure-activity relationships of HIV-1 integrase inhibitors-enzyme-ligand interactions
-
Maurin C, Bailly F, Cotelle P. Structure-activity relationships of HIV-1 integrase inhibitors-enzyme-ligand interactions. Curr Med Chem 2003 ; 10 : 1859-74.
-
(2003)
Curr Med Chem
, vol.10
, pp. 1859-1874
-
-
Maurin, C.1
Bailly, F.2
Cotelle, P.3
-
8
-
-
33845204239
-
A historical sketch of the discovery and development of HIV-1 integrase inhibitors
-
Savarino A. A historical sketch of the discovery and development of HIV-1 integrase inhibitors. Expert Opin Investig Drug 2006 ; 12 : 1507-22.
-
(2006)
Expert Opin Investig Drug
, vol.12
, pp. 1507-1522
-
-
Savarino, A.1
-
10
-
-
0028070994
-
Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds
-
Fesen MR, Pommier Y, Leteurtre F, Hiroguchi S, Yung J, Kohn KW. Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem Pharmacol 1994 ; 48 : 595-608.
-
(1994)
Biochem Pharmacol
, vol.48
, pp. 595-608
-
-
Fesen, M.R.1
Pommier, Y.2
Leteurtre, F.3
Hiroguchi, S.4
Yung, J.5
Kohn, K.W.6
-
11
-
-
0029845980
-
Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules
-
Farnet CM, Wang B, Lipford JR, Bushman FD. Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules. Proc Natl Acad Sci USA 1996 ; 93 : 9742-7.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 9742-9747
-
-
Farnet, C.M.1
Wang, B.2
Lipford, J.R.3
Bushman, F.D.4
-
12
-
-
0031660989
-
Human immunodeficiency virus type 1 cDNA integration : New aromatic hydroxylated inhibitors and studies of the inhibition mechanism
-
Farnet CM, Wang B, Hansen M, et al. Human immunodeficiency virus type 1 cDNA integration : new aromatic hydroxylated inhibitors and studies of the inhibition mechanism. Antimicrob Agents Chemother 1998 ; 42 : 2245-53.
-
(1998)
Antimicrob Agents Chemother
, vol.42
, pp. 2245-2253
-
-
Farnet, C.M.1
Wang, B.2
Hansen, M.3
-
13
-
-
0025312689
-
Anthraquinones as a new class of antiviral agents against human immunodeficiency virus
-
Schinazi RF, Chu CK, Babu JR, et al. Anthraquinones as a new class of antiviral agents against human immunodeficiency virus. Antivir Res 1990 ; 13 : 265-72.
-
(1990)
Antivir Res
, vol.13
, pp. 265-272
-
-
Schinazi, R.F.1
Chu, C.K.2
Babu, J.R.3
-
14
-
-
33846844941
-
Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol : Part I. Fusion inhibition
-
Lee-Huang S, Huang PL, Zhang D, et al. Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol : Part I. Fusion inhibition. Biochem Biophys Res Commun 2007 ; 354 : 872-8.
-
(2007)
Biochem Biophys Res Commun
, vol.354
, pp. 872-878
-
-
Lee-Huang, S.1
Huang, P.L.2
Zhang, D.3
-
15
-
-
33846821864
-
Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol : Part II. Integrase inhibition
-
Lee-Huang S, Huang PL, Zhang D, et al. Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol : Part II. Integrase inhibition. Biochem Biophys Res Commun 2007 ; 354 : 879-84.
-
(2007)
Biochem Biophys Res Commun
, vol.354
, pp. 879-884
-
-
Lee-Huang, S.1
Huang, P.L.2
Zhang, D.3
-
16
-
-
2642685126
-
Inhibitors of HIV-1 replication that inhibit integrase
-
Robinson Jr. WE, Reinecke MG, Abdel-Malek S, Jia Q, Chow SA. Inhibitors of HIV-1 replication that inhibit integrase. Proc Natl Acad Sci USA 1996;93:6326-31.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 6326-6331
-
-
Robinson Jr., W.E.1
Reinecke, M.G.2
Abdel-Malek, S.3
Jia, Q.4
Chow, S.A.5
-
17
-
-
33646269283
-
Anti-human immunodeficiency virus activity of 3,4,5-tricaffeoylquinic acid in cultured cells of lettuce leaves
-
Tamura H, Akioka T, Ueno K, et al. Anti-human immunodeficiency virus activity of 3,4,5-tricaffeoylquinic acid in cultured cells of lettuce leaves. Mol Nutr Food Res 2006 ; 50 : 396-400.
-
(2006)
Mol Nutr Food Res
, vol.50
, pp. 396-400
-
-
Tamura, H.1
Akioka, T.2
Ueno, K.3
-
18
-
-
0030805998
-
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action
-
Mazumder A, Neamati N, Sunder S, et al. Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action. J Med Chem 1997 ; 40 : 3057-63.
-
(1997)
J Med Chem
, vol.40
, pp. 3057-3063
-
-
Mazumder, A.1
Neamati, N.2
Sunder, S.3
-
19
-
-
0037357211
-
HIV-1 integrase inhibitory substances from Coleus parvifolius
-
Tewtrakul S, Miyashiro H, Nakamura N, et al. HIV-1 integrase inhibitory substances from Coleus parvifolius. Phytotherapy Res 2003 ; 17 : 232-9.
-
(2003)
Phytotherapy Res
, vol.17
, pp. 232-239
-
-
Tewtrakul, S.1
Miyashiro, H.2
Nakamura, N.3
-
20
-
-
9844224472
-
Inhibitory effects of Cordia spinescens extracts and their constituents on reverse transcriptase and protease from human immunodeficiency virus
-
Aura Lim Y, Kojima S, Nakamura N, et al. Inhibitory effects of Cordia spinescens extracts and their constituents on reverse transcriptase and protease from human immunodeficiency virus. Phytotherapy Res 1997 ; 11 : 490-5.
-
(1997)
Phytotherapy Res
, vol.11
, pp. 490-495
-
-
Aura Lim, Y.1
Kojima, S.2
Nakamura, N.3
-
21
-
-
0035997934
-
Isolation of two highly potent and non-toxic inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase from Salvia miltiorrhiza
-
Abd-Elazem IS, Chen HS, Bates RB, Huang RCC. Isolation of two highly potent and non-toxic inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase from Salvia miltiorrhiza. Antiviral Res 2002 ; 55 : 91-106.
-
(2002)
Antiviral Res
, vol.55
, pp. 91-106
-
-
Abd-Elazem, I.S.1
Chen, H.S.2
Bates, R.B.3
Huang, R.C.C.4
-
22
-
-
0033594376
-
Chicoric acid analogues as HIV-1 integrase inhibitors
-
Lin Z, Neamati N, Zhao H, et al. Chicoric acid analogues as HIV-1 integrase inhibitors. J Med Chem 1999 ; 42 : 1401-14.
-
(1999)
J Med Chem
, vol.42
, pp. 1401-1414
-
-
Lin, Z.1
Neamati, N.2
Zhao, H.3
-
23
-
-
0031973575
-
Dicaffeoylquinic and dicaffeoyltartaric acids are selective inhibitors of human immunodeficiency virus type 1 integrase
-
McDougall B, King PJ, Wu BW, Hostomsky Z, Reinecke MG, Robinson WE. Dicaffeoylquinic and dicaffeoyltartaric acids are selective inhibitors of human immunodeficiency virus type 1 integrase. Antimicrob Agents Chemother 1998 ; 42 : 140-6.
-
(1998)
Antimicrob Agents Chemother
, vol.42
, pp. 140-146
-
-
McDougall, B.1
King, P.J.2
Wu, B.W.3
Hostomsky, Z.4
Reinecke, M.G.5
Robinson, W.E.6
-
24
-
-
10244260392
-
Dicaffeoylquinic acid inhibitors of human immunodeficiency virus integrase : Inhibition of the core catalytic domain of human immunodeficiency virus integrase
-
Robinson WE, Cordeiro M, Abdel-Malek S, et al. Dicaffeoylquinic acid inhibitors of human immunodeficiency virus integrase : inhibition of the core catalytic domain of human immunodeficiency virus integrase. Mol Pharmacol 1996 ; 50 : 846-55.
-
(1996)
Mol Pharmacol
, vol.50
, pp. 846-855
-
-
Robinson, W.E.1
Cordeiro, M.2
Abdel-Malek, S.3
-
25
-
-
0031685017
-
Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase
-
King PJ, Robinson WE. Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase. J Virol 1998 ; 72 : 8420-4.
-
(1998)
J Virol
, vol.72
, pp. 8420-8424
-
-
King, P.J.1
Robinson, W.E.2
-
26
-
-
0033856959
-
Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters
-
Pluymers W, Neamati N, Pannecouque C, et al. Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters. Mol Pharmacol 2000 ; 58 : 641-8.
-
(2000)
Mol Pharmacol
, vol.58
, pp. 641-648
-
-
Pluymers, W.1
Neamati, N.2
Pannecouque, C.3
-
27
-
-
0031875905
-
Styrylquinoline derivatives : A new class of potent HIV-1 integrase inhibitors that block HIV replication in CEM cells
-
Mekouar K, Mouscadet JF, Desmaële D, et al. Styrylquinoline derivatives : a new class of potent HIV-1 integrase inhibitors that block HIV replication in CEM cells. J Med Chem 1998 ; 41 : 2846-57.
-
(1998)
J Med Chem
, vol.41
, pp. 2846-2857
-
-
Mekouar, K.1
Mouscadet, J.F.2
Desmaële, D.3
-
28
-
-
1642495629
-
Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro
-
Deprez E, Barbe S, Kolaski M, et al. Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro. Mol Pharmacol 2004 ; 65 : 85-98.
-
(2004)
Mol Pharmacol
, vol.65
, pp. 85-98
-
-
Deprez, E.1
Barbe, S.2
Kolaski, M.3
-
29
-
-
2442660260
-
Styrylquinolines, integrase inhibitors acting prior to integration : A new mechanism of action for anti-integrase agents
-
Bonnenfant S, Thomas CM, Vita C, et al. Styrylquinolines, integrase inhibitors acting prior to integration : a new mechanism of action for anti-integrase agents. J Virol 2004 ; 78 : 5728-36.
-
(2004)
J Virol
, vol.78
, pp. 5728-5736
-
-
Bonnenfant, S.1
Thomas, C.M.2
Vita, C.3
-
30
-
-
0034723439
-
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
-
Hazuda DJ, Felock P, Witmer M, et al. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 2000 ; 287 : 646-50.
-
(2000)
Science
, vol.287
, pp. 646-650
-
-
Hazuda, D.J.1
Felock, P.2
Witmer, M.3
-
31
-
-
34547108566
-
New developments in diketo-containing inhibitors of HIV-1 integrase
-
Zhao G, Wang C, Liu C, Lou H. New developments in diketo-containing inhibitors of HIV-1 integrase. Mini Rev Med Chem 2007 ; 7 : 707-25.
-
(2007)
Mini Rev Med Chem
, vol.7
, pp. 707-725
-
-
Zhao, G.1
Wang, C.2
Liu, C.3
Lou, H.4
-
32
-
-
0041353616
-
Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S)
-
Marchand C, Johnson AA, Karki RG, et al. Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S). Mol Pharmacol 2003 ; 64 : 600-9.
-
(2003)
Mol Pharmacol
, vol.64
, pp. 600-609
-
-
Marchand, C.1
Johnson, A.A.2
Karki, R.G.3
-
33
-
-
12944270496
-
HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase
-
Espeseth AS, Felock P, Wolfe A, et al. HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase. Proc Natl Acad Sci USA 2000 ; 97 : 11244-9.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 11244-11249
-
-
Espeseth, A.S.1
Felock, P.2
Wolfe, A.3
-
34
-
-
6044232037
-
Spectroscopic studies of diketoacids-metal interactions. A probing tool for the pharmacophoric intermetallic distance in the HIV-1 integrase active site
-
Maurin C, Bailly F, Buisine E, et al. Spectroscopic studies of diketoacids-metal interactions. A probing tool for the pharmacophoric intermetallic distance in the HIV-1 integrase active site. J Med Chem 2004 ; 47 : 5583-6.
-
(2004)
J Med Chem
, vol.47
, pp. 5583-5586
-
-
Maurin, C.1
Bailly, F.2
Buisine, E.3
-
35
-
-
33745825934
-
From ligand to complexes : Inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes
-
Sechi M, Bacchi A, Carcelli M, et al. From ligand to complexes : inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes. J Med Chem 2006 ; 49 : 4248-60.
-
(2006)
J Med Chem
, vol.49
, pp. 4248-4260
-
-
Sechi, M.1
Bacchi, A.2
Carcelli, M.3
-
36
-
-
0037076324
-
Diketo acid inhibitor mechanism and HIV-1 integrase : Implications for metal binding in the active site of phosphotransferase enzymes
-
Grobler JA, Stillmock K, Hu B, et al. Diketo acid inhibitor mechanism and HIV-1 integrase : implications for metal binding in the active site of phosphotransferase enzymes. Proc Natl Acad Sci USA 2002 ; 99 : 6661-6.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 6661-6666
-
-
Grobler, J.A.1
Stillmock, K.2
Hu, B.3
-
37
-
-
0037066730
-
Structural determinants for HIV-1 integrase inhibition by beta-diketo acids
-
Marchand C, Zhang X, Pais CG, et al. Structural determinants for HIV-1 integrase inhibition by beta-diketo acids. J Biol Chem 2002 ; 277 : 12596-603.
-
(2002)
J Biol Chem
, vol.277
, pp. 12596-12603
-
-
Marchand, C.1
Zhang, X.2
Pais, C.G.3
-
38
-
-
37549051065
-
-
Preparation of indole derivatives with antiviral activity. Fujishita T, Yoshinaga T. (Shionogi &Co., Ltd., Japan) PCT Int Appl 1999, WO 9950245.
-
Preparation of indole derivatives with antiviral activity. Fujishita T, Yoshinaga T. (Shionogi &Co., Ltd., Japan) PCT Int Appl 1999, WO 9950245.
-
-
-
-
40
-
-
13044295993
-
Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor : A platform for antiviral drug design
-
Goldgur Y, Craigie R, Cohen GH, et al. Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor : a platform for antiviral drug design. Proc Natl Acad Sci USA 1999 ; 96 : 13040-3.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 13040-13043
-
-
Goldgur, Y.1
Craigie, R.2
Cohen, G.H.3
-
41
-
-
0037303182
-
S-1360 Shionogi-GlaxoSmithKline
-
Billich A. S-1360 Shionogi-GlaxoSmithKline. Curr Opin Investig Drugs 2003 ; 4 : 206-9.
-
(2003)
Curr Opin Investig Drugs
, vol.4
, pp. 206-209
-
-
Billich, A.1
-
42
-
-
0037434509
-
Design and synthesis of 8-hydroxy- [1,6]-naphthyridines as novel inhibitors of HIV-1 integrase in vitro and infected cells
-
Zhuang L, Wai JS, Embrey MW, et al. Design and synthesis of 8-hydroxy- [1,6]-naphthyridines as novel inhibitors of HIV-1 integrase in vitro and infected cells. J Med Chem 2003 ; 46 : 453-6.
-
(2003)
J Med Chem
, vol.46
, pp. 453-456
-
-
Zhuang, L.1
Wai, J.S.2
Embrey, M.W.3
-
44
-
-
33644863638
-
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics
-
Sato M, Motomura T, Aramaki H, et al. Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. J Med Chem 2006 ; 49 : 1506-8.
-
(2006)
J Med Chem
, vol.49
, pp. 1506-1508
-
-
Sato, M.1
Motomura, T.2
Aramaki, H.3
-
45
-
-
34247611806
-
Dihydroxypyrimidine-4- carboxamides as novel potent and selective HIV integrase inhibitors
-
Pace P, Di Francesco ME, Gardelli C, et al. Dihydroxypyrimidine-4- carboxamides as novel potent and selective HIV integrase inhibitors. J Med Chem 2007 ; 50 : 2225-39.
-
(2007)
J Med Chem
, vol.50
, pp. 2225-2239
-
-
Pace, P.1
Di Francesco, M.E.2
Gardelli, C.3
-
46
-
-
33845366857
-
Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals
-
Markowitz M, Morales-Ramirez JO, Nguyen BY, et al. Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals. J Acquir Immune Defic Syndr 2006 ; 43 : 509-15.
-
(2006)
J Acquir Immune Defic Syndr
, vol.43
, pp. 509-515
-
-
Markowitz, M.1
Morales-Ramirez, J.O.2
Nguyen, B.Y.3
-
47
-
-
4043173359
-
Efficient 3D database screening for novel HIV-1 IN inhibitors
-
Barreca ML, Rao A, De Luca L, et al. Efficient 3D database screening for novel HIV-1 IN inhibitors. J Chem Inf Comput Sci 2004 ; 44 : 1450-5.
-
(2004)
J Chem Inf Comput Sci
, vol.44
, pp. 1450-1455
-
-
Barreca, M.L.1
Rao, A.2
De Luca, L.3
-
48
-
-
33644861936
-
Integration requires a specific interaction of the donor DNA terminal 5′-cytosine with glutamine 148 of the HIV-1 integrase flexible loop
-
Johnson AA, Santos W, Pais GC, et al. Integration requires a specific interaction of the donor DNA terminal 5′-cytosine with glutamine 148 of the HIV-1 integrase flexible loop. J Biol Chem 2006 ; 281 : 461-7.
-
(2006)
J Biol Chem
, vol.281
, pp. 461-467
-
-
Johnson, A.A.1
Santos, W.2
Pais, G.C.3
-
49
-
-
34447263572
-
Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance
-
Lataillade M, Chiarella J, Kozal MJ. Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance. Antivir Ther 2007 ; 12 : 563-70.
-
(2007)
Antivir Ther
, vol.12
, pp. 563-570
-
-
Lataillade, M.1
Chiarella, J.2
Kozal, M.J.3
-
51
-
-
0032544311
-
Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor : High level of similarity of the active site with other viral integrases
-
Maignan S, Guilloteau JP, Zhou-Liu Q, Clement-Mella C, Mikol V. Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor : high level of similarity of the active site with other viral integrases. J Mol Biol 1998 ; 28 : 359-68.
-
(1998)
J Mol Biol
, vol.28
, pp. 359-368
-
-
Maignan, S.1
Guilloteau, J.P.2
Zhou-Liu, Q.3
Clement-Mella, C.4
Mikol, V.5
|