Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 18, 1996, Pages 9742-9747

  Farnet, Chris M ^a   Wang, Beibei ^a   Lipford, J Russell ^b,c   Bushman, Frederic D ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALIZARIN; ALIZARIN RED S; ANTHRAQUINONE DERIVATIVE; ANTIVIRUS AGENT; EMODIN; INTEGRASE; INTEGRASE INHIBITOR; PURPURIN; QUINALIZARIN; QUINIZARIN; VIRUS PROTEIN;

ARTICLE; DRUG MECHANISM; DRUG POTENCY; ENZYME PURIFICATION; ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTHRAQUINONES; ANTIVIRAL AGENTS; BASE SEQUENCE; DNA; DNA NUCLEOTIDYLTRANSFERASES; DNA TOPOISOMERASES, TYPE I; DNA, COMPLEMENTARY; ESCHERICHIA COLI; HIV-1; INTEGRASES; MOLECULAR SEQUENCE DATA; RNA, VIRAL; THYMINE NUCLEOTIDES; VIRUS INTEGRATION; VIRUS REPLICATION; ZIDOVUDINE;

EID: 0029845980     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.18.9742     Document Type: Article

References (40)

1. Brown, P. O. (1990) Curr. Top. Microbiol. Immunol. 157, 19-48.
2. Farnet, C. M. & Bushman, F. D. (1996) AIDS, in press.
3. Brown, P. O., Bowerman, B., Varmus, H. E. & Bishop, J. M. (1987) Cell 49, 347-356.
4. Ellison, V. H., Abrams, H., Roe, T., Lifson, J. & Brown, P.O. (1990) J. Virol. 64, 2711-2715.
5. Farnet, C. M. & Haseltine, W. A. (1990) Proc. Natl. Acad. Sci USA 87, 4164-4168.
6. Bushman, F. D., Fujiwara, T. & Craigie, R. (1990) Science 249, 1555-1558.
7. Bushman, F. D. & Craigie, R. (1990) J. Virol. 64, 5645-5648.
8. Craigie, R., Fujiwara, T. & Bushman, F. (1990) Cell 62, 829-837.
9. Katzman, M., Katz, R. A., Skalka, A. M. & Leis, J. (1989) J. Virol. 63, 5319-5327.
10. Sherman, P. A. & Fyfe, J. A. (1990) Proc. Natl. Acad. Sci. USA 87, 5119-5123.
11. Bushman, F. D. & Craigie, R. (1991) Proc. Natl. Acad. Sci. USA 88, 1339-1343.
12. Chow, S. A., Vincent, K. A., Ellison, V. & Brown, P. O. (1992) Science 255, 723-726.
13. Chow, S. A. & Brown, P. O. (1994) J. Virol. 68, 3896-3907.
14. Fesen, M., Pommier, Y., Leteurtve, F., Hiroguchi, S., Yung, J. & Kohn, K. (1994) Biochem. Pharmacol. 48, 595-608.
15. Mazumder, A., Raghavan, K., Weinstein, J., Kohn, K. W. & Pommier, Y. (1995) Biochem. Pharmacol. 49, 1165-1170.
16. Mazumder, A., Gupta, M., Perrin, D., Sigman, D., Rabinovitz, M. & Pommier, Y. (1995) AIDS Res. Hum. Retroviruses 11, 115-125.
17. Puras Lutzke, R. A., Eppens, N. A., Weber, P. A., Houghten, R. A. & Plasterk, R. H. A. (1996) Proc. Natl. Acad. Sci. USA 92, 11456-11460.
18. LaFemina, R., Graham, P., LeGrow, K., Hastings, J., Wolfe, A., et al. (1995) Antimicrob. Agents Chemother. 39, 320-324.
19. Billich, A., Schauer, M., Frank, S., Rosenwirth, B. & Billich, S. (1992) Antiviral Chem. Chemother. 3, 113-119.
20. Carteau, S., Mouscadet, J. F., Goulaouic, H., Subra, F. & Auclair, C. (1993) Biochem. Biophys. Res. Commun. 192, 1409-1414.
21. Carteau, S., Mouscadet, J. F., Goulaouic, H., Subra, F. & Auclair, C. (1993) Arch. Biochem. Biophys. 305, 606-610.
22. Cushman, M. & Sherman, P. (1992) Biochem. Biophys. Res. Commun. 185, 85-90.
23. Cushman, M., Golegiewski, W., Pommier, Y., Mazumder, A., Reymen, D., et al. (1995) J. Med. Chem. 38, 443-452.
24. Mazumder, A., Cooney, D., Agbaria, R., Gupta, M. & Pommier, Y. (1994) Proc. Natl. Acad. Sci. USA 91, 5771-5775.
25. Lipford, J. R., Worland, S. T. & Farnet, C. M. (1994) J. Acquired Immune Defic. Syndr. 7, 1215-1223.
26. Mazumder, A., Gazit, A., Levitzki, A., Nicklaus, M., Yung, J., et al. (1995) Biochemistry 34, 15111-15122.
27. Fesen, M. R., Kohn, K. W., Leteurtre, F. & Pommier, Y. (1993) Proc. Natl. Acad. Sci. USA 90, 2399-2403.
28. Jenkins, T., Hickman, A., Dyda, F., Ghirlando, R., Davies, D. & Craigie, R. (1995) Proc. Natl. Acad. Sci. USA 92, 6057-6061.
29. Hickman, A. B., Palmer, L, Engelman, A., Craigie, R. & Wingfield, P. (1994) J. Biol. Chem. 269, 29279-29287.
30. Ellison, V. & Brown, P. O. (1994) Proc. Natl. Acad. Sci. USA 91, 7316-7320.
31. Miller, M., Bor, Y.-C. & Bushman, F. D. (1995) Curr. Biol. 5, 1047-1056.
32. Engelman, A. & Craigie, R. (1995) J. Virol. 69, 5908-5911.
33. Mitsuya, A., Looney, D., Kuno, S., Ueno, R., Wong-Staal, F. & Broder, S. (1988) Science 249, 646-649.
34. Schols, D., Baba, M., Pauwels, R., Desmyter, J. & De Celrcq, E. (1989) Proc. Natl. Acad. Sci. USA 86, 3322-3326.
35. Bor, Y.-C, Miller, M., Bushman, F. & Orgel, L. (1996) Virology, in press.
36. Bukrinsky, M., Sharova, N., McDonald, T., Pushkarskaya, T., Tarpley, G. & Stevenson, M. (1993) Proc. Natl. Acad. Sci. USA 90, 6125-6129.
37. Gallay, P., Swingler, S., Aiken, C. & Trono, D. (1995) Cell 80, 379-388.
38. Gallay, P., Swingler, S., Song, J., Bushman, F. & Trono, D. (1995) Cell 17, 569-576.
39. Schinazi, R., Chu, C, Babu, J., Oswald, B., Saalmann, V., et al. (1990) Antiviral Res. 13, 265-272.
40. Higuchi, H., Mori, K., Kato, A., Ohkuma, T., Endo, T., et al. (1991) Antiviral Res. 15, 205-216.