Spectroscopic studies of diketoacids-metal interactions. A probing tool for the pharmacophoric intermetallic distance in the HIV-1 integrase active site

Journal of Medicinal Chemistry

Volumn 47, Issue 22, 2004, Pages 5583-5586

  Maurin, Cédric ^a   Bailly, Fabrice ^a   Buisine, Eric ^a   Vezin, Hervé ^a   Mbemba, Gladys ^b   Mouscadet, Jean François ^b   Cotelle, Philippe ^a  

^a UNIV LILLE   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHENYL 4 OXO 2 HYDROXYBUTEN 2 OIC ACID DERIVATIVE; BENZOYLPYRUVIC ACID; CATION; INTEGRASE; PYRUVIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; HUMAN IMMUNODEFICIENCY VIRUS 1; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METAL BINDING; MOLECULAR DYNAMICS; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

CATIONS, DIVALENT; ELECTRON SPIN RESONANCE SPECTROSCOPY; HIV INTEGRASE; LIGANDS; MAGNESIUM; MANGANESE; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRUVIC ACID;

EID: 6044232037     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0408464     Document Type: Article

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