Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters

Molecular Pharmacology

Volumn 58, Issue 3, 2000, Pages 641-648

  Pluymers, Wim ^a   Neamati, Nouri ^b   Pannecouque, Christophe ^a   Fikkert, Valery ^a   Marchand, Christophe ^b   Burke Jr , Terrence R ^b   Pommier, Yves ^b   Schols, Dominique ^a   De Clercq, Erik ^a   Debyser, Zeger ^a   Witvrouw, Myriam ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CICHORIC ACID; ESTER; GLYCOPROTEIN GP 120; INTEGRASE;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG STRUCTURE; GENE; GENOTYPE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; LYMPHOID CELL; NONHUMAN; PRIORITY JOURNAL; VIRUS REPLICATION;

EID: 0033856959     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.3.641     Document Type: Article

References (41)

1. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
2. Isolation of a T-lymphotropic retrovirus from a patient at risk for AIDS
3. Green coffee beans may yield new class of anti-HIV-1 agents
4. Synthesis and structure-activity relationship of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker
5. Integration of retroviral DNA
6. Mode of interaction of G-quartets in the integrase of human immunodeficiency virus type 1
7. High-level expression of active HIV-1 integrase from a synthetic gone in human cells
8. Long-term persistent infection of macaque monkeys with simian immunodeficiency virus
9. The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication
10. Assays for the Evaluation of HIV-1 Integrase Inhibitors
11. Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir)
12. Development of resistance of human immunodeficiency virus type 1 to dextran sulfate associated with the emergence of specific mutations in the envelope gp120 glycoprotein
13. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 counts of 200 per cubic millimeter or less
14. Integration complexes derived from HIV vectors for rapid assays in vitro
15. Infection of HTLV-III/LAV in HTLV-I carrying cells MT-2 and MT-4: An application in a plaque assay
16. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
17. Nucleoside V. The monomesylates of 1-(2'-deoxy-β-D-lyxofuranosyl) thymine
18. Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates
19. A soluble active mutant of HIV-1 integrase: Involvement of both the core and carboxyl-terminal domains in multimerization
20. Structure-activity relationships: Analogues of dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication
21. Resistance to the anti-human immunodeficiency virus type 1 compound 1-chicoric acid results from a single mutation at amino acid 140 of integrase
22. Chicoric acid analogues as HIV-1 integrase inhibitors
23. Inhibition of HIV infection by caffeoylquinic acid derivatives
24. Retroviral integrase: A novel target in antiviral development. Basic in vitro assays with the purified enzyme
25. Dicaffeoylquinic and dicaffeoyltartaric acids are selective inhibitors of human immunodeficiency virus type 1 integrase
26. Design and discovery of HIV-1 integrase inhibitors
27. Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives
28. Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds
29. HIV-1 integrase as a target for antiviral drugs
30. Detection, isolation and continuous production of cytopathic retrovirus (HTLV-III) from patients with AIDS or pre-AIDS
31. Suppression of immunodeficiency virus type 1 activity in vitro by oligonucleotides which form intramolecular tetrads
32. L-chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of zidovudine plus a protease inhibitor (AG1350)
33. Dicaffeoylquinic acid inhibitors of human immunodeficiency virus integrase: Inhibition of the core catalytic domain of human immunodeficiency virus integrase
34. Inhibitors of HIV-1 replication that inhibit HIV integrase
35. Mutations in retroviral genes associated with drug resistance
36. T-cell-line-tropic human immunodeficiency virus type 1 that is made resistant to stromal cell-derived factor 1α contains mutations in the envelope gp120 but does not show a switch in coreceptor use
37. Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4
38. HIV integrase: A target for AIDS therapeutics
39. Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale
40. Facile syntheses of (2R,3R)-(-)- and (2S,3S)-(+)-chicoric acids
41. Irreversible inhibition of human immunodeficiency virus type 1 integrase by dicaffeoylquinic acids