Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors

Journal of Medicinal Chemistry

Volumn 50, Issue 9, 2007, Pages 2225-2239

  Pace, Paola ^a   Di Francesco, M Emilia ^a   Gardelli, Cristina ^a   Harper, Steven ^a   Muraglia, Ester ^a   Nizi, Emanuela ^a   Orvieto, Federica ^a   Petrocchi, Alessia ^a   Poma, Marco ^a,b   Rowley, Michael ^a   Scarpelli, Rita ^a   Laufer, Ralph ^a   Paz, Odalys Gonzalez ^a   Monteagudo, Edith ^a   Bonelli, Fabio ^a   Hazuda, Daria ^a   Stillmock, Kara A ^a   Summa, Vincenzo ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Merck Research Laboratories ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 [(DIMETHYLAMINO)PHENYLMETHYL] N (4 FLUOROBENZYL) 5,6 DIHYDROXYPYRIMIDINE 4 CARBOXAMIDE; 2 [1 (DIMETHYLAMINO) 1 METHYLETHYL] N (4 FLUOROBENZYL) 5,6 DIHYDROXYPYRIMIDINE 4 CARBOXAMIDE; AMIDE; INTEGRASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CATALYSIS; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MONKEY; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD PROTEINS; CELL LINE, TUMOR; DOGS; HALF-LIFE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; MACACA MULATTA; PROTEIN BINDING; PYRIDINES; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 34247611806     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070027u     Document Type: Article

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