Isolation of two highly potent and non-toxic inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase from Salvia miltiorrhiza

Antiviral Research

Volumn 55, Issue 1, 2002, Pages 91-106

  Abd Elazem, Ibrahim S ^a   Chen, Hong S ^b   Bates, Robert B ^c   Huang, Ru Chih C ^d  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^c UNIVERSITY OF ARIZONA   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

HIV 1; HIV 1 integrase; HPLC; Inhibition; Inhibitors; Purification

Indexed keywords

ANTIVIRUS AGENT; ENZYME INHIBITOR; INTEGRASE; LITHOSPERMIC ACID; LITHOSPERMIC ACID B; RNA DIRECTED DNA POLYMERASE; SALVIA MILTIORRHIZA EXTRACT; UNCLASSIFIED DRUG; VIRUS DNA; BENZOFURAN DERIVATIVE; DEPSIDE; PLANT EXTRACT;

ARTICLE; CATABOLISM; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG PURIFICATION; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SALVIA MILTIORRHIZA; STRUCTURE ANALYSIS; VIRUS INFECTION; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; ENZYMOLOGY; ISOLATION AND PURIFICATION; PLANT ROOT; VIRUS REPLICATION;

BENZOFURANS; CELL LINE; DNA, VIRAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HIV INTEGRASE; HIV-1; HUMAN; MAGNETIC RESONANCE SPECTROSCOPY; PLANT EXTRACTS; PLANT ROOTS; SALVIA MILTIORRHIZA; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; VIRUS REPLICATION; DEPSIDES; HUMANS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SALVIA; SALVIA MILTIORRHIZA;

EID: 0035997934     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(02)00011-6     Document Type: Article

References (55)

1. The plant ribosome inactivating proteins luffin and saporin are potent inhibitors of HIV-1 integrase
2. Retroviral integration: Structure of the initial covalent complex and its precursor and a role for the viral IN protein
3. Retroviral DNA integration directed by HIV integration protein in vitro
4. Antioxidant activities of caffeic acid and its related hydroxycinnamic acid compounds
5. Tanshinone production in Ti-transformed Salvia miltiorrhiza cell suspension cultures
6. Jiang su xin yi yuan
7. In vitro assays for activities of retroviral integrase
8. Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication
9. Human immunodeficiency virus glycoprotein gp 120 as the primary target for the antiviral action of AR177 (Zintevir)
10. Genetics of retroviral integration
11. Structure of HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design
12. Preventive effect of lithospermate B from Salvia miltiorrhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide
13. Isolation and characterization of novel human immunodeficiency virus integrase inhibitors from fungal metabolites
14. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
15. Mechanism of inhibition of HIV-1 integrase by G-tetra forming oligonucleotides
16. Endothelium-dependent vasodilator effects of the extract from Salvia miltiorrhiza radix. A study on the identification of lithospermic acid B in the extracts
17. Hypotensive effects of lithospermic acid B isolated from the extract of Salvia miltiorrhiza radix in the rat
18. Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase
19. Structure-activity relationship: Analogues of the dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication
20. Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells
21. Antibacterial activities of cryptotanshinone and dihydrotanshinone I from a medicinal herb, Salvia miltiorrhiza bunge
22. Chicoric acid analogues as HIV-1 integrase inhibitors
23. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes
24. Effect of Salvia miltiorrhiza on aflatoxin B1-induced oxidative stress in cultured rat hepatocytes
25. Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action
26. Styrylquinoline derivatives: A new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells
27. Production of lithospermic acid B and rosmarinic acid in callus tissue and regenerated plantlets of Salvia miltiorrhiza
28. Depside and depsidones as inhibitors of HIV-1 integrase: Discovery of novel inhibitors through 3-D database searching
29. Potent inhibitors of human immunodeficiency virus type 1 integrase: Identification of a novel four-point pharmacophore and tetracyclines as novel inhibitors
30. Salicylhydrazine-contaning inhibtors of HIV-1 integrase active site
31. Thiazolothiazepine inhibtors of HIV-1 integrase
32. Inhibition of endothelial cell-mediated oxidation of low-density lipoprotein by rosemary and plant phenolics
33. Retroviral integrase inhibitors year 2000: Update and perspectives
34. Lamellarin α-20 sulfate, an inhibitor of HIV-1 integrase active against HIV-1 virus in cell culture
35. L-chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of zidovudine plus a protease inhibitor (AG1350)
36. Analysis of mutations in the integration function of Moloney murine leukemia virus: Effects on DNA binding and cutting
37. Inhibition of mast cell degranulation by tanshinones from the roots of Salvia miltiorrhiza
38. Integration is essential for efficient gene expression of human immunodeficiency virus type 1
39. Genetic analysis of the human immunodeficiency virus type 1 integrase protein
40. Synthesis of full-length viral DNA in CD4-positive membrane vesicles exposed to HIV-1
41. Structure and absolute stereochemistry of HIV-1 integrase inhibitor integric acid. A novel eremophilane sesquiterpenoid produced by Xylariai sp
42. The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I. New complestatins, A and B, and acid-hydrolysis products of chloropeptin I
43. Recognition and inhibition of HIV integrase by novel dinucleotides
44. Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV integrase
45. Magnesium and ammonium-potassium lithospermates B, the active principles having a uremia-preventive effect from Salvia miltiorrhiza
46. Cytotoxic activity of epidermal growth factor-genistein against breast cancer cells
47. Monoclonal antibodies specific for p24, the major core protein of human T-cell leukemia virus type III
48. Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex
49. Solution structure of anti-HIV-1 and anti-tumor protein MAP30: Structural insights into its multiple functions
50. HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
51. Inhibition of HIV integrase by novel nucleotides bearing tricyclic bases
52. Irreversible inhibition of human immunodeficiency virus type 1 integrase by dicaffeoylquinic acids
53. Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture