Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part II. Integrase inhibition

Biochemical and Biophysical Research Communications

Volumn 354, Issue 4, 2007, Pages 879-884

  Lee Huang, Sylvia ^a   Huang, Philip Lin ^b   Zhang, Dawei ^a   Lee, Jae Wook ^c   Bao, Ju ^c   Sun, Yongtao ^a   Chang, Young Tae ^c   Zhang, John ^c   Huang, Paul Lee ^d  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b American Biosciences   (United States)

^c NEW YORK UNIVERSITY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

AIDS; HIV 1; HIV 1 integrase inhibitor; Hydroxytyrosol (HT); Molecular modeling; Natural product; Oleuropein (Ole); Olive leaf extract (OLE); Small molecule HIV 1 inhibitors; Structure function

Indexed keywords

AMINO ACID; HYDROXYTYROSOL; INTEGRASE; INTEGRASE INHIBITOR; OLEUROPEIN;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; INHIBITION KINETICS; MOLECULAR DOCKING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; TARGET CELL;

CATALYTIC DOMAIN; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; MODELS, MOLECULAR; PHENYLETHYL ALCOHOL; PYRANS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33846821864     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.01.058     Document Type: Article

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