Selective thymus settling regulated by cytokine and chemokine receptors

Journal of Immunology

Volumn 178, Issue 4, 2007, Pages 2008-2017

  Schwarz, Benjamin A ^a   Sambandam, Arivazhagan ^a   Maillard, Ivan ^a   Harman, Benjamin C ^a   Love, Paul E ^b   Bhandoola, Avinash ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR9; CYTOKINE RECEPTOR; VASCULOTROPIN RECEPTOR 1;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL LINEAGE; CELL SPECIFICITY; CONTROLLED STUDY; FEMALE; HEMATOPOIETIC STEM CELL; LYMPHOPOIESIS; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMUS;

EID: 33846902089     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.4.2008     Document Type: Article

References (65)

1. Miller, J. F., and D. Osoba. 1967. Current concepts of the immunological function of the thymus. Physiol. Rev. 47: 437-520.
2. Goldschneider, I., K. L. Komschlies, and D. L. Greiner. 1986. Studies of thymocytopoiesis in rats and mice. I. Kinetics of appearance of thymocytes using a direct intrathymic adoptive transfer assay for thymocyte precursors. J. Exp. Med. 163: 1-17.
3. Scollay, R., J. Smith, and V. Stauffer. 1986. Dynamics of early T cells: prothymocyte migration and proliferation in the adult mouse thymus. Immunol. Rev. 91: 129-157.
4. Shortman, K., and L. Wu. 1996. Early T lymphocyte progenitors. Annu. Rev. Immunol. 14: 29-47.
5. Foss, D. L., E. Donskoy, and I. Goldschneider. 2001. The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice. J. Exp. Med. 193: 365-374.
6. Donskoy, E., and I. Goldschneider. 1992. Thymocytopoiesis is maintained by blood-borne precursors throughout postnatal life: a study in parabiotic mice. J. Immunol. 148: 1604-1612.
7. Wallis, V. J., E. Leuchars, S. Chwalinski, and A. J. Davies. 1975. On the sparse seeding of bone marrow and thymus in radiation chimaeras. Transplantation 19: 2-11.
8. Kadish, J. L., and R. S. Basch. 1976. Hematopoietic thymocyte precursors. I. Assay and kinetics of the appearance of progeny. J. Exp. Med. 143: 1082-1099.
9. Spangrude, G. J., and R. Scollay. 1990. Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes: kinetics and phenotype of progeny. J. Immunol. 145: 3661-3668.
10. Bhandoola, A., and A. Sambandam. 2006. From stem cell to T cell: one route or many? Nat. Rev. Immunol. 6: 117-126.
11. Morrison, S. J., N. Uchida, and I. L. Weissman. 1995. The biology of hematopoietic stem cells. Annu. Rev. Cell. Dev. Biol. 11: 35-71.
12. + stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 15: 659-669.
13. Christensen, J. L., and I. L. Weissman. 2001. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc. Natl. Acad. Sci. USA 98: 14541-14546.
14. Kondo, M., I. L. Weissman, and K. Akashi. 1997. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91: 661-672.
15. + lymphoid-restricted bone marrow cells with T precursor potential. Nat. Immunol. 4: 866-873.
16. - hematopoietic progenitor with potent lymphoid and myeloid developmental potential. Eur. J. Immunol. 35: 2019-2030.
17. Wright, D. E., A. J. Wagers, A. P. Gulati, F. L. Johnson, and I. L. Weissman. 2001. Physiological migration of hematopoietic stem and progenitor cells. Science 294: 1933-1936.
18. Schwarz, B. A., and A. Bhandoola. 2004. Circulating hematopoietic progenitors with T lineage potential. Nat. Immunol. 5: 953-960.
19. Cyster, J. G. 2005. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 23: 127-159.
20. Rosen, S. D. 2004. Ligands for L-selectin: homing, inflammation, and beyond. Annu. Rev. Immunol. 22: 129-156.
21. von Andrian, U. H., and T. R. Mempel. 2003. Homing and cellular traffic in lymph nodes. Nat. Rev. Immunol. 3: 867-878.
22. Lesley, J., R. Hyman, and R. Schulte. 1985. Evidence that the Pgp-1 glycoprotein is expressed on thymus-homing progenitor cells of the thymus. Cell. Immunol. 91: 397-403.
23. Wu, L., P. W. Kincade, and K. Shortman. 1993. The CD44 expressed on the earliest intrathymic precursor population functions as a thymus homing molecule but does not bind to hyaluronate. Immunol. Lett. 38: 69-75.
24. Rossi, F. M., S. Y. Corbel, J. S. Merzaban, D. A. Carlow, K. Gossens, J. Duenas, L. So, L. Yi, and H. J. Ziltener. 2005. Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Nat. Immunol. 6: 626-634.
25. Zaballos, A., J. Gutierrez, R. Varona, C. Ardavin, and G. Marquez. 1999. Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J. Immunol. 162: 5671-5675.
26. Vicari, A. P., D. J. Figueroa, J. A. Hedrick, J. S. Foster, K. P. Singh, S. Menon, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, K. B. Bacon, and A. Zlotnik. 1997. TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity 7: 291-301.
27. + gut intraepithelial lymphocytes. Blood 98: 2626-2632.
28. Benz, C., K. Heinzel, and C. C. Bleul. 2004. Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development. Eur. J. Immunol. 34: 3652-3663.
29. Uehara, S., A. Grinberg, J. M. Farber, and P. E. Love. 2002. A role for CCR9 in T lymphocyte development and migration. J. Immunol. 168: 2811-2819.
30. Wurbel, M. A., B. Malissen, and J. J. Campbell. 2006. Complex regulation of CCR9 at multiple discrete stages of T cell development. Eur. J. Immunol. 36: 73-81.
31. Scimone, M. L., I. Aifantis, I. Apostolou, H. von Boehmer, and U. H. von Andrian. 2006. A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus. Proc. Natl. Acad. Sci. USA 103: 7006-7011.
32. Liu, C., T. Ueno, S. Kuse, F. Saito, T. Nitta, L. Kali, H. Nakano, T. Kakiuchi, M. Lipp, G. A. Hollander, and Y. Takahama. 2005. The role of CCL21 in recruitment of T precursor cells to fetal thymi. Blood 105: 31-39.
33. Liu, C., F. Saito, Z. Liu, Y. Lei, S. Uehara, P. Love, M. Lipp, S. Kondo, N. Manley, and Y. Takahama. 2006. Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization. Blood 108: 2531-2539.
34. Benz, C., and C. C. Bleul. 2005. A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision. J. Exp. Med. 202: 21-31.
35. Sambandam, A., I. Maillard, V. P. Zediak, L. Xu, R. M. Gerstein, J. C. Aster, W. S. Pear, and A. Bhandoola. 2005. Notch signaling controls the generation and differentiation of early T lineage progenitors. Nat. Immunol. 6: 663-670.
36. Tan, J. B., I. Visan, J. S. Yuan, and C. J. Guidos. 2005. Requirement for Notch1 signals at sequential early stages of intrathymic T cell development. Nat. Immunol. 6: 671-679.
37. Zediak, V. P., I. Maillard, and A. Bhandoola. 2005. Closer to the source: notch and the nature of thymus-settling cells. Immunity 23: 245-248.
38. Sitnicka, E., D. Bryder, K. Theilgaard-Monch, N. Buza-Vidas, J. Adolfsson, and S. E. Jacobsen. 2002. Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool. Immunity 17: 463-472.
39. Mackarehtschian, K., J. D. Hardin, K. A. Moore, S. Boast, S. P. Goff, and I. R. Lemischka. 1995. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 3: 147-161.
40. Igarashi, H., S. Gregory, T. Yokota, N. Sakaguchi, and P. Kincade. 2002. Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. Immunity 17: 117-130.
41. Yu, W., H. Nagaoka, M. Jankovic, Z. Misulovin, H. Suh, A. Rolink, F. Melchers, E. Meffre, and M. C. Nussenzweig. 1999. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature 400: 682-687.
42. Mori, S., K. Shortman, and L. Wu. 2001. Characterization of thymus-seeding precursor cells from mouse bone marrow. Blood 98: 696-704.
43. Till, J. E., and E. A. McCulloch. 1961. Direct measurement of radiation sensitivity of normal mouse bone marrow cells. Radiat. Res. 14: 213-222.
44. Maillard, I., B. A. Schwarz, A. Sambandam, T. Fang, O. Shestova, L. Xu, A. Bhandoola, and W. S. Pear. 2006. Notch-dependent T lineage commitment occurs at extrathymic sites following bone marrow transplantation. Blood 107: 3511-3519.
45. Zubkova, I., H. Mostowski, and M. Zaitseva. 2005. Up-regulation of IL-7, stromal-derived factor-1α, thymus-expressed chemokine, and secondary lymphoid tissue chemokine gene expression in the stromal cells in response to thymocyte depletion: implication for thymus reconstitution. J. Immunol. 175: 2321-2330.
46. Porritt, H. E., K. Gordon, and H. T. Petrie. 2003. Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice. J. Exp. Med. 198: 957-962.
47. Allman, D., A. Sambandam, S. Kim, J. P. Miller, A. Pagan, D. Well, A. Meraz, and A. Bhandoola. 2003. Thymopoiesis independent of common lymphoid progenitors. Nat. Immunol. 4: 168-174.
48. Okada, S., H. Nakauchi, K. Nagayoshi, S. Nishikawa, S. Nishikawa, Y. Miura, and T. Suda. 1991. Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule. Blood 78: 1706-1712.
49. Spangrude, G. J., S. Heimfeld, and I. L. Weissman. 1988. Purification and characterization of mouse hematopoietic stem cells. Science 241: 58-62.
50. Ikuta, K., and I. L. Weissman. 1992. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc. Natl. Acad. Sci. USA 89: 1502-1506.
51. - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 150: 4244-4252.
52. Pearse, M., L. Wu, M. Egerton, A. Wilson, K. Shortman, and R. Scollay. 1989. A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor. Proc. Natl. Acad. Sci. USA 86: 1614-1618.
53. Petric, H. 2003. Cell migration and the control of post-natal T cell lymphopoiesis in the thymus. Nat. Rev. Immunol. 3: 859-866.
54. Perry, S. S., R. S. Welner, T. Kouro, P. W. Kincade, and X. H. Sun. 2006. Primitive lymphoid progenitors in bone marrow with T lineage reconstituting potential. J. Immunol. 177: 2880-2887.
55. Singh, H., and J. M. Pongubala. 2006. Gene regulatory networks and the determination of lymphoid cell fates. Curr. Opin. Immunol. 18: 116-120.
56. Maillard, I., T. Fang, and W. S. Pear. 2005. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu. Rev. Immunol. 23: 945-974.
57. Rothenberg, E. V., and T. Taghon. 2005. Molecular genetics of T cell development. Annu. Rev. Immunol. 23: 601-649.
58. Bubnic, S. J., A. Nagy, and A. Keating. 2005. Donor hematopoietic cells from transgenic mice that express GFP are immunogenic in immunocompetent recipients. Hematology 10: 289-295.
59. + lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell 121: 295-306.
60. Lai, A. Y., and M. Kondo. 2006. Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors. J. Exp. Med. 203: 1867-1873.
61. Lancrin, C., E. Schneider, F. Lambolez, M. L. Arcangeli, C. Garcia-Cordier, B. Rocha, and S. Ezine. 2002. Major T cell progenitor activity in bone marrow-derived spleen colonies. J. Exp. Med. 195: 919-929.
62. Suda, T., F. Arai, and A. Hirao. 2005. Hematopoietic stem cells and their niche. Trends Immunol. 26: 426-433.
63. Krueger, A., A. I. Garbe, and H. von Boehmer. 2006. Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands. J. Exp. Med. 203: 1977-1984.
64. Massa, S., G. Balciunaite, R. Ceredig, and A. G. Rolink. 2006. Critical role for c-kit (CD117) in T cell lineage commitment and early thymocyte development in vitro. Eur. J. Immunol. 36: 526-532.
65. Hoflinger, S., K. Kesavan, M. Fuxa, C. Mutter, B. Heavey, F. Radtke, and M. Busslinger. 2004. Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors. J. Immunol. 173: 3935-3944.