The basic helix-loop-helix transcription factor HEBAlt is expressed in pro-T cells and enhances the generation of t cell precursors

Journal of Immunology

Volumn 177, Issue 1, 2006, Pages 109-119

  Wang, Duncheng ^a   Claus, Carol L ^a   Vaccarelli, Giovanna ^a   Braunstein, Marsela ^a   Schmitt, Thomas M ^a   Zúñiga Pflücker, Juan Carlos ^a   Rothenberg, Ellen V ^b   Anderson, Michele K ^a  

^a Sunnybrook Health Sciences Centre   (Canada)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; HELIX LOOP HELIX PROTEIN; MESSENGER RNA; NOTCH RECEPTOR; PROTEIN HEBCAN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2A; TRANSCRIPTION FACTOR HEB; TRANSCRIPTION FACTOR HEBALT; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL LINEAGE; CELL MATURATION; CELL SPECIFICITY; COCULTURE; CONTROLLED STUDY; DNA BINDING; DNA LIBRARY; E BOX ELEMENT; EXON; GENE CONTROL; GENE LOCUS; HEMATOPOIETIC STEM CELL; LYMPHOCYTE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRE T LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; RETROVIRUS; SIGNAL TRANSDUCTION; STEM CELL; T LYMPHOCYTE; THYMOCYTE; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSGENE;

EID: 33745321679     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.1.109     Document Type: Article

References (42)

1. Rothenberg, E. V., and M. K. Anderson. 2002. Elements of transcription factor network design for T-lineage specification. Dev. Biol. 246: 29-44.
2. Quong, M. W., M. E. Massari, R. Zwart, and C. Murre. 1993. A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells. Mol. Cell. Biol. 13: 792-800.
3. Benezra, R., R. L. Davis, D. Lockshon, D. L. Turner, and H. Weintraub. 1990. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61: 49-59.
4. Greenbaum, S., and Y. Zhuang. 2002. Regulation of early lymphocyte development by E2A family proteins. Semin. Immunol. 14: 405-414.
5. Engel, I., and C. Murre. 2001. The function of E- and Id proteins in lymphocyte development. Nat. Rev. Immunol. 1: 193-199.
6. Heemskerk, M. H., B. Blom, G. Nolan, A. P. Stegmann, A. Q. Bakker, K. Weijer, P. C. Res, and H. Spits. 1997. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3. J. Exp. Med. 186: 1597-1602.
7. Morrow, M. A., E. W. Mayer, C. A. Perez, M. Adlam, and G. Siu. 1999. Overexpression of the helix-loop-helix protein Id2 blocks T cell development at multiple stages. Mol. Immunol. 36: 491-503.
8. Allman, D., A. Sambandam, S. Kim, J. P. Miller, A. Pagan, D. Well, A. Meraz, and A. Bhandoola. 2003. Thymopoiesis independent of common lymphoid progenitors. Nat. Immunol. 4: 168-174.
9. Bain, G., I. Engel, E. C. Robanus Maandag, H. P. te Riele, J. R. Voland, L. L. Sharp, J. Chun, B. Huey, D. Pinkel, and C. Murre. 1997. E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas. Mol. Cell. Biol. 17: 4782-4791.
10. Engel, I., C. Johns, G. Bain, R. R. Rivera, and C. Murre. 2001. Early thymocyte development is regulated by modulation of E2A protein activity. J. Exp. Med. 194: 733-745.
11. Bamdt, R., M. F. Dai, and Y. Zhuang. 1999. A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during αβ thymopoiesis. J. Immunol. 163: 3331-3343.
12. Zhuang, Y., P. Cheng, and H. Weintraub. 1996. B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. Mol. Cell. Biol. 16: 2898-2905.
13. Buer, J., I. Aifantis, J. P. DiSanto, H. J. Fehling, and H. von Boehmer. 1997. Role of different T cell receptors in the development of pre-T cells. J. Exp. Med. 185: 1541-1547.
14. Takeda, J., A. Cheng, F. Mauxion, C. A. Nelson, R. D. Newberry, W. C. Sha, R. Sen, and D. Y. Loh. 1990. Functional analysis of the murine T-cell receptor β enhancer and characteristics of its DNA-binding proteins. Mol. Cell. Biol. 10: 5027-5035.
15. Ghosh, J. K., W. J. Romanow, and C. Murre. 2001. Induction of a diverse T cell receptor γ/δ repertoire by the helix-loop-helix proteins E2A and HEB in non-lymphoid cells. J. Exp. Med. 193: 769-776.
16. Langerak, A. W., I. L. Wolvers-Tettero, E. J. van Gastel-Mol, M. E. Oud, and J. J. van Dongen. 2001. Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells. Blood 98: 2456-2465.
17. Hsu, L. Y., J. Lauring, H. E. Liang, S. Greenbaum, D. Cado, Y. Zhuang, and M. S. Schlissel. 2003. A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. Immunity 19: 105-117.
18. Takeuchi, A., S. Yamasaki, K. Takase, F. Nakatsu, H. Arase, M. Onodera, and T. Saito. 2001. E2a and HEB activate the pre-TCRα promote during immature T cell development. J. Immunol. 167: 2157-2163.
19. Petersson, K., F. Ivars, and M. Sigvardsson. 2002, The pTα promoter and enhancer are direct targets for transactivation by E box-binding proteins. Eur. J. Immunol. 32:911-920.
20. Barndt, R. J., M. Dai, and Y. Zhuang. 2000. Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. Mol. Cell. Biol. 20: 6677-6685.
21. Engel, I., and C. Murre. 2004. E2A proteins enforce a proliferation checkpoint in developing thymocytes. EMBO J. 23: 202-211.
22. Anderson, M. K., A. H. Weiss, G. Hernández-Hoyos, C. J. Dionne, and E. V. Rothenberg. 2002. Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage. Immunity 16: 285-296.
23. Yui, M. A., and E. V. Rothenberg. 2004. Deranged early T cell development in immunodeficient strains of nonobese diabetic mice. J. Immunol. 173: 5381-5391.
24. Dionne, C. J., K. Y. Tse, A. H. Weiss, C. B. Franco, D. L. Wiest, M. K. Anderson, and E. V. Rothenberg. 2005. Subversion of T lineage commitment by PU.1 in a clonal cell line system. Dev. Biol. 280: 448-466.
25. Anderson, M. K., G. Hernández-Hoyos, R. A. Diamond, and E. V. Rothenberg. 1999. Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage. Development 126: 3131-3148.
26. Okazaki, Y., M. Furuno, T. Kasukawa, J. Adachi, H. Bono, S. Kondo, I. Nikaido, N. Osato, R. Saito, H. Suzuki, et al. 2002. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature 420: 563-573.
27. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215: 403-410.
28. Hernández-Hoyos, G., M. K. Anderson, C. Wang, E. V. Rothenberg, and J. Alberola-Ila. 2003. GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation. Immunity 19: 83-94.
29. Klein, E. S., D. M. Simmons, L. W. Swanson, and M. G. Rosenfeld. 1993. Tissue-specific RNA splicing generates an ankyrin-like domain that affects the dimerization and DNA-binding properties of a bHLH protein. Genes Dev. 7: 55-71.
30. Schmitt, T. M., and J. C. Zúñga-Pflücker. 2002. Induction of T cell development from hematopoietic progenitor cells by Delta-like-1 in vitro. Immunity 17: 749-756.
31. Skerjanc, I. S., J. Truong, P. Filion, and M. W. McBurney. 1996. A splice variant of the ITF-2 transcript encodes a transcription factor that inhibits MyoD activity. J. Biol. Chem. 271: 3555-3561.
32. Carleton, M., N. R. Ruetsch, M. A. Berger, M. Rhodes, S. Kaptik, and D. L. Wiest. 1999. Signals transduced by CD3ε, but not by surface pre-TCR complexes, are able to induce maturation of an early thymic lymphoma in vitro. J. Immunol. 163: 2576-2585.
33. DeKoter, R. P., and H. Singh. 2000. Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science 288: 1439-1441.
34. Zúñiga-Pflücker, J. C. 2004. T-cell development made simple. Nat. Rev. Immunol. 4: 67-72.
35. Radtke, F., A. Wilson, G. Stark, M. Bauer, J. van Meerwijk, H. R. MacDonald, and M. Aguet. 1999. Deficient T cell fate specification in mice with an induced inactivation of Notch 1. Immunity 10: 547-558.
36. Peschon, J. J., P. J. Morrissey, K. H. Grabstein, F. J. Ramsdell, E. Maraskovsky, B. C. Gliniak, L. S. Park, S. F. Ziegler, D. E. Williams, C. B. Ware, et al. 1994. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180: 1955-1960.
37. Pagliuca, A., P. Gallo, P. De Luca, and L. Lania. 2000. Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth. Cancer Res. 60: 1376-1382.
38. Deed, R. W., E. Hara, G. T. Atherton, G. Peters, and J. D. Norton. 1997. Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation. Mol. Cell. Biol. 17: 6815-6821.
39. Engel, I., and C. Murre. 1999. Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas. Proc. Natl Acad. Sci. USA 96: 996-1001.
40. Prabhu, S., A. Ignatova, S. T. Park, and X. H. Sun. 1997. Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins. Mol. Cell. Biol. 17: 5888-5896.
41. Zhang, J., M. Kalkum, S. Yamamura, B. T. Chait, and R. G. Roeder. 2004. E protein silencing by the leukemogenic AML1-ETO fusion protein. Science 305: 1286-1289.
42. Zhao, F., A. Vilardi, R. J. Neely, and J. K. Choi. 2001. Promotion of cell cycle progression by basic helix-loop-helix E2a. Mol. Cell. Biol. 21: 6346-6357.