XIAP inhibits caspase-3 and -7 using two binding sites: Evolutionary conserved mechanism of IAPs

EMBO Journal

Volumn 24, Issue 3, 2005, Pages 645-655

  Scott, Fiona L ^a   Denault, Jean Bernard ^a   Riedl, Stefan J ^a,b   Shin, Hwain ^a,c   Renatus, Martin ^a,d   Salvesen, Guy S ^a  

^a BURNHAM INSTITUTE   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c UNIVERSITY OF BASEL   (Switzerland)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Apoptosis; BIR domain; Caspase; IAP; Protease

Indexed keywords

CASPASE 3; CASPASE 7; EPITOPE; INHIBITOR OF APOPTOSIS PROTEIN; PROTEINASE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; X LINKED INHIBITOR OF APOPTOSIS;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BACULOVIRUS IAP REPEAT DOMAIN; BINDING SITE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBUNIT; HUMAN; HUMAN CELL; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BINDING SITES; CASPASE 3; CASPASE 7; CASPASES; CELL LINE; CONSERVED SEQUENCE; EVOLUTION, MOLECULAR; HUMANS; KINETICS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

INTRACISTERNAL A-PARTICLES; UNIDENTIFIED BACULOVIRUS;

EID: 14844323968     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600544     Document Type: Article

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