-
2
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 2001; 411: 355-365.
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
3
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science 2002; 298: 1912-1934.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
4
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
5
-
-
0034722888
-
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
-
Hidalgo M, Rowinsky EK. The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 2000; 19: 6680-6686.
-
(2000)
Oncogene
, vol.19
, pp. 6680-6686
-
-
Hidalgo, M.1
Rowinsky, E.K.2
-
6
-
-
0036362181
-
Why the epidermal growth factor receptor? The rationale for cancer therapy
-
Baselga J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist 2002; 7 (Suppl 4): 2-8.
-
(2002)
Oncologist
, vol.7
, Issue.SUPPL. 4
, pp. 2-8
-
-
Baselga, J.1
-
7
-
-
18644386251
-
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains
-
Ogiso H, Ishitani R, Nureki O et al. Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell 2002; 110: 775-787.
-
(2002)
Cell
, vol.110
, pp. 775-787
-
-
Ogiso, H.1
Ishitani, R.2
Nureki, O.3
-
8
-
-
0033779765
-
Single-molecule imaging of EGFR signalling on the surface of living cells
-
Sako Y, Minoghchi S, Yanagida T. Single-molecule imaging of EGFR signalling on the surface of living cells. Nat Cell Biol 2000; 2: 168-172.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 168-172
-
-
Sako, Y.1
Minoghchi, S.2
Yanagida, T.3
-
9
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000; 103: 211-225.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
10
-
-
0030795612
-
The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions
-
Alroy I, Yarden Y. The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett 1997; 410: 83-86.
-
(1997)
FEBS Lett
, vol.410
, pp. 83-86
-
-
Alroy, I.1
Yarden, Y.2
-
11
-
-
0031900740
-
Signal transduction through MAP kinase cascades
-
Lewis TS, Shapiro PS, Ahn NG. Signal transduction through MAP kinase cascades. Adv Cancer Res 1998; 74: 49-139.
-
(1998)
Adv Cancer Res
, vol.74
, pp. 49-139
-
-
Lewis, T.S.1
Shapiro, P.S.2
Ahn, N.G.3
-
12
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone MH, Roy N, Stennicke HR et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998; 282: 1318-1321.
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
-
13
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
14
-
-
0028168569
-
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity
-
Guy PM, Platko JV, Cantley LC, Cerione RA, Carraway KL, III. Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc Natl Acad Sci U S A 1994; 91: 8132-8136.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 8132-8136
-
-
Guy, P.M.1
Platko, J.V.2
Cantley, L.C.3
Cerione, R.A.4
Carraway III, K.L.5
-
15
-
-
0030944455
-
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
-
Graus-Porta D, Beerli RR, Daly JM, Hynes NE. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J 1997; 16: 1647-1655.
-
(1997)
EMBO J
, vol.16
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.R.2
Daly, J.M.3
Hynes, N.E.4
-
16
-
-
0028893444
-
Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling
-
Graus-Porta D, Beerli RR, Hynes NE. Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling. Mol Cell Biol 1995; 15: 1182-1191.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 1182-1191
-
-
Graus-Porta, D.1
Beerli, R.R.2
Hynes, N.E.3
-
17
-
-
0034773992
-
The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities
-
Yarden Y. The EGFR family and its ligands in human cancer: signalling mechanisms and therapeutic opportunities. Eur J Cancer 2001; 37 (Suppl 4): S3-S8.
-
(2001)
Eur J Cancer
, vol.37
, Issue.SUPPL. 4
-
-
Yarden, Y.1
-
18
-
-
0029831041
-
Quantitative immunohistochemical analysis of transforming growth factor-alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck
-
Rubin GJ, Melhem MF, Barnes EL, Tweardy DJ. Quantitative immunohistochemical analysis of transforming growth factor-alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck. Cancer 1996; 78: 1284-1292.
-
(1996)
Cancer
, vol.78
, pp. 1284-1292
-
-
Rubin, G.J.1
Melhem, M.F.2
Barnes, E.L.3
Tweardy, D.J.4
-
19
-
-
0035447953
-
Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: Implications for a standardized scoring system
-
Goldstein NS, Armin M. Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: implications for a standardized scoring system. Cancer 2001; 92: 1331-1346.
-
(2001)
Cancer
, vol.92
, pp. 1331-1346
-
-
Goldstein, N.S.1
Armin, M.2
-
20
-
-
0030980781
-
Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression
-
Rusch V, Klimstra D, Venkatraman E, Pisters PW, Langenfeld J, Dmitrovsky E. Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression. Clin Cancer Res 1997; 3: 515-522.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 515-522
-
-
Rusch, V.1
Klimstra, D.2
Venkatraman, E.3
Pisters, P.W.4
Langenfeld, J.5
Dmitrovsky, E.6
-
21
-
-
33645322927
-
Epithelial growth factor receptor status in primary and recurrent ovarian cancer
-
Stadlmann S, Gueth U, Reiser U et al. Epithelial growth factor receptor status in primary and recurrent ovarian cancer. Mod Pathol 2006; 19: 607-610.
-
(2006)
Mod Pathol
, vol.19
, pp. 607-610
-
-
Stadlmann, S.1
Gueth, U.2
Reiser, U.3
-
22
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
-
Shigematsu H, Lin L, Takahashi T II et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 2005; 97: 339-346.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi II, T.3
-
23
-
-
10844231985
-
Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications
-
Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T, Mitsudomi T. Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res 2004; 64: 8919-8923.
-
(2004)
Cancer Res
, vol.64
, pp. 8919-8923
-
-
Kosaka, T.1
Yatabe, Y.2
Endoh, H.3
Kuwano, H.4
Takahashi, T.5
Mitsudomi, T.6
-
24
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004; 304: 1497-1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
25
-
-
0036286452
-
Mutant epidermal growth factor receptors as targets for cancer therapy
-
Lorimer IA. Mutant epidermal growth factor receptors as targets for cancer therapy. Curr Cancer Drug Targets 2002; 2: 91-102.
-
(2002)
Curr Cancer Drug Targets
, vol.2
, pp. 91-102
-
-
Lorimer, I.A.1
-
26
-
-
0033841640
-
Co-expression of epidermal growth factor receptor and transforming growth factor-alpha is independent of ras mutations in lung adenocarcinoma
-
Hsieh ET, Shepherd FA, Tsao MS. Co-expression of epidermal growth factor receptor and transforming growth factor-alpha is independent of ras mutations in lung adenocarcinoma. Lung Cancer 2000; 29: 151-157.
-
(2000)
Lung Cancer
, vol.29
, pp. 151-157
-
-
Hsieh, E.T.1
Shepherd, F.A.2
Tsao, M.S.3
-
27
-
-
0032944473
-
Complex post-transcriptional regulation of EGF-receptor expression by EGF and TGF-alpha in human prostate cancer cells
-
Seth D, Shaw K, Jazayeri J, Leedman PJ. Complex post-transcriptional regulation of EGF-receptor expression by EGF and TGF-alpha in human prostate cancer cells. Br J Cancer 1999; 80: 657-669.
-
(1999)
Br J Cancer
, vol.80
, pp. 657-669
-
-
Seth, D.1
Shaw, K.2
Jazayeri, J.3
Leedman, P.J.4
-
28
-
-
0032780384
-
Expression of transforming growth factor-alpha and epidermal growth factor receptor in gastrointestinal stromal tumours
-
Cai YC, Jiang Z, Vittimberga F et al. Expression of transforming growth factor-alpha and epidermal growth factor receptor in gastrointestinal stromal tumours. Virchows Arch 1999; 435: 112-115.
-
(1999)
Virchows Arch
, vol.435
, pp. 112-115
-
-
Cai, Y.C.1
Jiang, Z.2
Vittimberga, F.3
-
29
-
-
0034693634
-
Co-expression of epidermal growth factor receptor and transforming growth factor-alpha predicts worse prognosis in breast-cancer patients
-
Umekita Y, Ohi Y, Sagara Y, Yoshida H. Co-expression of epidermal growth factor receptor and transforming growth factor-alpha predicts worse prognosis in breast-cancer patients. Int J Cancer 2000; 89: 484-497.
-
(2000)
Int J Cancer
, vol.89
, pp. 484-497
-
-
Umekita, Y.1
Ohi, Y.2
Sagara, Y.3
Yoshida, H.4
-
30
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon DJ, Godolphin W, Jones LA et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989; 244: 707-712.
-
(1989)
Science
, vol.244
, pp. 707-712
-
-
Slamon, D.J.1
Godolphin, W.2
Jones, L.A.3
-
31
-
-
0025901048
-
Amplification and overexpression of the EGF receptor and c-erbB-2 proto-oncogenes in human stomach cancer
-
Lemoine NR, Jain S, Silvestre F et al. Amplification and overexpression of the EGF receptor and c-erbB-2 proto-oncogenes in human stomach cancer. Br J Cancer 1991; 64: 79-83.
-
(1991)
Br J Cancer
, vol.64
, pp. 79-83
-
-
Lemoine, N.R.1
Jain, S.2
Silvestre, F.3
-
32
-
-
0034761739
-
HER2 as a prognostic factor in breast cancer
-
Menard S, Fortis S, Castiglioni F, Agresti R, Balsari A. HER2 as a prognostic factor in breast cancer. Oncology 2001; 61 (Suppl 2): 67-72.
-
(2001)
Oncology
, vol.61
, Issue.SUPPL. 2
, pp. 67-72
-
-
Menard, S.1
Fortis, S.2
Castiglioni, F.3
Agresti, R.4
Balsari, A.5
-
33
-
-
0035874981
-
Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells
-
Molina MA, Codony-Servat J, Albanell J, Rojo F, Arribas J, Baselga J. Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. Cancer Res 2001; 61: 4744-4749.
-
(2001)
Cancer Res
, vol.61
, pp. 4744-4749
-
-
Molina, M.A.1
Codony-Servat, J.2
Albanell, J.3
Rojo, F.4
Arribas, J.5
Baselga, J.6
-
34
-
-
0037434791
-
-
Cho HS, Mason K, Ramyar KX et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 2003; 421: 756-760.
-
Cho HS, Mason K, Ramyar KX et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 2003; 421: 756-760.
-
-
-
-
35
-
-
0037106273
-
Targeting the epidermal growth factor receptor for cancer therapy
-
Mendelsohn J. Targeting the epidermal growth factor receptor for cancer therapy. J Clin Oncol 2002; 20 (18 Suppl) 1S-13S.
-
(2002)
J Clin Oncol
, vol.20
, Issue.18 SUPPL.
-
-
Mendelsohn, J.1
-
36
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd FA, Rodrigues PJ, Ciuleanu T et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005; 353: 123-132.
-
(2005)
N Engl J Med
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues, P.J.2
Ciuleanu, T.3
-
37
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351: 337-345.
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
38
-
-
33646706078
-
Cetuximab plus radiotherapy for head and neck cancer
-
Hartig F, Pechlaner C. Cetuximab plus radiotherapy for head and neck cancer. N Engl J Med 2006; 354: 2187.
-
(2006)
N Engl J Med
, vol.354
, pp. 2187
-
-
Hartig, F.1
Pechlaner, C.2
-
39
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001; 344: 783-792.
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
40
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
Geyer CE, Forster J, Lindquist D et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006; 355: 2733-2743.
-
(2006)
N Engl J Med
, vol.355
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
-
41
-
-
0034092011
-
Tumor angiogenesis: Past, present and the near future
-
Kerbel RS. Tumor angiogenesis: past, present and the near future. Carcinogenesis 2000; 21: 505-515.
-
(2000)
Carcinogenesis
, vol.21
, pp. 505-515
-
-
Kerbel, R.S.1
-
42
-
-
0033565540
-
VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
-
Asahara T, Takahashi T, Masuda H et al. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO J 1999; 18: 3964-3972.
-
(1999)
EMBO J
, vol.18
, pp. 3964-3972
-
-
Asahara, T.1
Takahashi, T.2
Masuda, H.3
-
43
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285: 1182-1186.
-
(1971)
N Engl J Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
44
-
-
0024384470
-
Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
-
Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989; 161: 851-858.
-
(1989)
Biochem Biophys Res Commun
, vol.161
, pp. 851-858
-
-
Ferrara, N.1
Henzel, W.J.2
-
45
-
-
0031039243
-
The biology of vascular endothelial growth factor
-
Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997; 18: 4-25.
-
(1997)
Endocr Rev
, vol.18
, pp. 4-25
-
-
Ferrara, N.1
Davis-Smyth, T.2
-
46
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
47
-
-
0029920054
-
Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein
-
Siemeister G, Weindel K, Mohrs K, Barleon B, Martiny-Baron G, Marme D. Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res 1996; 56: 2299-2301.
-
(1996)
Cancer Res
, vol.56
, pp. 2299-2301
-
-
Siemeister, G.1
Weindel, K.2
Mohrs, K.3
Barleon, B.4
Martiny-Baron, G.5
Marme, D.6
-
48
-
-
0029083832
-
Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: A potential mechanism for inflammatory angiogenesis
-
Ben Av P, Crofford LJ, Wilder RL, Hla T. Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: a potential mechanism for inflammatory angiogenesis. FEBS Lett 1995; 372: 83-87.
-
(1995)
FEBS Lett
, vol.372
, pp. 83-87
-
-
Ben, A.P.1
Crofford, L.J.2
Wilder, R.L.3
Hla, T.4
-
50
-
-
0032549799
-
Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
-
Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998; 92: 735-745.
-
(1998)
Cell
, vol.92
, pp. 735-745
-
-
Soker, S.1
Takashima, S.2
Miao, H.Q.3
Neufeld, G.4
Klagsbrun, M.5
-
51
-
-
0036306121
-
Vascular growth factors and lymphangiogenesis
-
Jussila L, Alitalo K. Vascular growth factors and lymphangiogenesis. Physiol Rev 2002; 82: 673-700.
-
(2002)
Physiol Rev
, vol.82
, pp. 673-700
-
-
Jussila, L.1
Alitalo, K.2
-
52
-
-
0037699954
-
The biology of VEGF and its receptors
-
Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9: 669-676.
-
(2003)
Nat Med
, vol.9
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
LeCouter, J.3
-
53
-
-
30944440262
-
Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF)
-
Byrne AM, Bouchier-Hayes DJ, Harmey JH. Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J Cell Mol Med 2005; 9: 777-794.
-
(2005)
J Cell Mol Med
, vol.9
, pp. 777-794
-
-
Byrne, A.M.1
Bouchier-Hayes, D.J.2
Harmey, J.H.3
-
54
-
-
0028968307
-
Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells
-
Mandriota SJ, Seghezzi G, Vassalli JD et al. Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells. J Biol Chem 1995; 270: 9709-9716.
-
(1995)
J Biol Chem
, vol.270
, pp. 9709-9716
-
-
Mandriota, S.J.1
Seghezzi, G.2
Vassalli, J.D.3
-
55
-
-
0026321129
-
Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells
-
Pepper MS, Ferrara N, Orci L, Montesano R. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 1991; 181: 902-906.
-
(1991)
Biochem Biophys Res Commun
, vol.181
, pp. 902-906
-
-
Pepper, M.S.1
Ferrara, N.2
Orci, L.3
Montesano, R.4
-
56
-
-
0031870786
-
Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro
-
Lamoreaux WJ, Fitzgerald ME, Reiner A, Hasty KA, Charles ST. Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro. Microvasc Res 1998; 55: 29-42.
-
(1998)
Microvasc Res
, vol.55
, pp. 29-42
-
-
Lamoreaux, W.J.1
Fitzgerald, M.E.2
Reiner, A.3
Hasty, K.A.4
Charles, S.T.5
-
57
-
-
0029929716
-
The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis
-
Clauss M, Weich H, Breier G et al. The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J Biol Chem 1996; 271: 17629-17634.
-
(1996)
J Biol Chem
, vol.271
, pp. 17629-17634
-
-
Clauss, M.1
Weich, H.2
Breier, G.3
-
58
-
-
0028090642
-
Vascular endothelial growth factor and glioma angiogenesis: Coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms
-
Plate KH, Breier G, Weich HA, Mennel HD, Risau W. Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int J Cancer 1994; 59: 520-529.
-
(1994)
Int J Cancer
, vol.59
, pp. 520-529
-
-
Plate, K.H.1
Breier, G.2
Weich, H.A.3
Mennel, H.D.4
Risau, W.5
-
59
-
-
3042548695
-
Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
-
Inai T, Mancuso M, Hashizume H et al. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol 2004; 165: 35-52.
-
(2004)
Am J Pathol
, vol.165
, pp. 35-52
-
-
Inai, T.1
Mancuso, M.2
Hashizume, H.3
-
60
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307: 58-62.
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
61
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-2342.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
62
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006; 355: 2542-2550.
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
63
-
-
33749445317
-
Ranibizumab for neovascular age-related macular degeneration
-
Rosenfeld PJ, Brown DM, Heier JS et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006; 355: 1419-1431.
-
(2006)
N Engl J Med
, vol.355
, pp. 1419-1431
-
-
Rosenfeld, P.J.1
Brown, D.M.2
Heier, J.S.3
-
64
-
-
0022626874
-
A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family
-
Besmer P, Murphy JE, George PC et al. A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature 1986; 320: 415-421.
-
(1986)
Nature
, vol.320
, pp. 415-421
-
-
Besmer, P.1
Murphy, J.E.2
George, P.C.3
-
65
-
-
2742529418
-
Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand
-
Yarden Y, Kuang WJ, Yang-Feng T et al. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 1987; 6: 3341-3351.
-
(1987)
EMBO J
, vol.6
, pp. 3341-3351
-
-
Yarden, Y.1
Kuang, W.J.2
Yang-Feng, T.3
-
66
-
-
0036769119
-
Regulation and targets of receptor tyrosine kinases
-
Pawson T. Regulation and targets of receptor tyrosine kinases. Eur J Cancer 2002; 38 (Suppl 5): S3-S10.
-
(2002)
Eur J Cancer
, vol.38
, Issue.SUPPL. 5
-
-
Pawson, T.1
-
67
-
-
0034993741
-
Classes of c-KIT activating mutations: Proposed mechanisms of action and implications for disease classification and therapy
-
Longley BJ, Reguera MJ, Ma Y. Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy. Leuk Res 2001; 25: 571-576.
-
(2001)
Leuk Res
, vol.25
, pp. 571-576
-
-
Longley, B.J.1
Reguera, M.J.2
Ma, Y.3
-
68
-
-
0027477388
-
Interspecies molecular chimeras of kit help define the binding site of the stem cell factor
-
Lev S, Blechman J, Nishikawa S, Givol D, Yarden Y. Interspecies molecular chimeras of kit help define the binding site of the stem cell factor. Mol Cell Biol 1993; 13: 2224-2234.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 2224-2234
-
-
Lev, S.1
Blechman, J.2
Nishikawa, S.3
Givol, D.4
Yarden, Y.5
-
69
-
-
9744246909
-
Signal transduction via the stem cell factor receptor/ c-Kit
-
Ronnstrand L. Signal transduction via the stem cell factor receptor/ c-Kit. Cell Mol Life Sci 2004; 61: 2535-2548.
-
(2004)
Cell Mol Life Sci
, vol.61
, pp. 2535-2548
-
-
Ronnstrand, L.1
-
70
-
-
12144257058
-
Kit as a human oncogenic tyrosine kinase
-
Kitamura Y, Hirotab S. Kit as a human oncogenic tyrosine kinase. Cell Mol Life Sci 2004; 61: 2924-2931.
-
(2004)
Cell Mol Life Sci
, vol.61
, pp. 2924-2931
-
-
Kitamura, Y.1
Hirotab, S.2
-
71
-
-
0032519768
-
c-kit ligand and Flt3 ligand: Stem/progenitor cell factors with overlapping yet distinct activities
-
Lyman SD, Jacobsen SE. c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood 1998; 91: 1101-1134.
-
(1998)
Blood
, vol.91
, pp. 1101-1134
-
-
Lyman, S.D.1
Jacobsen, S.E.2
-
72
-
-
0025933325
-
Anemia and mast cell depletion in mutant rats that are homozygous at "white spotting (Ws)" locus
-
Niwa Y, Kasugai T, Ohno K et al. Anemia and mast cell depletion in mutant rats that are homozygous at "white spotting (Ws)" locus. Blood 1991; 78: 1936-1941.
-
(1991)
Blood
, vol.78
, pp. 1936-1941
-
-
Niwa, Y.1
Kasugai, T.2
Ohno, K.3
-
73
-
-
0037087531
-
Inhibition of KIT tyrosine kinase activity: A novel molecular approach to the treatment of KIT-positive malignancies
-
Heinrich MC, Blanke CD, Druker BJ, Corless CL. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. J Clin Oncol 2002; 20: 1692-1703.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1692-1703
-
-
Heinrich, M.C.1
Blanke, C.D.2
Druker, B.J.3
Corless, C.L.4
-
74
-
-
0030069519
-
Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor
-
Krystal GW, Hines SJ, Organ CP. Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor. Cancer Res 1996; 56: 370-376.
-
(1996)
Cancer Res
, vol.56
, pp. 370-376
-
-
Krystal, G.W.1
Hines, S.J.2
Organ, C.P.3
-
75
-
-
10744222923
-
Imatinib inhibits proliferation of Ewing tumor cells mediated by the stem cell factor/KIT receptor pathway, and sensitizes cells to vincristine and doxorubicin-induced apoptosis
-
Gonzalez I, Andreu EJ, Panizo A et al. Imatinib inhibits proliferation of Ewing tumor cells mediated by the stem cell factor/KIT receptor pathway, and sensitizes cells to vincristine and doxorubicin-induced apoptosis. Clin Cancer Res 2004; 10: 751-761.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 751-761
-
-
Gonzalez, I.1
Andreu, E.J.2
Panizo, A.3
-
76
-
-
0028849992
-
c-kit point mutation of extracellular domain in patients with myeloproliferative disorders
-
Nakata Y, Kimura A, Katoh O et al. c-kit point mutation of extracellular domain in patients with myeloproliferative disorders. Br J Haematol 1995; 91: 661-663.
-
(1995)
Br J Haematol
, vol.91
, pp. 661-663
-
-
Nakata, Y.1
Kimura, A.2
Katoh, O.3
-
77
-
-
0032935024
-
Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors
-
Sircar K, Hewlett BR, Huizinga JD, Chorneyko, K, Berezin I, Riddell RH. Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. Am J Surg Pathol 1999; 23: 377-389.
-
(1999)
Am J Surg Pathol
, vol.23
, pp. 377-389
-
-
Sircar, K.1
Hewlett, B.R.2
Huizinga, J.D.3
Chorneyko, K.4
Berezin, I.5
Riddell, R.H.6
-
78
-
-
15644363454
-
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
-
Hirota S, Isozaki K, Moriyama Y et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998; 279: 577-580.
-
(1998)
Science
, vol.279
, pp. 577-580
-
-
Hirota, S.1
Isozaki, K.2
Moriyama, Y.3
-
79
-
-
0036303804
-
Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations
-
Heinrich MC, Rubin BP, Longley BJ, Fletcher JA. Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations. Hum Pathol 2002; 33: 484-495.
-
(2002)
Hum Pathol
, vol.33
, pp. 484-495
-
-
Heinrich, M.C.1
Rubin, B.P.2
Longley, B.J.3
Fletcher, J.A.4
-
80
-
-
3042722245
-
Assessing the prognosis of gastrointestinal stromal tumors: A growing role for molecular testing
-
Corless CL. Assessing the prognosis of gastrointestinal stromal tumors: a growing role for molecular testing. Am J Clin Pathol 2004; 122: 11-13.
-
(2004)
Am J Clin Pathol
, vol.122
, pp. 11-13
-
-
Corless, C.L.1
-
81
-
-
16644381251
-
KIT and platelet-derived growth factor receptor alpha tyrosine kinase gene mutations and KIT amplifications in human solid tumors
-
Sihto H, Sarlomo-Rikala M, Tynninen O et al. KIT and platelet-derived growth factor receptor alpha tyrosine kinase gene mutations and KIT amplifications in human solid tumors. J Clin Oncol 2005; 23: 49-57.
-
(2005)
J Clin Oncol
, vol.23
, pp. 49-57
-
-
Sihto, H.1
Sarlomo-Rikala, M.2
Tynninen, O.3
-
82
-
-
0037405026
-
Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region
-
Chan PM, Ilangumaran S, La Rose J, Chakrabartty A, Rottapel R. Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region. Mol Cell Biol 2003; 23: 3067-3078.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 3067-3078
-
-
Chan, P.M.1
Ilangumaran, S.2
La Rose, J.3
Chakrabartty, A.4
Rottapel, R.5
-
83
-
-
0028959163
-
Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines
-
Kitayama H, Kanakura Y, Furitsu T et al. Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines. Blood 1995; 85: 790-798.
-
(1995)
Blood
, vol.85
, pp. 790-798
-
-
Kitayama, H.1
Kanakura, Y.2
Furitsu, T.3
-
84
-
-
0028856070
-
Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder
-
Nagata H, Worobec AS, Oh CK et al. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci U S A 1995; 92: 10560-10564.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 10560-10564
-
-
Nagata, H.1
Worobec, A.S.2
Oh, C.K.3
-
86
-
-
0033816156
-
Abl protein-tyrosine kinase inhibitor ST1571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
-
Buchdunger E, Cioffi CL, Law N et al. Abl protein-tyrosine kinase inhibitor ST1571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 2000; 295: 139-145.
-
(2000)
J Pharmacol Exp Ther
, vol.295
, pp. 139-145
-
-
Buchdunger, E.1
Cioffi, C.L.2
Law, N.3
-
87
-
-
0035899418
-
ST1571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: Biological and clinical implications
-
Tuveson DA, Willis NA, Jacks T et al. ST1571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications. Oncogene 2001; 20: 5054-5058.
-
(2001)
Oncogene
, vol.20
, pp. 5054-5058
-
-
Tuveson, D.A.1
Willis, N.A.2
Jacks, T.3
-
88
-
-
33845444046
-
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
-
Druker BJ, Guilhot F, O'Brien SG et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006; 355: 2408-2417.
-
(2006)
N Engl J Med
, vol.355
, pp. 2408-2417
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
-
89
-
-
33646462354
-
Advanced gastrointestinal stromal tumor patients with complete response after treatment with imatinib mesylate
-
Chiang KC, Chen TW, Yeh CN, Liu FY, Lee HL, Jan YY. Advanced gastrointestinal stromal tumor patients with complete response after treatment with imatinib mesylate. World J Gastroenterol 2006; 12: 2060-2064.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 2060-2064
-
-
Chiang, K.C.1
Chen, T.W.2
Yeh, C.N.3
Liu, F.Y.4
Lee, H.L.5
Jan, Y.Y.6
-
91
-
-
33645693156
-
Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate
-
Wardelmann E, Merkelbach-Bruse S, Pauls K et al. Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate. Clin Cancer Res 2006; 12: 1743-1749.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1743-1749
-
-
Wardelmann, E.1
Merkelbach-Bruse, S.2
Pauls, K.3
-
92
-
-
0032875460
-
Mechanism of action and in vivo role of platelet-derived growth factor
-
Heldin CH, Westerinark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 1999; 79: 1283-1316.
-
(1999)
Physiol Rev
, vol.79
, pp. 1283-1316
-
-
Heldin, C.H.1
Westerinark, B.2
-
93
-
-
0022541219
-
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors
-
Yarden Y, Escobedo JA, Kuang WJ et al. Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature 1986; 323: 226-232.
-
(1986)
Nature
, vol.323
, pp. 226-232
-
-
Yarden, Y.1
Escobedo, J.A.2
Kuang, W.J.3
-
94
-
-
0028589148
-
Platelet-derived growth factor receptor signals
-
Claesson-Welsh L. Platelet-derived growth factor receptor signals. J Biol Chem 1994; 269: 32023-32026.
-
(1994)
J Biol Chem
, vol.269
, pp. 32023-32026
-
-
Claesson-Welsh, L.1
-
95
-
-
0023722311
-
Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains
-
Beckmann MP, Betsholtz C, Heldin CH et al. Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Science 1988; 241: 1346-1349.
-
(1988)
Science
, vol.241
, pp. 1346-1349
-
-
Beckmann, M.P.1
Betsholtz, C.2
Heldin, C.H.3
-
96
-
-
0030808324
-
The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites
-
Soriano P. The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development 1997; 124: 2691-2700.
-
(1997)
Development
, vol.124
, pp. 2691-2700
-
-
Soriano, P.1
-
97
-
-
0036134353
-
PDGF and the testis
-
Mariani S, Basciani S, Arizzi M, Spera G, Gnessi L. PDGF and the testis. Trends Endocrinol Metab 2002; 13: 11-17.
-
(2002)
Trends Endocrinol Metab
, vol.13
, pp. 11-17
-
-
Mariani, S.1
Basciani, S.2
Arizzi, M.3
Spera, G.4
Gnessi, L.5
-
98
-
-
0033763567
-
Involvement of platelet-derived growth factor in disease: Development of specific antagonists
-
Ostman A, Heldin CH. Involvement of platelet-derived growth factor in disease: development of specific antagonists. Adv Cancer Res 2001; 80: 1-38.
-
(2001)
Adv Cancer Res
, vol.80
, pp. 1-38
-
-
Ostman, A.1
Heldin, C.H.2
-
99
-
-
0025998409
-
Angiogenesis during human extraembryonic development involves the spatiotemporal control of PDGF ligand and receptor gene expression
-
Holmgren L, Glaser A, Pfeifer-Ohlsson S, Ohlsson R. Angiogenesis during human extraembryonic development involves the spatiotemporal control of PDGF ligand and receptor gene expression. Development 1991; 113: 749-754.
-
(1991)
Development
, vol.113
, pp. 749-754
-
-
Holmgren, L.1
Glaser, A.2
Pfeifer-Ohlsson, S.3
Ohlsson, R.4
-
100
-
-
0032768156
-
Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
-
Hellstrom M, Kalen M, Lindahl P, Abramsson A, Betsholtz C. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 1999; 126: 3047-3055.
-
(1999)
Development
, vol.126
, pp. 3047-3055
-
-
Hellstrom, M.1
Kalen, M.2
Lindahl, P.3
Abramsson, A.4
Betsholtz, C.5
-
102
-
-
0033613119
-
Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3′ kinase signaling
-
Heuchel R, Berg A, Tallquist M et al. Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3′ kinase signaling. Proc Natl Acad Sci U S A 1999; 96: 11410-11415.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 11410-11415
-
-
Heuchel, R.1
Berg, A.2
Tallquist, M.3
-
103
-
-
0035207172
-
Platelet-derived growth factor receptors: A therapeutic target in solid tumors
-
George D. Platelet-derived growth factor receptors: a therapeutic target in solid tumors. Semin Oncol 2001; 28 (5 Suppl 17): 27-33.
-
(2001)
Semin Oncol
, vol.28
, Issue.5 SUPPL. 17
, pp. 27-33
-
-
George, D.1
-
104
-
-
0342264492
-
Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: Implications for tumorigenesis
-
Moinfar F, Man YG, Amould L, Bratthauer GL, Ratschek M, Tavassoli FA. Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res 2000; 60: 2562-2566.
-
(2000)
Cancer Res
, vol.60
, pp. 2562-2566
-
-
Moinfar, F.1
Man, Y.G.2
Amould, L.3
Bratthauer, G.L.4
Ratschek, M.5
Tavassoli, F.A.6
-
105
-
-
0030792998
-
Tumor cell and connective tissue cell interactions in human colorectal adenocarcinoma. Transfer of platelet-derived growth factor-AB/BB to stromal cells
-
Sundberg C, Branting M, Gerdin B, Rubin K. Tumor cell and connective tissue cell interactions in human colorectal adenocarcinoma. Transfer of platelet-derived growth factor-AB/BB to stromal cells. Am J Pathol 1997; 151: 479-492.
-
(1997)
Am J Pathol
, vol.151
, pp. 479-492
-
-
Sundberg, C.1
Branting, M.2
Gerdin, B.3
Rubin, K.4
-
106
-
-
0032323530
-
Pathogenesis and management of idiopathic myelolibrosis
-
Reilly JT. Pathogenesis and management of idiopathic myelolibrosis. Baillieres Clin Haematol 1998; 11: 751-767.
-
(1998)
Baillieres Clin Haematol
, vol.11
, pp. 751-767
-
-
Reilly, J.T.1
-
107
-
-
0026793260
-
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors
-
Fleming TP, Saxena A, Clark WC et al. Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res 1992; 52: 4550-4553.
-
(1992)
Cancer Res
, vol.52
, pp. 4550-4553
-
-
Fleming, T.P.1
Saxena, A.2
Clark, W.C.3
-
108
-
-
0034039961
-
Amplification of the platelet-derived growth factor receptor-A (PDGFRA) gene occurs in oligodendrogliomas with grade IV anaplastic features
-
Smith IS, Wang XY, Qian J et al. Amplification of the platelet-derived growth factor receptor-A (PDGFRA) gene occurs in oligodendrogliomas with grade IV anaplastic features. J Neuropathol Exp Neurol 2000; 59: 495-503.
-
(2000)
J Neuropathol Exp Neurol
, vol.59
, pp. 495-503
-
-
Smith, I.S.1
Wang, X.Y.2
Qian, J.3
-
109
-
-
0036645057
-
Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
-
Lokker NA, Sullivan CM, Hollenbach SJ, Israel MA, Giese NA. Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res 2002; 62: 3729-3735.
-
(2002)
Cancer Res
, vol.62
, pp. 3729-3735
-
-
Lokker, N.A.1
Sullivan, C.M.2
Hollenbach, S.J.3
Israel, M.A.4
Giese, N.A.5
-
110
-
-
0034794796
-
Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease
-
MacDonald TJ, Brown KM, LaFleur B et al. Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nat Genet 2001; 29: 143-152.
-
(2001)
Nat Genet
, vol.29
, pp. 143-152
-
-
MacDonald, T.J.1
Brown, K.M.2
LaFleur, B.3
-
111
-
-
0031012850
-
Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma
-
Simon MP, Pedeutour F, Sirvent N et al. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nat Genet 1997; 15: 95-98.
-
(1997)
Nat Genet
, vol.15
, pp. 95-98
-
-
Simon, M.P.1
Pedeutour, F.2
Sirvent, N.3
-
112
-
-
0242386261
-
Receptor tyrosine kinases in normal and malignant haematopoiesis
-
Reilly JT. Receptor tyrosine kinases in normal and malignant haematopoiesis. Blood Rev 2003; 17: 241-248.
-
(2003)
Blood Rev
, vol.17
, pp. 241-248
-
-
Reilly, J.T.1
-
113
-
-
0037421971
-
A human brain tumor-derived PDGFR-alpha deletion mutant is transforming
-
Clarke ID, Dirks PB. A human brain tumor-derived PDGFR-alpha deletion mutant is transforming. Oncogene 2003; 22: 722-733.
-
(2003)
Oncogene
, vol.22
, pp. 722-733
-
-
Clarke, I.D.1
Dirks, P.B.2
-
114
-
-
0023215263
-
Abnormalities of chromosome 12p13 and malignant proliferation of eosinophils: A nonrandom association
-
Keene P, Mendelow B, Pinto MR et al. Abnormalities of chromosome 12p13 and malignant proliferation of eosinophils: a nonrandom association. Br J Haematol 1987; 67: 25-31.
-
(1987)
Br J Haematol
, vol.67
, pp. 25-31
-
-
Keene, P.1
Mendelow, B.2
Pinto, M.R.3
-
115
-
-
0030669455
-
Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution
-
Abe A, Emi N, Tanimoto M, Terasaki H, Maranouchi T, Saito H. Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. Blood 1997; 90: 4271-4277.
-
(1997)
Blood
, vol.90
, pp. 4271-4277
-
-
Abe, A.1
Emi, N.2
Tanimoto, M.3
Terasaki, H.4
Maranouchi, T.5
Saito, H.6
-
116
-
-
0036682958
-
Activity of ST1571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene
-
Magnusson MK, Meade KE, Nakamura R, Barrett J, Dunbar CE. Activity of ST1571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene. Blood 2002; 100: 1088-1091.
-
(2002)
Blood
, vol.100
, pp. 1088-1091
-
-
Magnusson, M.K.1
Meade, K.E.2
Nakamura, R.3
Barrett, J.4
Dunbar, C.E.5
-
117
-
-
0036727124
-
Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans
-
Rubin BF, Schuetze SM, Eary JF et al. Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J Clin Oncol 2002; 20: 3586-3591.
-
(2002)
J Clin Oncol
, vol.20
, pp. 3586-3591
-
-
Rubin, B.F.1
Schuetze, S.M.2
Eary, J.F.3
-
118
-
-
0037093060
-
Phase 2 trial of imatinib mesylate in myelofibrosis with myeloid metaplasia
-
Tefferi A, Mesa RA, Gray LA et al. Phase 2 trial of imatinib mesylate in myelofibrosis with myeloid metaplasia. Blood 2002; 99: 3854-3856.
-
(2002)
Blood
, vol.99
, pp. 3854-3856
-
-
Tefferi, A.1
Mesa, R.A.2
Gray, L.A.3
-
119
-
-
0033835421
-
The importance of being K-Ras
-
Ellis CA, Clark G. The importance of being K-Ras. Cell Signal 2000; 12: 425-434.
-
(2000)
Cell Signal
, vol.12
, pp. 425-434
-
-
Ellis, C.A.1
Clark, G.2
-
120
-
-
0034777519
-
-
Adjei AA. Ras signaling pathway proteins as therapeutic targets. Curr Pharm Des 200 1; 7: 1581-1594.
-
Adjei AA. Ras signaling pathway proteins as therapeutic targets. Curr Pharm Des 200 1; 7: 1581-1594.
-
-
-
-
121
-
-
0020315258
-
Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses
-
Chang EH, Gonda MA, Ellis RW, Scolnick EM, Lowy DR. Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses. Proc Natl Acad Sci U S A 1982; 79: 4848-4852.
-
(1982)
Proc Natl Acad Sci U S A
, vol.79
, pp. 4848-4852
-
-
Chang, E.H.1
Gonda, M.A.2
Ellis, R.W.3
Scolnick, E.M.4
Lowy, D.R.5
-
122
-
-
0042530297
-
Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line
-
Shimizu K, Goldfarb M, Perucho M, Wigler M. Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc Natl Acad Sci U S A 1983; 80: 383-387.
-
(1983)
Proc Natl Acad Sci U S A
, vol.80
, pp. 383-387
-
-
Shimizu, K.1
Goldfarb, M.2
Perucho, M.3
Wigler, M.4
-
123
-
-
0020539047
-
Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1
-
Hall A, Marshall CJ, Spurr NK, Weiss RA. Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1. Nature 1983; 303: 396-400.
-
(1983)
Nature
, vol.303
, pp. 396-400
-
-
Hall, A.1
Marshall, C.J.2
Spurr, N.K.3
Weiss, R.A.4
-
124
-
-
0023068346
-
-
Barbacid M. ras genes. Annu Rev Biochem 1987; 56: 779-827.
-
Barbacid M. ras genes. Annu Rev Biochem 1987; 56: 779-827.
-
-
-
-
125
-
-
0032560850
-
-
Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J. The structural basis of the activation of Ras by Sos. Nature 1998; 394: 337-343.
-
Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J. The structural basis of the activation of Ras by Sos. Nature 1998; 394: 337-343.
-
-
-
-
126
-
-
0344885558
-
Structural evidence for feedback activation by Ras. GTP of the Ras-specific nucleotide exchange factor SOS
-
Margarit SM, Sondermann H, Hall BE et al. Structural evidence for feedback activation by Ras. GTP of the Ras-specific nucleotide exchange factor SOS. Cell 2003; 112: 685-695.
-
(2003)
Cell
, vol.112
, pp. 685-695
-
-
Margarit, S.M.1
Sondermann, H.2
Hall, B.E.3
-
127
-
-
0038003903
-
Chemistry and biology of Ras farnesyl-transferase
-
Cho KN, Lee KI. Chemistry and biology of Ras farnesyl-transferase. Arch Pharm Res 2002; 25: 759-769.
-
(2002)
Arch Pharm Res
, vol.25
, pp. 759-769
-
-
Cho, K.N.1
Lee, K.I.2
-
128
-
-
7444255626
-
Membrane targeting of lipid modified signal transduction proteins
-
Resh MD. Membrane targeting of lipid modified signal transduction proteins. Subcell Biochem 2004; 37: 217-232.
-
(2004)
Subcell Biochem
, vol.37
, pp. 217-232
-
-
Resh, M.D.1
-
129
-
-
0035787526
-
Ras activation of the Raf kinase: Tyrosine kinase recruitment of the MAP kinase cascade
-
Avruch J, Khokhlatchev A, Kyriakis JM et al. Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog Horm Res 2001; 56: 127-155.
-
(2001)
Recent Prog Horm Res
, vol.56
, pp. 127-155
-
-
Avruch, J.1
Khokhlatchev, A.2
Kyriakis, J.M.3
-
130
-
-
0141925955
-
Ras GTPases: Integrins' friends or foes?
-
Kinbara K, Goldfinger LE, Hansen M, Chou FL, Ginsberg MH. Ras GTPases: integrins' friends or foes? Nat Rev Mol Cell Biol 2003; 4: 767-776.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 767-776
-
-
Kinbara, K.1
Goldfinger, L.E.2
Hansen, M.3
Chou, F.L.4
Ginsberg, M.H.5
-
132
-
-
3042796979
-
GAP control: Regulating the regulators of small GTPases
-
Bernards A, Settleman J. GAP control: regulating the regulators of small GTPases. Trends Cell Biol 2004; 14: 377-385.
-
(2004)
Trends Cell Biol
, vol.14
, pp. 377-385
-
-
Bernards, A.1
Settleman, J.2
-
133
-
-
0037961574
-
Von Recklinghausen's neurofibromatosis: Neurofibromatosis type 1
-
Reynolds RM, Browning GG, Nawroz I, Campbell IW. Von Recklinghausen's neurofibromatosis: neurofibromatosis type 1. Lancet 2003; 361: 1552-1554.
-
(2003)
Lancet
, vol.361
, pp. 1552-1554
-
-
Reynolds, R.M.1
Browning, G.G.2
Nawroz, I.3
Campbell, I.W.4
-
134
-
-
22744445886
-
Signaling interplay in Ras superfamily function
-
Mitin N, Rossman KL, Der CJ. Signaling interplay in Ras superfamily function. Curr Biol 2005; 15: R563-R574.
-
(2005)
Curr Biol
, vol.15
-
-
Mitin, N.1
Rossman, K.L.2
Der, C.J.3
-
135
-
-
0024376173
-
-
Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989; 49: 4682-4689.
-
Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989; 49: 4682-4689.
-
-
-
-
136
-
-
0030772378
-
The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants
-
Scheffzek K, Ahmadian MR, Kabsch W et al. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 1997; 277: 333-338.
-
(1997)
Science
, vol.277
, pp. 333-338
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Kabsch, W.3
-
137
-
-
16644402183
-
Gemcitabine and ISIS-2503 for patients with locally advanced or metastatic pancreatic adenocarcinoma: A North Central Cancer Treatment Group phase II trial
-
Alberts SR, Schroeder M, Erlichman C et al. Gemcitabine and ISIS-2503 for patients with locally advanced or metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group phase II trial. J Clin Oncol 2004; 22: 4944-4950.
-
(2004)
J Clin Oncol
, vol.22
, pp. 4944-4950
-
-
Alberts, S.R.1
Schroeder, M.2
Erlichman, C.3
-
138
-
-
0037062951
-
RNA interference
-
Hannon GJ. RNA interference. Nature 2002; 418: 244-251.
-
(2002)
Nature
, vol.418
, pp. 244-251
-
-
Hannon, G.J.1
-
139
-
-
0032975450
-
A phase I vaccine trial with peptides reflecting ras oncogene mutations of solid tumors
-
Khleif SN, Abrams SI, Hamilton JM et al. A phase I vaccine trial with peptides reflecting ras oncogene mutations of solid tumors. J Immunother 1999; 22: 155-165.
-
(1999)
J Immunother
, vol.22
, pp. 155-165
-
-
Khleif, S.N.1
Abrams, S.I.2
Hamilton, J.M.3
-
140
-
-
0035031781
-
Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell-mediated immunity
-
Stubbs AC, Martin KS, Coeshott C et al. Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell-mediated immunity. Nat Med 2001; 7: 625-629.
-
(2001)
Nat Med
, vol.7
, pp. 625-629
-
-
Stubbs, A.C.1
Martin, K.S.2
Coeshott, C.3
-
141
-
-
5444241523
-
Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer
-
Rao S, Cunningham D, de Gramont A et al. Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer. J Clin Oncol 2004; 22: 3950-3957.
-
(2004)
J Clin Oncol
, vol.22
, pp. 3950-3957
-
-
Rao, S.1
Cunningham, D.2
de Gramont, A.3
-
142
-
-
2342645506
-
Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
-
Van Cutsem E, van de Velde H, Karasek P et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol 2004; 22: 1430-1438.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1430-1438
-
-
Van Cutsem, E.1
van de Velde, H.2
Karasek, P.3
-
143
-
-
0035678051
-
A phase I and pharmacological study of the farnesyl protein transferase inhibitor L-778, 123 in patients with solid malignancies
-
Britten CD, Rowinsky EK, Soignet S et al. A phase I and pharmacological study of the farnesyl protein transferase inhibitor L-778, 123 in patients with solid malignancies. Clin Cancer Res 2001; 7: 3894-3903.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3894-3903
-
-
Britten, C.D.1
Rowinsky, E.K.2
Soignet, S.3
|