메뉴 건너뛰기




Volumn 22, Issue 2, 1999, Pages 155-165

A phase I vaccine trial with peptides reflecting ras oncogene mutations of solid tumors

Author keywords

Ras oncogene mutations; Ras peptides; Ras vaccination

Indexed keywords

PHOSPHORYL LIPID A; RAS PROTEIN;

EID: 0032975450     PISSN: 15249557     EISSN: 15374513     Source Type: Journal    
DOI: 10.1097/00002371-199903000-00007     Document Type: Article
Times cited : (109)

References (34)
  • 1
    • 0023256456 scopus 로고
    • Prevelence of ras gene mutations in human colorectal cancers
    • Bos JL, Fearon ER, Hamilton SR, et al. Prevelence of ras gene mutations in human colorectal cancers. Nature 1987;327:293-7.
    • (1987) Nature , vol.327 , pp. 293-297
    • Bos, J.L.1    Fearon, E.R.2    Hamilton, S.R.3
  • 2
    • 0026908513 scopus 로고
    • Ras in signal transduction
    • Satoh T, Kaziro Y. Ras in signal transduction. Semin Cancer Biol 1992:3:169-177.
    • (1992) Semin Cancer Biol , vol.3 , pp. 169-177
    • Satoh, T.1    Kaziro, Y.2
  • 3
    • 0026079628 scopus 로고
    • The biochemistry of ras p21
    • Grand RJA, Owen D. The biochemistry of ras p21. Biochemistry 1991;279:609-31.
    • (1991) Biochemistry , vol.279 , pp. 609-631
    • Grand, R.J.A.1    Owen, D.2
  • 4
    • 0027733796 scopus 로고
    • K-ras oncogene activation in adenocarcinoma of the humanpancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization
    • Firuban RH, van Mansfeld AD. Offerhaus GJ, et al. K-ras oncogene activation in adenocarcinoma of the humanpancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 1993:143:545-54.
    • (1993) Am J Pathol , vol.143 , pp. 545-554
    • Firuban, R.H.1    van Mansfeld, A.D.2    Offerhaus, G.J.3
  • 5
    • 0028361705 scopus 로고
    • C-K-ras and p53 mutations occur very early in adenocarcinoma of the lung
    • Li ZH, Weiss SM, Shibata D. c-K-ras and p53 mutations occur very early in adenocarcinoma of the lung. Am J Pathol 1994;144:303-9.
    • (1994) Am J Pathol , vol.144 , pp. 303-309
    • Li, Z.H.1    Weiss, S.M.2    Shibata, D.3
  • 6
    • 0028053024 scopus 로고
    • K-ras mutations in colorectal cancer: Relations to patient age, sex and tumour location
    • Breivik J, Mehling G. Spurkland A, Rognum TO, Gaudernack G. K-ras mutations in colorectal cancer: Relations to patient age, sex and tumour location. Br J Cancer 1994;69:367-71.
    • (1994) Br J Cancer , vol.69 , pp. 367-371
    • Breivik, J.1    Mehling, G.2    Spurkland, A.3    Rognum, T.O.4    Gaudernack, G.5
  • 7
    • 0029886062 scopus 로고    scopus 로고
    • Antigen processing and presentation [see comments]
    • Brodsky FM, Lem L, Bresnahan PA. Antigen processing and presentation [see comments]. Tissue Antigens 1996;47:464-71.
    • (1996) Tissue Antigens , vol.47 , pp. 464-471
    • Brodsky, F.M.1    Lem, L.2    Bresnahan, P.A.3
  • 8
    • 0024383535 scopus 로고
    • Antigen recognition by class I-restricted T lymphocytes
    • Townsend A, Bodmer FI. Antigen recognition by class I-restricted T lymphocytes. Annu Rev Immunol 1989:7:601-24.
    • (1989) Annu Rev Immunol , vol.7 , pp. 601-624
    • Townsend, A.1    Bodmer, F.I.2
  • 9
    • 0025175893 scopus 로고
    • Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells
    • Rotzschke O, Falk K, Deres K, et al. Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells. Nature 1990:348:252.
    • (1990) Nature , vol.348 , pp. 252
    • Rotzschke, O.1    Falk, K.2    Deres, K.3
  • 10
    • 0026758135 scopus 로고
    • A transient transfection system for identifying biosynthesized proteins processed an presented to class I MHC restricted T lymphocytes
    • Eisenloh LC. Yewdell JW, Bennink JR. A transient transfection system for identifying biosynthesized proteins processed an presented to class I MHC restricted T lymphocytes. J Immunol Meth 1992:154:131.
    • (1992) J Immunol Meth , vol.154 , pp. 131
    • Eisenloh, L.C.1    Yewdell, J.W.2    Bennink, J.R.3
  • 11
    • 0026781534 scopus 로고
    • Analysis of the association of peptides of optimal length to class I molecules on the surface of cells
    • Rock KL, Rothstein L, Benacerraf B. Analysis of the association of peptides of optimal length to class I molecules on the surface of cells. Proc Natl Acad Sci USA 1992;89:8918-22.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 8918-8922
    • Rock, K.L.1    Rothstein, L.2    Benacerraf, B.3
  • 12
    • 0026664454 scopus 로고
    • Peptides presented to the immune system by the murine class II histocompatibility complex molecule I-Ad
    • Hunt DF, Michel H, Dickinson TA, et al. Peptides presented to the immune system by the murine class II histocompatibility complex molecule I-Ad. Science 1992;256:1817-20.
    • (1992) Science , vol.256 , pp. 1817-1820
    • Hunt, D.F.1    Michel, H.2    Dickinson, T.A.3
  • 14
    • 0027173536 scopus 로고
    • Cytolytic activity of murine CD4+ T cell clones correlates with gamma IFN production in mouse strains having BALB/c background
    • McKisic MD, Lancki DW, Fitch FW. Cytolytic activity of murine CD4+ T cell clones correlates with gamma IFN production in mouse strains having BALB/c background. J Immunol 1991:150: 3793.
    • (1991) J Immunol , vol.150 , pp. 3793
    • McKisic, M.D.1    Lancki, D.W.2    Fitch, F.W.3
  • 16
    • 0025082644 scopus 로고
    • Heterogeneity in direct cytotoxic function of L3T4 T cells: TH1 clones express higher cytotoxic activity to antigen presenting cells than TH2 clones
    • Chang JCC, Zhang TL, Edgerton TL, et al. Heterogeneity in direct cytotoxic function of L3T4 T cells: TH1 clones express higher cytotoxic activity to antigen presenting cells than TH2 clones. J Immunol 1990:145:409.
    • (1990) J Immunol , vol.145 , pp. 409
    • Chang, J.C.C.1    Zhang, T.L.2    Edgerton, T.L.3
  • 17
    • 0029143544 scopus 로고
    • Peptide specific activation of cytolytic CD4+ T lymphocytes against tumor cells harboring mutated epitopes of K-ras p21
    • Abrams SI, Dobrzanski MJ, Wells DT, et al. Peptide specific activation of cytolytic CD4+ T lymphocytes against tumor cells harboring mutated epitopes of K-ras p21. Eur J Immunol 1995;25:2588-97.
    • (1995) Eur J Immunol , vol.25 , pp. 2588-2597
    • Abrams, S.I.1    Dobrzanski, M.J.2    Wells, D.T.3
  • 18
    • 0027368821 scopus 로고
    • Induction of T cell specific for the mutated segement of the oncogenic p21 ras protein by immunization in vivo with the oncogenic protein
    • Peac DJ, Smith JW, Disis ML. Chen W, Cheever MA. Induction of T cell specific for the mutated segement of the oncogenic p21 ras protein by immunization in vivo with the oncogenic protein. J Immunother 1993;14:110-14.
    • (1993) J Immunother , vol.14 , pp. 110-114
    • Peac, D.J.1    Smith, J.W.2    Disis, M.L.3    Chen, W.4    Cheever, M.A.5
  • 19
    • 0028098172 scopus 로고
    • Lysis of ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitro immunization with mutated Ras peptide
    • Peace DJ, Smith JW, Chen W. et al. Lysis of ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitro immunization with mutated Ras peptide. J Exp Med 1994;179:473-9.
    • (1994) J Exp Med , vol.179 , pp. 473-479
    • Peace, D.J.1    Smith, J.W.2    Chen, W.3
  • 20
    • 0027405374 scopus 로고
    • Identification of two cytotoxic T lymphocyte-recognized epotopes in the ras protein
    • Skipper J, Stauss HJ. Identification of two cytotoxic T lymphocyte-recognized epotopes in the ras protein. J Exp Med 1993:177: 1493-8.
    • (1993) J Exp Med , vol.177 , pp. 1493-1498
    • Skipper, J.1    Stauss, H.J.2
  • 21
    • 0027281983 scopus 로고
    • Cytotoxic T-cell response and in vivo protection against tumor cells harboring activated ras proto-oncogene
    • Fenton RG, Taub DD, Kwak LW, Smith MR, Longo DL. Cytotoxic T-cell response and in vivo protection against tumor cells harboring activated ras proto-oncogene. J Natl Cancer Inst 1993;85:1294-1302.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1294-1302
    • Fenton, R.G.1    Taub, D.D.2    Kwak, L.W.3    Smith, M.R.4    Longo, D.L.5
  • 22
    • 0030027269 scopus 로고    scopus 로고
    • Identification of overlapping epitopes in mutant ras oncogene peptides that activate CD4+ an CD8+ T cell responses
    • Abrams SI, Stanziale SF, Lunin SD, Zaremba S, Schlom J. Identification of overlapping epitopes in mutant ras oncogene peptides that activate CD4+ an CD8+ T cell responses. Eur J Immunol 1996;26:435-43.
    • (1996) Eur J Immunol , vol.26 , pp. 435-443
    • Abrams, S.I.1    Stanziale, S.F.2    Lunin, S.D.3    Zaremba, S.4    Schlom, J.5
  • 23
    • 0028934910 scopus 로고
    • CD8+ T cells from a patient with colon carcinoma, specific for a mutant p21 ras derived peptide (13Gly-Asp). are cytotoxic towards a carcinoma cell line harbouring the same mutation
    • Fossum B, Olsen AC, Thorsby E, Gaudernack G. CD8+ T cells from a patient with colon carcinoma, specific for a mutant p21 ras derived peptide (13Gly-Asp). are cytotoxic towards a carcinoma cell line harbouring the same mutation. Cancer Immunol Immunother 1995;40:165-72.
    • (1995) Cancer Immunol Immunother , vol.40 , pp. 165-172
    • Fossum, B.1    Olsen, A.C.2    Thorsby, E.3    Gaudernack, G.4
  • 24
    • 0028057702 scopus 로고
    • P-21 ras-peptide-specific T-cell responses in a patient with colorectal cancer: CD4+ and CD8+ T cells recognize a peptide corresponding to a common mutation
    • Fossum B, Gedde-Dahl III T, Breivik J, et al. p-21 ras-peptide-specific T-cell responses in a patient with colorectal cancer: CD4+ and CD8+ T cells recognize a peptide corresponding to a common mutation. Int J Cancer 1994;56:40-5.
    • (1994) Int J Cancer , vol.56 , pp. 40-45
    • Fossum, B.1    Gedde-Dahl, T.2    Breivik, J.3
  • 25
    • 0028639458 scopus 로고
    • Induction of human cytotoxic T cell lines directed against point-mutated p21 rasderived synthetic peptides
    • Tsang KY, Nieroda CA, DeFilippi R, et al. Induction of human cytotoxic T cell lines directed against point-mutated p21 rasderived synthetic peptides. Vaccine Res 1994;3:183-93.
    • (1994) Vaccine Res , vol.3 , pp. 183-193
    • Tsang, K.Y.1    Nieroda, C.A.2    DeFilippi, R.3
  • 26
    • 0027477906 scopus 로고
    • T cell clones specific for p-21 ras-derived peptides: Characterization of their fine specificity and HLA restriction
    • Gedd-Dahl TI, Fossum B, Eriksen JA. Thorsby E, Guadernack G. T cell clones specific for p-21 ras-derived peptides: characterization of their fine specificity and HLA restriction. Eur F Immunol 1993;23:754-60.
    • (1993) Eur F Immunol , vol.23 , pp. 754-760
    • Gedd-Dahl, T.I.1    Fossum, B.2    Eriksen, J.A.3    Thorsby, E.4    Guadernack, G.5
  • 27
    • 0028924505 scopus 로고
    • Induction and characterization of cytotoxic T-lymphocytes recognizing a mutated p21 Ras peptide presented by HLA-A0201
    • Van Elsas A, Nijman HW, Van der Minne CE, et al. Induction and characterization of cytotoxic T-lymphocytes recognizing a mutated p21 Ras peptide presented by HLA-A0201. Int J Cancer 1995;61:389-96.
    • (1995) Int J Cancer , vol.61 , pp. 389-396
    • Van Elsas, A.1    Nijman, H.W.2    Van der Minne, C.E.3
  • 28
    • 0026074766 scopus 로고
    • Human T lymphocytes recognize a peptide of single point-mutated oncogene ras protein
    • Jung S, Schluesener HJ. Human T lymphocytes recognize a peptide of single point-mutated oncogene ras protein. J Exp Med 1991;73:273-6.
    • (1991) J Exp Med , vol.73 , pp. 273-276
    • Jung, S.1    Schluesener, H.J.2
  • 29
    • 0028856743 scopus 로고
    • Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation
    • Gjertsen MK. Bakka A, Breivik J. et al. Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation. Lancet 1995:346:1399-1400.
    • (1995) Lancet , vol.346 , pp. 1399-1400
    • Gjertsen, M.K.1    Bakka, A.2    Breivik, J.3
  • 30
    • 0030749292 scopus 로고    scopus 로고
    • Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12Val) peptide vaccination of a patient, recognize 12Val-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation
    • Gjertsen MK, Bjorheim J, Saeterdal I. Myklebust J, Gaudernack G. Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12Val) peptide vaccination of a patient, recognize 12Val-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation. Int J Cancer 1997:72:784-90.
    • (1997) Int J Cancer , vol.72 , pp. 784-790
    • Gjertsen, M.K.1    Bjorheim, J.2    Saeterdal, I.3    Myklebust, J.4    Gaudernack, G.5
  • 31
    • 0002538655 scopus 로고
    • Sample preparation from paraffin-embeded tissues
    • Wright, Manos, eds
    • Sample preparation from paraffin-embeded tissues. In: Wright, Manos, eds. PCR Protocols: A Guide to Methods and Application, 1990:153-8.
    • (1990) PCR Protocols: A Guide to Methods and Application , pp. 153-158
  • 32
    • 0031573840 scopus 로고    scopus 로고
    • Generation of stable CD4+ and CD8+ T cell lines from patients immunized with mutated Ras oncogene-derived peptides reflecting codon 12 mutations
    • Abrams SI, Khleif SN. Bergmann-Leitner ES, et al. Generation of stable CD4+ and CD8+ T cell lines from patients immunized with mutated Ras oncogene-derived peptides reflecting codon 12 mutations. Cell Immunol 1997:182:137-51.
    • (1997) Cell Immunol , vol.182 , pp. 137-151
    • Abrams, S.I.1    Khleif, S.N.2    Bergmann-Leitner, E.S.3
  • 33
    • 0028153777 scopus 로고
    • Growth inhibition of a colonic adenocarcinoma cell line (HT29) by T cells specific for mutant P21 Ras
    • Gedd-Dahl T, Nelsen E. Thorsby E, Gaudernack G. Growth inhibition of a colonic adenocarcinoma cell line (HT29) by T cells specific for mutant P21 Ras. Cancer Immunol Immunother 1994;38:127-34.
    • (1994) Cancer Immunol Immunother , vol.38 , pp. 127-134
    • Gedd-Dahl, T.1    Nelsen, E.2    Thorsby, E.3    Gaudernack, G.4
  • 34
    • 0031890206 scopus 로고    scopus 로고
    • Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma [see comments]
    • Rosenberg SA, Yang JC. Schwartzentruber DJ, et al. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma [see comments]. Nat Med 1998;4:321-7.
    • (1998) Nat Med , vol.4 , pp. 321-327
    • Rosenberg, S.A.1    Yang, J.C.2    Schwartzentruber, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.