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Volumn 3, Issue 5, 2002, Pages 360-368

The active metabolite of leflunomide, an immunosuppressive agent, reduces mechanical sensitivity in a rat mononeuropathy model

Author keywords

Astrocytes; MHC class II; Microglia; Neuropathic pain

Indexed keywords

DRUG METABOLITE; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOSUPPRESSIVE AGENT; LEFLUNOMIDE; TERIFLUNOMIDE;

EID: 0036796293     PISSN: 15265900     EISSN: None     Source Type: Journal    
DOI: 10.1054/jpai.2002.125181     Document Type: Article
Times cited : (27)

References (54)
  • 1
    • 0032171575 scopus 로고    scopus 로고
    • Nitric oxide signaling in pain and nociceptor sensitization in the rat
    • Aley K, McCarter G, Levine J: Nitric oxide signaling in pain and nociceptor sensitization in the rat. J Neurosci 18:7008-7014, 1998
    • (1998) J Neurosci , vol.18 , pp. 7008-7014
    • Aley, K.1    McCarter, G.2    Levine, J.3
  • 2
    • 0032570035 scopus 로고    scopus 로고
    • Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: Potential role of IL-6 in neuropathic pain
    • Arruda JL, Colburn RW, Rickman AJ, Rutkowski MD, DeLeo JA: Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: Potential role of IL-6 in neuropathic pain. Mol Brain Res 62:228-235, 1998
    • (1998) Mol Brain Res , vol.62 , pp. 228-235
    • Arruda, J.L.1    Colburn, R.W.2    Rickman, A.J.3    Rutkowski, M.D.4    DeLeo, J.A.5
  • 3
    • 0034613224 scopus 로고    scopus 로고
    • Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: Possible immune modulation in neuropathic pain
    • Arruda J, Sweitzer S, Rutkowski M, DeLeo JA: Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: Possible immune modulation in neuropathic pain. Brain Res 879:216-225, 2000
    • (2000) Brain Res , vol.879 , pp. 216-225
    • Arruda, J.1    Sweitzer, S.2    Rutkowski, M.3    DeLeo, J.A.4
  • 4
    • 0031947121 scopus 로고    scopus 로고
    • Astrocytes as mediators of immune and inflammatory responses in the CNS
    • Aschner M: Astrocytes as mediators of immune and inflammatory responses in the CNS. Neurotoxicology 19:269-280, 1998
    • (1998) Neurotoxicology , vol.19 , pp. 269-280
    • Aschner, M.1
  • 5
    • 0035318421 scopus 로고    scopus 로고
    • Presence of B-7.2 (CD86) and lack of B7-1 (CD80) on myelin-phagocytosing MHC-II positive rat microglia are associated with non-destructive immunity in vivo
    • Bechmann I, Peter S, Beyer M, Gimsa U, Nitsch R: Presence of B-7.2 (CD86) and lack of B7-1 (CD80) on myelin-phagocytosing MHC-II positive rat microglia are associated with non-destructive immunity in vivo. FASEB J 10:1096, 2001
    • (2001) FASEB J , vol.10 , pp. 1096
    • Bechmann, I.1    Peter, S.2    Beyer, M.3    Gimsa, U.4    Nitsch, R.5
  • 6
    • 0029847123 scopus 로고    scopus 로고
    • A novel mechanism of action of the immunomodulatory drug, leflunomide: Augmentation of the immunosuppressive cytokine, TGF-β1, and suppression of the immunostimulatory cytokine, IL-2
    • Cao W, Kao P, Aoki Y, Xu JC, Shorthouse RA, Morris RE: A novel mechanism of action of the immunomodulatory drug, leflunomide: Augmentation of the immunosuppressive cytokine, TGF-β1, and suppression of the immunostimulatory cytokine, IL-2. Transplant Proc 28:3079-3080, 1996
    • (1996) Transplant Proc , vol.28 , pp. 3079-3080
    • Cao, W.1    Kao, P.2    Aoki, Y.3    Xu, J.C.4    Shorthouse, R.A.5    Morris, R.E.6
  • 8
    • 0030859754 scopus 로고    scopus 로고
    • Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat
    • Colburn RW, DeLeo JA, Rickman AJ, Yeager MP, Kwon P, Hickey WF: Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat. J Neuroimmunol 79:163-175, 1997
    • (1997) J Neuroimmunol , vol.79 , pp. 163-175
    • Colburn, R.W.1    DeLeo, J.A.2    Rickman, A.J.3    Yeager, M.P.4    Kwon, P.5    Hickey, W.F.6
  • 9
    • 0032079675 scopus 로고    scopus 로고
    • Partial peripheral nerve injury leads to activation of astroglia and microglia which parallel the development of allodynic behavior
    • Coyle D: Partial peripheral nerve injury leads to activation of astroglia and microglia which parallel the development of allodynic behavior. Glia 23:75-83, 1998
    • (1998) Glia , vol.23 , pp. 75-83
    • Coyle, D.1
  • 11
    • 0028972547 scopus 로고
    • Tumor necrosis factor-alpha induces substance P in sympathetic ganglia through sequential induction of interleukin-1 and leukemia inhibitory factor
    • Ding M, Hart R, Jonakait F: Tumor necrosis factor-alpha induces substance P in sympathetic ganglia through sequential induction of interleukin-1 and leukemia inhibitory factor. J Neurobiol 28:445-454, 1995
    • (1995) J Neurobiol , vol.28 , pp. 445-454
    • Ding, M.1    Hart, R.2    Jonakait, F.3
  • 12
    • 0031179645 scopus 로고    scopus 로고
    • The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms
    • Elder R, Xu X, Williams J, Gong H, Finnegan A, Chong AS: The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms. J Immunol 159:22-27, 1997
    • (1997) J Immunol , vol.159 , pp. 22-27
    • Elder, R.1    Xu, X.2    Williams, J.3    Gong, H.4    Finnegan, A.5    Chong, A.S.6
  • 13
    • 0029047781 scopus 로고
    • Two distinct inward rectifying conductances are expressed in long term dibutyryi-cyclic-AMP treated rat cultured cortical astrocytes
    • Ferroni S, Marchini C, Schubert P, Rapisarda C: Two distinct inward rectifying conductances are expressed in long term dibutyryi-cyclic-AMP treated rat cultured cortical astrocytes. FEBS Lett 267:319-325, 1995
    • (1995) FEBS Lett , vol.267 , pp. 319-325
    • Ferroni, S.1    Marchini, C.2    Schubert, P.3    Rapisarda, C.4
  • 15
    • 0031865023 scopus 로고    scopus 로고
    • Mechanism of action of leflunomide in rheumatoid arthritis
    • Fox R: Mechanism of action of leflunomide in rheumatoid arthritis. J Rheumatol Suppl 53:20-26, 1998
    • (1998) J Rheumatol Suppl , vol.53 , pp. 20-26
    • Fox, R.1
  • 16
    • 0030964023 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6): A molecule with both beneficial and destructive potentials
    • Gadient R, Otten U: Interleukin-6 (IL-6): A molecule with both beneficial and destructive potentials. Prog Neurobiol 52:379-390, 1997
    • (1997) Prog Neurobiol , vol.52 , pp. 379-390
    • Gadient, R.1    Otten, U.2
  • 17
    • 0034255085 scopus 로고    scopus 로고
    • Central administration of methotrexate reduces mechanical allodynia in an animal model of radiculopathy/sciatica
    • Hashizume H, Rutkowski M, Weinstein J, DeLeo JA: Central administration of methotrexate reduces mechanical allodynia in an animal model of radiculopathy/sciatica. Pain 87:159-169, 2000
    • (2000) Pain , vol.87 , pp. 159-169
    • Hashizume, H.1    Rutkowski, M.2    Weinstein, J.3    DeLeo, J.A.4
  • 18
    • 0028980313 scopus 로고
    • Interleukin-1β induces long term increase of axonally transported opioate receptors and substance P
    • Jeanjean A, Moussaoui S, Maloteaux J, Laduron PM: Interleukin-1β induces long term increase of axonally transported opioate receptors and substance P. Neuroscience 68:151-157, 1995
    • (1995) Neuroscience , vol.68 , pp. 151-157
    • Jeanjean, A.1    Moussaoui, S.2    Maloteaux, J.3    Laduron, P.M.4
  • 19
    • 0033490464 scopus 로고    scopus 로고
    • Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
    • Ji R, Baba H, Brenner G, Woolf CJ: Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci 2:1114-1119, 1999
    • (1999) Nat Neurosci , vol.2 , pp. 1114-1119
    • Ji, R.1    Baba, H.2    Brenner, G.3    Woolf, C.J.4
  • 20
    • 0028464973 scopus 로고
    • Microglial tyrosine phosphorylation systems in normal and degenerating brain
    • Karp H, Tillotson M, Soria J, Reich C, Wood JG: Microglial tyrosine phosphorylation systems in normal and degenerating brain. Glia 11:284-290, 1994
    • (1994) Glia , vol.11 , pp. 284-290
    • Karp, H.1    Tillotson, M.2    Soria, J.3    Reich, C.4    Wood, J.G.5
  • 21
    • 0030453517 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha increases intracellular Ca2+ and induces a depolarization in cultured astroglial cells
    • Koller H, Thiem K, Siebler M: Tumour necrosis factor-alpha increases intracellular Ca2+ and induces a depolarization in cultured astroglial cells. Brain 119:2021-2027, 1996
    • (1996) Brain , vol.119 , pp. 2021-2027
    • Koller, H.1    Thiem, K.2    Siebler, M.3
  • 22
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor of pathological events in the CNS
    • Kreutzberg G: Microglia: A sensor of pathological events in the CNS. Trends Neurosci 19:312-318, 1996
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.1
  • 24
    • 0033557695 scopus 로고    scopus 로고
    • Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-KB activation and gene expression
    • Manna S, Aggarwal B: Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-KB activation and gene expression. J Immunol 162:2095-2102, 1999
    • (1999) J Immunol , vol.162 , pp. 2095-2102
    • Manna, S.1    Aggarwal, B.2
  • 25
    • 0035363487 scopus 로고    scopus 로고
    • Local immune regulation in the central nervous system by substance P vs glutamate
    • McCluskey L, Lampson L: Local immune regulation in the central nervous system by substance P vs glutamate. J Neuroimmunol 116:136-146, 2001
    • (2001) J Neuroimmunol , vol.116 , pp. 136-146
    • McCluskey, L.1    Lampson, L.2
  • 26
    • 0028027868 scopus 로고
    • The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat
    • Meller S, Dykstra C, Grzybycki D, Murphy S, Gebhart GF: The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat. Neuropharmacology 33:1471-1478, 1994
    • (1994) Neuropharmacology , vol.33 , pp. 1471-1478
    • Meller, S.1    Dykstra, C.2    Grzybycki, D.3    Murphy, S.4    Gebhart, G.F.5
  • 28
    • 0034615875 scopus 로고    scopus 로고
    • Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120
    • Milligan E, Mehmert K, Hinde J, Harvey LO, Martin D, Tracey KJ, Maier SF, Watkins LR: Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120. Brain Res 861:105-116, 2000
    • (2000) Brain Res , vol.861 , pp. 105-116
    • Milligan, E.1    Mehmert, K.2    Hinde, J.3    Harvey, L.O.4    Martin, D.5    Tracey, K.J.6    Maier, S.F.7    Watkins, L.R.8
  • 30
    • 0026511491 scopus 로고
    • Progressive expression of immunomolecules on microglial cells in rat dorsal hippocampus following transient forebrain ischemia
    • Morioka T, Kalehua A, Streit W: Progressive expression of immunomolecules on microglial cells in rat dorsal hippocampus following transient forebrain ischemia. Acta Neuropathol 83:149-157, 1992
    • (1992) Acta Neuropathol , vol.83 , pp. 149-157
    • Morioka, T.1    Kalehua, A.2    Streit, W.3
  • 31
    • 0025942874 scopus 로고
    • Expression of immunomolecules on microglial cells following neonatal sciatic nerve axotomy
    • Morioka T, Streit W: Expression of immunomolecules on microglial cells following neonatal sciatic nerve axotomy. J Neuroimmunol 35:21-30, 1991
    • (1991) J Neuroimmunol , vol.35 , pp. 21-30
    • Morioka, T.1    Streit, W.2
  • 32
    • 0032968705 scopus 로고    scopus 로고
    • Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice
    • Murphy P, Ramer M, Borthwick L, Gauldie J, Richardson PM, Bisby MA: Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice. Eur J Neurosci 11:2243-2253, 1999
    • (1999) Eur J Neurosci , vol.11 , pp. 2243-2253
    • Murphy, P.1    Ramer, M.2    Borthwick, L.3    Gauldie, J.4    Richardson, P.M.5    Bisby, M.A.6
  • 33
    • 0027302532 scopus 로고    scopus 로고
    • Differential expression of MHC class II antigen in the contused rat spinal cord
    • Popovich P, Streit W, Stokes B: Differential expression of MHC class II antigen in the contused rat spinal cord. J Neurotrauma 1993;10:37-46, 1999
    • (1999) J Neurotrauma , vol.1993 , Issue.10 , pp. 37-46
    • Popovich, P.1    Streit, W.2    Stokes, B.3
  • 35
    • 0032814562 scopus 로고    scopus 로고
    • Neuroglial activation repertoire in the injured brain: Graded response, molecular mechanisms and cues to physiological function
    • Raivich G, Bohatschek M, Kloss C, Werner A, Jones LL, Kreutzberg GW: Neuroglial activation repertoire in the injured brain: Graded response, molecular mechanisms and cues to physiological function. Brain Res Rev 30:77-105, 1999
    • (1999) Brain Res Rev , vol.30 , pp. 77-105
    • Raivich, G.1    Bohatschek, M.2    Kloss, C.3    Werner, A.4    Jones, L.L.5    Kreutzberg, G.W.6
  • 36
    • 0031795813 scopus 로고    scopus 로고
    • Spinal nerve lesion-induced mechanoallodynia and adrenergic sprouting in sensory ganglia are attenuated in interleukin-6 knockout mice
    • Ramer M, Murphy P, Richardson P, Bisby MA: Spinal nerve lesion-induced mechanoallodynia and adrenergic sprouting in sensory ganglia are attenuated in interleukin-6 knockout mice. Pain 78:115-121, 1998
    • (1998) Pain , vol.78 , pp. 115-121
    • Ramer, M.1    Murphy, P.2    Richardson, P.3    Bisby, M.A.4
  • 39
    • 0032821690 scopus 로고    scopus 로고
    • Acute inflammatory responses to mechanical lesions in the CNS: Differences between brain and spinal cord
    • Schnell L, Fearn S, Klassen H, Schwab ME, Perry VH: Acute inflammatory responses to mechanical lesions in the CNS: Differences between brain and spinal cord. Eur J Neurosci 11:3648-3658, 1999
    • (1999) Eur J Neurosci , vol.11 , pp. 3648-3658
    • Schnell, L.1    Fearn, S.2    Klassen, H.3    Schwab, M.E.4    Perry, V.H.5
  • 40
    • 0034114456 scopus 로고    scopus 로고
    • Cascading glia reactions: A common pathomechanism and its differentiated control by cyclic nucleotide signaling
    • Schubert P, Morino T, Miyazaki H, Ogata T, Nakamura Y, Marchini C, Ferroni S: Cascading glia reactions: A common pathomechanism and its differentiated control by cyclic nucleotide signaling. Ann N Y Acad Sci 903:24-33, 2000
    • (2000) Ann N Y Acad Sci , vol.903 , pp. 24-33
    • Schubert, P.1    Morino, T.2    Miyazaki, H.3    Ogata, T.4    Nakamura, Y.5    Marchini, C.6    Ferroni, S.7
  • 41
    • 0032460149 scopus 로고    scopus 로고
    • Interfering with the pathologic activation of microglial cells and astrocytes in dementia
    • Schubert P, Rudolphi K: Interfering with the pathologic activation of microglial cells and astrocytes in dementia. Alzheimer Dis Assoc Disord 12:S21-28, 1998
    • (1998) Alzheimer Dis Assoc Disord , vol.12
    • Schubert, P.1    Rudolphi, K.2
  • 42
    • 0035866039 scopus 로고    scopus 로고
    • Beneficial immune activity after CNS injury: Prospects for vaccination
    • Schwartz M, Moalem G: Beneficial immune activity after CNS injury: Prospects for vaccination. J Neuroimmunol 113:185-192, 2001
    • (2001) J Neuroimmunol , vol.113 , pp. 185-192
    • Schwartz, M.1    Moalem, G.2
  • 43
    • 0033664605 scopus 로고    scopus 로고
    • Differential patterns of ERK and STAT3 phosphorylation after sciatic nerve transection in the rat
    • Sheu J, Kulhanek D, Eckenstein F: Differential patterns of ERK and STAT3 phosphorylation after sciatic nerve transection in the rat. Exp Neurol 166:392-402, 2000
    • (2000) Exp Neurol , vol.166 , pp. 392-402
    • Sheu, J.1    Kulhanek, D.2    Eckenstein, F.3
  • 44
    • 0032519992 scopus 로고    scopus 로고
    • Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgGl production
    • Siemasko K, Chong A, Jack H, Gong H, Williams JW, Finnegan A: Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgGl production. J Immunol 160:1581, 1998
    • (1998) J Immunol , vol.160 , pp. 1581
    • Siemasko, K.1    Chong, A.2    Jack, H.3    Gong, H.4    Williams, J.W.5    Finnegan, A.6
  • 45
    • 0024538004 scopus 로고
    • Peripheral nerve lesion produces increased levels of major histocompatibility complex antigens in the central nervous system
    • Streit W, Graeber M, Kreutzberg G: Peripheral nerve lesion produces increased levels of major histocompatibility complex antigens in the central nervous system. J Neuroimmunol 21:117-123, 1989
    • (1989) J Neuroimmunol , vol.21 , pp. 117-123
    • Streit, W.1    Graeber, M.2    Kreutzberg, G.3
  • 47
    • 0033594738 scopus 로고    scopus 로고
    • Acute peripheral inflammation induces moderate glial activation and spinal IL-1β expression that correlates with pain behavior in the rat
    • Sweitzer S, Colburn RW, Rukowski M, DeLeo JA: Acute peripheral inflammation induces moderate glial activation and spinal IL-1β expression that correlates with pain behavior in the rat. Brain Res 829:209-221, 1999
    • (1999) Brain Res , vol.829 , pp. 209-221
    • Sweitzer, S.1    Colburn, R.W.2    Rukowski, M.3    DeLeo, J.A.4
  • 48
    • 0035857748 scopus 로고    scopus 로고
    • Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibit an anti-allodynic action in a rat model of neuropathic pain
    • Sweitzer S, Martin D, DeLeo J: Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibit an anti-allodynic action in a rat model of neuropathic pain. Neuroscience 103:529-539, 2001
    • (2001) Neuroscience , vol.103 , pp. 529-539
    • Sweitzer, S.1    Martin, D.2    DeLeo, J.3
  • 49
    • 0035018058 scopus 로고    scopus 로고
    • Propentofylline, a glial modulating agent, exhibits anti-allodynic properties in a rat model of neuropathic pain
    • Sweitzer S, Schubert P, DeLeo J: Propentofylline, a glial modulating agent, exhibits anti-allodynic properties in a rat model of neuropathic pain. J Pharmacol Exp Therap 297:1210-1217, 2001
    • (2001) J Pharmacol Exp Therap , vol.297 , pp. 1210-1217
    • Sweitzer, S.1    Schubert, P.2    DeLeo, J.3
  • 50
    • 0036228048 scopus 로고    scopus 로고
    • The differential role of spinal MHC class II and cellular adhesion molecules in inflammatory versus neuropathic pain in rodents
    • Sweitzer S, White K, Dutta C, DeLeo JA: The differential role of spinal MHC class II and cellular adhesion molecules in inflammatory versus neuropathic pain in rodents. J Neuroimmunol 125:82-93, 2002
    • (2002) J Neuroimmunol , vol.125 , pp. 82-93
    • Sweitzer, S.1    White, K.2    Dutta, C.3    DeLeo, J.A.4
  • 51
    • 0029999725 scopus 로고    scopus 로고
    • Is IL-6 both a cytokine and a neurotrophic factor?
    • Wagner J: Is IL-6 both a cytokine and a neurotrophic factor? J Exp Med 183:2417-2419, 1996
    • (1996) J Exp Med , vol.183 , pp. 2417-2419
    • Wagner, J.1
  • 52
    • 0030840882 scopus 로고    scopus 로고
    • Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat
    • Watkins L, Martin D, Ulrich P, Tracey KJ, Maier SF: Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat. Pain 71:225-235, 1997
    • (1997) Pain , vol.71 , pp. 225-235
    • Watkins, L.1    Martin, D.2    Ulrich, P.3    Tracey, K.J.4    Maier, S.F.5
  • 53
    • 0035426434 scopus 로고    scopus 로고
    • Glial activation: A driving force for pathological pain
    • Watkins L, Milligan E, Maier S: Glial activation: A driving force for pathological pain. Trends Neurosci 24:450-455, 2001
    • (2001) Trends Neurosci , vol.24 , pp. 450-455
    • Watkins, L.1    Milligan, E.2    Maier, S.3
  • 54
    • 0031180972 scopus 로고    scopus 로고
    • In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-Ipr/Ipr mice
    • Xu X, Blinder L, Shen J, Gong H, Finnegan A, Williams JW, Chong ASF: In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-Ipr/Ipr mice. J Immunol 159:167, 1997
    • (1997) J Immunol , vol.159 , pp. 167
    • Xu, X.1    Blinder, L.2    Shen, J.3    Gong, H.4    Finnegan, A.5    Williams, J.W.6    Chong, A.S.F.7


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