Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain

Pain

Volumn 126, Issue 1-3, 2006, Pages 294-308

  Milligan, Erin D ^a   Sloane, Evan M ^a   Langer, Stephen J ^a   Hughes, Travis S ^a   Jekich, Brian M ^a   Frank, Matthew G ^a   Mahoney, John H ^a   Levkoff, Lindsay H ^a   Maier, Steven F ^a   Cruz, Pedro E ^b   Flotte, Terence R ^b   Johnson, Kirk W ^c   Mahoney, Melissa M ^a   Chavez, Raymond A ^c   Leinwand, Leslie A ^a   Watkins, Linda R ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c Avigen Inc   (United States)

Author keywords

Gene therapy; Glia; Naked DNA; Neuropathic pain; Rats

Indexed keywords

INTERLEUKIN 10; NAKED DNA; PLASMID DNA;

ADENOVIRUS VECTOR; ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA VECTOR; DRUG EFFICACY; DRUG REEXPOSURE; EMBRYO; HUMAN; HUMAN CELL; MALE; MEDICAL DOCUMENTATION; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PAIN ASSESSMENT; PRIORITY JOURNAL; RAT; THERAPY EFFECT; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ANIMALS; DNA; DRUG ADMINISTRATION SCHEDULE; GENE THERAPY; HUMANS; HYPERESTHESIA; INJECTIONS, SPINAL; INTERLEUKIN-10; LIGATION; MALE; MICROINJECTIONS; NEURALGIA; PLASMIDS; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; SPINAL CORD; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 33750991074     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2006.07.009     Document Type: Article

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