Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux

Molecular and Cellular Biology

Volumn 27, Issue 20, 2007, Pages 7345-7353

  Li, Jinping ^a   Wang, Enfeng ^a   Dutta, Shamit ^a   Lau, Julie S ^a   Jiang, Shi Wen ^b   Datta, Kaustubh ^a   Mukhopadhyay, Debabrata ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CUT LIKE HOMEODOMAIN PROTEIN; HOMEODOMAIN PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; PROTEIN FIH1; PROTEIN KINASE C; PROTEIN KINASE C ZETA; REGULATOR PROTEIN; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPOXIA; KIDNEY CARCINOMA; METASTASIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CARCINOMA, RENAL CELL; CELL LINE; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; KIDNEY NEOPLASMS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN KINASE C; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 35148860529     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.02201-06     Document Type: Article

References (44)

1. Acker, T., and H. Acker. 2004. Cellular oxygen sensing need in CNS function: physiological and pathological implications. J. Exp. Biol. 207:3171-3188.
2. Arany, Z., L. E. Huang, R. Eckner, S. Bhattacharya, C. Jiang, M. A. Goldberg, H. F. Bunn, and D. M. Livingston. 1996. An essential role for p300/CBP in the cellular response to hypoxia. Proc. Natl. Acad. Sci. USA 93:12969-12973.
3. Axelson, H., E. Fredlund, M. Ovenberger, G. Landberg, and S. Pahlman. 2005. Hypoxia-induced dedifferentiation of tumor cells - a mechanism behind heterogeneity and aggressiveness of solid tumors. Semin. Cell Dev. Biol. 16:554-563.
4. Coqueret, O., G. Berube, and A. Nepveu. 1996. DNA binding by cut homeodomain proteins is down-modulated by protein kinase C. J. Biol. Chem. 271:24862-24868.
5. Dann, C. E., III, R. K. Bruick, and J. Deisenhofer. 2002. Structure of factor-inhibiting hypoxia-inducible factor 1: an asparaginyl hydroxylase involved in the hypoxic response pathway. Proc. Natl. Acad. Sci. USA 99: 15351-15356.
6. Datta, K., J. Li, R. Bhattacharya, L. Gasparian, E. Wang, and D. Mukhopadhyay. 2004. Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer. Cancer Res. 64:456-462.
7. Elkins, J. M., K. S. Hewitson, L. A. McNeill, J. F. Seibel, I. Schlemminger, C. W. Pugh, P. J. Ratcliffe, and C. J. Schofield. 2003. Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. J. Biol. Chem. 278:1802-1806.
8. Freedman, S. J., Z. Y. Sun, F. Poy, A. L. Kung, D. M. Livingston, G. Wagner, and M. J. Eck. 2002. Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc. Natl. Acad. Sci. USA 99:5367-5372.
9. Greijer, A. E., P. van der Groep, D. Kemming, A. Shvarts, G. L. Semenza, G. A. Meijer, M. A. van de Wiel, J. A. Belien, P. J. van Diest, and E. van der Wall. 2005. Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). J. Pathol. 206:291-304.
10. Gupta, S., M. X. Luong, S. A. Bleuming, A. Miele, M. Luong, D. Young, E. S. Knudsen, A. J. Van Wijnen, J. L. Stein, and G. S. Stein. 2003. Tumor suppressor pRB functions as a co-repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled histone H4 transcription. J. Cell. Physiol. 196:541-556.
11. Hewitson, K. S., L. A. McNeill, M. V. Riordan, Y. M. Tian, A. N. Bullock, R. W. Welford, J. M. Elkins, N. J. Oldham, S. Bhattacharya, J. M. Gleadle, P. J. Ratclifle, C. W. Pugh, and C. J. Schofield. 2002. Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J. Biol. Chem. 277:26351-26355.
12. Hirota, K., and G. L. Semenza. 2005. Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. Biochem. Biophys. Res. Commun. 338:610-616.
13. Ivan, M., K. Kondo, H. Yang, W. Kim, J. Valiando, M. Ohh, A. Salic, J. M. Asara, W. S. Lane, and W. G. Kaelin, Jr. 2001. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292:464-468.
14. Kaelin, W. G. 2005. Proline hydroxylation and gene expression. Annu. Rev. Biochem. 74:115-128.
15. Kallio, P. J., K. Okamoto, S. O'Brien, P. Carrero, Y. Makino, H. Tanaka, and L. Poellinger. 1998. Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J. 17:6573-6586.
16. Kim, W., and W. G. Kaelin, Jr. 2003. The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer. Curr. Opin. Genet. Dev. 13:55-60.
17. Koivunen, P., M. Hirsila, V. Gunzler, K. I. Kivirikko, and J. Myllyharju. 2004. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J. Biol. Chem. 279:9899-9904.
18. Kondo, K., J. Klco, E. Nakamura, M. Lechpammer, and W. G. Kaelin, Jr. 2002. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1:237-246.
19. Lahiri, S., A. Roy, S. M. Baby, T. Hoshi, G. L. Semenza, and N. R. Prabhakar. 2006. Oxygen sensing in the body. Prog. Biophys. Mol. Biol. 91:249-286.
20. Lancaster, D. E., L. A. McNeill, M. A. McDonough, R. T. Aplin, K. S. Hewitson, C. W. Pugh, P. J. Ratcliffe, and C. J. Schofield. 2004. Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity. Biochem. J. 383:429-437.
21. Lando, D., D. J. Peet, J. J. Gorman, D. A. Whelan, M. L. Whitelaw, and R. K. Bruick. 2002. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16:1466-1471.
22. Lee, C., S. J. Kim, D. G. Jeong, S. M. Lee, and S. E. Ryu. 2003. Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau. J. Biol. Chem. 278:7558-7563.
23. Linke, S., C. Stojkoski, R. J. Kewley, G. W. Booker, M. L. Whitelaw, and D. J. Peet. 2004. Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor. J. Biol. Chem. 279:14391-14397.
24. Mahon, P. C., K. Hirota, and G. L. Semenza. 2001. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15:2675-2686.
25. Maxwell, P. H., M. S. Wiesener, G. W. Chang, S. C. Clifford, E. C. Vaux, M. E. Cockman, C. C. Wykoff, C. W. Pugh, E. R. Maher, and P. J. Ratcliffe. 1999. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271-275.
26. Maynard, M. A., and M. Ohh. 2004. Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer. Am. J. Nephrol. 24:1-13.
27. Mazure, N. M., M. C. Brahimi-Horn, M. A. Berta, E. Benizri, R. L. Bilton, F. Dayan, A. Ginouves, E. Berra, and J. Pouyssegur. 2004. HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs. Biochem. Pharmacol. 68:971-980.
28. McNeill, L. A., K. S. Hewitson, T. D. Claridge, J. F. Seibel, L. E. Horsfall, and C. J. Schofield. 2002. Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803. Biochem. J. 367:571-575.
29. Metzen, E., U. Berchner-Pfannschmidt, P. Stengel, J. H. Marxsen, I. Stolze, M. Klinger, W. Q. Huang, C. Wotzlaw, T. Hellwig-Burgel, W. Jelkmann, H. Acker, and J. Fandrey. 2003. Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing. J. Cell Sci. 116:1319-1326.
30. Metzen, E., and P. J. Ratcliffe. 2004. HIF hydroxylation and cellular oxygen sensing. Biol. Chem. 385:223-230.
31. Morris, M. R., E. Maina, N. V. Morgan, D. Gentle, D. Astuti, H. Moch, T. Kishida, M. Yao, P. Schraml, F. M. Richards, F. Latif, and E. R. Maher. 2004. Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma. J. Clin. Pathol. 57:706-711.
32. Nepveu, A. 2001. Role of the multifunctional CDP/Cut/Cux homeodomain transcription factor in regulating differentiation, cell growth and development. Gene 270:1-15.
33. Nirodi, C., J. Hart, P. Dhawan, N. S. Moon, A. Nepveu, and A. Richmond. 2001. The role of CDP in the negative regulation of CXCL1 gene expression. J. Biol. Chem. 276:26122-26131.
34. Ohh, M., C. W. Park, M. Ivan, M. A. Hoffman, T. Y. Kim, L. E. Huang, N. Pavletich, V. Chau, and W. G. Kaelin. 2000. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat. Cell Biol. 2:423-427.
35. Safran, M., and W. G. Kaelin, Jr. 2003. HIF hydroxylation and the mammalian oxygen-sensing pathway. J. Clin. Investig. 111:779-783.
36. Semenza, G. L. 2004. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda) 19:176-182.
37. Soilleux, E. J., H. Turley, Y. M. Tian, C. W. Pugh, K. C. Gatter, and A. L. Harris. 2005. Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues. Histopathology 47:602-610.
38. Stolze, I. P., Y. M. Tian, R. J. Appelhoff, H. Turley, C. C. Wykoff, J. M. Gleadle, and P. J. Ratcliffe. 2004. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (HIF) in regulating HIF transcriptional target genes. J. Biol. Chem. 279:42719- 42725.
39. van Wijnen, A. J., M. F. van Gurp, M. C. de Ridder, C. Tufarelli, T. J. Last, M. Birnbaum, P. S. Vaughan, A. Giordano, W. Krek, E. J. Neufeld, J. L. Stein, and G. S. Stein. 1996. CDP/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: a mechanism for gene regulation at the G1/S phase cell cycle transition point independent of transcription factor E2F. Proc. Natl. Acad. Sci. USA 93:11516-11521.
40. Wang, G. L., B. H. Jiang, E. A. Rue, and G. L. Semenza. 1995. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA 92:5510-5514.
41. Wang, G. L., and G. L. Semenza. 1995. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 270:1230-1237.
42. Wiesener, M. S., P. M. Munchenhagen, I. Berger, N. V. Morgan, J. Roigas, A. Schwiertz, J. S. Jurgensen, G. Gruber, P. H. Maxwell, S. A. Loning, U. Frei, E. R. Maher, H. J. Grone, and K. U. Eckardt. 2001. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. Cancer Res. 61:5215-5222.
43. Yeo, E. J., Y. S. Chun, and J. W. Park. 2004. New anticancer strategies targeting HIF-1. Biochem. Pharmacol. 68:1061-1069.
44. Yu, F., S. B. White, Q. Zhao, and F. S. Lee. 2001. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl. Acad. Sci. USA 98:9630-9635.