Protein Kinase C ζ Transactivates Hypoxia-Inducible Factor α by Promoting Its Association with p300 in Renal Cancer

Cancer Research

Volumn 64, Issue 2, 2004, Pages 456-462

  Datta, Kaustubh ^a   Li, Jinping ^a   Bhattacharya, Resham ^a   Gasparian, Levon ^a   Wang, Enfeng ^a   Mukhopadhyay, Debabrata ^b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Dept of Biochem and Molec Biology   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MESSENGER RNA; OXYGENASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C ZETA; PROTEIN P300; SMALL INTERFERING RNA; VASCULOTROPIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL HYPOXIA; CONTROLLED STUDY; EMBRYO; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYDROXYLATION; KIDNEY CANCER; KIDNEY CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ACETYLTRANSFERASES; CARCINOMA, RENAL CELL; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA PRIMERS; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE ACETYLTRANSFERASES; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY NEOPLASMS; LUCIFERASES; PROTEIN KINASE C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 1642556829     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-2706     Document Type: Article

References (34)

1. Folkman, J. Tumor angiogensis: role in regulation of tumor growth. Symp. Soc. Dev. Biol., 30: 43-52, 1974.
2. Folkman, J., and Cotran, R. Relation of vascular proliferation to tumor growth. Int. Rev. Exp. Pathol., 16: 207-248, 1976.
3. Folkman, J. Tumor angiogenesis. Adv. Cancer Res., 43: 175-203, 1985.
4. Dvorak, H. F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J. Clin. Oncol., 20: 4368-4380, 2002.
5. Zhang, X., Yamashita, M., Uetsuki, H., and Kakehi, Y. Angiogenesis in renal cell carcinoma: evaluation of microvessel density, vascular endothelial growth factor and matrix metalloproteinases. Int. J. Urol., 9: 509-514, 2002.
6. Dekel, Y., Koren, R., Kugel, V., Livne, P. M., and Gal, R. Significance of angiogenesis and microvascular invasion in renal cell carcinoma. Pathol. Oncol. Res. 8: 129-132, 2002.
7. Meloni-Ehrig, A. M. Renal cancer cytogenetic and molecular genetic aspects. Am. J. Med. Genet., 115: 164-172, 2002.
8. Gettman, M. T., and Blute, M. L. Update on pathologic staging of renal cell carcinoma. Urology, 60: 209-217, 2002.
9. Maxwell, P. H., Wiesener, M. S., Chang, G. W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., and Ratcliffe, P. J. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature (Lond.), 399: 271-275, 1999.
10. Mukhopadhyay, D., Knebelmann, B., Cohen, H. T., Ananth, S., and Sukhatme, V. P. The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity. Mol. Cell. Biol., 17: 5629-5639, 1997.
11. Junker, U., Knoefel, B., Nuske, K., Rebstock, K., Steiner, T., Wunderlich, H., Junker, K., and Reinhold, D. Transforming growth factor β1 is significantly elevated in plasma of patients suffering from renal cell carcinoma. Cytokine, 8: 794-798, 1996.
12. Iliopoulos, O., Levy, A. P., Jiang, C., Kaelin, W. G., Jr., and Goldberg, M. A. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc. Natl. Acad. Sci. USA, 93: 10595-10599, 1996.
13. Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T. Y., Huang, L. E., Pavletich, N., Chau, V., and Kaelin, W. G. Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein. Nat. Cell Biol., 2: 423-427, 2000.
14. 2 tension. Proc. Natl. Acad. Sci. USA. 92: 5510-5514, 1995.
15. Luo, G., Gu, Y. Z., Jain, S., Chan, W. K., Carr, K. M., Hogenesch, J. B., and Bradfield, C. A. Molecular characterization of the murine Hif-1 α locus. Gene Expr., 6: 287-299, 1997.
16. Gu, Y. Z., Moran, S. M., Hogenesch, J. B., Wartman, L., and Bradfield, C. A. Molecular characterization and chromosomal localization of a third α-class hypoxia inducible factor subunit, HIF3α. Gene Expr., 7: 205-213, 1998.
17. 2 sensing. Science (Wash. DC), 292: 464-468, 2001.
18. Yu, F., White, S. B., Zhao, Q., and Lee, F. S. HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl. Acad. Sci. USA, 98: 9630-9635, 2001.
19. Arany, Z., Huang, L. E., Eckner, R., Bhattacharya, S., Jiang, C., Goldberg, M. A., Bunn, H. F., and Livingston, D. M. An essential role for p300/CBP in the cellular response to hypoxia. Proc. Natl. Acad. Sci. USA, 93: 12969-12973, 1996.
20. Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J., and Whitelaw, M. L. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science (Wash. DC), 295: 858-861, 2002.
21. Brown, L. F., Berse, B., Jackman, R. W., Tognazzi, K., Manseau, E. J., Dvorak, H. F., and Senger, D. R. Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. Am. J. Pathol., 143: 1255-1262, 1993.
22. Mukhopadhyay, D., Tsiokas, L., and Sukhatme, V. P. High cell density induces vascular endothelial growth factor expression via protein tyrosine phosphorylation. Gene Expr., 7: 53-60, 1998.
23. Kondo, K., Klco, J., Nakamura, E., Lechpammer, M., and Kaelin, W. G., Jr. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell, 1: 237-246, 2002.
24. Wiesener, M. S., Munchenhagen, P. M., Berger, I., Morgan, N. V., Roigas, J., Schwiertz, A., Jurgensen, J. S., Gruber, G., Maxwell, P. H., Loning, S. A., Frei, U., Maher, E. R., Grone, H. J., and Eckardt, K. U. Constitutive activation of hypoxia-inducible genes related to overexpressiod of hypoxia-inducible factor-1α in clear cell renal carcinomas. Cancer Res., 61: 5215-5222, 2001.
25. Pal, S., Claffey, K. P., Dvorak, H. F., and Mukhopadhyay, D. The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways. J. Biol. Chem., 272: 27509-27512, 1997.
26. Pal, S., Datta, K., Khosravi-Far, R., and Mukhopadhyay, D. Role of protein kinase Cζ in Ras-mediated transcriptional activation of vascular permeability factor/vascular endothelial growth factor expression. J. Biol. Chem., 276: 2395-2403, 2001.
27. Mahon, P. C., Hirota, K., and Semenza, G. L. FIH-1-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev., 15: 2675-2686, 2001.
28. Shih, S. C., Mullen, A., Abrams, K., Mukhopadhyay, D., and Claffey, K. P. Role of protein kinase C isoforms in phorbol ester-induced vascular endothelial growth factor expression in human glioblastoma cells. J. Biol. Chem., 274: 15407-15414, 1999.
29. Folgueira, L., McElhinny, J. A., Bren, G. D., MacMorran, W. S., Diaz-Meco, M. T., Moscat, J., and Paya, C. V. Protein kinase C-ζ mediates NF-κB activation in human immunodeficiency virus-infected monocytes. J. Virol., 70: 223-231, 1996.
30. Pessino, A., Passalacqua, M., Sparatore, B., Patrone, M., Melloni, E., and Pontremoli, S. Antisense oligodeoxynucleotide inhibition of 8 protein kinase C expression accelerates induced differentiation of murine erythroleukaemia cells. Biochem. J., 312: 549-554, 1995.
31. Carlin, S., Poronnik, P., Cook, D. L., Carpenter, L., Biden, T. J., Johnson, P. R., and Black, J. L. An antisense of protein kinase C-ζ inhibits proliferation of human airway smooth muscle cells. Am. J. Respir. Cell Mol. Biol., 23: 555-559, 2000.
32. Saito, Y., Hojo, Y., Tanimoto, T., Abe, J., and Berk, B. C. Protein kinase C-α and protein kinase C-ε are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J. Biol. Chem., 277: 23216-23222, 2002.
33. Dean, N. M., McKay, R., Miraglia, L., Geiger, T., Muller, M., Fabbro, D., and Bennett, C. F. Antisense oligonucleotides as inhibitors of signal transduction: development from research tools to therapeutic agents. Biochem. Soc. Trans., 24: 623-629, 1996.
34. Monia, B. P., Holmlund, J., and Dorr, F. A. Antisense approaches for the treatment of cancer. Cancer Investig., 18: 635-650, 2000.