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Volumn 199, Issue 6, 2004, Pages 831-842

CD152 (CTLA-4) Determines the Unequal Resistance of Th1 and Th2 Cells against Activation-induced Cell Death by a Mechanism Requiring PI3 Kinase Function

Author keywords

Apoptosis; Costimulation; FasL; Signal transduction; Survival

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS ANTIGEN; FAS LIGAND; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; TRANSCRIPTION FACTOR FKHR;

EID: 1642305625     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20031058     Document Type: Article
Times cited : (93)

References (50)
  • 1
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    • Watanabe-Fukunaga, R., C.I. Brannan, N.G. Copeland, N.A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature. 356:314-317.
    • (1992) Nature , vol.356 , pp. 314-317
    • Watanabe-Fukunaga, R.1    Brannan, C.I.2    Copeland, N.G.3    Jenkins, N.A.4    Nagata, S.5
  • 3
    • 0033007321 scopus 로고    scopus 로고
    • Mature T lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment
    • Lenardo, M., K.M. Chan, F. Hornung, H. McFarland, R. Siegel, J. Wang, and L. Zheng. 1999. Mature T lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment. Annu. Rev. Immunol. 17:221-253.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 221-253
    • Lenardo, M.1    Chan, K.M.2    Hornung, F.3    McFarland, H.4    Siegel, R.5    Wang, J.6    Zheng, L.7
  • 4
    • 0036134971 scopus 로고    scopus 로고
    • Lymphocyte apoptosis: Refining the paths to perdition
    • Pinkoski, M.J., and D.R. Green. 2002. Lymphocyte apoptosis: refining the paths to perdition. Curr. Opin. Hematol. 9:43-49.
    • (2002) Curr. Opin. Hematol. , vol.9 , pp. 43-49
    • Pinkoski, M.J.1    Green, D.R.2
  • 5
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta, S.R., A. Brunet, and M.E. Greenberg. 1999. Cellular survival: a play in three Akts. Genes Dev. 13:2905-2927.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 6
    • 0033747351 scopus 로고    scopus 로고
    • Apoptosis genes and autoimmunity
    • Vaux, D.L., and R.A. Flavell. 2000. Apoptosis genes and autoimmunity. Curr. Opin. Immunol. 12:719-724.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 719-724
    • Vaux, D.L.1    Flavell, R.A.2
  • 7
    • 0032005484 scopus 로고    scopus 로고
    • The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens
    • Van Parijs, L., D.A. Peterson, and A.K. Abbas. 1998. The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens. Immunity. 8:265-274.
    • (1998) Immunity , vol.8 , pp. 265-274
    • Van Parijs, L.1    Peterson, D.A.2    Abbas, A.K.3
  • 8
    • 0032031457 scopus 로고    scopus 로고
    • Functional roles of Fas and Bcl-2-regulated apoptosis of T lymphocytes
    • Van Parijs, L., A. Biuckians, and A.K. Abbas. 1998. Functional roles of Fas and Bcl-2-regulated apoptosis of T lymphocytes. J. Immunol. 160:2065-2071.
    • (1998) J. Immunol. , vol.160 , pp. 2065-2071
    • Van Parijs, L.1    Biuckians, A.2    Abbas, A.K.3
  • 9
    • 0033790128 scopus 로고    scopus 로고
    • Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-costimulated human T cells
    • Kirchhoff, S., W.W. Muller, M. Li-Weber, and P.H. Krammer. 2000. Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-costimulated human T cells. Eur. J. Immunol. 30:2765-2774.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 2765-2774
    • Kirchhoff, S.1    Muller, W.W.2    Li-Weber, M.3    Krammer, P.H.4
  • 10
    • 0037074012 scopus 로고    scopus 로고
    • Molecular and functional profiling of memory CD8 T cell differentiation
    • Kaech, S.M., S. Hemby, E. Kersh, and R. Ahmed. 2002. Molecular and functional profiling of memory CD8 T cell differentiation. Cell. 111:837-851.
    • (2002) Cell , vol.111 , pp. 837-851
    • Kaech, S.M.1    Hemby, S.2    Kersh, E.3    Ahmed, R.4
  • 11
    • 0032959278 scopus 로고    scopus 로고
    • Costimulatory molecules and modulation
    • Brunner, M.C. 1999. Costimulatory molecules and modulation. The Immunologist. 7:9-12.
    • (1999) The Immunologist , vol.7 , pp. 9-12
    • Brunner, M.C.1
  • 13
    • 0036301503 scopus 로고    scopus 로고
    • CTLA-4: New insights into its biological function and use in tumor immunotherapy
    • Egen, J.G., M.S. Kuhns, and J.P. Allison. 2002. CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat. Immunol. 3:611-618.
    • (2002) Nat. Immunol. , vol.3 , pp. 611-618
    • Egen, J.G.1    Kuhns, M.S.2    Allison, J.P.3
  • 16
    • 0028221022 scopus 로고
    • T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif
    • Prasad, K.V., Y.C. Cai, M. Raab, B. Duckworth, L. Cantley, S.E. Shoelson, and C.E. Rudd. 1994. T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. Proc. Natl. Acad. Sci. USA. 91:2834-2838.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 2834-2838
    • Prasad, K.V.1    Cai, Y.C.2    Raab, M.3    Duckworth, B.4    Cantley, L.5    Shoelson, S.E.6    Rudd, C.E.7
  • 18
    • 0028910221 scopus 로고
    • CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
    • Schneider, H., K.V. Prasad, S.E. Shoelson, and C.E. Rudd. 1995. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. J. Exp. Med. 181:351-355.
    • (1995) J. Exp. Med. , vol.181 , pp. 351-355
    • Schneider, H.1    Prasad, K.V.2    Shoelson, S.E.3    Rudd, C.E.4
  • 19
    • 0030001318 scopus 로고    scopus 로고
    • Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
    • Marengere, L.E., P. Waterhouse, G.S. Duncan, H.W. Mittrucker, G.S. Feng, and T.W. Mak. 1996. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science. 272:1170-1173.
    • (1996) Science , vol.272 , pp. 1170-1173
    • Marengere, L.E.1    Waterhouse, P.2    Duncan, G.S.3    Mittrucker, H.W.4    Feng, G.S.5    Mak, T.W.6
  • 20
    • 0035803552 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function
    • Martin, M., H. Schneider, A. Azouz, and C.E. Rudd. 2001. Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function. J. Exp. Med. 194:1675-1681.
    • (2001) J. Exp. Med. , vol.194 , pp. 1675-1681
    • Martin, M.1    Schneider, H.2    Azouz, A.3    Rudd, C.E.4
  • 21
    • 0030176371 scopus 로고    scopus 로고
    • Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
    • Linsley, P.S., J. Bradshaw, J. Greene, R. Peach, K.L. Bennett, and R.S. Mittler. 1996. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity. 4:535-543.
    • (1996) Immunity , vol.4 , pp. 535-543
    • Linsley, P.S.1    Bradshaw, J.2    Greene, J.3    Peach, R.4    Bennett, K.L.5    Mittler, R.S.6
  • 22
    • 0036172220 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
    • Egen, J.G., and J.P. Allison. 2002. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity. 16:23-35.
    • (2002) Immunity , vol.16 , pp. 23-35
    • Egen, J.G.1    Allison, J.P.2
  • 23
    • 0032543987 scopus 로고    scopus 로고
    • Fas-independent death of activated CD4(+) T lymphocytes induced by CTLA-4 crosslinking
    • Scheipers, P., and H. Reiser. 1998. Fas-independent death of activated CD4(+) T lymphocytes induced by CTLA-4 crosslinking. Proc. Natl. Acad. Sci. USA. 95:10083-10088.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10083-10088
    • Scheipers, P.1    Reiser, H.2
  • 25
    • 0030970526 scopus 로고    scopus 로고
    • Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis
    • Zhang, X., T. Brunner, L. Carter, R.W. Dutton, P. Rogers, L. Bradley, T. Sato, J.C. Reed, D. Green, and S.L. Swain. 1997. Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J. Exp. Med. 185:1837-1849.
    • (1997) J. Exp. Med. , vol.185 , pp. 1837-1849
    • Zhang, X.1    Brunner, T.2    Carter, L.3    Dutton, R.W.4    Rogers, P.5    Bradley, L.6    Sato, T.7    Reed, J.C.8    Green, D.9    Swain, S.L.10
  • 26
    • 17544398702 scopus 로고    scopus 로고
    • Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
    • Refaeli, Y., L. Van Parijs, C.A. London, J. Tschopp, and A.K. Abbas. 1998. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity. 8:615-623.
    • (1998) Immunity , vol.8 , pp. 615-623
    • Refaeli, Y.1    Van Parijs, L.2    London, C.A.3    Tschopp, J.4    Abbas, A.K.5
  • 29
    • 0032193228 scopus 로고    scopus 로고
    • Expression and function of CTLA-4 in Th1 and Th2 cells
    • Alegre, M.L., H. Shiels, C.B. Thompson, and T.F. Gajewski. 1998. Expression and function of CTLA-4 in Th1 and Th2 cells. J. Immunol. 161:3347-3356.
    • (1998) J. Immunol. , vol.161 , pp. 3347-3356
    • Alegre, M.L.1    Shiels, H.2    Thompson, C.B.3    Gajewski, T.F.4
  • 31
    • 0034176009 scopus 로고    scopus 로고
    • Polarization of naive CD4(+) T cells toward the Th1 subset by CTLA-4 costimulation
    • Kato, T., and H. Nariuchi. 2000. Polarization of naive CD4(+) T cells toward the Th1 subset by CTLA-4 costimulation. J. Immunol. 164:3654-3562.
    • (2000) J. Immunol. , vol.164 , pp. 3654-3562
    • Kato, T.1    Nariuchi, H.2
  • 32
    • 0141920628 scopus 로고    scopus 로고
    • Diversity of clonal T cell proliferation is mediated by differential expression of CD152 (CTLA-4) on the cell surface of activated individual T lymphocytes
    • Maszyna, F., H. Hoff, D. Kunkel, A. Radbruch, and M.C. Brunner-Weinzierl. 2003. Diversity of clonal T cell proliferation is mediated by differential expression of CD152 (CTLA-4) on the cell surface of activated individual T lymphocytes. J. Immunol. 171:3459-3466.
    • (2003) J. Immunol. , vol.171 , pp. 3459-3466
    • Maszyna, F.1    Hoff, H.2    Kunkel, D.3    Radbruch, A.4    Brunner-Weinzierl, M.C.5
  • 33
    • 0033135406 scopus 로고    scopus 로고
    • Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction
    • Wesselborg, S., I.H. Engels, E. Rossmann, M. Los, and K. Schulze-Osthoff. 1999. Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction. Blood. 93:3053-3063.
    • (1999) Blood , vol.93 , pp. 3053-3063
    • Wesselborg, S.1    Engels, I.H.2    Rossmann, E.3    Los, M.4    Schulze-Osthoff, K.5
  • 35
    • 0029899783 scopus 로고    scopus 로고
    • CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
    • Krummel, M.F., and J.P. Allison. 1996. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183:2533-2540.
    • (1996) J. Exp. Med. , vol.183 , pp. 2533-2540
    • Krummel, M.F.1    Allison, J.P.2
  • 36
    • 0037037582 scopus 로고    scopus 로고
    • Interferon gamma is required for activation-induced death of T lymphocytes
    • Refaeli, Y., L. Van Parijs, S.I. Alexander, and A.K. Abbas. 2002. Interferon gamma is required for activation-induced death of T lymphocytes. J. Exp. Med. 196:999-1005.
    • (2002) J. Exp. Med. , vol.196 , pp. 999-1005
    • Refaeli, Y.1    Van Parijs, L.2    Alexander, S.I.3    Abbas, A.K.4
  • 37
    • 0033199317 scopus 로고    scopus 로고
    • Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death
    • Van Parijs, L., Y. Refaeli, J.D. Lord, B.H. Nelson, A.K. Abbas, and D. Baltimore. 1999. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity. 11:281-288.
    • (1999) Immunity , vol.11 , pp. 281-288
    • Van Parijs, L.1    Refaeli, Y.2    Lord, J.D.3    Nelson, B.H.4    Abbas, A.K.5    Baltimore, D.6
  • 38
    • 0029939945 scopus 로고    scopus 로고
    • The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance
    • Van Parijs, L., A. Ibraghimov, and A.K. Abbas. 1996. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity. 4:321-328.
    • (1996) Immunity , vol.4 , pp. 321-328
    • Van Parijs, L.1    Ibraghimov, A.2    Abbas, A.K.3
  • 40
    • 0344806280 scopus 로고    scopus 로고
    • Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression
    • Richter, A., M. Lohning, and A. Radbruch. 1999. Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression. J. Exp. Med. 190:1439-1450.
    • (1999) J. Exp. Med. , vol.190 , pp. 1439-1450
    • Richter, A.1    Lohning, M.2    Radbruch, A.3
  • 41
    • 0032561341 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cells
    • Eder, A.M., L. Dominguez, T.F. Franke, and J.D. Ashwell. 1998. Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cells. J. Biol. Chem. 273:28025-28031.
    • (1998) J. Biol. Chem. , vol.273 , pp. 28025-28031
    • Eder, A.M.1    Dominguez, L.2    Franke, T.F.3    Ashwell, J.D.4
  • 44
    • 0037080219 scopus 로고    scopus 로고
    • IL-2 and related cytokines can promote T cell survival by activating AKT
    • Kelly, E., A. Won, Y. Refaeli, and L. Van Parijs. 2002. IL-2 and related cytokines can promote T cell survival by activating AKT. J. Immunol. 168:597-603.
    • (2002) J. Immunol. , vol.168 , pp. 597-603
    • Kelly, E.1    Won, A.2    Refaeli, Y.3    Van Parijs, L.4
  • 45
    • 0035865522 scopus 로고    scopus 로고
    • CTLA-4 blockade of antigen-induced cell death
    • da Rocha, D.S., and C.E. Rudd. 2001. CTLA-4 blockade of antigen-induced cell death. Blood. 97:1134-1137.
    • (2001) Blood , vol.97 , pp. 1134-1137
    • Da Rocha, D.S.1    Rudd, C.E.2
  • 47
    • 0035107510 scopus 로고    scopus 로고
    • Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: A paradigm reconsidered
    • Bachmann, M.F., A. Gallimore, E. Jones, B. Ecabert, H. Acha-Orbea, and M. Kopf. 2001. Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered. Eur. J. Immunol. 31:450-458.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 450-458
    • Bachmann, M.F.1    Gallimore, A.2    Jones, E.3    Ecabert, B.4    Acha-Orbea, H.5    Kopf, M.6
  • 48
    • 0036134975 scopus 로고    scopus 로고
    • Suppression of Akt signaling induces Fas ligand expression: Involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation
    • Suhara, T., H.S. Kim, L.A. Kirshenbaum, and K. Walsh. 2002. Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation. Mol. Cell. Biol. 22:680-691.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 680-691
    • Suhara, T.1    Kim, H.S.2    Kirshenbaum, L.A.3    Walsh, K.4
  • 49
    • 1442342360 scopus 로고    scopus 로고
    • Following the development of a CD4 T cell response in vivo: From activation to memory formation
    • Garcia, S., J. DiSanto, and B. Stockinger. 1999. Following the development of a CD4 T cell response in vivo: from activation to memory formation. Immunity. 11:163-171.
    • (1999) Immunity , vol.11 , pp. 163-171
    • Garcia, S.1    DiSanto, J.2    Stockinger, B.3
  • 50
    • 0034655122 scopus 로고    scopus 로고
    • Increased expression of Bcl-2 in antigen-specific memory CD8+ T cells
    • Grayson, J.M., A.J. Zajac, J.D. Altman, and R. Ahmed. 2000. Increased expression of Bcl-2 in antigen-specific memory CD8+ T cells. J. Immunol. 164:3950-3954.
    • (2000) J. Immunol. , vol.164 , pp. 3950-3954
    • Grayson, J.M.1    Zajac, A.J.2    Altman, J.D.3    Ahmed, R.4


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