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Volumn 14, Issue 5, 2007, Pages 344-352

The sonic hedgehog signaling network in development and neoplasia

Author keywords

Cancer; Metastasis; Oncogene; Sonic hedgehog; Therapy

Indexed keywords

ANTINEOPLASTIC AGENT; BENZOQUINONE DERIVATIVE; BETA CATENIN; CASEIN KINASE IALPHA; CELL ADHESION MOLECULE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOPAMINE; GEFITINIB; GELDANAMYCIN; GLYCOGEN SYNTHASE KINASE 3BETA; N (3 METHOXYBENZYL) 3,3 DIMETHYL N [1 (3,4 METHYLENEDIOXYBENZYL) 2 (1 PIPERAZINYLCARBONYL) 4 PYRROLIDINYL]BUTYRAMIDE; PROTEIN SERINE THREONINE KINASE; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 34548170996     PISSN: 10724109     EISSN: 15334031     Source Type: Journal    
DOI: 10.1097/PAP.0b013e3180ca8a1d     Document Type: Review
Times cited : (88)

References (95)
  • 1
    • 33646127578 scopus 로고    scopus 로고
    • Wilson CW, Chuang PT. New hogs in Hedgehog transport and signal reception. Cell. 2006;125:435-438.
    • Wilson CW, Chuang PT. New "hogs" in Hedgehog transport and signal reception. Cell. 2006;125:435-438.
  • 2
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 2001;15:3059-3087.
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 3
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nusslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature. 1980;287:795-801.
    • (1980) Nature , vol.287 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 4
    • 0030742749 scopus 로고    scopus 로고
    • CDO: An oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family
    • Kang JS, Gao M, Feinleib JL, et al. CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. J Cell Biol. 1997;138:203-213.
    • (1997) J Cell Biol , vol.138 , pp. 203-213
    • Kang, J.S.1    Gao, M.2    Feinleib, J.L.3
  • 5
    • 0037080787 scopus 로고    scopus 로고
    • BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation
    • Kang JS, Mulieri PJ, Hu Y, et al. BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. Embo J. 2002;21:114-124.
    • (2002) Embo J , vol.21 , pp. 114-124
    • Kang, J.S.1    Mulieri, P.J.2    Hu, Y.3
  • 6
    • 33646120095 scopus 로고    scopus 로고
    • Cdo functions at multiple points in the sonic hedgehog pathway, and cdo-deficient mice accurately model human holoprosencephaly
    • Zhang W, Kang JS, Cole F, et al. Cdo functions at multiple points in the sonic hedgehog pathway, and cdo-deficient mice accurately model human holoprosencephaly. Dev Cell. 2006;10:657-665.
    • (2006) Dev Cell , vol.10 , pp. 657-665
    • Zhang, W.1    Kang, J.S.2    Cole, F.3
  • 7
    • 33646103902 scopus 로고    scopus 로고
    • The cell surface membrane proteins cdo and boc are components and targets of the hedgehog signaling pathway and feedback network in mice
    • Tenzen T, Allen BL, Cole F, et al. The cell surface membrane proteins cdo and boc are components and targets of the hedgehog signaling pathway and feedback network in mice. Dev Cell. 2006;10:647-656.
    • (2006) Dev Cell , vol.10 , pp. 647-656
    • Tenzen, T.1    Allen, B.L.2    Cole, F.3
  • 8
    • 33751078546 scopus 로고    scopus 로고
    • Boc is a receptor for sonic hedgehog in the guidance of commissural axons
    • Okada A, Charron F, Morin S, et al. Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature. 2006;444:369-373.
    • (2006) Nature , vol.444 , pp. 369-373
    • Okada, A.1    Charron, F.2    Morin, S.3
  • 9
    • 0142153787 scopus 로고    scopus 로고
    • The hedgehog signaling network
    • Cohen MM Jr. The hedgehog signaling network. Am J Med Genet. 2003;123A:5-28.
    • (2003) Am J Med Genet , vol.123 A , pp. 5-28
    • Cohen Jr., M.M.1
  • 10
    • 33646235390 scopus 로고    scopus 로고
    • Regulation of Ci and Su(fu) nuclear import in Drosophila
    • Sisson BE, Ziegenhorn SL, Holmgren RA. Regulation of Ci and Su(fu) nuclear import in Drosophila. Dev Biol. 2006;294:258-270.
    • (2006) Dev Biol , vol.294 , pp. 258-270
    • Sisson, B.E.1    Ziegenhorn, S.L.2    Holmgren, R.A.3
  • 12
    • 31744436876 scopus 로고    scopus 로고
    • Divergence of hedgehog signal transduction mechanism between Drosophila and mammals
    • Varjosalo M, Li SP, Taipale J. Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev Cell. 2006;10:177-186.
    • (2006) Dev Cell , vol.10 , pp. 177-186
    • Varjosalo, M.1    Li, S.P.2    Taipale, J.3
  • 13
    • 0032506115 scopus 로고    scopus 로고
    • Characterization of two patched receptors for the vertebrate hedgehog protein family
    • Carpenter D, Stone DM, Brush J, et al. Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc Natl Acad Sci USA. 1998;95:13630-13634.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13630-13634
    • Carpenter, D.1    Stone, D.M.2    Brush, J.3
  • 14
    • 0011102935 scopus 로고    scopus 로고
    • The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    • Stone DM, Hynes M, Armanini M, et al. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature. 1996;384:129-134.
    • (1996) Nature , vol.384 , pp. 129-134
    • Stone, D.M.1    Hynes, M.2    Armanini, M.3
  • 15
    • 0029948270 scopus 로고    scopus 로고
    • Biochemical evidence that patched is the Hedgehog receptor
    • Marigo V, Davey RA, Zuo Y, et al. Biochemical evidence that patched is the Hedgehog receptor. Nature. 1996;384:176-179.
    • (1996) Nature , vol.384 , pp. 176-179
    • Marigo, V.1    Davey, R.A.2    Zuo, Y.3
  • 16
    • 40749144679 scopus 로고    scopus 로고
    • Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
    • Haycraft CJ, Banizs B, Aydin-Son Y, et al. Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 2005;1:e53.
    • (2005) PLoS Genet , vol.1
    • Haycraft, C.J.1    Banizs, B.2    Aydin-Son, Y.3
  • 17
    • 31744441904 scopus 로고    scopus 로고
    • Mammalian variations on a theme: A Smo and Sufu surprise
    • Oro AE. Mammalian variations on a theme: a Smo and Sufu surprise. Dev Cell. 2006;10:156-158.
    • (2006) Dev Cell , vol.10 , pp. 156-158
    • Oro, A.E.1
  • 18
    • 0037117611 scopus 로고    scopus 로고
    • Suppressor of fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex
    • Cheng SY, Bishop JM. Suppressor of fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. Proc Natl Acad Sci USA. 2002;99:5442-5447.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5442-5447
    • Cheng, S.Y.1    Bishop, J.M.2
  • 19
    • 1642370648 scopus 로고    scopus 로고
    • The negative regulator of Gli, suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins
    • Paces-Fessy M, Boucher D, Petit E, et al. The negative regulator of Gli, suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. Biochem J. 2004;378(Pt 2):353-362.
    • (2004) Biochem J , vol.378 , Issue.PART 2 , pp. 353-362
    • Paces-Fessy, M.1    Boucher, D.2    Petit, E.3
  • 20
    • 33845721880 scopus 로고    scopus 로고
    • GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells
    • Takenaka K, Kise Y, Miki H. GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells. Biochem Biophys Res Commun. 2007;353:501-508.
    • (2007) Biochem Biophys Res Commun , vol.353 , pp. 501-508
    • Takenaka, K.1    Kise, Y.2    Miki, H.3
  • 21
    • 0033580269 scopus 로고    scopus 로고
    • Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
    • Chuang PT, McMahon AP. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature. 1999;397:617-621.
    • (1999) Nature , vol.397 , pp. 617-621
    • Chuang, P.T.1    McMahon, A.P.2
  • 22
    • 0041852606 scopus 로고    scopus 로고
    • Gli proteins and the control of spinal-cord patterning
    • 2003;4:761-765
    • Jacob J, Briscoe J. Gli proteins and the control of spinal-cord patterning. EMBO Rep. 2003;4:761-765.
    • EMBO Rep
    • Jacob, J.1    Briscoe, J.2
  • 23
    • 0033590144 scopus 로고    scopus 로고
    • Gli genes in development and cancer
    • Matise MP, Joyner AL. Gli genes in development and cancer. Oncogene. 1999;18:7852-7859.
    • (1999) Oncogene , vol.18 , pp. 7852-7859
    • Matise, M.P.1    Joyner, A.L.2
  • 24
    • 33846609167 scopus 로고    scopus 로고
    • Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate
    • Flynt AS, Li N, Thatcher EJ, et al. Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate. Nat Genet. 2007;39:259-263.
    • (2007) Nat Genet , vol.39 , pp. 259-263
    • Flynt, A.S.1    Li, N.2    Thatcher, E.J.3
  • 25
    • 0032852267 scopus 로고    scopus 로고
    • Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin
    • Ghali L, Wong ST, Green J, et al. Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin. J Invest Dermatol. 1999;113:595-599.
    • (1999) J Invest Dermatol , vol.113 , pp. 595-599
    • Ghali, L.1    Wong, S.T.2    Green, J.3
  • 26
    • 15844381336 scopus 로고    scopus 로고
    • Human homolog of patched, a candidate gene for the basal cell nevus syndrome
    • Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science. 1996;272:1668-1671.
    • (1996) Science , vol.272 , pp. 1668-1671
    • Johnson, R.L.1    Rothman, A.L.2    Xie, J.3
  • 27
    • 16044363842 scopus 로고    scopus 로고
    • The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
    • Gailani MR, Stahle-Backdahl M, Leffell DJ, et al. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. Nat Genet. 1996;14:78-81.
    • (1996) Nat Genet , vol.14 , pp. 78-81
    • Gailani, M.R.1    Stahle-Backdahl, M.2    Leffell, D.J.3
  • 28
    • 0031913524 scopus 로고    scopus 로고
    • Activating smoothened mutations in sporadic basal-cell carcinoma
    • Xie J, Murone M, Luoh SM, et al. Activating smoothened mutations in sporadic basal-cell carcinoma. Nature. 1998;391:90-92.
    • (1998) Nature , vol.391 , pp. 90-92
    • Xie, J.1    Murone, M.2    Luoh, S.M.3
  • 29
    • 0346463039 scopus 로고    scopus 로고
    • Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1
    • Bigelow RL, Chari NS, Unden AB, et al. Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J Biol Chem. 2004;279:1197-1205.
    • (2004) J Biol Chem , vol.279 , pp. 1197-1205
    • Bigelow, R.L.1    Chari, N.S.2    Unden, A.B.3
  • 30
    • 7444247429 scopus 로고    scopus 로고
    • Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2
    • Regl G, Kasper M, Schnidar H, et al. Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2. Cancer Res. 2004;64:7724-7731.
    • (2004) Cancer Res , vol.64 , pp. 7724-7731
    • Regl, G.1    Kasper, M.2    Schnidar, H.3
  • 31
    • 12944263652 scopus 로고    scopus 로고
    • Sonic hedgehog induces epidermal growth factor dependent matrix infiltration in HaCaT keratinocytes
    • Bigelow RL, Jen EY, Delehedde M, et al. Sonic hedgehog induces epidermal growth factor dependent matrix infiltration in HaCaT keratinocytes. J Invest Dermatol. 2005;124:457-465.
    • (2005) J Invest Dermatol , vol.124 , pp. 457-465
    • Bigelow, R.L.1    Jen, E.Y.2    Delehedde, M.3
  • 32
    • 0036648241 scopus 로고    scopus 로고
    • Mutations in SUFU predispose to medulloblastoma
    • Taylor MD, Liu L, Raffel C, et al. Mutations in SUFU predispose to medulloblastoma. Nat Genet. 2002;31:306-310.
    • (2002) Nat Genet , vol.31 , pp. 306-310
    • Taylor, M.D.1    Liu, L.2    Raffel, C.3
  • 33
    • 21644448546 scopus 로고    scopus 로고
    • Analysis of the PTCH1 signaling pathway in ovarian dermoids
    • Levanat S, Kappler R, Hemmerlein B, et al. Analysis of the PTCH1 signaling pathway in ovarian dermoids. Int J Mol Med. 2004;14:793-799.
    • (2004) Int J Mol Med , vol.14 , pp. 793-799
    • Levanat, S.1    Kappler, R.2    Hemmerlein, B.3
  • 34
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    • Berman DM, Karhadkar SS, Maitra A, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 2003;425:846-851.
    • (2003) Nature , vol.425 , pp. 846-851
    • Berman, D.M.1    Karhadkar, S.S.2    Maitra, A.3
  • 35
    • 1542357306 scopus 로고    scopus 로고
    • Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis
    • Berman DM, Desai N, Wang X, et al. Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol. 2004;267:387-398.
    • (2004) Dev Biol , vol.267 , pp. 387-398
    • Berman, D.M.1    Desai, N.2    Wang, X.3
  • 36
    • 4344586961 scopus 로고    scopus 로고
    • Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer
    • Kubo M, Nakamura M, Tasaki A, et al. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res. 2004;64:6071-6074.
    • (2004) Cancer Res , vol.64 , pp. 6071-6074
    • Kubo, M.1    Nakamura, M.2    Tasaki, A.3
  • 37
    • 25144461600 scopus 로고    scopus 로고
    • Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms
    • Martin ST, Sato N, Dhara S, et al. Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms. Cancer Biol Ther. 2005;4:728-733.
    • (2005) Cancer Biol Ther , vol.4 , pp. 728-733
    • Martin, S.T.1    Sato, N.2    Dhara, S.3
  • 38
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    • Watkins DN, Berman DM, Burkholder SG, et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature. 2003;422:313-317.
    • (2003) Nature , vol.422 , pp. 313-317
    • Watkins, D.N.1    Berman, D.M.2    Burkholder, S.G.3
  • 39
    • 0032563948 scopus 로고    scopus 로고
    • Sonic hedgehog regulates branching morphogenesis in the mammalian lung
    • Pepicelli CV, Lewis PM, McMahon AP. Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol. 1998;8:1083-1086.
    • (1998) Curr Biol , vol.8 , pp. 1083-1086
    • Pepicelli, C.V.1    Lewis, P.M.2    McMahon, A.P.3
  • 40
    • 0031683165 scopus 로고    scopus 로고
    • Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
    • Motoyama J, Liu J, Mo R, et al. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet. 1998;20:54-57.
    • (1998) Nat Genet , vol.20 , pp. 54-57
    • Motoyama, J.1    Liu, J.2    Mo, R.3
  • 41
    • 0031260579 scopus 로고    scopus 로고
    • Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
    • Apelqvist A, Ahlgren U, Edlund H. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol. 1997;7:801-804.
    • (1997) Curr Biol , vol.7 , pp. 801-804
    • Apelqvist, A.1    Ahlgren, U.2    Edlund, H.3
  • 42
    • 33846237601 scopus 로고    scopus 로고
    • HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
    • Clement V, Sanchez P, de Tribolet N, et al. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol. 2007;17:165-172.
    • (2007) Curr Biol , vol.17 , pp. 165-172
    • Clement, V.1    Sanchez, P.2    de Tribolet, N.3
  • 43
    • 27144541492 scopus 로고    scopus 로고
    • Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas
    • Ma X, Chen K, Huang S, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. 2005;26:1698-1705.
    • (2005) Carcinogenesis , vol.26 , pp. 1698-1705
    • Ma, X.1    Chen, K.2    Huang, S.3
  • 44
    • 13144298531 scopus 로고    scopus 로고
    • Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors
    • Olsen CL, Hsu PP, Glienke J, et al. Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. BMC Cancer. 2004;4:43.
    • (2004) BMC Cancer , vol.4 , pp. 43
    • Olsen, C.L.1    Hsu, P.P.2    Glienke, J.3
  • 45
    • 33751264968 scopus 로고    scopus 로고
    • Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells
    • Tsuda N, Ishiyama S, Li Y, et al. Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells. Clin Cancer Res. 2006;12:6557-6564.
    • (2006) Clin Cancer Res , vol.12 , pp. 6557-6564
    • Tsuda, N.1    Ishiyama, S.2    Li, Y.3
  • 46
    • 0033136040 scopus 로고    scopus 로고
    • Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium
    • Podlasek CA, Barnett DH, Clemens JQ, et al. Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium. Dev Biol. 1999;209:28-39.
    • (1999) Dev Biol , vol.209 , pp. 28-39
    • Podlasek, C.A.1    Barnett, D.H.2    Clemens, J.Q.3
  • 47
    • 0033966897 scopus 로고    scopus 로고
    • New mouse models of congenital anorectal malformations
    • Discussion 230-231
    • Kimmel SG, Mo R, Hui CC, et al. New mouse models of congenital anorectal malformations. J Pediatr Surg. 2000;35:227-230. Discussion 230-231.
    • (2000) J Pediatr Surg , vol.35 , pp. 227-230
    • Kimmel, S.G.1    Mo, R.2    Hui, C.C.3
  • 48
    • 0034880142 scopus 로고    scopus 로고
    • Anorectal malformations caused by defects in sonic hedgehog signaling
    • Mo R, Kim JH, Zhang J, et al. Anorectal malformations caused by defects in sonic hedgehog signaling. Am J Pathol. 2001;159:765-774.
    • (2001) Am J Pathol , vol.159 , pp. 765-774
    • Mo, R.1    Kim, J.H.2    Zhang, J.3
  • 49
    • 0022967338 scopus 로고
    • Whole-mount autoradiography study of DNA synthetic activity during postnatal development and androgen-induced regeneration in the mouse prostate
    • Sugimura Y, Cunha GR, Donjacour AA, et al. Whole-mount autoradiography study of DNA synthetic activity during postnatal development and androgen-induced regeneration in the mouse prostate. Biol Reprod. 1986;34:985-995.
    • (1986) Biol Reprod , vol.34 , pp. 985-995
    • Sugimura, Y.1    Cunha, G.R.2    Donjacour, A.A.3
  • 50
    • 0036837651 scopus 로고    scopus 로고
    • The human prostate expresses sonic hedgehog during fetal development
    • Barnett DH, Huang HY, Wu XR, et al. The human prostate expresses sonic hedgehog during fetal development. J Urol. 2002;168:2206-2210.
    • (2002) J Urol , vol.168 , pp. 2206-2210
    • Barnett, D.H.1    Huang, H.Y.2    Wu, X.R.3
  • 51
    • 0031034866 scopus 로고    scopus 로고
    • Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis
    • Bellusci S, Furuta Y, Rush MG, et al. Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development. 1997;124:53-63.
    • (1997) Development , vol.124 , pp. 53-63
    • Bellusci, S.1    Furuta, Y.2    Rush, M.G.3
  • 52
    • 0036385832 scopus 로고    scopus 로고
    • Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation
    • Lamm ML, Catbagan WS, Laciak RJ, et al. Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Dev Biol. 2002;249:349-366.
    • (2002) Dev Biol , vol.249 , pp. 349-366
    • Lamm, M.L.1    Catbagan, W.S.2    Laciak, R.J.3
  • 53
    • 0038381478 scopus 로고    scopus 로고
    • Inhibition of epithelial ductal branching in the prostate by sonic hedgehog is indirectly mediated by stromal cells
    • Wang BE, Shou J, Ross S, et al. Inhibition of epithelial ductal branching in the prostate by sonic hedgehog is indirectly mediated by stromal cells. J Biol Chem. 2003;278:18506-18513.
    • (2003) J Biol Chem , vol.278 , pp. 18506-18513
    • Wang, B.E.1    Shou, J.2    Ross, S.3
  • 54
    • 4344655390 scopus 로고    scopus 로고
    • Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: Lobe-specific suppression by neonatal estrogens reduces ductal growth and branching
    • Pu Y, Huang L, Prins GS. Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching. Dev Biol. 2004;273:257-275.
    • (2004) Dev Biol , vol.273 , pp. 257-275
    • Pu, Y.1    Huang, L.2    Prins, G.S.3
  • 55
    • 33645075720 scopus 로고    scopus 로고
    • Hedgehog signaling in pancreas development and disease
    • Lau J, Kawahira H, Hebrok M. Hedgehog signaling in pancreas development and disease. Cell Mol Life Sci. 2006;63:642-652.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 642-652
    • Lau, J.1    Kawahira, H.2    Hebrok, M.3
  • 56
    • 23844542076 scopus 로고    scopus 로고
    • Hedgehog signaling pathway as a therapeutic target in breast cancer
    • Katano M. Hedgehog signaling pathway as a therapeutic target in breast cancer. Cancer Lett. 2005;227:99-104.
    • (2005) Cancer Lett , vol.227 , pp. 99-104
    • Katano, M.1
  • 57
    • 6044243650 scopus 로고    scopus 로고
    • Hedgehog signalling in prostate regeneration, neoplasia and metastasis
    • Karhadkar SS, Bova GS, Abdallah N, et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature. 2004;431:707-712.
    • (2004) Nature , vol.431 , pp. 707-712
    • Karhadkar, S.S.1    Bova, G.S.2    Abdallah, N.3
  • 58
    • 0141834796 scopus 로고    scopus 로고
    • Hedgehog signaling: Progenitor phenotype in small-cell lung cancer
    • Watkins DN, Berman DM, Baylin SB. Hedgehog signaling: progenitor phenotype in small-cell lung cancer. Cell Cycle. 2003;2:196-198.
    • (2003) Cell Cycle , vol.2 , pp. 196-198
    • Watkins, D.N.1    Berman, D.M.2    Baylin, S.B.3
  • 59
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale J, Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature. 2001;411:349-354.
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 60
    • 3843089435 scopus 로고    scopus 로고
    • Hedgehog signaling promotes prostate xenograft tumor growth
    • Fan L, Pepicelli CV, Dibble CC, et al. Hedgehog signaling promotes prostate xenograft tumor growth. Endocrinology. 2004;145:3961-3970.
    • (2004) Endocrinology , vol.145 , pp. 3961-3970
    • Fan, L.1    Pepicelli, C.V.2    Dibble, C.C.3
  • 61
    • 13644261744 scopus 로고    scopus 로고
    • Activation of the hedgehog pathway in advanced prostate cancer
    • Sheng T, Li C, Zhang X, et al. Activation of the hedgehog pathway in advanced prostate cancer. Mol Cancer. 2004;3:29.
    • (2004) Mol Cancer , vol.3 , pp. 29
    • Sheng, T.1    Li, C.2    Zhang, X.3
  • 62
    • 4344659678 scopus 로고    scopus 로고
    • Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
    • Sanchez P, Hernandez AM, Stecca B, et al. Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc Natl Acad Sci USA. 2004;101:12561-12566.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 12561-12566
    • Sanchez, P.1    Hernandez, A.M.2    Stecca, B.3
  • 63
    • 31744451535 scopus 로고    scopus 로고
    • Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
    • Svard J, Heby-Henricson K, Persson-Lek M, et al. Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell. 2006;10:187-197.
    • (2006) Dev Cell , vol.10 , pp. 187-197
    • Svard, J.1    Heby-Henricson, K.2    Persson-Lek, M.3
  • 64
    • 0035955642 scopus 로고    scopus 로고
    • Suppressor of fused negatively regulates beta-catenin signaling
    • Meng X, Poon R, Zhang X, et al. Suppressor of fused negatively regulates beta-catenin signaling. J Biol Chem. 2001;276:40113-40119.
    • (2001) J Biol Chem , vol.276 , pp. 40113-40119
    • Meng, X.1    Poon, R.2    Zhang, X.3
  • 65
    • 3042665321 scopus 로고    scopus 로고
    • Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling
    • Taylor MD, Zhang X, Liu L, et al. Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling. Oncogene. 2004;23:4577-4583.
    • (2004) Oncogene , vol.23 , pp. 4577-4583
    • Taylor, M.D.1    Zhang, X.2    Liu, L.3
  • 66
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St-Jacques B, Hammerschmidt M, McMahon AP. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 1999;13:2072-2086.
    • (1999) Genes Dev , vol.13 , pp. 2072-2086
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 67
    • 1842611651 scopus 로고    scopus 로고
    • Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton
    • Long F, Chung UI, Ohba S, et al. Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development. 2004;131:1309-1318.
    • (2004) Development , vol.131 , pp. 1309-1318
    • Long, F.1    Chung, U.I.2    Ohba, S.3
  • 68
    • 0035135642 scopus 로고    scopus 로고
    • Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development
    • Chung UI, Schipani E, McMahon AP, et al. Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest. 2001;107:295-304.
    • (2001) J Clin Invest , vol.107 , pp. 295-304
    • Chung, U.I.1    Schipani, E.2    McMahon, A.P.3
  • 69
    • 0031042224 scopus 로고    scopus 로고
    • Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation
    • Kinto N, Iwamoto M, Enomoto-Iwamoto M, et al. Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation. FEBS Lett. 1997;404:319-323.
    • (1997) FEBS Lett , vol.404 , pp. 319-323
    • Kinto, N.1    Iwamoto, M.2    Enomoto-Iwamoto, M.3
  • 70
    • 0034949211 scopus 로고    scopus 로고
    • Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation
    • Spinella-Jaegle S, Rawadi G, Kawai S, et al. Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation. J Cell Sci. 2001;114(Pt 11):2085-2094.
    • (2001) J Cell Sci , vol.114 , Issue.PART 11 , pp. 2085-2094
    • Spinella-Jaegle, S.1    Rawadi, G.2    Kawai, S.3
  • 71
    • 0002452569 scopus 로고    scopus 로고
    • Developmental roles and clinical significance of hedgehog signaling
    • McMahon AP, Ingham PW, Tabin CJ. Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol. 2003;53:1-114.
    • (2003) Curr Top Dev Biol , vol.53 , pp. 1-114
    • McMahon, A.P.1    Ingham, P.W.2    Tabin, C.J.3
  • 72
    • 0032486433 scopus 로고    scopus 로고
    • Teratogen-mediated inhibition of target tissue response to Shh signaling
    • Cooper MK, Porter JA, Young KE, et al. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science. 1998;280:1603-1607.
    • (1998) Science , vol.280 , pp. 1603-1607
    • Cooper, M.K.1    Porter, J.A.2    Young, K.E.3
  • 73
    • 0036829397 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling by direct binding of cyclopamine to smoothened
    • Chen JK, Taipale J, Cooper MK, et al. Inhibition of Hedgehog signaling by direct binding of cyclopamine to smoothened. Genes Dev. 2002;16:2743-2748.
    • (2002) Genes Dev , vol.16 , pp. 2743-2748
    • Chen, J.K.1    Taipale, J.2    Cooper, M.K.3
  • 74
    • 33749329022 scopus 로고    scopus 로고
    • Roughing up Smoothened: Chemical modulators of hedgehog signaling
    • King RW. Roughing up Smoothened: chemical modulators of hedgehog signaling. J Biol. 2002;1:8.
    • (2002) J Biol , vol.1 , pp. 8
    • King, R.W.1
  • 75
    • 30744466891 scopus 로고    scopus 로고
    • Sonic hedgehog myocardial gene therapy: Tissue repair through transient reconstitution of embryonic signaling
    • Kusano KF, Pola R, Murayama T, et al. Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling. Nat Med. 2005;11:1197-1204.
    • (2005) Nat Med , vol.11 , pp. 1197-1204
    • Kusano, K.F.1    Pola, R.2    Murayama, T.3
  • 76
    • 33744466786 scopus 로고    scopus 로고
    • Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling
    • Asai J, Takenaka H, Kusano KF, et al. Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation. 2006;113:2413-2424.
    • (2006) Circulation , vol.113 , pp. 2413-2424
    • Asai, J.1    Takenaka, H.2    Kusano, K.F.3
  • 77
    • 0037195074 scopus 로고    scopus 로고
    • Small molecule modulation of Smoothened activity
    • Chen JK, Taipale J, Young KE, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci USA. 2002;99:14071-14076.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14071-14076
    • Chen, J.K.1    Taipale, J.2    Young, K.E.3
  • 78
    • 0037447269 scopus 로고    scopus 로고
    • Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions
    • Williams JA, Guicherit OM, Zaharian BI, et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci USA. 2003;100:4616-4621.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4616-4621
    • Williams, J.A.1    Guicherit, O.M.2    Zaharian, B.I.3
  • 79
    • 1942473030 scopus 로고    scopus 로고
    • Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity
    • Tabs S, Avci O. Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity. Eur J Dermatol. 2004;14:96-102.
    • (2004) Eur J Dermatol , vol.14 , pp. 96-102
    • Tabs, S.1    Avci, O.2
  • 80
    • 4544285754 scopus 로고    scopus 로고
    • Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice
    • Romer JT, Kimura H, Magdaleno S, et al. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell. 2004;6:229-240.
    • (2004) Cancer Cell , vol.6 , pp. 229-240
    • Romer, J.T.1    Kimura, H.2    Magdaleno, S.3
  • 81
    • 0037200078 scopus 로고    scopus 로고
    • Medulloblastoma growth inhibition by hedgehog pathway blockade
    • Berman DM, Karhadkar SS, Hallahan AR, et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science. 2002; 297:1559-1561.
    • (2002) Science , vol.297 , pp. 1559-1561
    • Berman, D.M.1    Karhadkar, S.S.2    Hallahan, A.R.3
  • 82
    • 31544458968 scopus 로고    scopus 로고
    • Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells
    • Mimeault M, Moore E, Moniaux N, et al. Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells. Int J Cancer. 2006;118:1022-1031.
    • (2006) Int J Cancer , vol.118 , pp. 1022-1031
    • Mimeault, M.1    Moore, E.2    Moniaux, N.3
  • 83
    • 27144441838 scopus 로고    scopus 로고
    • The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: What's genetics got to do with it?
    • Shelton JG, Steelman LS, Abrams SL, et al. The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it? Expert Opin Ther Targets. 2005;9:1009-1030.
    • (2005) Expert Opin Ther Targets , vol.9 , pp. 1009-1030
    • Shelton, J.G.1    Steelman, L.S.2    Abrams, S.L.3
  • 84
    • 0344953585 scopus 로고    scopus 로고
    • A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis
    • Cooper MK, Wassif CA, Krakowiak PA, et al. A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nat Genet. 2003;33:508-513.
    • (2003) Nat Genet , vol.33 , pp. 508-513
    • Cooper, M.K.1    Wassif, C.A.2    Krakowiak, P.A.3
  • 85
    • 33846448142 scopus 로고    scopus 로고
    • Cholesterol, statins and cancer
    • Brown AJ. Cholesterol, statins and cancer. Clin Exp Pharmacol Physiol. 2007;34:135-141.
    • (2007) Clin Exp Pharmacol Physiol , vol.34 , pp. 135-141
    • Brown, A.J.1
  • 86
    • 33750362031 scopus 로고    scopus 로고
    • Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels
    • Kise Y, Takenaka K, Tezuka T, et al. Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels. Biochem Biophys Res Commun. 2006;351:78-84.
    • (2006) Biochem Biophys Res Commun , vol.351 , pp. 78-84
    • Kise, Y.1    Takenaka, K.2    Tezuka, T.3
  • 87
    • 32444449871 scopus 로고    scopus 로고
    • GLI transcription factors: Mediators of oncogenic Hedgehog signalling
    • Kasper M, Regl G, Frischauf AM, et al. GLI transcription factors: mediators of oncogenic Hedgehog signalling. Eur J Cancer. 2006;42:437-445.
    • (2006) Eur J Cancer , vol.42 , pp. 437-445
    • Kasper, M.1    Regl, G.2    Frischauf, A.M.3
  • 88
    • 0037108828 scopus 로고    scopus 로고
    • Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation
    • Louro ID, Bailey EC, Li X, et al. Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation. Cancer Res. 2002;62:5867-5873.
    • (2002) Cancer Res , vol.62 , pp. 5867-5873
    • Louro, I.D.1    Bailey, E.C.2    Li, X.3
  • 89
    • 0028178786 scopus 로고
    • Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
    • Tabata T, Kornberg TB. Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell. 1994;76:89-102.
    • (1994) Cell , vol.76 , pp. 89-102
    • Tabata, T.1    Kornberg, T.B.2
  • 90
    • 0033728201 scopus 로고    scopus 로고
    • Hexokinase I is a Gli2-responsive gene expressed in the embryonic CNS
    • Brewster R, Ruiz i Altaba A. Hexokinase I is a Gli2-responsive gene expressed in the embryonic CNS. Mech Dev. 2000;99:159-162.
    • (2000) Mech Dev , vol.99 , pp. 159-162
    • Brewster, R.1    Ruiz i Altaba, A.2
  • 91
    • 0037314331 scopus 로고    scopus 로고
    • Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung
    • Chuang PT, Kawcak T, McMahon AP. Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev. 2003;17:342-347.
    • (2003) Genes Dev , vol.17 , pp. 342-347
    • Chuang, P.T.1    Kawcak, T.2    McMahon, A.P.3
  • 92
    • 0037102232 scopus 로고    scopus 로고
    • FOXM1 is a downstream target of Gli1 in basal cell carcinomas
    • Teh MT, Wong ST, Neill GW, et al. FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res. 2002;62:4773-4780.
    • (2002) Cancer Res , vol.62 , pp. 4773-4780
    • Teh, M.T.1    Wong, S.T.2    Neill, G.W.3
  • 93
    • 2442423841 scopus 로고    scopus 로고
    • FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma
    • Eichberger T, Regl G, Ikram MS, et al. FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma. J Invest Dermatol. 2004;122:1180-1187.
    • (2004) J Invest Dermatol , vol.122 , pp. 1180-1187
    • Eichberger, T.1    Regl, G.2    Ikram, M.S.3
  • 94
    • 0034665975 scopus 로고    scopus 로고
    • Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma
    • Hahn H, Wojnowski L, Specht K, et al. Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma. J Biol Chem. 2000;275:28341-28344.
    • (2000) J Biol Chem , vol.275 , pp. 28341-28344
    • Hahn, H.1    Wojnowski, L.2    Specht, K.3
  • 95
    • 0031436999 scopus 로고    scopus 로고
    • Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase
    • Krishnan V, Pereira FA, Qiu Y, et al. Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. Science. 1997;278:1947-1950.
    • (1997) Science , vol.278 , pp. 1947-1950
    • Krishnan, V.1    Pereira, F.A.2    Qiu, Y.3


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