Pharmacological modulation of lung cancer cells for potassium ion depletion

Anticancer Research

Volumn 25, Issue 4, 2005, Pages 2609-2616

  Andersson, Britta ^a   Behnam Motlagh, Parviz ^a   Henriksson, Roger ^a   Grankvist, Kjell ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

86Rb+; Amphotericin B; Ionophores; Mesothelioma; Potassium ion flux; Small cell lung cancer

Indexed keywords

AMPHOTERICIN B; BUMETANIDE; DIGITONIN; LACTATE DEHYDROGENASE; NIGERICIN; OUABAIN; POTASSIUM DERIVATIVE; PROTEIN INHIBITOR; RUBIDIUM 86;

APOPTOSIS; ARTICLE; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME RELEASE; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; POTASSIUM CELL LEVEL; POTASSIUM DEPLETION; POTASSIUM TRANSPORT; PRIORITY JOURNAL;

AMPHOTERICIN B; BUMETANIDE; CARCINOMA, SMALL CELL; CELL LINE, TUMOR; DIGITONIN; DRUG INTERACTIONS; HUMANS; IONOPHORES; LUNG NEOPLASMS; MESOTHELIOMA; NIGERICIN; OUABAIN; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RUBIDIUM RADIOISOTOPES;

EID: 22944463348     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. + efflux in the activation of apoptosis. J Biol Chem 272: 32436-32442, 1997.
2. + channels induces apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol 280: C970-C979, 2001.
3. + efflux and neuronal apoptosis. Science 284: 336-339, 1999.
4. Yu SP, Yeh CH, Sensi SL, Gwag BJ, Canzoniero LM, Farhangrazi ZS, Ying HS, Tian M, Dugan LL and Choi DW: Mediation of neuronal apoptosis by enhancement of outward potassium current. Science 278: 114-117, 1997.
5. Wang X, Xiao AY, Ichinose T and Yu SP: Effects of tetraethylammonium analogs on apoptosis and membrane currents in cultured cortical neurons. J Pharmacol Exp Ther 295: 524-530, 2000.
6. - cotransporter in the rectal gland of Squalus acanthias is activated by cell shrinkage. Pflugers Arch Eur J Physiol 438: 165-176, 1999.
7. Hoffman EK and Dunham PB: Membrane mechanisms and intracellular signalling in cell volume regulation. Int Rev Cytol 161: 173-262, 1995.
8. - cotransport protein by cell shrinkage, cAMP, fluoride, and calyculin-A involves phosphorylation at common sites. J Biol Chem 272: 15069-15077, 1997.
9. Lang F, Busch GL, Ritter M, Volkl H, Waldegger S, Gulbins E and Häussinger D: Functional significance of cell volume regulatory mechanisms. Physiol Rev 78: 247-306, 1998.
10. Sandström P-E, Jonsson Ö, Grankvist K and Henriksson R: Identification of potassium flux pathways and their role in the cytotoxicity of estramustine in human malignant glioma, prostatic carcinoma and pulmonary carcinoma cell lines. Eur J Cancer 30A: 1822-1826, 1994.
11. Marklund L, Andersson B, Behnam-Motlagh P, Sandström P-E, Henriksson R and Grankvist K: Cellular potassium ion deprivation enhances apoptosis induced by cisplatin. Basic Clin Pharmacol Toxicol 94: 245-251, 2004.
12. Cheng CS, Alderman D, Kwash J, Dessaint J, Patel R, Lescoe MK, Kinrade MB and Yu W: A high-throughput HERG potassium channel function assay: an old assay with a new look. Drug Dev Ind Pharm 28: 177-191, 2002.
13. Marklund SL, Westman GN, Lundgren E and Roos G: Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues. Cancer Res 42: 1955-1961, 1982.
14. Bergh J, Nilsson K, Ekman R and Giovanella B: Establishment and characterization of cell lines from human small cell and large cell carcinomas of the lung. Acta Pathol Microbiol Immunol Scand Sect A93: 133-147, 1985.
15. + channels: function, pharmacology and drugs. Curr Med Chem 9: 1385-1395, 2002.
16. + channel in malignant astrocytoma cell lines. Neurosci Res 48: 122-127, 1997.
17. Felix JP, Bugianesi RM, Schmalhofer WA, Borris R, Goetz MA, Hensens OD, Bao JM, Kayser F, Parsons WH, Rupprecht K, Garcia ML, Kaczorowski GJ and Slaughter RS: Identification and biochemical characterization of a novel nortriterpene inhibition of the human lymphocyte voltage-gated potassium channel Kv1.3. Biochemistry 38: 4922-4930, 1999.
18. Fraser SP, Grimes JA and Djamgoz MB: Effects of voltage-ion channel modulators on rat prostatic cancer cell proliferation: comparison of strongly and weakly metastatic cell lines. Prostate 44: 61-76, 2000.
19. + channel currents in rat ventral prostate epithelial cells. Prostate 51: 201-210, 2002.
20. Shieh CC, Coghlan M, Sullivan JP and Gopalakrishnan M: Potassium channels: molecular defects, diseases, and therapeutic opportunities. Pharmacol Rev 52: 557-593, 2000.
21. Tahara S, Fukuda K, Kodama H, Kato T, Miyoshi S and Ogava S: Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes. J Am Coll Cardiol 38: 1554-1563, 2001.
22. Utermark T, Alekov A, Lerche H, Abramowski V, Giovannini M and Hanemann CO: Quinidine impairs proliferation of neurofibromatosis type 2-deficient human malignant mesothelioma cells. Cancer 97: 1955-1962, 2003.
23. Allbritton NL, Verret CR, Wolley RC and Eisen HN: Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes. J Exp Med 167: 514-527, 1988.
24. Calo L, Fornelli F, Ramires R, Nenna S, Tursi A, Caiaffa MF and Macchia L: Cytotoxic effects of the mycotoxin beauvericin to human cell lines of myeloid origin. Pharmacol Res 49: 73-77, 2004.
25. Gottlieb RA and Granville DJ: Analyzing mitochondrial changes during apoptosis. Methods 26: 341-347, 2002.
26. Deckers CLP, Lyons AB, Samuel K, Sanderson A and Maddy AH: Alternative pathways of apoptosis induced by methylprednisolone and valinomycin analyzed by flow cytometry. Exp Cell Res 208: 362-370, 1993.
27. Doebler JA: Effects of neutral ionophores on membrane electrical characteristics of NG1O8-15 cells. Toxicol Lett 114: 27-38, 2000.
28. Harnois DM, Que FG, Celli A, LaRusso NF and Gores GJ: Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line. Hepatology 26: 884-890, 1997.
29. Lacour S, Hammann A, Grazide S, Lagadic-Gossmann D, Athias A, Sergent O, Laurent G, Gambert P, Solary E and Dimanche-Boitrel MT: Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells. Cancer Res 64: 3593-3598, 2004.
30. Maeno E, Ishizaki Y, Kanaseki T, Hazama A and Okada Y: Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis. Proc Natl Acad Sci USA 97: 9487-9492, 2000.
31. Nash PB, Purner MB, Leon RP, Clarke P, Duke RC and Curiel TJ: Toxoplasma gondii-infected cells are resistant to multiple inducers of apoptosis. J Immunol 160: 1824-1830, 1998.
32. Pelassy C, Breittmayer JP and Aussel C: Regulation of phosphatidylserine exposure at the cell surface by the serine-base exchange enzyme system during CD95-induced apoptosis. Biochem Pharmacol 59: 855-863, 2000.
33. Penning LC, Denecker G, Vercammen D, Declercq W, Schipper RG and Vandenabeele P: A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines. Cytokine 12: 747-750, 2000.
34. Segal R and Milo-Goldzweig I: The susceptiblility of cholesterol-depleted erythrocytes to sapinin and sapogen hemolysis. Biochim Biophys Acta 512: 223-226, 1978.
35. Vercesi AE, Bernardes CF, Hoffmann ME, Gadelha FR and Docampo R: Digitonin permeabilization does not affect mitochondrial function and allows the determination of the mitochondrial membrane potential of Trypanosoma cruzi in situ. J Biol Chem 266: 14431-14434, 1991.
36. Atkinson AJ Jr and Bennett JE: Amphotericin B pharmacokinetics in humans. Antimicrob Agents Chemother 13: 271-276, 1978.
37. Skryma RN, Prevarskaya NB, Dufy-Barbe L, Odessa MF, Audin J and Dufy B: Potassium conductance in the androgen-prostate cancer cell line, LNCaP: involvement in cell proliferation. Prostate 33: 112-122, 1997.
38. Abdul M and Hoosein N: Voltage-gated potassium ion channels in colon cancer. Oncol Rep 9: 961-964, 2002.
39. Abdul M, Santo A and Hoosein N: Activity of potassium channel-blockers in breast cancer. Anticancer Res 23: 3347-3351, 2003.
40. Sharp SY, Mistry P, Valenti MR, Bryant AP and Kelland LR: Selective potentiation of platinum drug cytotoxicity in cisplatin- sensitive and -resistant human ovarian carcinoma cell lines by amphotericin B. Cancer Chemother Pharmacol 35: 137-143, 1994.
41. Hsu SF and Burnette RR: The effect of amphotericin B on the K-channel activity of MDCK cells. Biochim Biophys Acta 1152: 189-191, 1993.
42. Marklund L, Henriksson R and Grankvist K: Cisplatin-induced apoptosis of mesothelioma cells is affected by potassium ion flux modulator amphotericin B and bumetanide. Int J Cancer 93: 577-583, 2000.
43. - cotransport blocker bumetanide. Life Sci 66: PL319-324, 2000.