Intracerebral injection of adenovirus harboring the HSVtk gene combined with ganciclovir administration: Toxicity study in nonhuman primates

Gene Therapy

Volumn 5, Issue 8, 1998, Pages 1122-1129

  Driesse, M J ^a   Vincent, A J P E ^a   Sillevis Smitt, P A E ^a   Kros, J M ^a   Hoogerbrugge, P M ^b   Avezaat, C J J ^a   Valerio, D ^c,d   Bout, A ^d  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

^d CRUCELL HOLLAND BV   (Netherlands)

Author keywords

Brain tumors; Gene therapy; HSVtk; Recombinant adenovirus; Toxicity

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; B LYMPHOCYTE; CONTROLLED STUDY; EXPRESSION VECTOR; FRONTAL LOBE; GENE TRANSFER; HERPES SIMPLEX VIRUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; INTRAVENOUS DRUG ADMINISTRATION; MALE; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; T LYMPHOCYTE; VIRUS GENE; WHITE MATTER;

ADENOVIRIDAE; ANIMALIA; HERPES; MACACA MULATTA; PRIMATES; SIMPLEXVIRUS;

EID: 0031687273     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300695     Document Type: Article

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