In vivo knockdown of gene expression in brain cancer with intravenous RNAi in adult rats

Journal of Gene Medicine

Volumn 5, Issue 12, 2003, Pages 1039-1045

  Zhang, Yun ^a   Boado, Ruben J ^a   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Blood brain barrier; Gene therapy; Non viral gene transfer; RNAi; Transferrin receptor

Indexed keywords

GAMMA GLUTAMYLTRANSFERASE; IMMUNOLIPOSOME; LUCIFERASE; MACROGOL; MESSENGER RNA; MONOCLONAL ANTIBODY; PLASMID DNA; SHORT HAIRPIN RNA; TRANSFERRIN RECEPTOR; LIPOSOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN LEVEL; CANCER CELL; CAUDATE NUCLEUS; CELL MEMBRANE; CONJUGATION; CONTROLLED STUDY; DOSE RESPONSE; ENCAPSULATION; EXPERIMENTAL NEOPLASM; GENE DELIVERY SYSTEM; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; GLIOMA; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MAMMAL CELL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUTAMEN; RAT; RNA HYBRIDIZATION; RNA INTERFERENCE; RNA SEQUENCE; ANIMAL; BIOSYNTHESIS; BRAIN TUMOR; DISEASE MODEL; FISCHER 344 RAT; GENE THERAPY; GENE TRANSFER; GENETICS; INTRAVENOUS DRUG ADMINISTRATION; METHODOLOGY; PLASMID;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENE THERAPY; GENE TRANSFER TECHNIQUES; GLIOMA; INFUSIONS, INTRAVENOUS; LIPOSOMES; LUCIFERASES; MALE; PLASMIDS; RATS; RATS, INBRED F344; RECEPTORS, TRANSFERRIN; RNA INTERFERENCE; TRANSFECTION;

EID: 1942523210     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jgm.449     Document Type: Article

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