Pharmacokinetics, tissue distribution, and expression Efficiency of plasmid [33P]DNA following intravenous administration of DNA/cationic lipid complexes in mice: Use of a novel radionuclide approach

Journal of Pharmaceutical Sciences

Volumn 85, Issue 6, 1996, Pages 612-618

  Osaka, Gary ^a   Carey, Kendall ^a   Cuthbertson, Andrew ^a   Godowski, Paul ^a   Patapoff, Tom ^a   Ryan, Anne ^a   Gadek, Tom ^a   Mordenti, Joyce ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYLDIOCTADECYLAMMONIUM BROMIDE; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; LIPOSOME; LUCIFERASE; PHOSPHOLIPID; PHOSPHORUS; PLASMID DNA; RADIOISOTOPE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DOSE RESPONSE; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HALF LIFE; DRUG TISSUE LEVEL; GENE TRANSFER; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; WHOLE BODY AUTORADIOGRAPHY;

ANIMALS; AUTORADIOGRAPHY; CATIONS; DNA; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; INJECTIONS, INTRAVENOUS; LIPOSOMES; LUCIFERASES; MALE; MICE; MICE, INBRED BALB C; PHOSPHORUS RADIOISOTOPES; PLASMIDS; TISSUE DISTRIBUTION;

EID: 0030008620     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js9504494     Document Type: Article

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33. Whole body sections were collected at the midsection of the organs of interest. This allows for quantitation of all structures within the organ. For organs such as liver, kidney, heart, gut, and spleen, slices appeared in several sections and were quantitated.
34. Several whole body sections were cut at different levels/depths of the frozen animal. Organs were quantitated in each level in which they were present, and the average value was obtained. All levels were relatively equivalent unless there was a deviation in section thickness, which was corrected for using the agar standard.
35. (1/60 g) is the adjustment for dilution of the dose in the agar internal standard. The animals received 300 μL of the dosing solution, and the agar standards were made with 100 μL of the dosing solution, diluted in 20 mL of agar. Thus the dose correction factor is (100 μL)/(300 μL)(20 mL)or 1/60 mL, which is converted to grams assuming density = 1.
36. DMRIE is 1,2-dimyristoyl-oxypropyl-3-dimethylammonium bromide.