Cationic lipids are essential for gene delivery mediated by intravenous administration of lipoplexes

Gene Therapy

Volumn 6, Issue 6, 1999, Pages 1179-1183

  Barron, L G ^a   Uyechi, L S ^a   Szoka Jr , F C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

DNA; Infusion; Mechanism; Nonviral

Indexed keywords

LIPID; LIPOPLEX; LIPOSOME; PLASMID DNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DNA TRANSFECTION; GENE TARGETING; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE;

ANIMALS; GENE TRANSFER TECHNIQUES; GENES, REPORTER; INFUSIONS, INTRAVENOUS; LIPIDS; MICE; PLASMIDS; VACCINES, DNA;

ANIMALIA;

EID: 0033022958     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300929     Document Type: Article

References (24)

1. Felgner PL et al. Lipofection: a highly efficient, lipid-mediated DNA transfection procedure. Proc Natl Acad Sci USA 1987; 84: 7413-7417.
2. Felgner PL et al. Nomenclature for synthetic gene delivery systems (editorial). Hum Gene Ther 1997; 8: 511-512.
3. Brigham KL et al. In vivo transfection of murine lungs with a functioning prokaryotic gene using a cationic liposome vehicle. Am J Med Sci 1989; 298: 278-281.
4. Caplen NJ et al. Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nature Med 1995; 1: 39-46.
5. Chadwick SL et al. Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG5000 formulation to the lungs of normal volunteers. Gene Therapy 1997; 4: 937-942.
6. McLachlan G et al. Laboratory and clinical studies in support of cystic fibrosis gene therapy using pCMV-CFTR-DOTAP. Gene Therapy 1996; 3: 1113-1123.
7. Nabel GJ et al. Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc Natl Acad Sci USA 1993; 90: 11307-11311.
8. Nabel GJ et al. Immunotherapy for cancer by direct gene transfer into tumors. Hum Gene Ther 1994; 5: 57-77.
9. Stopeck AT et al. Phase I study of direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7, in patients with metastatic melanoma. J Clin Oncol 1997; 15: 341-349.
10. Song YK, Liu F, Liu D. Enhanced gene expression in mouse lung by prolonging the retention time of intravenously injected plasmid DNA. Gene Therapy 1998; 5: 1531-1537.
11. Wolff JA et al. Direct gene transfer into mouse muscle in vivo. Science 1990; 247: 1465-1468.
12. Buttrick PM et al. Behavior of genes directly injected into the rat heart in vivo. Circ Res 1992; 70: 193-198.
13. Sikes ML, O'Malley BW Jr, Finegold MJ, Ledley FD. In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection. Hum Gene Ther 1994; 5: 837-844.
14. Hickman MA et al. Gene expression following direct injection of DNA into liver. Hum Gene Ther 1994; 5: 1477-1483.
15. Meyer KB et al. Intratracheal gene delivery to the mouse airway: characterization of plasmid DNA expression and pharmacokinetics. Gene Therapy 1995; 2: 450-460.
16. Yang JP, Huang L. Direct gene transfer to mouse melanoma by intratumor injection of free DNA. Gene Therapy 1996; 3: 542-548.
17. Nita I et al. Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo. Arthritis Rheum 1996; 39: 820-828.
18. Xu Y, Szoka FC Jr. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry 1996; 35: 5616-5623.
19. Barron LG, Meyer KB, Szoka FC Jr. Effects of complement depletion on the pharmacokinetics and gene delivery mediated by cationic lipid-DNA complexes. Human Gene Ther 1998; 9: 315-323.
20. Kawabata K, Takakura Y, Hashida M. The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake. Pharm Res 1995; 12: 825-830.
21. Emlen W, Mannik M. Kinetics and mechanisms for removal of circulating single-stranded DNA in mice. J Exp Med 1978; 147: 684-699.
22. Tang MX, Redemann CT, Szoka FC Jr. In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconj Chem 1996; 7: 703-714.
23. Legendre JY, Szoka FC Jr. Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes. Pharm Res 1992; 9: 1235-1242.
24. Sambrook J, Fritsch E, Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Press, Cold Spring Harbor, 1989.