-
1
-
-
0033588882
-
The INK4 family of cell cycle inhibitors in cancer
-
Roussel, M. F. (1999) The INK4 family of cell cycle inhibitors in cancer. Oncogene 18, 5311-5317.
-
(1999)
Oncogene
, vol.18
, pp. 5311-5317
-
-
Roussel, M.F.1
-
2
-
-
0035754080
-
To cycle or not to cycle: A critical decision in cancer
-
Malumbres, M. and Barbacid, M. (2001) To cycle or not to cycle: a critical decision in cancer. Nat. Rev. Cancer 1, 222-231.
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 222-231
-
-
Malumbres, M.1
Barbacid, M.2
-
3
-
-
9244239811
-
G1 cell-cycle control and cancer
-
Massague, J. (2004) G1 cell-cycle control and cancer. Nature 432, 298-306.
-
(2004)
Nature
, vol.432
, pp. 298-306
-
-
Massague, J.1
-
4
-
-
0033564697
-
CDK inhibitors: Positive and negative regulators of G1-phase progression
-
Sherr, C. J., and Roberts, J. M. (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13, 1501-1512.
-
(1999)
Genes Dev
, vol.13
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
5
-
-
0033578816
-
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
-
Harbour, J. W., Luo, R. X., Dei Santi, A., Postigo, A. A., and Dean, D. C. (1999) Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 98, 859-869.
-
(1999)
Cell
, vol.98
, pp. 859-869
-
-
Harbour, J.W.1
Luo, R.X.2
Dei Santi, A.3
Postigo, A.A.4
Dean, D.C.5
-
7
-
-
18344369616
-
Biochemical and cellular mechanisms of mammalian CDK inhibitors: A few unresolved issues
-
Pei, X. H., and Xiong, Y. (2005) Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues. Oncogene 24, 2787-2795.
-
(2005)
Oncogene
, vol.24
, pp. 2787-2795
-
-
Pei, X.H.1
Xiong, Y.2
-
8
-
-
0037075887
-
Cyclin D-dependent kinases, INK4 inhibitors and cancer
-
Ortega, S., Malumbres, M., and Barbacid, M. (2002) Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim. Biophys. Acta 1602, 73-87.
-
(2002)
Biochim. Biophys. Acta
, vol.1602
, pp. 73-87
-
-
Ortega, S.1
Malumbres, M.2
Barbacid, M.3
-
9
-
-
33750030758
-
The regulation of INK4/ARF in cancer and aging
-
Kim, W. Y., and Sharpless, N. E. (2006) The regulation of INK4/ARF in cancer and aging. Cell 127, 265-275.
-
(2006)
Cell
, vol.127
, pp. 265-275
-
-
Kim, W.Y.1
Sharpless, N.E.2
-
10
-
-
0842265035
-
The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis
-
Sharpless, N. E., Ramsey, M. R., Balasubramanian, P., Castrillon, D. H., and DePinho, R. A. (2004) The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis. Oncogene 23, 379-3785.
-
(2004)
Oncogene
, vol.23
, pp. 379-3785
-
-
Sharpless, N.E.1
Ramsey, M.R.2
Balasubramanian, P.3
Castrillon, D.H.4
DePinho, R.A.5
-
11
-
-
33645824724
-
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
-
Bardeesy, N., Aguirre, A. J., Chu, G. C., Cheng, K. H., Lopez, L. V., Hezel, A. F., Feng, B., Brennan, C., Weissleder, R., Mahmood, U., Hanahan, D., Redston, M. S., Chin, L., and Depinho, R. A. (2006) Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc. Natl. Acad. Sci. USA 103, 5947-5952.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 5947-5952
-
-
Bardeesy, N.1
Aguirre, A.J.2
Chu, G.C.3
Cheng, K.H.4
Lopez, L.V.5
Hezel, A.F.6
Feng, B.7
Brennan, C.8
Weissleder, R.9
Mahmood, U.10
Hanahan, D.11
Redston, M.S.12
Chin, L.13
Depinho, R.A.14
-
12
-
-
8644284936
-
Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging
-
Matheu, A., Pantoja, C., Efeyan, A., Criado, L. M., Martin-Caballero, J., Flores, J. M., Klatt, P., and Serrano, M. (2004) Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. Genes Dev. 18, 2736-2746.
-
(2004)
Genes Dev
, vol.18
, pp. 2736-2746
-
-
Matheu, A.1
Pantoja, C.2
Efeyan, A.3
Criado, L.M.4
Martin-Caballero, J.5
Flores, J.M.6
Klatt, P.7
Serrano, M.8
-
13
-
-
0032517341
-
The p16INK4a/CDKN2A tumor suppressor and its relatives
-
Ruas, M., and Peters, G. (1998) The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim. Biophys. Acta 1378, F115-177.
-
(1998)
Biochim. Biophys. Acta
, vol.1378
-
-
Ruas, M.1
Peters, G.2
-
14
-
-
31444451841
-
Cosmic 2005
-
Forbes, S., Clements, J., Dawson, E., Bamford, S., Webb, T., Dogan, A., Flanagan, A., Teague, J., Wooster, R., Futreal, P. A., and Stratton, M. R. (2006) Cosmic 2005. Br. J. Cancer 94, 318-322.
-
(2006)
Br. J. Cancer
, vol.94
, pp. 318-322
-
-
Forbes, S.1
Clements, J.2
Dawson, E.3
Bamford, S.4
Webb, T.5
Dogan, A.6
Flanagan, A.7
Teague, J.8
Wooster, R.9
Futreal, P.A.10
Stratton, M.R.11
-
15
-
-
0035870248
-
A gene hypermethylation profile of human cancer
-
Esteller,M., Corn, P. G., Baylin, S. B., and Herman, J. G. (2001) A gene hypermethylation profile of human cancer. Cancer Res. 61, 3225-3229.
-
(2001)
Cancer Res
, vol.61
, pp. 3225-3229
-
-
Esteller, M.1
Corn, P.G.2
Baylin, S.B.3
Herman, J.G.4
-
16
-
-
33644878393
-
Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients
-
Aggerholm, A., Holm, M. S., Guldberg, P., Olesen, L. H., and Hokland, P. (2006) Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients. Eur. J. Haematol. 76, 23-32.
-
(2006)
Eur. J. Haematol
, vol.76
, pp. 23-32
-
-
Aggerholm, A.1
Holm, M.S.2
Guldberg, P.3
Olesen, L.H.4
Hokland, P.5
-
17
-
-
0037317415
-
Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis
-
Bai, F., Pei, X. H., Godfrey, V. L., and Xiong, Y. (2003) Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Mol. Cell. Biol. 23, 1269-1277.
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 1269-1277
-
-
Bai, F.1
Pei, X.H.2
Godfrey, V.L.3
Xiong, Y.4
-
18
-
-
3142775003
-
Activation of protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c)
-
Matsuzaki, Y., Takaoka, Y., Hitomi, T., Nishino, H., and Sakai, T. (2004) Activation of protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c). Oncogene 23, 5409-5414.
-
(2004)
Oncogene
, vol.23
, pp. 5409-5414
-
-
Matsuzaki, Y.1
Takaoka, Y.2
Hitomi, T.3
Nishino, H.4
Sakai, T.5
-
19
-
-
0036045471
-
A novel treatment approach for low grade lymphoproliferative disorders using PKC412 (CGP41251), an inhibitor of protein kinase C
-
Virchis, A., Ganeshaguru, K., Hart, S., Jones, D., Fletcher, L., Wright, F., Wickremasinghe, R., Man, A., Csermak, K., Meyer, T., Fabbro, D., Champain, K., Yap, A., Prentice, H. G., and Mehta, A. (2002) A novel treatment approach for low grade lymphoproliferative disorders using PKC412 (CGP41251), an inhibitor of protein kinase C. Hematol. J. 3, 131-126.
-
(2002)
Hematol. J
, vol.3
, pp. 131-126
-
-
Virchis, A.1
Ganeshaguru, K.2
Hart, S.3
Jones, D.4
Fletcher, L.5
Wright, F.6
Wickremasinghe, R.7
Man, A.8
Csermak, K.9
Meyer, T.10
Fabbro, D.11
Champain, K.12
Yap, A.13
Prentice, H.G.14
Mehta, A.15
-
20
-
-
1542313894
-
Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas
-
Sanchez-Aguilera, A., Delgado, J., Camacho, F. I., Sanchez-Beato, M., Sanchez, L., Montalban, C., Fresno, M. F., Martin, C., Piris, M. A., and Garcia, J. F. (2004) Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas. Blood 103, 2351-2357.
-
(2004)
Blood
, vol.103
, pp. 2351-2357
-
-
Sanchez-Aguilera, A.1
Delgado, J.2
Camacho, F.I.3
Sanchez-Beato, M.4
Sanchez, L.5
Montalban, C.6
Fresno, M.F.7
Martin, C.8
Piris, M.A.9
Garcia, J.F.10
-
21
-
-
27744450224
-
The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation
-
Uziel, T., Zindy, F., Xie, S., Lee, Y., Forget, A., Magdaleno, S., Rehg, J. E., Calabrese, C., Solecki, D., Eberhart, C. G., Sherr, S. E., Plimmer, S., Clifford, S. C., Hatten, M. E., McKinnon, P. J., Gilbertson, R. J., Curran, T., Sherr, C. J., and Roussel, M. F. (2005) The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev. 19, 2656-2667.
-
(2005)
Genes Dev
, vol.19
, pp. 2656-2667
-
-
Uziel, T.1
Zindy, F.2
Xie, S.3
Lee, Y.4
Forget, A.5
Magdaleno, S.6
Rehg, J.E.7
Calabrese, C.8
Solecki, D.9
Eberhart, C.G.10
Sherr, S.E.11
Plimmer, S.12
Clifford, S.C.13
Hatten, M.E.14
McKinnon, P.J.15
Gilbertson, R.J.16
Curran, T.17
Sherr, C.J.18
Roussel, M.F.19
-
22
-
-
0035050874
-
Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18(Ink4c) and p19(Ink4d)
-
Zindy, F., den Besten, W., Chen, B., Rehg, J. E., Latres, E., Barbacid, M., Pollard, J. W., Sherr, C. J., Cohen, P. E., and Roussel, M. F. (2001) Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18(Ink4c) and p19(Ink4d). Mol. Cell. Biol. 21, 3244-3255.
-
(2001)
Mol. Cell. Biol
, vol.21
, pp. 3244-3255
-
-
Zindy, F.1
den Besten, W.2
Chen, B.3
Rehg, J.E.4
Latres, E.5
Barbacid, M.6
Pollard, J.W.7
Sherr, C.J.8
Cohen, P.E.9
Roussel, M.F.10
-
23
-
-
0033988257
-
INK4d-deficient mice are fertile despite testicular atrophy
-
Zindy, F., van Deursen, J., Grosveld, G., Sherr, C. J., and Roussel, M. F. (2000) INK4d-deficient mice are fertile despite testicular atrophy. Mol. Cell. Biol. 20, 372-378.
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 372-378
-
-
Zindy, F.1
van Deursen, J.2
Grosveld, G.3
Sherr, C.J.4
Roussel, M.F.5
-
24
-
-
0034710395
-
Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis
-
Bartkova, J., Thullberg, M., Rajpert-De Meyts, E., Skakkebaek, N. E., and Bartek, J. (2000) Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis. Oncogene 19, 4146-4150.
-
(2000)
Oncogene
, vol.19
, pp. 4146-4150
-
-
Bartkova, J.1
Thullberg, M.2
Rajpert-De Meyts, E.3
Skakkebaek, N.E.4
Bartek, J.5
-
25
-
-
33747587608
-
Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all
-
Gil, J., and Peters, G. (2006) Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat. Rev. Mol. Cell. Biol. 7, 667-677.
-
(2006)
Nat. Rev. Mol. Cell. Biol
, vol.7
, pp. 667-677
-
-
Gil, J.1
Peters, G.2
-
26
-
-
33645460360
-
Oncogenic activity of Cdc6 through repression of the INK4/ARF locus
-
Gonzalez, S., Klatt, P., Delgado, S., Conde, E., Lopez-Rios, F., Sanchez-Cespedes, M., Mendez, J., Antequera, F., and Serrano, M. (2006) Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. Nature 440, 702-706.
-
(2006)
Nature
, vol.440
, pp. 702-706
-
-
Gonzalez, S.1
Klatt, P.2
Delgado, S.3
Conde, E.4
Lopez-Rios, F.5
Sanchez-Cespedes, M.6
Mendez, J.7
Antequera, F.8
Serrano, M.9
-
27
-
-
31344436655
-
Cell cycle requirements in assembling silent chromatin in Saccharomyces cerevisiae
-
Kirchmaier, A. L., and Rine, J. (2006) Cell cycle requirements in assembling silent chromatin in Saccharomyces cerevisiae. Mol. Cell. Biol. 26, 852-862.
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 852-862
-
-
Kirchmaier, A.L.1
Rine, J.2
-
28
-
-
4644292460
-
-
Karakaidos, P., Taraviras, S., Vassiliou, L. V., Zacharatos, P., Kastrinakis, N. G., Kougiou, D., Kouloukoussa, M., Nishitani, H., Papavassiliou, A. G., Lygerou, Z., and Gorgoulis, V. G. (2004) Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability - evidence of E2F-1 transcriptional control over hCdt1. Am. J. Pathol. 165, 1351-1365.
-
Karakaidos, P., Taraviras, S., Vassiliou, L. V., Zacharatos, P., Kastrinakis, N. G., Kougiou, D., Kouloukoussa, M., Nishitani, H., Papavassiliou, A. G., Lygerou, Z., and Gorgoulis, V. G. (2004) Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability - evidence of E2F-1 transcriptional control over hCdt1. Am. J. Pathol. 165, 1351-1365.
-
-
-
-
29
-
-
20844443130
-
p16INK4A, CDC6, and MCM5: Predictive biomarkers in cervical preinvasive neoplasia and cervical cancer
-
Murphy, N., Ring, M., Heffron, C. C., King, B., Killalea, A. G., Hughes, C., Martin, C. M., McGuinness, E., Sheils, O., and O'Leary, J. J. (2005) p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer. J. Clin. Pathol. 58, 525-534.
-
(2005)
J. Clin. Pathol
, vol.58
, pp. 525-534
-
-
Murphy, N.1
Ring, M.2
Heffron, C.C.3
King, B.4
Killalea, A.G.5
Hughes, C.6
Martin, C.M.7
McGuinness, E.8
Sheils, O.9
O'Leary, J.J.10
-
30
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
Campisi, J. (2005) Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120, 513-522.
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
31
-
-
0037148342
-
Telomeres, aging and cancer: In search of a happy ending
-
Kim, S. H., Kaminker, P., and Campisi, J. (2002) Telomeres, aging and cancer: in search of a happy ending. Oncogene 21, 503-511.
-
(2002)
Oncogene
, vol.21
, pp. 503-511
-
-
Kim, S.H.1
Kaminker, P.2
Campisi, J.3
-
32
-
-
14644410453
-
The signals and pathways activating cellular senescence
-
Ben-Porath, I., and Weinberg, R. A. (2005) The signals and pathways activating cellular senescence. Int. J. Biochem. Cell. Biol. 37, 961-976.
-
(2005)
Int. J. Biochem. Cell. Biol
, vol.37
, pp. 961-976
-
-
Ben-Porath, I.1
Weinberg, R.A.2
-
33
-
-
0030612349
-
Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging
-
Zindy, F., Quelle, D. E., Roussel, M. F., and Sherr, C. J. (1997) Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15, 203-211.
-
(1997)
Oncogene
, vol.15
, pp. 203-211
-
-
Zindy, F.1
Quelle, D.E.2
Roussel, M.F.3
Sherr, C.J.4
-
34
-
-
23244447893
-
Tumour biology: Senescence in premalignant tumours
-
Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguria, A., Zaballos, A., Flores, J. M., Barbacid, M., Beach, D., and Serrano, M. (2005) Tumour biology: senescence in premalignant tumours. Nature 436, 642.
-
(2005)
Nature
, vol.436
, pp. 642
-
-
Collado, M.1
Gil, J.2
Efeyan, A.3
Guerra, C.4
Schuhmacher, A.J.5
Barradas, M.6
Benguria, A.7
Zaballos, A.8
Flores, J.M.9
Barbacid, M.10
Beach, D.11
Serrano, M.12
-
35
-
-
19944427674
-
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA
-
Zhang, R., Poustovoitov, M. V., Ye, X., Santos, H. A., Chen, W., Daganzo, S. M., Erzberger, J. P., Serebriiskii, I. G., Canutescu, A. A., Dunbrack, R. L., Pehrson, J. R., Berger, J. M., Kaufman, P. D., and Adams, P. D. (2005) Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell 8, 19-30.
-
(2005)
Dev Cell
, vol.8
, pp. 19-30
-
-
Zhang, R.1
Poustovoitov, M.V.2
Ye, X.3
Santos, H.A.4
Chen, W.5
Daganzo, S.M.6
Erzberger, J.P.7
Serebriiskii, I.G.8
Canutescu, A.A.9
Dunbrack, R.L.10
Pehrson, J.R.11
Berger, J.M.12
Kaufman, P.D.13
Adams, P.D.14
-
36
-
-
33947236204
-
Molecular dissection of formation of senescence-associated heterochromatin foci
-
Zhang, R., Chen, W., and Adams, P. D. (2007) Molecular dissection of formation of senescence-associated heterochromatin foci. Mol. Cell. Biol. 27, 2343-2358.
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 2343-2358
-
-
Zhang, R.1
Chen, W.2
Adams, P.D.3
-
37
-
-
33746752125
-
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation
-
Narita, M., Narita, M., Krizhanovsky, V., Nunez, S., Chicas, A., Hearn, S. A., Myers, M. P., and Lowe, S. W. (2006) A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126, 503-514.
-
(2006)
Cell
, vol.126
, pp. 503-514
-
-
Narita, M.1
Narita, M.2
Krizhanovsky, V.3
Nunez, S.4
Chicas, A.5
Hearn, S.A.6
Myers, M.P.7
Lowe, S.W.8
-
38
-
-
84900969225
-
Ink4a/Arf expression is a biomarker of aging
-
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., and Sharpless, N. E. (2004) Ink4a/Arf expression is a biomarker of aging. J. Clin. Invest. 114, 1299-307.
-
(2004)
J. Clin. Invest
, vol.114
, pp. 1299-1307
-
-
Krishnamurthy, J.1
Torrice, C.2
Ramsey, M.R.3
Kovalev, G.I.4
Al-Regaiey, K.5
Su, L.6
Sharpless, N.E.7
-
39
-
-
0035931859
-
Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
-
Ohtani, N., Zebedee, Z., Huot, T. J., Stinson, J. A., Sugimoto, M., Ohashi, Y., Sharrocks, A. D., Peters, G., and Hara, E. (2001) Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 409, 1067-1070.
-
(2001)
Nature
, vol.409
, pp. 1067-1070
-
-
Ohtani, N.1
Zebedee, Z.2
Huot, T.J.3
Stinson, J.A.4
Sugimoto, M.5
Ohashi, Y.6
Sharrocks, A.D.7
Peters, G.8
Hara, E.9
-
40
-
-
33748327046
-
p16INK4A is a robust in vivo biomarker of cellular aging in human skin
-
Ressler, S., Bartkova, J., Niederegger, H., Bartek, J., Scharffetter-Kochanek, K., Jansen-Durr, P., and Wlaschek, M. (2006) p16INK4A is a robust in vivo biomarker of cellular aging in human skin. Aging Cell 5, 379-389.
-
(2006)
Aging Cell
, vol.5
, pp. 379-389
-
-
Ressler, S.1
Bartkova, J.2
Niederegger, H.3
Bartek, J.4
Scharffetter-Kochanek, K.5
Jansen-Durr, P.6
Wlaschek, M.7
-
41
-
-
17444379015
-
Deregulated expression of Polycomb-group oncogenes in human malignant lymphomas and epithelial tumors
-
Raaphorst, F. M. (2005) Deregulated expression of Polycomb-group oncogenes in human malignant lymphomas and epithelial tumors. Hum. Mol. Genet. 14 Spec No. 1, R93-R100.
-
(2005)
Hum. Mol. Genet
, vol.14
, Issue.SPEC 1
-
-
Raaphorst, F.M.1
-
42
-
-
33947134834
-
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
-
Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Monch, K., Minucci, S., Porse, B. T., Marine, J. C., Hansen, K. H., and Helin, K. (2007) The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 21, 525-530.
-
(2007)
Genes Dev
, vol.21
, pp. 525-530
-
-
Bracken, A.P.1
Kleine-Kohlbrecher, D.2
Dietrich, N.3
Pasini, D.4
Gargiulo, G.5
Beekman, C.6
Theilgaard-Monch, K.7
Minucci, S.8
Porse, B.T.9
Marine, J.C.10
Hansen, K.H.11
Helin, K.12
-
43
-
-
0036771637
-
Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: Implications for cellular senescence
-
Zhu, D., Xu, G., Ghandhi, S., and Hubbard, K. (2002) Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: implications for cellular senescence. J. Cell. Physiol. 193, 19-25.
-
(2002)
J. Cell. Physiol
, vol.193
, pp. 19-25
-
-
Zhu, D.1
Xu, G.2
Ghandhi, S.3
Hubbard, K.4
-
44
-
-
14644422293
-
Increased stability of the p16 mRNA with replicative senescence
-
Wang, W., Martindale, J. L., Yang, X., Chrest, F. J., and Gorospe, M. (2005) Increased stability of the p16 mRNA with replicative senescence. EMBO Rep. 6, 158-164.
-
(2005)
EMBO Rep
, vol.6
, pp. 158-164
-
-
Wang, W.1
Martindale, J.L.2
Yang, X.3
Chrest, F.J.4
Gorospe, M.5
-
45
-
-
0037376674
-
Oxidant signals and oxidative stress
-
Finkel, T. (2003) Oxidant signals and oxidative stress. Curr. Opin. Cell Biol. 15, 247-254.
-
(2003)
Curr. Opin. Cell Biol
, vol.15
, pp. 247-254
-
-
Finkel, T.1
-
46
-
-
33750510904
-
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence
-
Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H., Nakayama, K., Nakayama, K. I., Ide, T., Saya, H., and Hara, E. (2006) Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat. Cell Biol. 8, 1291-1297.
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 1291-1297
-
-
Takahashi, A.1
Ohtani, N.2
Yamakoshi, K.3
Iida, S.4
Tahara, H.5
Nakayama, K.6
Nakayama, K.I.7
Ide, T.8
Saya, H.9
Hara, E.10
-
47
-
-
0038049143
-
Cancer and ageing: Rival demons?
-
Campisi, J. (2003) Cancer and ageing: rival demons? Nat. Rev. Cancer 3, 339-349.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 339-349
-
-
Campisi, J.1
-
48
-
-
14644411092
-
Stem cell: Balancing aging and cancer
-
Krtolica, A. (2005) Stem cell: balancing aging and cancer. Int. J. Biochem. Cell. Biol. 37, 935-941.
-
(2005)
Int. J. Biochem. Cell. Biol
, vol.37
, pp. 935-941
-
-
Krtolica, A.1
-
49
-
-
33749172559
-
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
-
Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., and Scadden, D. T. (2006) Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443, 421-426.
-
(2006)
Nature
, vol.443
, pp. 421-426
-
-
Janzen, V.1
Forkert, R.2
Fleming, H.E.3
Saito, Y.4
Waring, M.T.5
Dombkowski, D.M.6
Cheng, T.7
DePinho, R.A.8
Sharpless, N.E.9
Scadden, D.T.10
-
50
-
-
33749187810
-
p16INK4a induces an age-dependent decline in islet regenerative potential
-
Krishnamurthy, J., Ramsey, M. R., Ligon, K. L., Torrice, C., Koh, A., Bonner-Weir, S., and Sharpless, N. E. (2006) p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 443, 453-457.
-
(2006)
Nature
, vol.443
, pp. 453-457
-
-
Krishnamurthy, J.1
Ramsey, M.R.2
Ligon, K.L.3
Torrice, C.4
Koh, A.5
Bonner-Weir, S.6
Sharpless, N.E.7
-
51
-
-
33749171885
-
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
-
Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., and Morrison, S. J. (2006) Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443, 448-452.
-
(2006)
Nature
, vol.443
, pp. 448-452
-
-
Molofsky, A.V.1
Slutsky, S.G.2
Joseph, N.M.3
He, S.4
Pardal, R.5
Krishnamurthy, J.6
Sharpless, N.E.7
Morrison, S.J.8
-
52
-
-
30344463835
-
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
-
Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C., Lukas, J., and Jackson, S. P. (2006) ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol. 8, 37-45.
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
Falck, J.2
Lukas, C.3
Bartek, J.4
Smith, G.C.5
Lukas, J.6
Jackson, S.P.7
-
53
-
-
3943107573
-
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
-
Sancar, A., Lindsey-Boltz, L. A., Unsal-Kacmaz, K., and Linn, S. (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 73, 39-85.
-
(2004)
Annu. Rev. Biochem
, vol.73
, pp. 39-85
-
-
Sancar, A.1
Lindsey-Boltz, L.A.2
Unsal-Kacmaz, K.3
Linn, S.4
-
55
-
-
2342459790
-
DNA damage-induced apoptosis
-
Norbury, C. J., and Zhivotovsky, B. (2004) DNA damage-induced apoptosis. Oncogene 23, 2797-808.
-
(2004)
Oncogene
, vol.23
, pp. 2797-2808
-
-
Norbury, C.J.1
Zhivotovsky, B.2
-
56
-
-
1842715589
-
Apoptotic signaling in response to a single type of DNA lesion, O(6)-methylguanine
-
Hickman, M. J., and Samson, L. D. (2004) Apoptotic signaling in response to a single type of DNA lesion, O(6)-methylguanine. Mol. Cell 14, 105-116.
-
(2004)
Mol. Cell
, vol.14
, pp. 105-116
-
-
Hickman, M.J.1
Samson, L.D.2
-
57
-
-
0942301170
-
The tumor suppressor p16(INK4a) gene is a regulator of apoptosis induced by ultraviolet light and cisplatin
-
Al-Mohanna, M. A., Manogaran, P. S., Al-Mukhalafi, Z. K., Al-Hussein, A., and Aboussekhra, A. (2004) The tumor suppressor p16(INK4a) gene is a regulator of apoptosis induced by ultraviolet light and cisplatin. Oncogene 23, 201-212.
-
(2004)
Oncogene
, vol.23
, pp. 201-212
-
-
Al-Mohanna, M.A.1
Manogaran, P.S.2
Al-Mukhalafi, Z.K.3
Al-Hussein, A.4
Aboussekhra, A.5
-
58
-
-
24744462701
-
Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in DNA-damaged cancer cells
-
Le, H. V., Minn, A. J., and Massague, J. (2005) Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in DNA-damaged cancer cells. J. Biol. Chem. 280, 32018-32025.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 32018-32025
-
-
Le, H.V.1
Minn, A.J.2
Massague, J.3
-
59
-
-
33745786808
-
The tumor suppressor p16Ink4a regulates T lymphocyte survival
-
Bianchi, T., Rufer, N., MacDonald, H. R., and Migliaccio, M. (2006) The tumor suppressor p16Ink4a regulates T lymphocyte survival. Oncogene 25, 4110-4115.
-
(2006)
Oncogene
, vol.25
, pp. 4110-4115
-
-
Bianchi, T.1
Rufer, N.2
MacDonald, H.R.3
Migliaccio, M.4
-
60
-
-
21244454008
-
Induction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells
-
Ceruti, J. M., Scassa, M. E., Flo, J. M., Varone, C. L., and Cánepa, E. T. (2005) Induction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells. Oncogene 24, 4065-4080.
-
(2005)
Oncogene
, vol.24
, pp. 4065-4080
-
-
Ceruti, J.M.1
Scassa, M.E.2
Flo, J.M.3
Varone, C.L.4
Cánepa, E.T.5
-
61
-
-
34047171404
-
Cell cycle inhibitor, p19INK4d, promotes cell survival and decreases chromosomal aberrations after genotoxic insult due to enhanced DNA repair
-
Scassa, M. E., Marazita, M. C., Ceruti, J. M., Carcagno, A. L., Sirkin, P. F., Gonzalez-Cid, M., Pignataro, O. P., and Cánepa, E. T. (2007) Cell cycle inhibitor, p19INK4d, promotes cell survival and decreases chromosomal aberrations after genotoxic insult due to enhanced DNA repair. DNA Repair (Amst) 6, 626-638.
-
(2007)
DNA Repair (Amst)
, vol.6
, pp. 626-638
-
-
Scassa, M.E.1
Marazita, M.C.2
Ceruti, J.M.3
Carcagno, A.L.4
Sirkin, P.F.5
Gonzalez-Cid, M.6
Pignataro, O.P.7
Cánepa, E.T.8
-
62
-
-
33645282971
-
Convergence of vitamin D and retinoic acid signalling at a common hormone response element
-
Tavera-Mendoza, L., Wang, T. T., Lallemant, B., Zhang, R., Nagai, Y., Bourdeau, V., Ramirez-Calderon, M., Desbarats, J., Mader, S., and White, J. H. (2006) Convergence of vitamin D and retinoic acid signalling at a common hormone response element. EMBO Rep. 7, 180-185.
-
(2006)
EMBO Rep
, vol.7
, pp. 180-185
-
-
Tavera-Mendoza, L.1
Wang, T.T.2
Lallemant, B.3
Zhang, R.4
Nagai, Y.5
Bourdeau, V.6
Ramirez-Calderon, M.7
Desbarats, J.8
Mader, S.9
White, J.H.10
-
63
-
-
33645275179
-
p19INK4D and cell death
-
Tavera-Mendoza, L. E., Wang, T. T., and White, J. H. (2006) p19INK4D and cell death. Cell Cycle 5, 596-598.
-
(2006)
Cell Cycle
, vol.5
, pp. 596-598
-
-
Tavera-Mendoza, L.E.1
Wang, T.T.2
White, J.H.3
-
64
-
-
0036270993
-
DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: Fail-safe protection against carcinogenesis
-
Bernstein, C., Bernstein, H., Payne, C. M., and Garewal, H. (2002) DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat. Res. 511, 145-178.
-
(2002)
Mutat. Res
, vol.511
, pp. 145-178
-
-
Bernstein, C.1
Bernstein, H.2
Payne, C.M.3
Garewal, H.4
|