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Volumn 103, Issue 6, 2004, Pages 2351-2357

Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P18; CDKN2C PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2C; TUMOR SUPPRESSOR PROTEIN;

EID: 1542313894     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-07-2356     Document Type: Article
Times cited : (60)

References (41)
  • 1
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999;13:1501-1512.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 3
    • 0029091503 scopus 로고
    • Frequency of homozygous deletion at p16/CDKN2 in primary human tumours
    • Cairns P, Polascik TJ, Eby Y, et al. Frequency of homozygous deletion at p16/CDKN2 in primary human tumours. Nat Genet. 1995;11:210-212.
    • (1995) Nat Genet , vol.11 , pp. 210-212
    • Cairns, P.1    Polascik, T.J.2    Eby, Y.3
  • 5
    • 0031655803 scopus 로고    scopus 로고
    • Loss of p16/INK4A protein expression in non-Hodgkin's lymphomas is a frequent finding associated with tumor progression
    • Villuendas R, Sanchez-Beato M, Martinez JC, et al. Loss of p16/INK4A protein expression in non-Hodgkin's lymphomas is a frequent finding associated with tumor progression. Am J Pathol. 1998; 153:887-897.
    • (1998) Am J Pathol , vol.153 , pp. 887-897
    • Villuendas, R.1    Sanchez-Beato, M.2    Martinez, J.C.3
  • 6
    • 0031025368 scopus 로고    scopus 로고
    • Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies
    • Herman JG, Civin CI, Issa JP, Collector MI, Sharkis SJ, Baylin SB. Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Res. 1997;57:837-841.
    • (1997) Cancer Res , vol.57 , pp. 837-841
    • Herman, J.G.1    Civin, C.I.2    Issa, J.P.3    Collector, M.I.4    Sharkis, S.J.5    Baylin, S.B.6
  • 7
    • 0034171059 scopus 로고    scopus 로고
    • Hypermethylation of P16ink4a and P15ink4b genes as a marker of disease in the follow-up of non-Hodgkin's lymphomas
    • Martinez-Delgado B, Richart A, Garcia MJ, et al. Hypermethylation of P16ink4a and P15ink4b genes as a marker of disease in the follow-up of non-Hodgkin's lymphomas. Br J Haematol. 2000; 109:97-103.
    • (2000) Br J Haematol , vol.109 , pp. 97-103
    • Martinez-Delgado, B.1    Richart, A.2    Garcia, M.J.3
  • 8
    • 0033391985 scopus 로고    scopus 로고
    • Loss of p16 protein expression associated with methylation of the p16INK4A gene is a frequent finding in Hodgkin's disease
    • Garcia JF, Villuendas R, Algara P, et al. Loss of p16 protein expression associated with methylation of the p16INK4A gene is a frequent finding in Hodgkin's disease. Lab Invest. 1999;79:1453-1459.
    • (1999) Lab Invest , vol.79 , pp. 1453-1459
    • Garcia, J.F.1    Villuendas, R.2    Algara, P.3
  • 9
    • 0036733566 scopus 로고    scopus 로고
    • Different incidence and pattern of p15INK4b and p16INK4a promoter region hypermethylation in Hodgkin's and CD30-positive non-Hodgkin's lymphomas
    • Garcia MJ, Martinez-Delgado B, Cebrian A, Martinez A, Benitez J, Rivas C. Different incidence and pattern of p15INK4b and p16INK4a promoter region hypermethylation in Hodgkin's and CD30-positive non-Hodgkin's lymphomas. Am J Pathol. 2002;161:1007-1013.
    • (2002) Am J Pathol , vol.161 , pp. 1007-1013
    • Garcia, M.J.1    Martinez-Delgado, B.2    Cebrian, A.3    Martinez, A.4    Benitez, J.5    Rivas, C.6
  • 10
    • 0028967263 scopus 로고
    • Deletions and rearrangement of CDKN2 in lymphoid malignancy
    • Stranks G, Height SE, Mitchell P, et al. Deletions and rearrangement of CDKN2 in lymphoid malignancy. Blood. 1995;85:893-901.
    • (1995) Blood , vol.85 , pp. 893-901
    • Stranks, G.1    Height, S.E.2    Mitchell, P.3
  • 11
    • 0028987262 scopus 로고
    • Involvement of CDKN2 (p16INKA1 MTS1) and p15INK4B/MTS2 in human leukemias and lymphomas
    • Otsuki T, Clark HM, Wellmann A, Jaffe ES, Raffeld M. Involvement of CDKN2 (p16INKA1 MTS1) and p15INK4B/MTS2 in human leukemias and lymphomas. Cancer Res. 1995;55:1436-1440.
    • (1995) Cancer Res , vol.55 , pp. 1436-1440
    • Otsuki, T.1    Clark, H.M.2    Wellmann, A.3    Jaffe, E.S.4    Raffeld, M.5
  • 12
    • 0031860559 scopus 로고    scopus 로고
    • Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells
    • Drexler HG. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. Leukemia. 1998;12:845-859.
    • (1998) Leukemia , vol.12 , pp. 845-859
    • Drexler, H.G.1
  • 13
    • 0028582034 scopus 로고
    • Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function
    • Guan KL, Jenkins CW, Li Y, et al. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 1994;8:2939-2952.
    • (1994) Genes Dev , vol.8 , pp. 2939-2952
    • Guan, K.L.1    Jenkins, C.W.2    Li, Y.3
  • 14
    • 0034600841 scopus 로고    scopus 로고
    • Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis
    • Latres E, Malumbres M, Sotillo R, et al. Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. Embo J. 2000;19:3496-3506.
    • (2000) Embo J , vol.19 , pp. 3496-3506
    • Latres, E.1    Malumbres, M.2    Sotillo, R.3
  • 15
    • 0032530112 scopus 로고    scopus 로고
    • CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis
    • Franklin DS, Godfrey VL, Lee H, et al. CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev. 1998;12:2899-2911.
    • (1998) Genes Dev , vol.12 , pp. 2899-2911
    • Franklin, D.S.1    Godfrey, V.L.2    Lee, H.3
  • 16
    • 0029881994 scopus 로고    scopus 로고
    • Homozygous deletions of cyclin-dependent kinase inhibitor genes, p16(INK4A) and p18, in childhood T cell lineage acute lymphoblastic leukemias
    • Iolascon A, Faienza MF, Coppola B, della Ragione F, Schettini F, Biondi A. Homozygous deletions of cyclin-dependent kinase inhibitor genes, p16(INK4A) and p18, in childhood T cell lineage acute lymphoblastic leukemias. Leukemia. 1996; 10:255-260.
    • (1996) Leukemia , vol.10 , pp. 255-260
    • Iolascon, A.1    Faienza, M.F.2    Coppola, B.3    Della Ragione, F.4    Schettini, F.5    Biondi, A.6
  • 17
    • 0030751625 scopus 로고    scopus 로고
    • Analysis of the cyclin-dependent kinase inhibitors p18 and p19 in mantle-cell lymphoma and chronic lymphocytic leukemia
    • Williams ME, Whitefield M, Swerdlow SH. Analysis of the cyclin-dependent kinase inhibitors p18 and p19 in mantle-cell lymphoma and chronic lymphocytic leukemia. Ann Oncol. 1997;8:71-73.
    • (1997) Ann Oncol , vol.8 , pp. 71-73
    • Williams, M.E.1    Whitefield, M.2    Swerdlow, S.H.3
  • 18
    • 0032499621 scopus 로고    scopus 로고
    • Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer
    • Blais A, Labrie Y, Pouliot F, Lachance Y, Labrie C. Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer. Biochem Biophys Res Commun. 1998;247:146-153.
    • (1998) Biochem Biophys Res Commun , vol.247 , pp. 146-153
    • Blais, A.1    Labrie, Y.2    Pouliot, F.3    Lachance, Y.4    Labrie, C.5
  • 19
    • 0030891628 scopus 로고    scopus 로고
    • Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6
    • Morse L, Chen D, Franklin D, Xiong Y, Chen-Kiang S. Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6. Immunity. 1997;6:47-56.
    • (1997) Immunity , vol.6 , pp. 47-56
    • Morse, L.1    Chen, D.2    Franklin, D.3    Xiong, Y.4    Chen-Kiang, S.5
  • 20
    • 18644374059 scopus 로고    scopus 로고
    • CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells
    • Tourigny MR, Ursini-Siegel J, Lee H, et al. CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells. Immunity. 2002;17: 179-189.
    • (2002) Immunity , vol.17 , pp. 179-189
    • Tourigny, M.R.1    Ursini-Siegel, J.2    Lee, H.3
  • 22
    • 0029869054 scopus 로고    scopus 로고
    • Analysis of the novel cyclin-dependent kinase 4 and 6 inhibitor gene p18 in lymphoma and leukemia cell lines
    • Siebert R, Willers CP, Fossa A, et al. Analysis of the novel cyclin-dependent kinase 4 and 6 inhibitor gene p18 in lymphoma and leukemia cell lines. Leuk Res. 1996;20:197-200.
    • (1996) Leuk Res , vol.20 , pp. 197-200
    • Siebert, R.1    Willers, C.P.2    Fossa, A.3
  • 23
    • 0030614848 scopus 로고    scopus 로고
    • Analysis of the p16INK4A, p15INK4B and p18INK4C genes in multiple myeloma
    • Tasaka T, Berenson J, Vescio R, et al. Analysis of the p16INK4A, p15INK4B and p18INK4C genes in multiple myeloma. Br J Haematol. 1997;96:98-102.
    • (1997) Br J Haematol , vol.96 , pp. 98-102
    • Tasaka, T.1    Berenson, J.2    Vescio, R.3
  • 24
    • 85009921564 scopus 로고    scopus 로고
    • Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: Ectopic p18 expression inhibits growth and induces apoptosis
    • Kulkami MS, Daggett JL, Bender TP, Kuehl WM, Bergsagel PL, Williams ME. Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: ectopic p18 expression inhibits growth and induces apoptosis. Leukemia. 2002;16:127-134.
    • (2002) Leukemia , vol.16 , pp. 127-134
    • Kulkami, M.S.1    Daggett, J.L.2    Bender, T.P.3    Kuehl, W.M.4    Bergsagel, P.L.5    Williams, M.E.6
  • 25
    • 0037438584 scopus 로고    scopus 로고
    • Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: Analyses using tissue microarrays
    • Garcia JF, Camacho FI, Morente M, et al. Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays. Blood. 2003;101:681-689.
    • (2003) Blood , vol.101 , pp. 681-689
    • Garcia, J.F.1    Camacho, F.I.2    Morente, M.3
  • 26
    • 0037173743 scopus 로고    scopus 로고
    • Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma
    • Hertel CB, Zhou XG, Hamilton-Dutoit SJ, Junker S. Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma. Oncogene. 2002;21:4908-4920.
    • (2002) Oncogene , vol.21 , pp. 4908-4920
    • Hertel, C.B.1    Zhou, X.G.2    Hamilton-Dutoit, S.J.3    Junker, S.4
  • 27
    • 0037441887 scopus 로고    scopus 로고
    • Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma
    • Schwering I, Brauninger A, Klein U, et al. Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood. 2003;101:1505-1512.
    • (2003) Blood , vol.101 , pp. 1505-1512
    • Schwering, I.1    Brauninger, A.2    Klein, U.3
  • 29
    • 0031822837 scopus 로고    scopus 로고
    • Tissue microarrays for high-throughput molecular profiling of tumor specimens
    • Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med. 1998;4: 844-847.
    • (1998) Nat Med , vol.4 , pp. 844-847
    • Kononen, J.1    Bubendorf, L.2    Kallioniemi, A.3
  • 30
    • 0036800867 scopus 로고    scopus 로고
    • Application of tissue microarray technology to the study of non-Hodgkin's and Hodgkin's lymphoma
    • Hedvat CV, Hegde A, Chaganti RS, et al. Application of tissue microarray technology to the study of non-Hodgkin's and Hodgkin's lymphoma. Hum Pathol. 2002;33:968-974.
    • (2002) Hum Pathol , vol.33 , pp. 968-974
    • Hedvat, C.V.1    Hegde, A.2    Chaganti, R.S.3
  • 31
    • 0037314550 scopus 로고    scopus 로고
    • High-throughput tissue microarray analysis of G1-cyclin alterations in classical Hodgkin's lymphoma indicates overexpression of cyclin E1
    • Tzankov A, Zimpfer A, Lugli A, et al. High-throughput tissue microarray analysis of G1-cyclin alterations in classical Hodgkin's lymphoma indicates overexpression of cyclin E1. J Pathol. 2003;199:201-207.
    • (2003) J Pathol , vol.199 , pp. 201-207
    • Tzankov, A.1    Zimpfer, A.2    Lugli, A.3
  • 33
    • 0026546877 scopus 로고
    • A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
    • Frommer M, McDonald LE, Millar DS, et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci U S A. 1992;89:1827-1831.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 1827-1831
    • Frommer, M.1    McDonald, L.E.2    Millar, D.S.3
  • 34
    • 0036311221 scopus 로고    scopus 로고
    • Methylation sequencing from limiting DNA: Embryonic, fixed, and microdissected cells
    • Millar DS, Warnecke PM, Melki JR, Clark SJ. Methylation sequencing from limiting DNA: embryonic, fixed, and microdissected cells. Methods. 2002;27:108-113.
    • (2002) Methods , vol.27 , pp. 108-113
    • Millar, D.S.1    Warnecke, P.M.2    Melki, J.R.3    Clark, S.J.4
  • 35
    • 0032548107 scopus 로고    scopus 로고
    • A prognostic score for advanced Hodgkin's disease: International Prognostic Factors Project on Advanced Hodgkin's Disease
    • Hasenclever D, Diehl V. A prognostic score for advanced Hodgkin's disease: International Prognostic Factors Project on Advanced Hodgkin's Disease. N Engl J Med. 1998;339:1506-1514.
    • (1998) N Engl J Med , vol.339 , pp. 1506-1514
    • Hasenclever, D.1    Diehl, V.2
  • 36
    • 0035324928 scopus 로고    scopus 로고
    • Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Stemberg cells
    • Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C. Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Stemberg cells. Blood. 2001;97:2798-2807.
    • (2001) Blood , vol.97 , pp. 2798-2807
    • Hinz, M.1    Loser, P.2    Mathas, S.3    Krappmann, D.4    Dorken, B.5    Scheidereit, C.6
  • 37
    • 0032457532 scopus 로고    scopus 로고
    • Clonality and germinal centre B-cell derivation of Hodgkin/ Reed-Sternberg cells in Hodgkin's disease
    • Kuppers R, Hansmann ML, Rajewsky K. Clonality and germinal centre B-cell derivation of Hodgkin/Reed-Sternberg cells in Hodgkin's disease. Ann Oncol. 1998;9(suppl 5):S17-S20.
    • (1998) Ann Oncol , vol.9 , Issue.SUPPL. 5
    • Kuppers, R.1    Hansmann, M.L.2    Rajewsky, K.3
  • 38
    • 0037089229 scopus 로고    scopus 로고
    • Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease
    • Jundt F, Kley K, Anagnostopoulos I, et al. Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease. Blood. 2002;99:3060-3062.
    • (2002) Blood , vol.99 , pp. 3060-3062
    • Jundt, F.1    Kley, K.2    Anagnostopoulos, I.3
  • 39
    • 0037317415 scopus 로고    scopus 로고
    • Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis
    • Bai F, Pei XH, Godfrey VL, Xiong Y. Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Mol Cell Biol. 2003; 23:1269-1277.
    • (2003) Mol Cell Biol , vol.23 , pp. 1269-1277
    • Bai, F.1    Pei, X.H.2    Godfrey, V.L.3    Xiong, Y.4
  • 40
    • 0035884934 scopus 로고    scopus 로고
    • An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation
    • Kovalev GI, Franklin DS, Coffield VM, Xiong Y, Su L. An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation. J Immunol. 2001;167:3285-3292.
    • (2001) J Immunol , vol.167 , pp. 3285-3292
    • Kovalev, G.I.1    Franklin, D.S.2    Coffield, V.M.3    Xiong, Y.4    Su, L.5
  • 41
    • 0037199915 scopus 로고    scopus 로고
    • Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1
    • Blais A, Monte D, Pouliot F, Labrie C. Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1. J Biol Chem. 2002;277:31679-31693.
    • (2002) J Biol Chem , vol.277 , pp. 31679-31693
    • Blais, A.1    Monte, D.2    Pouliot, F.3    Labrie, C.4


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