Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in DNA-damaged cancer cells

Journal of Biological Chemistry

Volumn 280, Issue 36, 2005, Pages 32018-32025

  Le, Hong Van ^a   Minn, Andy J ^a   Massagué, Joan ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; DNA; ENZYME INHIBITION; MOLECULAR BIOLOGY; TUMORS;

CASPASE ACTIVATION; CDK INHIBITORS; DNA DAMAGE-INDUCED APOPTOTIC EVENTS; P53 UP-REGULATED MODULATOR OF APOPTOSIS (PUMA);

CELLS;

CASPASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOCHROME C; PROTEIN BCL 2; PROTEIN P53; PROTEIN PUMA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL CYCLE G2 PHASE; COLORECTAL CANCER; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; GENE INDUCTION; HUMAN; HUMAN CELL; MEMBRANE DEPOLARIZATION; MITOCHONDRION; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASES; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYTOCHROMES C; DNA DAMAGE; HUMANS; MITOCHONDRIA; NEOPLASMS; PROTO-ONCOGENE PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 24744462701     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M504689200     Document Type: Article

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