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Volumn 13, Issue 21, 2007, Pages 2129-2145

Targeting vascular cell migration as a strategy for blocking angiogenesis: The central role of focal adhesion protein tyrosine kinase family

Author keywords

Angiotensin II; Endothelial cells; Focal adhesion; Focal adhesion kinase (FAK); Proline rich tyrosine kinase 2 (PYK2); Vascular endothelial growth factor (VEGF); Vascular smooth muscle cells

Indexed keywords

ADAPTOR PROTEIN; ANGIOTENSIN II; FIBROBLAST GROWTH FACTOR; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE 2; GROWTH FACTOR RECEPTOR; INTEGRIN; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; VASCULOTROPIN;

EID: 34447288669     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161207781039643     Document Type: Review
Times cited : (30)

References (222)
  • 1
    • 27644557532 scopus 로고    scopus 로고
    • The role of pericytes in blood-vessel formation and maintenance
    • Bergers G, Song S. The role of pericytes in blood-vessel formation and maintenance. Neuro-oncol 2005; 7: 452-64.
    • (2005) Neuro-oncol , vol.7 , pp. 452-464
    • Bergers, G.1    Song, S.2
  • 2
    • 0026249489 scopus 로고
    • Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein
    • Guan JL, Trevithick JE, Hynes RO. Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regul 1991; 2: 951-64.
    • (1991) Cell Regul , vol.2 , pp. 951-964
    • Guan, J.L.1    Trevithick, J.E.2    Hynes, R.O.3
  • 3
    • 0026674919 scopus 로고
    • Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin
    • Hanks SK, Calalb MB, Harper MC, Patel SK. Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc Natl Acad Sci USA 1992; 89: 8487-91.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 8487-8491
    • Hanks, S.K.1    Calalb, M.B.2    Harper, M.C.3    Patel, S.K.4
  • 4
    • 0027055575 scopus 로고
    • Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase
    • Kornberg L, Earp HS, Parsons JT, Schaller M, Juliano RL. Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J Biol Chem 1992; 267: 23439-42.
    • (1992) J Biol Chem , vol.267 , pp. 23439-23442
    • Kornberg, L.1    Earp, H.S.2    Parsons, J.T.3    Schaller, M.4    Juliano, R.L.5
  • 6
    • 0028018234 scopus 로고
    • Potential role for focal adhesion kinase in migrating and proliferating keratinocytes near epidermal wounds and in culture
    • Gates RE, King LE Jr, Hanks SK, Nanney LB. Potential role for focal adhesion kinase in migrating and proliferating keratinocytes near epidermal wounds and in culture. Cell Growth Differ 1994; 5: 891-9.
    • (1994) Cell Growth Differ , vol.5 , pp. 891-899
    • Gates, R.E.1    King Jr, L.E.2    Hanks, S.K.3    Nanney, L.B.4
  • 7
    • 0028331263 scopus 로고
    • Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells
    • Romer LH, McLean N, Turner CE, Burridge K. Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells. Mol Biol Cell 1994; 5: 349-61.
    • (1994) Mol Biol Cell , vol.5 , pp. 349-361
    • Romer, L.H.1    McLean, N.2    Turner, C.E.3    Burridge, K.4
  • 8
    • 0029092674 scopus 로고
    • Focal adhesion kinase (p125FAK) expression correlates with motility of human melanoma cell lines
    • Akasaka T, van Leeuwen RL, Yoshinaga IG, Mihm MC Jr, Byers HR. Focal adhesion kinase (p125FAK) expression correlates with motility of human melanoma cell lines. J Invest Dermatol 1995; 105: 104-8.
    • (1995) J Invest Dermatol , vol.105 , pp. 104-108
    • Akasaka, T.1    van Leeuwen, R.L.2    Yoshinaga, I.G.3    Mihm Jr, M.C.4    Byers, H.R.5
  • 9
    • 0029087478 scopus 로고
    • Modulation of cell spreading and migration by pp125FAK phosphorylation
    • Sankar S, Mahooti-Brooks N, Hu G, Madri JA. Modulation of cell spreading and migration by pp125FAK phosphorylation. Am J Pathol 1995; 147: 601-8.
    • (1995) Am J Pathol , vol.147 , pp. 601-608
    • Sankar, S.1    Mahooti-Brooks, N.2    Hu, G.3    Madri, J.A.4
  • 11
    • 0029120440 scopus 로고
    • Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
    • Ilic D, Furuta Y, Kanazawa S, Takeda N, Sobue K, Nakatsuji N, et al. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 1995; 377: 539-44.
    • (1995) Nature , vol.377 , pp. 539-544
    • Ilic, D.1    Furuta, Y.2    Kanazawa, S.3    Takeda, N.4    Sobue, K.5    Nakatsuji, N.6
  • 12
    • 0029948080 scopus 로고    scopus 로고
    • Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn
    • Cary LA, Chang JF, Guan JL. Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J Cell Sci 1996; 109 (Pt 7): 1787-94.
    • (1996) J Cell Sci , vol.109 , Issue.PART 7 , pp. 1787-1794
    • Cary, L.A.1    Chang, J.F.2    Guan, J.L.3
  • 13
    • 0037082377 scopus 로고    scopus 로고
    • Pyk2/ CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells
    • Tang H, Hao Q, Fitzgerald T, Sasaki T, Landon EJ, Inagami T. Pyk2/ CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells. J Biol Chem 2002; 277: 5441-7.
    • (2002) J Biol Chem , vol.277 , pp. 5441-5447
    • Tang, H.1    Hao, Q.2    Fitzgerald, T.3    Sasaki, T.4    Landon, E.J.5    Inagami, T.6
  • 14
    • 0035793591 scopus 로고    scopus 로고
    • Inhibition of the calcium-dependent tyrosine kinase (CADTK) blocks monocyte spreading and motility
    • Watson JM, Harding TW, Golubovskaya V, Morris JS, Hunter D, Li X, et al. Inhibition of the calcium-dependent tyrosine kinase (CADTK) blocks monocyte spreading and motility. J Biol Chem 2001; 276: 3536-42.
    • (2001) J Biol Chem , vol.276 , pp. 3536-3542
    • Watson, J.M.1    Harding, T.W.2    Golubovskaya, V.3    Morris, J.S.4    Hunter, D.5    Li, X.6
  • 15
    • 0031915950 scopus 로고    scopus 로고
    • Regulation of a calcium-dependent tyrosine kinase in vascular smooth muscle cells by angiotensin II and platelet-derived growth factor. Dependence on calcium and the actin cytoskeleton
    • Brinson AE, Harding T, Diliberto PA, He Y, Li X, Hunter D, et al. Regulation of a calcium-dependent tyrosine kinase in vascular smooth muscle cells by angiotensin II and platelet-derived growth factor. Dependence on calcium and the actin cytoskeleton. J Biol Chem 1998; 273: 1711-8.
    • (1998) J Biol Chem , vol.273 , pp. 1711-1718
    • Brinson, A.E.1    Harding, T.2    Diliberto, P.A.3    He, Y.4    Li, X.5    Hunter, D.6
  • 16
    • 0033615525 scopus 로고    scopus 로고
    • Anchorage-dependent regulation of the mitogen-activated protein kinase cascade by growth factors is supported by a variety of integrin alpha chains
    • Aplin AE, Short SM, Juliano RL. Anchorage-dependent regulation of the mitogen-activated protein kinase cascade by growth factors is supported by a variety of integrin alpha chains. J Biol Chem 1999; 274: 31223-8.
    • (1999) J Biol Chem , vol.274 , pp. 31223-31228
    • Aplin, A.E.1    Short, S.M.2    Juliano, R.L.3
  • 17
    • 0036292747 scopus 로고    scopus 로고
    • Thrombin-stimulated Pyk2 phosphorylation in human endothelium is dependent on intracellular calcium and independent of protein kinase C and Src kinases
    • Keogh RJ, Houliston RA, Wheeler-Jones CP. Thrombin-stimulated Pyk2 phosphorylation in human endothelium is dependent on intracellular calcium and independent of protein kinase C and Src kinases. Biochem Biophys Res Commun 2002; 294: 1001-8.
    • (2002) Biochem Biophys Res Commun , vol.294 , pp. 1001-1008
    • Keogh, R.J.1    Houliston, R.A.2    Wheeler-Jones, C.P.3
  • 18
    • 22344434300 scopus 로고    scopus 로고
    • Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis
    • Shen TL, Park AY, Alcaraz A, Peng X, Jang I, Koni P, et al. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol 2005; 169: 941-52.
    • (2005) J Cell Biol , vol.169 , pp. 941-952
    • Shen, T.L.1    Park, A.Y.2    Alcaraz, A.3    Peng, X.4    Jang, I.5    Koni, P.6
  • 19
    • 0029739950 scopus 로고    scopus 로고
    • Control of adhesion-dependent cell survival by focal adhesion kinase
    • Frisch SM, Vuori K, Ruoslahti E, Chan-Hui PY. Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol 1996; 134: 793-9.
    • (1996) J Cell Biol , vol.134 , pp. 793-799
    • Frisch, S.M.1    Vuori, K.2    Ruoslahti, E.3    Chan-Hui, P.Y.4
  • 20
    • 0032510801 scopus 로고    scopus 로고
    • Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD
    • Claesson-Welsh L, Welsh M, Ito N, Anand-Apte B, Soker S, Zetter B, et al. Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD. Proc Natl Acad Sci USA 1998; 95: 5579-83.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5579-5583
    • Claesson-Welsh, L.1    Welsh, M.2    Ito, N.3    Anand-Apte, B.4    Soker, S.5    Zetter, B.6
  • 21
    • 0031845562 scopus 로고    scopus 로고
    • Modulation of apoptotic cell death by extracellular matrix proteins and a fibronectin-derived antiadhesive peptide
    • Fukai F, Mashimo M, Akiyama K, Goto T, Tanuma S, Katayama T. Modulation of apoptotic cell death by extracellular matrix proteins and a fibronectin-derived antiadhesive peptide. Exp Cell Res 1998; 242: 92-9.
    • (1998) Exp Cell Res , vol.242 , pp. 92-99
    • Fukai, F.1    Mashimo, M.2    Akiyama, K.3    Goto, T.4    Tanuma, S.5    Katayama, T.6
  • 22
    • 0032536543 scopus 로고    scopus 로고
    • Caspase-mediated cleavage of focal adhesion kinase pp125FAK and disassembly of focal adhesions in human endothelial cell apoptosis
    • Levkau B, Herren B, Koyama H, Ross R, Raines EW. Caspase-mediated cleavage of focal adhesion kinase pp125FAK and disassembly of focal adhesions in human endothelial cell apoptosis. J Exp Med 1998; 187: 579-86.
    • (1998) J Exp Med , vol.187 , pp. 579-586
    • Levkau, B.1    Herren, B.2    Koyama, H.3    Ross, R.4    Raines, E.W.5
  • 25
    • 3142521875 scopus 로고    scopus 로고
    • Control of motile and invasive cell phenotypes by focal adhesion kinase
    • Schlaepfer DD, Mitra SK, Ilic D. Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim Biophys Acta 2004; 1692: 77-102.
    • (2004) Biochim Biophys Acta , vol.1692 , pp. 77-102
    • Schlaepfer, D.D.1    Mitra, S.K.2    Ilic, D.3
  • 26
  • 27
    • 0035433356 scopus 로고    scopus 로고
    • Overexpression of the focal adhesion kinase (p125FAK) in the vascular smooth muscle cells of intimal hyperplasia
    • Owens LV, Xu L, Marston WA, Yang X, Farber MA, Iacocca MV, et al. Overexpression of the focal adhesion kinase (p125FAK) in the vascular smooth muscle cells of intimal hyperplasia. J Vasc Surg 2001; 34: 344-9.
    • (2001) J Vasc Surg , vol.34 , pp. 344-349
    • Owens, L.V.1    Xu, L.2    Marston, W.A.3    Yang, X.4    Farber, M.A.5    Iacocca, M.V.6
  • 28
    • 0028223702 scopus 로고
    • Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II
    • Polte TR, Naftilan AJ, Hanks SK. Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II. J Cell Biochem 1994; 55: 106-19.
    • (1994) J Cell Biochem , vol.55 , pp. 106-119
    • Polte, T.R.1    Naftilan, A.J.2    Hanks, S.K.3
  • 30
    • 0027448821 scopus 로고
    • Expression of focal adhesion kinase gene and invasive cancer
    • Weiner TM, Liu ET, Craven RJ, Cance WG. Expression of focal adhesion kinase gene and invasive cancer. Lancet 1993; 342: 1024-5.
    • (1993) Lancet , vol.342 , pp. 1024-1025
    • Weiner, T.M.1    Liu, E.T.2    Craven, R.J.3    Cance, W.G.4
  • 31
    • 0028826350 scopus 로고
    • Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain
    • Avraham S, London R, Fu Y, Ota S, Hiregowdara D, Li J, et al. Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J Biol Chem 1995; 270: 27742-51.
    • (1995) J Biol Chem , vol.270 , pp. 27742-27751
    • Avraham, S.1    London, R.2    Fu, Y.3    Ota, S.4    Hiregowdara, D.5    Li, J.6
  • 32
    • 0031846188 scopus 로고    scopus 로고
    • Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein
    • Xiong WC, Macklem M, Parsons JT. Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein. J Cell Sci 1998; 111 (Pt 14): 1981-91.
    • (1998) J Cell Sci , vol.111 , Issue.PART 14 , pp. 1981-1991
    • Xiong, W.C.1    Macklem, M.2    Parsons, J.T.3
  • 33
    • 0032531732 scopus 로고    scopus 로고
    • Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration
    • Sieg DJ, Ilic D, Jones KC, Damsky CH, Hunter T, Schlaepfer DD. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration. EMBO J 1998; 17: 5933-47.
    • (1998) EMBO J , vol.17 , pp. 5933-5947
    • Sieg, D.J.1    Ilic, D.2    Jones, K.C.3    Damsky, C.H.4    Hunter, T.5    Schlaepfer, D.D.6
  • 34
    • 0032168740 scopus 로고    scopus 로고
    • PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase
    • Duong LT, Lakkakorpi PT, Nakamura I, Machwate M, Nagy RM, Rodan GA. PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase. J Clin Invest 1998; 102: 881-92.
    • (1998) J Clin Invest , vol.102 , pp. 881-892
    • Duong, L.T.1    Lakkakorpi, P.T.2    Nakamura, I.3    Machwate, M.4    Nagy, R.M.5    Rodan, G.A.6
  • 35
    • 0032079554 scopus 로고    scopus 로고
    • Fluoroaluminate induces activation and association of Src and Pyk2 tyrosine kinases in osteoblastic MC3T3-E1 cells
    • Jeschke M, Standke GJ, Scaronuscarona M. Fluoroaluminate induces activation and association of Src and Pyk2 tyrosine kinases in osteoblastic MC3T3-E1 cells. J Biol Chem 1998; 273: 11354-61.
    • (1998) J Biol Chem , vol.273 , pp. 11354-11361
    • Jeschke, M.1    Standke, G.J.2    Scaronuscarona, M.3
  • 36
    • 0032521212 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor-mediated signaling in mouse mesentery vascular endothelium
    • Mukhopadhyay D, Nagy JA, Manseau EJ, Dvorak HF. Vascular permeability factor/vascular endothelial growth factor-mediated signaling in mouse mesentery vascular endothelium. Cancer Res 1998; 58: 1278-84.
    • (1998) Cancer Res , vol.58 , pp. 1278-1284
    • Mukhopadhyay, D.1    Nagy, J.A.2    Manseau, E.J.3    Dvorak, H.F.4
  • 37
    • 0031659004 scopus 로고    scopus 로고
    • Urea and NaCl differentially regulate FAK and RAFTK/PYK2 in mIMCD3 renal medullary cells
    • Zhang Z, Avraham H, Cohen DM. Urea and NaCl differentially regulate FAK and RAFTK/PYK2 in mIMCD3 renal medullary cells. Am J Physiol 1998; 275: F447-51.
    • (1998) Am J Physiol , vol.275
    • Zhang, Z.1    Avraham, H.2    Cohen, D.M.3
  • 38
    • 0032907677 scopus 로고    scopus 로고
    • Angiotensin II signal transduction in vascular smooth muscle: Pathways activated by specific tyrosine kinases
    • Berk BC. Angiotensin II signal transduction in vascular smooth muscle: pathways activated by specific tyrosine kinases. J Am Soc Nephrol 1999; 10 (Suppl 11): S62-8.
    • (1999) J Am Soc Nephrol , vol.10 , Issue.SUPPL. 11
    • Berk, B.C.1
  • 39
    • 0034594914 scopus 로고    scopus 로고
    • RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion
    • Zrihan-Licht S, Fu Y, Settleman J, Schinkmann K, Shaw L, Keydar I, et al. RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion. Oncogene 2000; 19: 1318-28.
    • (2000) Oncogene , vol.19 , pp. 1318-1328
    • Zrihan-Licht, S.1    Fu, Y.2    Settleman, J.3    Schinkmann, K.4    Shaw, L.5    Keydar, I.6
  • 40
    • 0035837360 scopus 로고    scopus 로고
    • Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: Analysis of specific phosphorylation events using site-directed antibodies
    • Nakamura K, Yano H, Schaefer E, Sabe H. Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies. Oncogene 2001; 20: 2626-35.
    • (2001) Oncogene , vol.20 , pp. 2626-2635
    • Nakamura, K.1    Yano, H.2    Schaefer, E.3    Sabe, H.4
  • 43
    • 0035825168 scopus 로고    scopus 로고
    • Targeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells
    • Klingbeil CK, Hauck CR, Hsia DA, Jones KC, Reider SR, Schlaepfer DD. Targeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells. J Cell Biol 2001; 152: 97-110.
    • (2001) J Cell Biol , vol.152 , pp. 97-110
    • Klingbeil, C.K.1    Hauck, C.R.2    Hsia, D.A.3    Jones, K.C.4    Reider, S.R.5    Schlaepfer, D.D.6
  • 44
    • 0036257483 scopus 로고    scopus 로고
    • Nuclear translocation of cell adhesion kinase beta/proline-rich tyrosine kinase 2
    • Aoto H, Sasaki H, Ishino M, Sasaki T. Nuclear translocation of cell adhesion kinase beta/proline-rich tyrosine kinase 2. Cell Struct Funct 2002; 27: 47-61.
    • (2002) Cell Struct Funct , vol.27 , pp. 47-61
    • Aoto, H.1    Sasaki, H.2    Ishino, M.3    Sasaki, T.4
  • 45
    • 0029055784 scopus 로고
    • Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase
    • Hildebrand JD, Schaller MD, Parsons JT. Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase. Mol Biol Cell 1995; 6: 637-47.
    • (1995) Mol Biol Cell , vol.6 , pp. 637-647
    • Hildebrand, J.D.1    Schaller, M.D.2    Parsons, J.T.3
  • 48
    • 0027428367 scopus 로고
    • Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions
    • Hildebrand JD, Schaller MD, Parsons JT. Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions. J Cell Biol 1993; 123: 993-1005.
    • (1993) J Cell Biol , vol.123 , pp. 993-1005
    • Hildebrand, J.D.1    Schaller, M.D.2    Parsons, J.T.3
  • 49
    • 0036172186 scopus 로고    scopus 로고
    • The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin
    • Hayashi I, Vuori K, Liddington RC. The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin. Nat Struct Biol 2002; 9: 101-6.
    • (2002) Nat Struct Biol , vol.9 , pp. 101-106
    • Hayashi, I.1    Vuori, K.2    Liddington, R.C.3
  • 50
    • 4143083987 scopus 로고    scopus 로고
    • Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle
    • Papagrigoriou E, Gingras AR, Barsukov IL, Bate N, Fillingham IJ, Patel B, et al. Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle. EMBO J 2004; 23: 2942-51.
    • (2004) EMBO J , vol.23 , pp. 2942-2951
    • Papagrigoriou, E.1    Gingras, A.R.2    Barsukov, I.L.3    Bate, N.4    Fillingham, I.J.5    Patel, B.6
  • 51
    • 0037450657 scopus 로고    scopus 로고
    • Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin
    • Wang Q, Xie Y, Du QS, Wu XJ, Feng X, Mei L, et al. Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin. J Cell Biol 2003; 160: 565-75.
    • (2003) J Cell Biol , vol.160 , pp. 565-575
    • Wang, Q.1    Xie, Y.2    Du, Q.S.3    Wu, X.J.4    Feng, X.5    Mei, L.6
  • 52
    • 0037057293 scopus 로고    scopus 로고
    • Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397
    • Leu TH, Maa MC. Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397. Oncogene 2002; 21: 6992-7000.
    • (2002) Oncogene , vol.21 , pp. 6992-7000
    • Leu, T.H.1    Maa, M.C.2
  • 53
    • 3142779450 scopus 로고    scopus 로고
    • Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts
    • Lim Y, Han I, Jeon J, Park H, Bahk YY, Oh ES. Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts. J Biol Chem 2004; 279: 29060-5.
    • (2004) J Biol Chem , vol.279 , pp. 29060-29065
    • Lim, Y.1    Han, I.2    Jeon, J.3    Park, H.4    Bahk, Y.Y.5    Oh, E.S.6
  • 54
    • 0030597218 scopus 로고    scopus 로고
    • Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src
    • Calalb MB, Zhang X, Polte TR, Hanks SK. Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src. Biochem Biophys Res Commun 1996; 228: 662-8.
    • (1996) Biochem Biophys Res Commun , vol.228 , pp. 662-668
    • Calalb, M.B.1    Zhang, X.2    Polte, T.R.3    Hanks, S.K.4
  • 55
    • 0035176458 scopus 로고    scopus 로고
    • Serine phosphorylation of focal adhesion kinase in interphase and mitosis: A possible role in modulating binding to p130(Cas)
    • Ma A, Richardson A, Schaefer EM, Parsons JT. Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130(Cas). Mol Biol Cell 2001; 12: 1-12.
    • (2001) Mol Biol Cell , vol.12 , pp. 1-12
    • Ma, A.1    Richardson, A.2    Schaefer, E.M.3    Parsons, J.T.4
  • 56
    • 21244494930 scopus 로고    scopus 로고
    • G protein-coupled receptor activation rapidly stimulates focal adhesion kinase phosphorylation at Ser-843. Mediation by Ca2+, calmodulin, and Ca2+/calmodulin-dependent kinase II
    • Fan RS, Jacamo RO, Jiang X, Sinnett-Smith J, Rozengurt E. G protein-coupled receptor activation rapidly stimulates focal adhesion kinase phosphorylation at Ser-843. Mediation by Ca2+, calmodulin, and Ca2+/calmodulin-dependent kinase II. J Biol Chem 2005; 280: 24212-20.
    • (2005) J Biol Chem , vol.280 , pp. 24212-24220
    • Fan, R.S.1    Jacamo, R.O.2    Jiang, X.3    Sinnett-Smith, J.4    Rozengurt, E.5
  • 57
    • 0027439594 scopus 로고
    • Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK
    • Schaller MD, Borgman CA, Parsons JT. Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK. Mol Cell Biol 1993; 13: 785-91.
    • (1993) Mol Cell Biol , vol.13 , pp. 785-791
    • Schaller, M.D.1    Borgman, C.A.2    Parsons, J.T.3
  • 58
    • 0035137373 scopus 로고    scopus 로고
    • Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells
    • Taylor JM, Mack CP, Nolan K, Regan CP, Owens GK, Parsons JT. Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells. Mol Cell Biol 2001; 21: 1565-72.
    • (2001) Mol Cell Biol , vol.21 , pp. 1565-1572
    • Taylor, J.M.1    Mack, C.P.2    Nolan, K.3    Regan, C.P.4    Owens, G.K.5    Parsons, J.T.6
  • 59
    • 0029971297 scopus 로고    scopus 로고
    • A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK
    • Richardson A, Parsons T. A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK. Nature 1996; 380: 538-40.
    • (1996) Nature , vol.380 , pp. 538-540
    • Richardson, A.1    Parsons, T.2
  • 62
    • 0035813119 scopus 로고    scopus 로고
    • Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion
    • Poullet P, Gautreau A, Kadare G, Girault JA, Louvard D, Arpin M. Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion. J Biol Chem 2001; 276: 37686-91.
    • (2001) J Biol Chem , vol.276 , pp. 37686-37691
    • Poullet, P.1    Gautreau, A.2    Kadare, G.3    Girault, J.A.4    Louvard, D.5    Arpin, M.6
  • 63
    • 0035003136 scopus 로고    scopus 로고
    • Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain
    • Chen R, Kim O, Li M, Xiong X, Guan JL, Kung HJ, Chen H, et al. Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. Nat Cell Biol 2001; 3: 439-44.
    • (2001) Nat Cell Biol , vol.3 , pp. 439-444
    • Chen, R.1    Kim, O.2    Li, M.3    Xiong, X.4    Guan, J.L.5    Kung, H.J.6    Chen, H.7
  • 64
    • 17744411662 scopus 로고    scopus 로고
    • PYK2 and FAK in osteoclasts
    • Xiong WC, Feng X. PYK2 and FAK in osteoclasts. Front Biosci 2003; 8: d1219-26.
    • (2003) Front Biosci , vol.8
    • Xiong, W.C.1    Feng, X.2
  • 65
    • 0037265829 scopus 로고    scopus 로고
    • Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin
    • Messina S, Onofri F, Bongiorno-Borbone L, Giovedi S, Valtorta F, Girault JA, et al. Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin. J Neurochem 2003; 84: 253-65.
    • (2003) J Neurochem , vol.84 , pp. 253-265
    • Messina, S.1    Onofri, F.2    Bongiorno-Borbone, L.3    Giovedi, S.4    Valtorta, F.5    Girault, J.A.6
  • 66
    • 0035931748 scopus 로고    scopus 로고
    • Convergence of alpha(v)beta(3) integrin- and macrophage colony stimulating factor-mediated signals on phospholipase Cgamma in prefusion osteoclasts
    • Nakamura I, Lipfert L, Rodan GA, Le TD. Convergence of alpha(v)beta(3) integrin- and macrophage colony stimulating factor-mediated signals on phospholipase Cgamma in prefusion osteoclasts. J Cell Biol 2001; 152: 361-73.
    • (2001) J Cell Biol , vol.152 , pp. 361-373
    • Nakamura, I.1    Lipfert, L.2    Rodan, G.A.3    Le, T.D.4
  • 67
    • 0034598996 scopus 로고    scopus 로고
    • Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain
    • Chow A, Davis AJ, Gawler DJ. Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain. FEBS Lett 2000; 469: 88-92.
    • (2000) FEBS Lett , vol.469 , pp. 88-92
    • Chow, A.1    Davis, A.J.2    Gawler, D.J.3
  • 68
    • 0034934786 scopus 로고    scopus 로고
    • RAFTK/Pyk2 involvement in platelet activation is mediated by phosphoinositide 3-kinase
    • Koziak K, Kaczmarek E, Park SY, Fu Y, Avraham S, Avraham H. RAFTK/Pyk2 involvement in platelet activation is mediated by phosphoinositide 3-kinase. Br J Haematol 2001; 114: 134-40.
    • (2001) Br J Haematol , vol.114 , pp. 134-140
    • Koziak, K.1    Kaczmarek, E.2    Park, S.Y.3    Fu, Y.4    Avraham, S.5    Avraham, H.6
  • 71
    • 0035242371 scopus 로고    scopus 로고
    • VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase
    • Qi JH, Claesson-Welsh L. VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase. Exp Cell Res 2001; 263: 173-82.
    • (2001) Exp Cell Res , vol.263 , pp. 173-182
    • Qi, J.H.1    Claesson-Welsh, L.2
  • 72
    • 8644263977 scopus 로고    scopus 로고
    • Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice
    • Peng X, Ueda H, Zhou H, Stokol T, Shen TL, Alcaraz A, et al. Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice. Cardiovasc Res 2004; 64: 421-30.
    • (2004) Cardiovasc Res , vol.64 , pp. 421-430
    • Peng, X.1    Ueda, H.2    Zhou, H.3    Stokol, T.4    Shen, T.L.5    Alcaraz, A.6
  • 75
    • 0036119796 scopus 로고    scopus 로고
    • Proline-rich tyrosine kinase 2 and focal adhesion kinase are involved in different phases of platelet activation by vWF
    • Canobbio I, Lova P, Sinigaglia F, Balduini C, Torti M. Proline-rich tyrosine kinase 2 and focal adhesion kinase are involved in different phases of platelet activation by vWF. Thromb Haemost 2002; 87: 509-17.
    • (2002) Thromb Haemost , vol.87 , pp. 509-517
    • Canobbio, I.1    Lova, P.2    Sinigaglia, F.3    Balduini, C.4    Torti, M.5
  • 76
    • 1442278553 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-mediated activation of p38 is dependent upon Src and RAFTK/Pyk2
    • McMullen M, Keller R, Sussman M, Pumiglia K. Vascular endothelial growth factor-mediated activation of p38 is dependent upon Src and RAFTK/Pyk2. Oncogene 2004; 23: 1275-82.
    • (2004) Oncogene , vol.23 , pp. 1275-1282
    • McMullen, M.1    Keller, R.2    Sussman, M.3    Pumiglia, K.4
  • 77
    • 0032803067 scopus 로고    scopus 로고
    • Focal adhesion targeting: The critical determinant of FAK regulation and substrate phosphorylation
    • Shen Y, Schaller MD. Focal adhesion targeting: the critical determinant of FAK regulation and substrate phosphorylation. Mol Biol Cell 1999; 10: 2507-18.
    • (1999) Mol Biol Cell , vol.10 , pp. 2507-2518
    • Shen, Y.1    Schaller, M.D.2
  • 78
    • 0037188927 scopus 로고    scopus 로고
    • GFP-FRNK disrupts focal adhesions and induces anoikis in neonatal rat ventricular myocytes
    • Heidkamp MC, Bayer AL, Kalina JA, Eble DM, Samarel AM. GFP-FRNK disrupts focal adhesions and induces anoikis in neonatal rat ventricular myocytes. Circ Res 2002; 90: 1282-9.
    • (2002) Circ Res , vol.90 , pp. 1282-1289
    • Heidkamp, M.C.1    Bayer, A.L.2    Kalina, J.A.3    Eble, D.M.4    Samarel, A.M.5
  • 79
    • 0036142219 scopus 로고    scopus 로고
    • The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling
    • Hagel M, George EL, Kim A, Tamimi R, Opitz SL, Turner CE, et al. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol 2002; 22: 901-15.
    • (2002) Mol Cell Biol , vol.22 , pp. 901-915
    • Hagel, M.1    George, E.L.2    Kim, A.3    Tamimi, R.4    Opitz, S.L.5    Turner, C.E.6
  • 80
    • 0037012038 scopus 로고    scopus 로고
    • Paxillin null embryonic stem cells are impaired in cell spreading and tyrosine phosphorylation of focal adhesion kinase
    • Wade R, Bohl J, Vande Pol S. Paxillin null embryonic stem cells are impaired in cell spreading and tyrosine phosphorylation of focal adhesion kinase. Oncogene 2002; 21: 96-107.
    • (2002) Oncogene , vol.21 , pp. 96-107
    • Wade, R.1    Bohl, J.2    Vande Pol, S.3
  • 81
    • 0033942173 scopus 로고    scopus 로고
    • The cytoplasmic tyrosines of integrin subunit beta1 are involved in focal adhesion kinase activation
    • Wennerberg K, Armulik A, Sakai T, Karlsson M, Fassler R, Schaefer EM, et al. The cytoplasmic tyrosines of integrin subunit beta1 are involved in focal adhesion kinase activation. Mol Cell Biol 2000; 20: 5758-65.
    • (2000) Mol Cell Biol , vol.20 , pp. 5758-5765
    • Wennerberg, K.1    Armulik, A.2    Sakai, T.3    Karlsson, M.4    Fassler, R.5    Schaefer, E.M.6
  • 82
    • 0031917388 scopus 로고    scopus 로고
    • Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion
    • Zheng C, Xing Z, Bian ZC, Guo C, Akbay A, Warner L, et al. Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion. J Biol Chem 1998; 273: 2384-9.
    • (1998) J Biol Chem , vol.273 , pp. 2384-2389
    • Zheng, C.1    Xing, Z.2    Bian, Z.C.3    Guo, C.4    Akbay, A.5    Warner, L.6
  • 83
    • 0141814993 scopus 로고    scopus 로고
    • Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase
    • Avraham HK, Lee TH, Koh Y, Kim TA, Jiang S, Sussman M, et al. Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase. J Biol Chem 2003; 278: 36661-8.
    • (2003) J Biol Chem , vol.278 , pp. 36661-36668
    • Avraham, H.K.1    Lee, T.H.2    Koh, Y.3    Kim, T.A.4    Jiang, S.5    Sussman, M.6
  • 84
    • 0034851713 scopus 로고    scopus 로고
    • Inhibition of PYK2-induced actin cytoskeleton reorganization, PYK2 autophosphorylation and focal adhesion targeting by FAK
    • Du QS, Ren XR, Xie Y, Wang Q, Mei L, Xiong WC. Inhibition of PYK2-induced actin cytoskeleton reorganization, PYK2 autophosphorylation and focal adhesion targeting by FAK. J Cell Sci 2001; 114: 2977-87.
    • (2001) J Cell Sci , vol.114 , pp. 2977-2987
    • QS, D.1    Ren, X.R.2    Xie, Y.3    Wang, Q.4    Mei, L.5    Xiong, W.C.6
  • 85
    • 0037160058 scopus 로고    scopus 로고
    • The N termini of focal adhesion kinase family members regulate substrate phosphorylation, localization, and cell morphology
    • Dunty JM, Schaller MD. The N termini of focal adhesion kinase family members regulate substrate phosphorylation, localization, and cell morphology. J Biol Chem 2002; 277: 45644-54.
    • (2002) J Biol Chem , vol.277 , pp. 45644-45654
    • Dunty, J.M.1    Schaller, M.D.2
  • 86
    • 0035136875 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase phi regulates paxillin tyrosine phosphorylation and mediates colony-stimulating factor 1-induced morphological changes in macrophages
    • Pixley FJ, Lee PS, Condeelis JS, Stanley ER. Protein tyrosine phosphatase phi regulates paxillin tyrosine phosphorylation and mediates colony-stimulating factor 1-induced morphological changes in macrophages. Mol Cell Biol 2001; 21: 1795-809.
    • (2001) Mol Cell Biol , vol.21 , pp. 1795-1809
    • Pixley, F.J.1    Lee, P.S.2    Condeelis, J.S.3    Stanley, E.R.4
  • 87
    • 0028877919 scopus 로고
    • Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src family kinases
    • Calalb MB, Polte TR, Hanks SK. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol 1995; 15: 954-63.
    • (1995) Mol Cell Biol , vol.15 , pp. 954-963
    • Calalb, M.B.1    Polte, T.R.2    Hanks, S.K.3
  • 88
    • 0343340035 scopus 로고    scopus 로고
    • Phosphospecific antibodies reveal focal adhesion kinase activation loop phosphorylation in nascent and mature focal adhesions and requirement for the autophosphorylation site
    • Ruest PJ, Roy S, Shi E, Mernaugh RL, Hanks SK. Phosphospecific antibodies reveal focal adhesion kinase activation loop phosphorylation in nascent and mature focal adhesions and requirement for the autophosphorylation site. Cell Growth Differ 2000; 11: 41-8.
    • (2000) Cell Growth Differ , vol.11 , pp. 41-48
    • Ruest, P.J.1    Roy, S.2    Shi, E.3    Mernaugh, R.L.4    Hanks, S.K.5
  • 90
    • 0035947577 scopus 로고    scopus 로고
    • Src family kinases are required for integrin-mediated but not for G protein-coupled receptor stimulation of focal adhesion kinase autophosphorylation at Tyr-397
    • Salazar EP, Rozengurt E. Src family kinases are required for integrin-mediated but not for G protein-coupled receptor stimulation of focal adhesion kinase autophosphorylation at Tyr-397. J Biol Chem 2001; 276: 17788-95.
    • (2001) J Biol Chem , vol.276 , pp. 17788-17795
    • Salazar, E.P.1    Rozengurt, E.2
  • 92
    • 0242495710 scopus 로고    scopus 로고
    • Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction
    • Cooper LA, Shen TL, Guan JL. Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction. Mol Cell Biol 2003; 23: 8030-41.
    • (2003) Mol Cell Biol , vol.23 , pp. 8030-8041
    • Cooper, L.A.1    Shen, T.L.2    Guan, J.L.3
  • 93
    • 23044467828 scopus 로고    scopus 로고
    • A truncated FAK lacking the FERM domain displays high catalytic activity but retains responsiveness to adhesion-mediated signals
    • Jacamo RO, Rozengurt E. A truncated FAK lacking the FERM domain displays high catalytic activity but retains responsiveness to adhesion-mediated signals. Biochem Biophys Res Commun 2005; 334: 1299-304.
    • (2005) Biochem Biophys Res Commun , vol.334 , pp. 1299-1304
    • Jacamo, R.O.1    Rozengurt, E.2
  • 94
    • 10744222629 scopus 로고    scopus 로고
    • Human cytomegalovirus chemokine receptor US28-induced smooth muscle cell migration is mediated by focal adhesion kinase and Src
    • Streblow DN, Vomaske J, Smith P, Melnychuk R, Hall L, Pancheva D, et al. Human cytomegalovirus chemokine receptor US28-induced smooth muscle cell migration is mediated by focal adhesion kinase and Src. J Biol Chem 2003; 278: 50456-65.
    • (2003) J Biol Chem , vol.278 , pp. 50456-50465
    • Streblow, D.N.1    Vomaske, J.2    Smith, P.3    Melnychuk, R.4    Hall, L.5    Pancheva, D.6
  • 95
    • 0028918391 scopus 로고
    • Identification of Tyr-397 as the primary site of tyrosine phosphorylation and pp60src association in the focal adhesion kinase, pp125FAK
    • Eide BL, Turck CW, Escobedo JA. Identification of Tyr-397 as the primary site of tyrosine phosphorylation and pp60src association in the focal adhesion kinase, pp125FAK. Mol Cell Biol 1995; 15: 2819-27.
    • (1995) Mol Cell Biol , vol.15 , pp. 2819-2827
    • Eide, B.L.1    Turck, C.W.2    Escobedo, J.A.3
  • 96
    • 1842848073 scopus 로고    scopus 로고
    • Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography
    • Nowakowski J, Cronin CN, McRee DE, Knuth MW, Nelson CG, Pavletich NP, et al. Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography. Structure 2002; 10: 1659-67.
    • (2002) Structure , vol.10 , pp. 1659-1667
    • Nowakowski, J.1    Cronin, C.N.2    McRee, D.E.3    Knuth, M.W.4    Nelson, C.G.5    Pavletich, N.P.6
  • 98
    • 0029979722 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase
    • Chen HC, Appeddu PA, Isoda H, Guan JL. Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase. J Biol Chem 1996; 271: 26329-34.
    • (1996) J Biol Chem , vol.271 , pp. 26329-26334
    • Chen, H.C.1    Appeddu, P.A.2    Isoda, H.3    Guan, J.L.4
  • 99
    • 0000226650 scopus 로고    scopus 로고
    • Association of focal adhesion kinase with Grb7 and its role in cell migration
    • Han DC, Guan JL. Association of focal adhesion kinase with Grb7 and its role in cell migration. J Biol Chem 1999; 274: 24425-30.
    • (1999) J Biol Chem , vol.274 , pp. 24425-24430
    • Han, D.C.1    Guan, J.L.2
  • 100
    • 0031921101 scopus 로고    scopus 로고
    • Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: Summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events
    • Schlaepfer DD, Jones KC, Hunter T. Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol Cell Biol 1998; 18: 2571-85.
    • (1998) Mol Cell Biol , vol.18 , pp. 2571-2585
    • Schlaepfer, D.D.1    Jones, K.C.2    Hunter, T.3
  • 102
    • 0141865509 scopus 로고    scopus 로고
    • Negative regulation of FAK signaling by SOCS proteins
    • Liu E, Cote JF, Vuori K. Negative regulation of FAK signaling by SOCS proteins. EMBO J 2003; 22: 5036-46.
    • (2003) EMBO J , vol.22 , pp. 5036-5046
    • Liu, E.1    Cote, J.F.2    Vuori, K.3
  • 103
    • 0037421205 scopus 로고    scopus 로고
    • PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration
    • Zeng L, Si X, Yu WP, Le HT, Ng KP, Teng RM, et al. PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration. J Cell Biol 2003; 160: 137-46.
    • (2003) J Cell Biol , vol.160 , pp. 137-146
    • Zeng, L.1    Si, X.2    Yu, W.P.3    Le HT, N.K.4    Teng, R.M.5
  • 104
    • 0141865507 scopus 로고    scopus 로고
    • Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2
    • von Wichert G, Haimovich B, Feng GS, Sheetz MP. Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2. EMBO J 2003; 22: 5023-35.
    • (2003) EMBO J , vol.22 , pp. 5023-5035
    • von Wichert, G.1    Haimovich, B.2    Feng, G.S.3    Sheetz, M.P.4
  • 105
    • 0037780966 scopus 로고    scopus 로고
    • Reactive oxygen species as essential mediators of cell adhesion: The oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion
    • Chiarugi P, Pani G, Giannoni E, Taddei L, Colavitti R, Raugei G, et al. Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion. J Cell Biol 2003; 161: 933-44.
    • (2003) J Cell Biol , vol.161 , pp. 933-944
    • Chiarugi, P.1    Pani, G.2    Giannoni, E.3    Taddei, L.4    Colavitti, R.5    Raugei, G.6
  • 106
    • 0029907265 scopus 로고    scopus 로고
    • A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
    • Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 1996; 383: 547-50.
    • (1996) Nature , vol.383 , pp. 547-550
    • Dikic, I.1    Tokiwa, G.2    Lev, S.3    Courtneidge, S.A.4    Schlessinger, J.5
  • 107
    • 0029154733 scopus 로고
    • Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions
    • Lev S, Moreno H, Martinez R, Canoll P, Peles E, Musacchio JM, et al. Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature 1995; 376: 737-45.
    • (1995) Nature , vol.376 , pp. 737-745
    • Lev, S.1    Moreno, H.2    Martinez, R.3    Canoll, P.4    Peles, E.5    Musacchio, J.M.6
  • 108
    • 0034636863 scopus 로고    scopus 로고
    • G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha - induced serum response element-dependent transcription
    • Shi CS, Sinnarajah S, Cho H, Kozasa T, Kehrl JH. G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha - induced serum response element-dependent transcription. J Biol Chem 2000; 275: 24470-6.
    • (2000) J Biol Chem , vol.275 , pp. 24470-24476
    • Shi, C.S.1    Sinnarajah, S.2    Cho, H.3    Kozasa, T.4    Kehrl, J.H.5
  • 109
    • 0035827528 scopus 로고    scopus 로고
    • Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade
    • Andreev J, Galisteo ML, Kranenburg O, Logan SK, Chiu ES, Okigaki M, et al. Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade. J Biol Chem 2001; 276: 20130-5.
    • (2001) J Biol Chem , vol.276 , pp. 20130-20135
    • Andreev, J.1    Galisteo, M.L.2    Kranenburg, O.3    Logan, S.K.4    Chiu, E.S.5    Okigaki, M.6
  • 110
    • 0029840588 scopus 로고    scopus 로고
    • Differential regulation of proline-rich tyrosine kinase 2/cell adhesion kinase beta (PYK2/CAKbeta) and pp125(FAK) by glutamate and depolarization in rat hippocampus
    • Siciliano JC, Toutant M, Derkinderen P, Sasaki T, Girault JA. Differential regulation of proline-rich tyrosine kinase 2/cell adhesion kinase beta (PYK2/CAKbeta) and pp125(FAK) by glutamate and depolarization in rat hippocampus. J Biol Chem 1996; 271: 28942-6.
    • (1996) J Biol Chem , vol.271 , pp. 28942-28946
    • Siciliano, J.C.1    Toutant, M.2    Derkinderen, P.3    Sasaki, T.4    Girault, J.A.5
  • 111
    • 0035825121 scopus 로고    scopus 로고
    • Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility
    • Sanjay A, Houghton A, Neff L, DiDomenico E, Bardelay C, Antoine E, et al. Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility. J Cell Biol 2001; 152: 181-95.
    • (2001) J Cell Biol , vol.152 , pp. 181-195
    • Sanjay, A.1    Houghton, A.2    Neff, L.3    DiDomenico, E.4    Bardelay, C.5    Antoine, E.6
  • 112
    • 0034842699 scopus 로고    scopus 로고
    • Osmotic stress induces HB-EGF gene expression via Ca(2+)/ Pyk2/JNK signal cascades in rat aortic smooth muscle cells
    • Koh YH, Che W, Higashiyama S, Takahashi M, Miyamoto Y, Suzuki K, et al. Osmotic stress induces HB-EGF gene expression via Ca(2+)/ Pyk2/JNK signal cascades in rat aortic smooth muscle cells. J Biochem (Tokyo) 2001; 130: 351-8.
    • (2001) J Biochem (Tokyo) , vol.130 , pp. 351-358
    • Koh, Y.H.1    Che, W.2    Higashiyama, S.3    Takahashi, M.4    Miyamoto, Y.5    Suzuki, K.6
  • 113
    • 0034995547 scopus 로고    scopus 로고
    • A role for PYK2 in regulation of ERK1/2 MAP kinases and PI 3-kinase by ANG II in vascular smooth muscle
    • Rocic P, Govindarajan G, Sabri A, Lucchesi PA. A role for PYK2 in regulation of ERK1/2 MAP kinases and PI 3-kinase by ANG II in vascular smooth muscle. Am J Physiol Cell Physiol 2001; 280: C90-9.
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Rocic, P.1    Govindarajan, G.2    Sabri, A.3    Lucchesi, P.A.4
  • 114
    • 0042090276 scopus 로고    scopus 로고
    • Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway
    • Loeser RF, Forsyth CB, Samarel AM, Im HJ. Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway. J Biol Chem 2003; 278: 24577-85.
    • (2003) J Biol Chem , vol.278 , pp. 24577-24585
    • Loeser, R.F.1    Forsyth, C.B.2    Samarel, A.M.3    Im, H.J.4
  • 115
    • 17644397421 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of beta3 integrin provides a binding site for Pyk2
    • Butler B, Blystone SD. Tyrosine phosphorylation of beta3 integrin provides a binding site for Pyk2. J Biol Chem 2005; 280: 14556-62.
    • (2005) J Biol Chem , vol.280 , pp. 14556-14562
    • Butler, B.1    Blystone, S.D.2
  • 116
    • 0037838889 scopus 로고    scopus 로고
    • PYK2 autophosphorylation, but not kinase activity, is necessary for adhesion-induced association with c-Src, osteoclast spreading, and bone resorption
    • Lakkakorpi PT, Bett AJ, Lipfert L, Rodan GA, Duong le T. PYK2 autophosphorylation, but not kinase activity, is necessary for adhesion-induced association with c-Src, osteoclast spreading, and bone resorption. J Biol Chem 2003; 278: 11502-12.
    • (2003) J Biol Chem , vol.278 , pp. 11502-11512
    • Lakkakorpi, P.T.1    Bett, A.J.2    Lipfert, L.3    Rodan, G.A.4    Duong le, T.5
  • 117
    • 0034801768 scopus 로고    scopus 로고
    • Unique regulation of c-Jun N-terminal kinase by PYK2/CAK-beta in angiotensin II-stimulated vascular smooth muscle cells
    • Frank GD, Eguchi S, Motley ED, Sasaki T, Inagami T. Unique regulation of c-Jun N-terminal kinase by PYK2/CAK-beta in angiotensin II-stimulated vascular smooth muscle cells. Biochem Biophys Res Commun 2001; 286: 692-6.
    • (2001) Biochem Biophys Res Commun , vol.286 , pp. 692-696
    • Frank, G.D.1    Eguchi, S.2    Motley, E.D.3    Sasaki, T.4    Inagami, T.5
  • 118
    • 0029955660 scopus 로고    scopus 로고
    • An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase
    • Hildebrand JD, Taylor JM, Parsons JT. An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Mol Cell Biol 1996; 16: 3169-78.
    • (1996) Mol Cell Biol , vol.16 , pp. 3169-3178
    • Hildebrand, J.D.1    Taylor, J.M.2    Parsons, J.T.3
  • 119
    • 0035809922 scopus 로고    scopus 로고
    • Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein
    • Ren XR, Du QS, Huang YZ, Ao SZ, Mei L, Xiong WC. Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. J Cell Biol 2001; 152: 971-84.
    • (2001) J Cell Biol , vol.152 , pp. 971-984
    • Ren, X.R.1    Du, Q.S.2    Huang, Y.Z.3    Ao, S.Z.4    Mei, L.5    Xiong, W.C.6
  • 120
    • 0035985220 scopus 로고    scopus 로고
    • The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly
    • Liu Y, Loijens JC, Martin KH, Karginov AV, Parsons JT. The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly. Mol Biol Cell 2002; 13: 2147-56.
    • (2002) Mol Biol Cell , vol.13 , pp. 2147-2156
    • Liu, Y.1    Loijens, J.C.2    Martin, K.H.3    Karginov, A.V.4    Parsons, J.T.5
  • 121
    • 0028609382 scopus 로고
    • Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
    • Schlaepfer DD, Hanks SK, Hunter T, van der Geer P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 1994; 372: 786-91.
    • (1994) Nature , vol.372 , pp. 786-791
    • Schlaepfer, D.D.1    Hanks, S.K.2    Hunter, T.3    van der Geer, P.4
  • 122
    • 0033229747 scopus 로고    scopus 로고
    • Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase
    • Renshaw MW, Price LS, Schwartz MA. Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase. J Cell Biol 1999; 147: 611-8.
    • (1999) J Cell Biol , vol.147 , pp. 611-618
    • Renshaw, M.W.1    Price, L.S.2    Schwartz, M.A.3
  • 123
    • 3042776220 scopus 로고    scopus 로고
    • PDGF and FGF induce focal adhesion kinase (FAK) phosphorylation at Ser-910: Dissociation from Tyr-397 phosphorylation and requirement for ERK activation
    • Hunger-Glaser I, Fan RS, Perez-Salazar E, Rozengurt E. PDGF and FGF induce focal adhesion kinase (FAK) phosphorylation at Ser-910: dissociation from Tyr-397 phosphorylation and requirement for ERK activation. J Cell Physiol 2004; 200: 213-22.
    • (2004) J Cell Physiol , vol.200 , pp. 213-222
    • Hunger-Glaser, I.1    Fan, R.S.2    Perez-Salazar, E.3    Rozengurt, E.4
  • 124
    • 2442606429 scopus 로고    scopus 로고
    • Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility
    • Subauste MC, Pertz O, Adamson ED, Turner CE, Junger S, Hahn KM. Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J Cell Biol 2004; 165: 371-81.
    • (2004) J Cell Biol , vol.165 , pp. 371-381
    • Subauste, M.C.1    Pertz, O.2    Adamson, E.D.3    Turner, C.E.4    Junger, S.5    Hahn, K.M.6
  • 125
    • 0029166094 scopus 로고
    • Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase
    • Bellis SL, Miller JT, Turner CE. Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. J Biol Chem 1995; 270: 17437-41.
    • (1995) J Biol Chem , vol.270 , pp. 17437-17441
    • Bellis, S.L.1    Miller, J.T.2    Turner, C.E.3
  • 126
    • 0033577810 scopus 로고    scopus 로고
    • Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling
    • Turner CE, Brown MC, Perrotta JA, Riedy MC, Nikolopoulos SN, McDonald AR, et al. Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. J Cell Biol 1999; 145: 851-63.
    • (1999) J Cell Biol , vol.145 , pp. 851-863
    • Turner, C.E.1    Brown, M.C.2    Perrotta, J.A.3    Riedy, M.C.4    Nikolopoulos, S.N.5    McDonald, A.R.6
  • 127
    • 18644371169 scopus 로고    scopus 로고
    • Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin
    • Di Paolo G, Pellegrini L, Letinic K, Cestra G, Zoncu R, Voronov S, et al. Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. Nature 2002; 420: 85-9.
    • (2002) Nature , vol.420 , pp. 85-89
    • Di Paolo, G.1    Pellegrini, L.2    Letinic, K.3    Cestra, G.4    Zoncu, R.5    Voronov, S.6
  • 128
    • 0037038412 scopus 로고    scopus 로고
    • Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions
    • Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA. Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature 2002; 420: 89-93.
    • (2002) Nature , vol.420 , pp. 89-93
    • Ling, K.1    Doughman, R.L.2    Firestone, A.J.3    Bunce, M.W.4    Anderson, R.A.5
  • 129
    • 0043234288 scopus 로고    scopus 로고
    • Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain
    • Barsukov IL, Prescot A, Bate N, Patel B, Floyd DN, Bhanji N, et al. Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain. J Biol Chem 2003; 278: 31202-9.
    • (2003) J Biol Chem , vol.278 , pp. 31202-31209
    • Barsukov, I.L.1    Prescot, A.2    Bate, N.3    Patel, B.4    Floyd, D.N.5    Bhanji, N.6
  • 130
    • 0347993703 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrintalin switch
    • Ling K, Doughman RL, Iyer VV, Firestone AJ, Bairstow SF, Mosher DF, et al. Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrintalin switch. J Cell Biol 2003; 163: 1339-49.
    • (2003) J Cell Biol , vol.163 , pp. 1339-1349
    • Ling, K.1    Doughman, R.L.2    Iyer, V.V.3    Firestone, A.J.4    Bairstow, S.F.5    Mosher, D.F.6
  • 131
    • 14644397216 scopus 로고    scopus 로고
    • Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion
    • Tvorogov D, Wang XJ, Zent R, Carpenter G. Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion. J Cell Sci 2005; 118: 601-10.
    • (2005) J Cell Sci , vol.118 , pp. 601-610
    • Tvorogov, D.1    Wang, X.J.2    Zent, R.3    Carpenter, G.4
  • 133
    • 0029856623 scopus 로고    scopus 로고
    • The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells
    • Salgia R, Avraham S, Pisick E, Li JL, Raja S, Greenfield EA, et al. The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells. J Biol Chem 1996; 271: 31222-6.
    • (1996) J Biol Chem , vol.271 , pp. 31222-31226
    • Salgia, R.1    Avraham, S.2    Pisick, E.3    Li, J.L.4    Raja, S.5    Greenfield, E.A.6
  • 134
    • 0028986116 scopus 로고
    • pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk
    • Schaller MD, Parsons JT. pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk. Mol Cell Biol 1995; 15: 2635-45.
    • (1995) Mol Cell Biol , vol.15 , pp. 2635-2645
    • Schaller, M.D.1    Parsons, J.T.2
  • 135
    • 0034610997 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells
    • Petit V, Boyer B, Lentz D, Turner CE, Thiery JP, Valles AM. Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells. J Cell Biol 2000; 148: 957-70.
    • (2000) J Cell Biol , vol.148 , pp. 957-970
    • Petit, V.1    Boyer, B.2    Lentz, D.3    Turner, C.E.4    Thiery, J.P.5    Valles, A.M.6
  • 136
    • 0034940161 scopus 로고    scopus 로고
    • Hic-5-reduced cell spreading on fibronectin: Competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase
    • Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K. Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase. Mol Cell Biol 2001; 21: 5332-45.
    • (2001) Mol Cell Biol , vol.21 , pp. 5332-5345
    • Nishiya, N.1    Tachibana, K.2    Shibanuma, M.3    Mashimo, J.I.4    Nose, K.5
  • 137
    • 0035340492 scopus 로고    scopus 로고
    • Involvement of Hic-5 in platelet activation: Integrin alphaIIbbeta3-dependent tyrosine phosphorylation and association with prolinerich tyrosine kinase 2
    • Osada M, Ohmori T, Yatomi Y, Satoh K, Hosogaya S, Ozaki Y. Involvement of Hic-5 in platelet activation: integrin alphaIIbbeta3-dependent tyrosine phosphorylation and association with prolinerich tyrosine kinase 2. Biochem J 2001; 355: 691-7.
    • (2001) Biochem J , vol.355 , pp. 691-697
    • Osada, M.1    Ohmori, T.2    Yatomi, Y.3    Satoh, K.4    Hosogaya, S.5    Ozaki, Y.6
  • 138
    • 0034769929 scopus 로고    scopus 로고
    • Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src
    • Ruest PJ, Shin NY, Polte TR, Zhang X, Hanks SK. Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src. Mol Cell Biol 2001; 21: 7641-52.
    • (2001) Mol Cell Biol , vol.21 , pp. 7641-7652
    • Ruest, P.J.1    Shin, N.Y.2    Polte, T.R.3    Zhang, X.4    Hanks, S.K.5
  • 139
    • 0034194714 scopus 로고    scopus 로고
    • Matrix survival signaling: From fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase
    • Almeida EA, Ilic D, Han Q, Hauck CR, Jin F, Kawakatsu H, et al. Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase. J Cell Biol 2000; 149: 741-54.
    • (2000) J Cell Biol , vol.149 , pp. 741-754
    • Almeida, E.A.1    Ilic, D.2    Han, Q.3    Hauck, C.R.4    Jin, F.5    Kawakatsu, H.6
  • 140
    • 0033591228 scopus 로고    scopus 로고
    • Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades
    • Blaukat A, Ivankovic-Dikic I, Gronroos E, Dolfi F, Tokiwa G, Vuori K, et al. Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades. J Biol Chem 1999; 274: 14893-901.
    • (1999) J Biol Chem , vol.274 , pp. 14893-14901
    • Blaukat, A.1    Ivankovic-Dikic, I.2    Gronroos, E.3    Dolfi, F.4    Tokiwa, G.5    Vuori, K.6
  • 141
    • 0034711221 scopus 로고    scopus 로고
    • Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK
    • Barberis L, Wary KK, Fiucci G, Liu F, Hirsch E, Brancaccio M, et al. Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK. J Biol Chem 2000; 275: 36532-40.
    • (2000) J Biol Chem , vol.275 , pp. 36532-36540
    • Barberis, L.1    Wary, K.K.2    Fiucci, G.3    Liu, F.4    Hirsch, E.5    Brancaccio, M.6
  • 142
    • 0034666146 scopus 로고    scopus 로고
    • Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration
    • Han DC, Shen TL, Guan JL. Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration. J Biol Chem 2000; 275: 28911-7.
    • (2000) J Biol Chem , vol.275 , pp. 28911-28917
    • Han, D.C.1    Shen, T.L.2    Guan, J.L.3
  • 143
    • 2542490290 scopus 로고    scopus 로고
    • Grb7 in intracellular signaling and its role in cell regulation
    • Shen TL, Guan JL. Grb7 in intracellular signaling and its role in cell regulation. Front Biosci 2004; 9: 192-200.
    • (2004) Front Biosci , vol.9 , pp. 192-200
    • Shen, T.L.1    Guan, J.L.2
  • 145
    • 0029664531 scopus 로고    scopus 로고
    • Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: A role for Src family kinases
    • Vuori K, Hirai H, Aizawa S, Ruoslahti E. Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol Cell Biol 1996; 16: 2606-13.
    • (1996) Mol Cell Biol , vol.16 , pp. 2606-2613
    • Vuori, K.1    Hirai, H.2    Aizawa, S.3    Ruoslahti, E.4
  • 147
    • 24344508125 scopus 로고    scopus 로고
    • Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness
    • Brown MC, Cary LA, Jamieson JS, Cooper JA, Turner CE. Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. Mol Biol Cell 2005; 16: 4316-28.
    • (2005) Mol Biol Cell , vol.16 , pp. 4316-4328
    • Brown, M.C.1    Cary, L.A.2    Jamieson, J.S.3    Cooper, J.A.4    Turner, C.E.5
  • 148
    • 20444374515 scopus 로고    scopus 로고
    • p85 beta-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase
    • Lee J, Jung ID, Chang WK, Park CG, Cho do Y, Shin EY, et al. p85 beta-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase. Exp Cell Res 2005; 307: 315-28.
    • (2005) Exp Cell Res , vol.307 , pp. 315-328
    • Lee, J.1    Jung, I.D.2    Chang, W.K.3    Park, C.G.4    Cho do, Y.5    Shin, E.Y.6
  • 151
    • 1542304700 scopus 로고    scopus 로고
    • Focal adhesion kinase regulation of N-WASP subcellular localization and function
    • Wu X, Suetsugu S, Cooper LA, Takenawa T, Guan JL. Focal adhesion kinase regulation of N-WASP subcellular localization and function. J Biol Chem 2004; 279: 9565-76.
    • (2004) J Biol Chem , vol.279 , pp. 9565-9576
    • Wu, X.1    Suetsugu, S.2    Cooper, L.A.3    Takenawa, T.4    Guan, J.L.5
  • 152
    • 0032991640 scopus 로고    scopus 로고
    • Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho
    • Taylor JM, Macklem MM, Parsons JT. Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho. J Cell Sci 1999; 112 (Pt 2): 231-42.
    • (1999) J Cell Sci , vol.112 , Issue.PART 2 , pp. 231-242
    • Taylor, J.M.1    Macklem, M.M.2    Parsons, J.T.3
  • 153
    • 0033731010 scopus 로고    scopus 로고
    • Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover
    • Ren XD, Kiosses WB, Sieg DJ, Otey CA, Schlaepfer DD, Schwartz MA. Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover. J Cell Sci 2000; 113 (Pt 20): 3673-8.
    • (2000) J Cell Sci , vol.113 , Issue.PART 20 , pp. 3673-3678
    • Ren, X.D.1    Kiosses, W.B.2    Sieg, D.J.3    Otey, C.A.4    Schlaepfer, D.D.5    Schwartz, M.A.6
  • 154
    • 0037175385 scopus 로고    scopus 로고
    • Localized suppression of RhoA activity by Tyr31/ 118-phosphorylated paxillin in cell adhesion and migration
    • Tsubouchi A, Sakakura J, Yagi R, Mazaki Y, Schaefer E, Yano H, et al. Localized suppression of RhoA activity by Tyr31/ 118-phosphorylated paxillin in cell adhesion and migration. J Cell Biol 2002; 159: 673-83.
    • (2002) J Cell Biol , vol.159 , pp. 673-683
    • Tsubouchi, A.1    Sakakura, J.2    Yagi, R.3    Mazaki, Y.4    Schaefer, E.5    Yano, H.6
  • 155
    • 0037386266 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone
    • Shiota M, Tanihiro T, Nakagawa Y, Aoki N, Ishida N, Miyazaki K, et al. Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone. Mol Endocrinol 2003; 17: 534-49.
    • (2003) Mol Endocrinol , vol.17 , pp. 534-549
    • Shiota, M.1    Tanihiro, T.2    Nakagawa, Y.3    Aoki, N.4    Ishida, N.5    Miyazaki, K.6
  • 156
    • 0028236960 scopus 로고
    • The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-delta to focal adhesions
    • Barry ST, Critchley DR. The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-delta to focal adhesions. J Cell Sci 1994; 107 (Pt 7): 2033-45.
    • (1994) J Cell Sci , vol.107 , Issue.PART 7 , pp. 2033-2045
    • Barry, S.T.1    Critchley, D.R.2
  • 157
    • 10344236528 scopus 로고    scopus 로고
    • Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly
    • Orr AW, Pallero MA, Xiong WC, Murphy-Ullrich JE. Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly. J Biol Chem 2004; 279: 48983-92.
    • (2004) J Biol Chem , vol.279 , pp. 48983-48992
    • Orr, A.W.1    Pallero, M.A.2    Xiong, W.C.3    Murphy-Ullrich, J.E.4
  • 158
    • 24944479209 scopus 로고    scopus 로고
    • PKCdelta regulates endothelial basal barrier function through modulation of RhoA GTPase activity
    • Harrington EO, Shannon CJ, Morin N, Rowlett H, Murphy C, Lu Q. PKCdelta regulates endothelial basal barrier function through modulation of RhoA GTPase activity. Exp Cell Res 2005; 308: 407-21.
    • (2005) Exp Cell Res , vol.308 , pp. 407-421
    • Harrington, E.O.1    Shannon, C.J.2    Morin, N.3    Rowlett, H.4    Murphy, C.5    Lu, Q.6
  • 160
    • 0033229742 scopus 로고    scopus 로고
    • Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talin
    • Carragher NO, Levkau B, Ross R, Raines EW. Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talin. J Cell Biol 1999; 147: 619-30.
    • (1999) J Cell Biol , vol.147 , pp. 619-630
    • Carragher, N.O.1    Levkau, B.2    Ross, R.3    Raines, E.W.4
  • 162
    • 0029741102 scopus 로고    scopus 로고
    • Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation
    • Gilmore AP, Romer LH. Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol Biol Cell 1996; 7: 1209-24.
    • (1996) Mol Biol Cell , vol.7 , pp. 1209-1224
    • Gilmore, A.P.1    Romer, L.H.2
  • 163
    • 0036083164 scopus 로고    scopus 로고
    • Ets-1 upregulates matrix metalloproteinase-1 expression through extracellular matrix adhesion in vascular endothelial cells
    • Naito S, Shimizu S, Matsuu M, Nakashima M, Nakayama T, Yamashita S, et al. Ets-1 upregulates matrix metalloproteinase-1 expression through extracellular matrix adhesion in vascular endothelial cells. Biochem Biophys Res Commun 2002; 291: 130-8.
    • (2002) Biochem Biophys Res Commun , vol.291 , pp. 130-138
    • Naito, S.1    Shimizu, S.2    Matsuu, M.3    Nakashima, M.4    Nakayama, T.5    Yamashita, S.6
  • 164
    • 0041529697 scopus 로고    scopus 로고
    • An endogenous inhibitor of focal adhesion kinase blocks Rac1/JNK but not Ras/ ERK-dependent signaling in vascular smooth muscle cells
    • Sundberg LJ, Galante LM, Bill HM, Mack CP, Taylor JM. An endogenous inhibitor of focal adhesion kinase blocks Rac1/JNK but not Ras/ ERK-dependent signaling in vascular smooth muscle cells. J Biol Chem 2003; 278: 29783-91.
    • (2003) J Biol Chem , vol.278 , pp. 29783-29791
    • Sundberg, L.J.1    Galante, L.M.2    Bill, H.M.3    Mack, C.P.4    Taylor, J.M.5
  • 165
    • 0040627311 scopus 로고    scopus 로고
    • Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation
    • Klint P, Kanda S, Kloog Y, Claesson-Welsh L. Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation. Oncogene 1999; 18: 3354-64.
    • (1999) Oncogene , vol.18 , pp. 3354-3364
    • Klint, P.1    Kanda, S.2    Kloog, Y.3    Claesson-Welsh, L.4
  • 166
    • 0030756325 scopus 로고    scopus 로고
    • Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    • Lindahl P, Johansson BR, Leveen P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 1997; 277: 242-5.
    • (1997) Science , vol.277 , pp. 242-245
    • Lindahl, P.1    Johansson, B.R.2    Leveen, P.3    Betsholtz, C.4
  • 167
    • 0030908042 scopus 로고    scopus 로고
    • Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells
    • Abedi H, Zachary I. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J Biol Chem 1997; 272: 15442-51.
    • (1997) J Biol Chem , vol.272 , pp. 15442-15451
    • Abedi, H.1    Zachary, I.2
  • 168
    • 0036297147 scopus 로고    scopus 로고
    • Human endothelial Pyk2 is expressed in two isoforms and associates with paxillin and p130Cas
    • Keogh RJ, Houliston RA, Wheeler-Jones CP. Human endothelial Pyk2 is expressed in two isoforms and associates with paxillin and p130Cas. Biochem Biophys Res Commun 2002; 290: 1470-7.
    • (2002) Biochem Biophys Res Commun , vol.290 , pp. 1470-1477
    • Keogh, R.J.1    Houliston, R.A.2    Wheeler-Jones, C.P.3
  • 169
    • 0030770897 scopus 로고    scopus 로고
    • Characterization of signal transduction pathways in human bone marrow endothelial cells
    • Liu ZY, Ganju RK, Wang JF, Schweitzer K, Weksler B, Avraham S, et al. Characterization of signal transduction pathways in human bone marrow endothelial cells. Blood 1997; 90: 2253-9.
    • (1997) Blood , vol.90 , pp. 2253-2259
    • Liu, Z.Y.1    Ganju, R.K.2    Wang, J.F.3    Schweitzer, K.4    Weksler, B.5    Avraham, S.6
  • 170
    • 0034690028 scopus 로고    scopus 로고
    • Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells
    • Kanno S, Oda N, Abe M, Terai Y, Ito M, Shitara K, Tabayashi K, et al. Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells. Oncogene 2000; 19: 2138-46.
    • (2000) Oncogene , vol.19 , pp. 2138-2146
    • Kanno, S.1    Oda, N.2    Abe, M.3    Terai, Y.4    Ito, M.5    Shitara, K.6    Tabayashi, K.7
  • 171
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004; 25: 581-611.
    • (2004) Endocr Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 172
    • 4644301879 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities
    • Le Boeuf F, Houle F, Huot J. Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities. J Biol Chem 2004; 279: 39175-85.
    • (2004) J Biol Chem , vol.279 , pp. 39175-39185
    • Le Boeuf, F.1    Houle, F.2    Huot, J.3
  • 173
    • 0034615992 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase
    • Rousseau S, Houle F, Kotanides H, Witte L, Waltenberger J, Landry J, et al. Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase. J Biol Chem 2000; 275: 10661-72.
    • (2000) J Biol Chem , vol.275 , pp. 10661-10672
    • Rousseau, S.1    Houle, F.2    Kotanides, H.3    Witte, L.4    Waltenberger, J.5    Landry, J.6
  • 174
    • 0031032777 scopus 로고    scopus 로고
    • Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: Involvement of the Grb2, p130cas, and Nck adaptor proteins
    • Schlaepfer DD, Broome MA, Hunter T. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol 1997; 17: 1702-13.
    • (1997) Mol Cell Biol , vol.17 , pp. 1702-1713
    • Schlaepfer, D.D.1    Broome, M.A.2    Hunter, T.3
  • 175
    • 0035933713 scopus 로고    scopus 로고
    • NCK and PAK participate in the signaling pathway by which vascular endothelial growth factor stimulates the assembly of focal adhesions
    • Stoletov KV, Ratcliffe KE, Spring SC, Terman BI. NCK and PAK participate in the signaling pathway by which vascular endothelial growth factor stimulates the assembly of focal adhesions. J Biol Chem 2001; 276: 22748-55.
    • (2001) J Biol Chem , vol.276 , pp. 22748-22755
    • Stoletov, K.V.1    Ratcliffe, K.E.2    Spring, S.C.3    Terman, B.I.4
  • 176
    • 0034681392 scopus 로고    scopus 로고
    • Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation
    • Wu LW, Mayo LD, Dunbar JD, Kessler KM, Baerwald MR, Jaffe EA, et al. Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation. J Biol Chem 2000; 275: 5096-103.
    • (2000) J Biol Chem , vol.275 , pp. 5096-5103
    • Wu, L.W.1    Mayo, L.D.2    Dunbar, J.D.3    Kessler, K.M.4    Baerwald, M.R.5    Jaffe, E.A.6
  • 177
    • 0042386426 scopus 로고    scopus 로고
    • Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis
    • Hood JD, Frausto R, Kiosses WB, Schwartz MA, Cheresh DA. Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. J Cell Biol 2003; 162: 933-43.
    • (2003) J Cell Biol , vol.162 , pp. 933-943
    • Hood, J.D.1    Frausto, R.2    Kiosses, W.B.3    Schwartz, M.A.4    Cheresh, D.A.5
  • 178
    • 0038143237 scopus 로고    scopus 로고
    • Thymidine phosphorylase and 2-deoxyribose stimulate human endothelial cell migration by specific activation of the integrins alpha 5 beta 1 and alpha V beta 3
    • Hotchkiss KA, Ashton AW, Schwartz EL. Thymidine phosphorylase and 2-deoxyribose stimulate human endothelial cell migration by specific activation of the integrins alpha 5 beta 1 and alpha V beta 3. J Biol Chem 2003; 278: 19272-9.
    • (2003) J Biol Chem , vol.278 , pp. 19272-19279
    • Hotchkiss, K.A.1    Ashton, A.W.2    Schwartz, E.L.3
  • 179
    • 0037358192 scopus 로고    scopus 로고
    • Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF
    • Masson-Gadais B, Houle F, Laferriere J, Huot J. Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF. Cell Stress Chaperones 2003; 8: 37-52.
    • (2003) Cell Stress Chaperones , vol.8 , pp. 37-52
    • Masson-Gadais, B.1    Houle, F.2    Laferriere, J.3    Huot, J.4
  • 180
    • 0035890906 scopus 로고    scopus 로고
    • Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells
    • Abu-Ghazaleh R, Kabir J, Jia H, Lobo M, Zachary I. Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells. Biochem J 2001; 360: 255-64.
    • (2001) Biochem J , vol.360 , pp. 255-264
    • Abu-Ghazaleh, R.1    Kabir, J.2    Jia, H.3    Lobo, M.4    Zachary, I.5
  • 181
    • 0036544562 scopus 로고    scopus 로고
    • Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling
    • Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, et al. Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol 2002; 157: 149-60.
    • (2002) J Cell Biol , vol.157 , pp. 149-160
    • Eliceiri, B.P.1    Puente, X.S.2    Hood, J.D.3    Stupack, D.G.4    Schlaepfer, D.D.5    Huang, X.Z.6
  • 182
    • 0033541411 scopus 로고    scopus 로고
    • Signaling via fibroblast growth factor receptor-1 is dependent on extracellular matrix in capillary endothelial cell differentiation
    • Kanda S, Tomasini-Johansson B, Klint P, Dixelius J, Rubin K, Claesson-Welsh L. Signaling via fibroblast growth factor receptor-1 is dependent on extracellular matrix in capillary endothelial cell differentiation. Exp Cell Res 1999; 248: 203-13.
    • (1999) Exp Cell Res , vol.248 , pp. 203-213
    • Kanda, S.1    Tomasini-Johansson, B.2    Klint, P.3    Dixelius, J.4    Rubin, K.5    Claesson-Welsh, L.6
  • 183
    • 0034544536 scopus 로고    scopus 로고
    • Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells
    • Larsson H, Sjoblom T, Dixelius J, Ostman A, Ylinenjarvi K, Bjork I, et al. Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells. Cancer Res 2000; 60: 6723-9.
    • (2000) Cancer Res , vol.60 , pp. 6723-6729
    • Larsson, H.1    Sjoblom, T.2    Dixelius, J.3    Ostman, A.4    Ylinenjarvi, K.5    Bjork, I.6
  • 184
    • 0029068160 scopus 로고
    • Differential effects of platelet-derived growth factor BB on p125 focal adhesion kinase and paxillin tyrosine phosphorylation and on cell migration in rabbit aortic vascular smooth muscle cells and Swiss 3T3 fibroblasts
    • Abedi H, Dawes KE, Zachary I. Differential effects of platelet-derived growth factor BB on p125 focal adhesion kinase and paxillin tyrosine phosphorylation and on cell migration in rabbit aortic vascular smooth muscle cells and Swiss 3T3 fibroblasts. J Biol Chem 1995; 270: 11367-76.
    • (1995) J Biol Chem , vol.270 , pp. 11367-11376
    • Abedi, H.1    Dawes, K.E.2    Zachary, I.3
  • 185
    • 0029801657 scopus 로고    scopus 로고
    • Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways
    • discussion 432
    • Jiang B, Yamamura S, Nelson PR, Mureebe L, Kent KC. Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways. Surgery 1996; 120: 427-31; discussion 432.
    • (1996) Surgery , vol.120 , pp. 427-431
    • Jiang, B.1    Yamamura, S.2    Nelson, P.R.3    Mureebe, L.4    Kent, K.C.5
  • 186
    • 0027371722 scopus 로고
    • Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens
    • Olivera A, Spiegel S. Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 1993; 365: 557-60.
    • (1993) Nature , vol.365 , pp. 557-560
    • Olivera, A.1    Spiegel, S.2
  • 187
    • 0035196711 scopus 로고    scopus 로고
    • EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration
    • Rosenfeldt HM, Hobson JP, Maceyka M, Olivera A, Nava VE, Milstien S, et al. EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration. FASEB J 2001; 15: 2649-59.
    • (2001) FASEB J , vol.15 , pp. 2649-2659
    • Rosenfeldt, H.M.1    Hobson, J.P.2    Maceyka, M.3    Olivera, A.4    Nava, V.E.5    Milstien, S.6
  • 188
    • 0034607070 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway
    • Lee OH, Lee DJ, Kim YM, Kim YS, Kwon HJ, Kim KW, et al. Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway. Biochem Biophys Res Commun 2000; 268: 47-53.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 47-53
    • Lee, O.H.1    Lee, D.J.2    Kim, Y.M.3    Kim, Y.S.4    Kwon, H.J.5    Kim, K.W.6
  • 189
    • 0345529916 scopus 로고    scopus 로고
    • Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: Role of Src and GIT
    • Shikata Y, Birukov KG, Birukova AA, Verin A, Garcia JG. Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT. FASEB J 2003; 17: 2240-9.
    • (2003) FASEB J , vol.17 , pp. 2240-2249
    • Shikata, Y.1    Birukov, K.G.2    Birukova, A.A.3    Verin, A.4    Garcia, J.G.5
  • 190
    • 0034087516 scopus 로고    scopus 로고
    • Rhomediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets
    • Miura Y, Yatomi Y, Rile G, Ohmori T, Satoh K, Ozaki Y. Rhomediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets. J Biochem (Tokyo) 2000; 127: 909-14.
    • (2000) J Biochem (Tokyo) , vol.127 , pp. 909-914
    • Miura, Y.1    Yatomi, Y.2    Rile, G.3    Ohmori, T.4    Satoh, K.5    Ozaki, Y.6
  • 191
    • 0344875587 scopus 로고    scopus 로고
    • Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors
    • Olivera A, Rosenfeldt HM, Bektas M, Wang F, Ishii I, Chun J, et al. Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. J Biol Chem 2003; 278: 46452-60.
    • (2003) J Biol Chem , vol.278 , pp. 46452-46460
    • Olivera, A.1    Rosenfeldt, H.M.2    Bektas, M.3    Wang, F.4    Ishii, I.5    Chun, J.6
  • 192
    • 0032532242 scopus 로고    scopus 로고
    • Differential stimulation of proline-rich tyrosine kinase 2 and mitogen-activated protein kinase by sphingosine 1-phosphate
    • Guo C, Zheng C, Martin-Padura I, Bian ZC, Guan JL. Differential stimulation of proline-rich tyrosine kinase 2 and mitogen-activated protein kinase by sphingosine 1-phosphate. Eur J Biochem 1998; 257: 403-8.
    • (1998) Eur J Biochem , vol.257 , pp. 403-408
    • Guo, C.1    Zheng, C.2    Martin-Padura, I.3    Bian, Z.C.4    Guan, J.L.5
  • 193
    • 0030570427 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activity is required for the activation process of focal adhesion kinase by platelet-derived growth factor
    • Saito Y, Mori S, Yokote K, Kanzaki T, Morisaki N. Phosphatidylinositol 3-kinase activity is required for the activation process of focal adhesion kinase by platelet-derived growth factor. Biochem Biophys Res Commun 1996; 224: 23-6.
    • (1996) Biochem Biophys Res Commun , vol.224 , pp. 23-26
    • Saito, Y.1    Mori, S.2    Yokote, K.3    Kanzaki, T.4    Morisaki, N.5
  • 194
    • 13444249472 scopus 로고    scopus 로고
    • Modification of PI3K- and MAPK-dependent chemotaxis in aortic vascular smooth muscle cells by protein kinase CbetaII
    • Campbell M, Trimble ER. Modification of PI3K- and MAPK-dependent chemotaxis in aortic vascular smooth muscle cells by protein kinase CbetaII. Circ Res 2005; 96: 197-206.
    • (2005) Circ Res , vol.96 , pp. 197-206
    • Campbell, M.1    Trimble, E.R.2
  • 195
    • 0000537463 scopus 로고    scopus 로고
    • Tyrosine phosphatase SHP-2 is involved in regulation of platelet-derived growth factor-induced migration
    • Qi JH, Ito N, Claesson-Welsh L. Tyrosine phosphatase SHP-2 is involved in regulation of platelet-derived growth factor-induced migration. J Biol Chem 1999; 274: 14455-63.
    • (1999) J Biol Chem , vol.274 , pp. 14455-14463
    • Qi, J.H.1    Ito, N.2    Claesson-Welsh, L.3
  • 196
    • 0033065928 scopus 로고    scopus 로고
    • Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: Roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases
    • Cospedal R, Abedi H, Zachary I. Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases. Cardiovasc Res 1999; 41: 708-21.
    • (1999) Cardiovasc Res , vol.41 , pp. 708-721
    • Cospedal, R.1    Abedi, H.2    Zachary, I.3
  • 197
    • 0034731351 scopus 로고    scopus 로고
    • Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for chemotaxis migration of vascular smooth muscle cells
    • Hauck CR, Hsia DA, Schlaepfer DD. Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for chemotaxis migration of vascular smooth muscle cells. J Biol Chem 2000; 275: 41092-9.
    • (2000) J Biol Chem , vol.275 , pp. 41092-41099
    • Hauck, C.R.1    Hsia, D.A.2    Schlaepfer, D.D.3
  • 198
    • 0028924260 scopus 로고
    • Angiotensin II stimulates tyrosine phosphorylation of the focal adhesion-associated protein paxillin in aortic smooth muscle cells
    • Leduc I, Meloche S. Angiotensin II stimulates tyrosine phosphorylation of the focal adhesion-associated protein paxillin in aortic smooth muscle cells. J Biol Chem 1995; 270: 4401-4.
    • (1995) J Biol Chem , vol.270 , pp. 4401-4404
    • Leduc, I.1    Meloche, S.2
  • 199
    • 0029070786 scopus 로고
    • Angiotensin II transduces its signal to focal adhesions via angiotensin II type 1 receptors in vascular smooth muscle cells
    • Okuda M, Kawahara Y, Nakayama I, Hoshijima M, Yokoyama M. Angiotensin II transduces its signal to focal adhesions via angiotensin II type 1 receptors in vascular smooth muscle cells. FEBS Lett 1995; 368: 343-7.
    • (1995) FEBS Lett , vol.368 , pp. 343-347
    • Okuda, M.1    Kawahara, Y.2    Nakayama, I.3    Hoshijima, M.4    Yokoyama, M.5
  • 200
    • 0030892406 scopus 로고    scopus 로고
    • Angiotensin II signal transduction in vascular smooth muscle: Role of tyrosine kinases
    • Berk BC, Corson MA. Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases. Circ Res 1997; 80: 607-16.
    • (1997) Circ Res , vol.80 , pp. 607-616
    • Berk, B.C.1    Corson, M.A.2
  • 201
    • 0032547831 scopus 로고    scopus 로고
    • Calcium- and protein kinase C-dependent activation of the tyrosine kinase PYK2 by angiotensin II in vascular smooth muscle
    • Sabri A, Govindarajan G, Griffin TM, Byron KL, Samarel AM, Lucchesi PA. Calcium- and protein kinase C-dependent activation of the tyrosine kinase PYK2 by angiotensin II in vascular smooth muscle. Circ Res 1998; 83: 841-51.
    • (1998) Circ Res , vol.83 , pp. 841-851
    • Sabri, A.1    Govindarajan, G.2    Griffin, T.M.3    Byron, K.L.4    Samarel, A.M.5    Lucchesi, P.A.6
  • 202
    • 24144470454 scopus 로고    scopus 로고
    • Signal-crosstalk between Rho/ROCK and c-Jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II
    • Ohtsu H, Mifune M, Frank GD, Saito S, Inagami T, Kim-Mitsuyama S, et al. Signal-crosstalk between Rho/ROCK and c-Jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II. Arterioscler Thromb Vasc Biol 2005; 25: 1831-6.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1831-1836
    • Ohtsu, H.1    Mifune, M.2    Frank, G.D.3    Saito, S.4    Inagami, T.5    Kim-Mitsuyama, S.6
  • 203
  • 205
    • 0035877835 scopus 로고    scopus 로고
    • Down-regulation by antisense oligonucleotides establishes a role for the proline-rich tyrosine kinase PYK2 in angiotensin ii-induced signaling in vascular smooth muscle
    • Rocic P, Lucchesi PA. Down-regulation by antisense oligonucleotides establishes a role for the proline-rich tyrosine kinase PYK2 in angiotensin ii-induced signaling in vascular smooth muscle. J Biol Chem 2001; 276: 21902-6.
    • (2001) J Biol Chem , vol.276 , pp. 21902-21906
    • Rocic, P.1    Lucchesi, P.A.2
  • 206
    • 12344334474 scopus 로고    scopus 로고
    • Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells
    • Montiel M, de la Blanca EP, Jimenez E. Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells. Biochem Biophys Res Commun 2005; 327: 971-8.
    • (2005) Biochem Biophys Res Commun , vol.327 , pp. 971-978
    • Montiel, M.1    de la Blanca, E.P.2    Jimenez, E.3
  • 207
    • 0034708488 scopus 로고    scopus 로고
    • Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin II in endothelial cells. Roles of Yes tyrosine kinase and tyrosine phosphatase SHP-2
    • Tang H, Zhao ZJ, Landon EJ, Inagami T. Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin II in endothelial cells. Roles of Yes tyrosine kinase and tyrosine phosphatase SHP-2. J Biol Chem 2000; 275: 8389-96.
    • (2000) J Biol Chem , vol.275 , pp. 8389-8396
    • Tang, H.1    Zhao, Z.J.2    Landon, E.J.3    Inagami, T.4
  • 208
    • 0035844167 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors block calcium-dependent tyrosine kinase Pyk2 activation by angiotensin II in vascular endothelial cells. involvement of geranylgeranylation of small G protein Rap1
    • Satoh K, Ichihara K, Landon EJ, Inagami T, Tang H. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors block calcium-dependent tyrosine kinase Pyk2 activation by angiotensin II in vascular endothelial cells. involvement of geranylgeranylation of small G protein Rap1. J Biol Chem 2001; 276: 15761-7.
    • (2001) J Biol Chem , vol.276 , pp. 15761-15767
    • Satoh, K.1    Ichihara, K.2    Landon, E.J.3    Inagami, T.4    Tang, H.5
  • 209
    • 0028901094 scopus 로고
    • Stimulation of tyrosine phosphorylation of distinct proteins in response to antibody-mediated ligation and clustering of alpha 3 and alpha 6 integrins
    • Jewell K, Kapron-Bras C, Jeevaratnam P, Dedhar S. Stimulation of tyrosine phosphorylation of distinct proteins in response to antibody-mediated ligation and clustering of alpha 3 and alpha 6 integrins. J Cell Sci 1995; 108 (Pt 3): 1165-74.
    • (1995) J Cell Sci , vol.108 , Issue.PART 3 , pp. 1165-1174
    • Jewell, K.1    Kapron-Bras, C.2    Jeevaratnam, P.3    Dedhar, S.4
  • 210
    • 0028237367 scopus 로고
    • Integrin-mediated signal transduction in human endothelial cells: Analysis of tyrosine phosphorylation events
    • Defilippi P, Bozzo C, Volpe G, Romano G, Venturino M, Silengo L, et al. Integrin-mediated signal transduction in human endothelial cells: analysis of tyrosine phosphorylation events. Cell Adhes Commun 1994; 2: 75-86.
    • (1994) Cell Adhes Commun , vol.2 , pp. 75-86
    • Defilippi, P.1    Bozzo, C.2    Volpe, G.3    Romano, G.4    Venturino, M.5    Silengo, L.6
  • 211
    • 0034720452 scopus 로고    scopus 로고
    • Control of smooth muscle cell proliferation and phenotype by integrin signaling through focal adhesion kinase
    • Morla AO, Mogford JE. Control of smooth muscle cell proliferation and phenotype by integrin signaling through focal adhesion kinase. Biochem Biophys Res Commun 2000; 272: 298-302.
    • (2000) Biochem Biophys Res Commun , vol.272 , pp. 298-302
    • Morla, A.O.1    Mogford, J.E.2
  • 212
    • 0037113036 scopus 로고    scopus 로고
    • Thrombospondin-1 differentially induces chemotaxis and DNA synthesis of human venous smooth muscle cells at the receptor-binding level
    • Lymn JS, Patel MK, Clunn GF, Rao SJ, Gallagher KL, Hughes AD. Thrombospondin-1 differentially induces chemotaxis and DNA synthesis of human venous smooth muscle cells at the receptor-binding level. J Cell Sci 2002; 115: 4353-60.
    • (2002) J Cell Sci , vol.115 , pp. 4353-4360
    • Lymn, J.S.1    Patel, M.K.2    Clunn, G.F.3    Rao, S.J.4    Gallagher, K.L.5    Hughes, A.D.6
  • 213
    • 0035834697 scopus 로고    scopus 로고
    • Differential regulation of phosphoinositide metabolism by alphaVbeta3 and alphaVbeta5 integrins upon smooth muscle cell migration
    • Paulhe F, Racaud-Sultan C, Ragab A, Albiges-Rizo C, Chap H, Iberg N, et al. Differential regulation of phosphoinositide metabolism by alphaVbeta3 and alphaVbeta5 integrins upon smooth muscle cell migration. J Biol Chem 2001; 276: 41832-40.
    • (2001) J Biol Chem , vol.276 , pp. 41832-41840
    • Paulhe, F.1    Racaud-Sultan, C.2    Ragab, A.3    Albiges-Rizo, C.4    Chap, H.5    Iberg, N.6
  • 214
    • 18044367325 scopus 로고    scopus 로고
    • Targeting of alpha(v) integrins interferes with FAK activation and smooth muscle cell migration and invasion
    • Varadarajulu J, Laser M, Hupp M, Wu R, Hauck CR. Targeting of alpha(v) integrins interferes with FAK activation and smooth muscle cell migration and invasion. Biochem Biophys Res Commun 2005; 331: 404-12.
    • (2005) Biochem Biophys Res Commun , vol.331 , pp. 404-412
    • Varadarajulu, J.1    Laser, M.2    Hupp, M.3    Wu, R.4    Hauck, C.R.5
  • 215
    • 0034886701 scopus 로고    scopus 로고
    • Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycle
    • Mettouchi A, Klein S, Guo W, Lopez-Lago M, Lemichez E, Westwick JK, et al. Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycle. Mol Cell 2001; 8: 115-27.
    • (2001) Mol Cell , vol.8 , pp. 115-127
    • Mettouchi, A.1    Klein, S.2    Guo, W.3    Lopez-Lago, M.4    Lemichez, E.5    Westwick, J.K.6
  • 217
    • 3142736457 scopus 로고    scopus 로고
    • Bix G, Fu J, Gonzalez EM, Macro L, Barker A, Campbell S, et al. Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin. J Cell Biol 2004; 166: 97-109.
    • Bix G, Fu J, Gonzalez EM, Macro L, Barker A, Campbell S, et al. Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin. J Cell Biol 2004; 166: 97-109.
  • 218
    • 0037446897 scopus 로고    scopus 로고
    • Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins
    • Sudhakar A, Sugimoto H, Yang C, Lively J, Zeisberg M, Kalluri R. Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. Proc Natl Acad Sci USA 2003; 100: 4766-71.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4766-4771
    • Sudhakar, A.1    Sugimoto, H.2    Yang, C.3    Lively, J.4    Zeisberg, M.5    Kalluri, R.6
  • 219
    • 0032746309 scopus 로고    scopus 로고
    • Regulation of the RhoA pathway in human endothelial cell spreading on type IV collagen: Role of calcium influx
    • Masiero L, Lapidos KA, Ambudkar I, Kohn EC. Regulation of the RhoA pathway in human endothelial cell spreading on type IV collagen: role of calcium influx. J Cell Sci 1999; 112 (Pt 19): 3205-13.
    • (1999) J Cell Sci , vol.112 , Issue.PART 19 , pp. 3205-3213
    • Masiero, L.1    Lapidos, K.A.2    Ambudkar, I.3    Kohn, E.C.4
  • 220
    • 0035839636 scopus 로고    scopus 로고
    • Regulation of the L-type calcium channel by alpha 5beta 1 integrin requires signaling between focal adhesion proteins
    • Wu X, Davis GE, Meininger GA, Wilson E, Davis MJ. Regulation of the L-type calcium channel by alpha 5beta 1 integrin requires signaling between focal adhesion proteins. J Biol Chem 2001; 276: 30285-92.
    • (2001) J Biol Chem , vol.276 , pp. 30285-30292
    • Wu, X.1    Davis, G.E.2    Meininger, G.A.3    Wilson, E.4    Davis, M.J.5
  • 221
    • 0031858633 scopus 로고    scopus 로고
    • Integrin-mediated signaling events in human endothelial cells
    • Short SM, Talbott GA, Juliano RL. Integrin-mediated signaling events in human endothelial cells. Mol Biol Cell 1998; 9: 1969-80.
    • (1998) Mol Biol Cell , vol.9 , pp. 1969-1980
    • Short, S.M.1    Talbott, G.A.2    Juliano, R.L.3
  • 222
    • 0035035159 scopus 로고    scopus 로고
    • Structural analysis of the role of the beta 3 subunit of the alpha V beta 3 integrin in IGF-I signaling
    • Maile LA, Badley-Clarke J, Clemmons DR. Structural analysis of the role of the beta 3 subunit of the alpha V beta 3 integrin in IGF-I signaling. J Cell Sci 2001; 114: 1417-25.
    • (2001) J Cell Sci , vol.114 , pp. 1417-1425
    • Maile, L.A.1    Badley-Clarke, J.2    Clemmons, D.R.3


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