3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors block calcium-dependent tyrosine kinase Pyk2 activation by angiotensin II in vascular endothelial cells: Involvement of geranylgeranylation of small G protein Rap1

Journal of Biological Chemistry

Volumn 276, Issue 19, 2001, Pages 15761-15767

  Satoh, Kumi ^a,b   Ichihara, Kazuo ^b   Landon, Erwin J ^d   Inagami, Tadashi ^a   Tang, Hua ^a,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

^c UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD VESSELS; CALCIUM; CELLS; CHOLESTEROL; DRUG PRODUCTS; ENZYME INHIBITION; POSITIVE IONS;

ENDOTHELIAL CELLS;

ENZYMES;

ANGIOTENSIN; ATORVASTATIN; CALCIUM; CHOLESTEROL; FLUINDOSTATIN; FOCAL ADHESION KINASE 2; GERANYLGERANIOL; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; MEVINOLIN; OLMESARTAN; PRAVASTATIN; PROTEIN TYROSINE KINASE; RAP PROTEIN; SIMVASTATIN; UNCLASSIFIED DRUG; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; CALCIMYCIN; CALMODULIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHORBOL 13 ACETATE 12 MYRISTATE; PTK2B PROTEIN, RAT; RAP1 PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PULMONARY VEIN; RAT; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; ANIMAL; CELL CULTURE; CELL MEMBRANE; CYTOLOGY; DRUG EFFECT; METABOLISM; PHYSIOLOGY; PROTEIN PROCESSING;

ANIMALIA;

ANGIOTENSIN II; ANIMALS; CALCIMYCIN; CALCIUM; CALMODULIN; CELL MEMBRANE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; FOCAL ADHESION KINASE 2; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN ISOPRENYLATION; PROTEIN-TYROSINE KINASES; PULMONARY VEINS; RAP1 GTP-BINDING PROTEINS; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, ANGIOTENSIN; SIMVASTATIN; TETRADECANOYLPHORBOL ACETATE;

EID: 0035844167     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009165200     Document Type: Article

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