Structural analysis of the role β3 subunit of the αVβ3 integrin in IGF-I signaling

Journal of Cell Science

Volumn 114, Issue 7, 2001, Pages 1417-1425

  Maile, L A ^a   Badley Clarke, J ^a   Clemmons, D R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Disintegrin; Extracellular matrix; Growth factors; Integrin; Smooth muscle cells

Indexed keywords

ECHISTATIN; INTEGRIN; PROTEIN SUBUNIT; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CHO CELL; CONTROLLED STUDY; GENETIC TRANSFECTION; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; STRUCTURE ANALYSIS; SWINE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; CELL MOVEMENT; CHO CELLS; CRICETINAE; CYTOPLASM; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE EXPRESSION; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTEGRIN BETA3; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOSPHORYLATION; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN-TYROSINE KINASES; RECEPTORS, VITRONECTIN; SIGNAL TRANSDUCTION;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 0035035159     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. FAK focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors
2. Insulin like growth factor I and platelet derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation
3. FAK accompanies cell adhesion to extracellular matrix. A role in cytoskeletal assembly
4. Mapping regions of the beta 1 integrin cytoplasmic domain involved in migration and survival in primary oligodendrocyte precursors using cell-permeable homeopeptides
5. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for src family kinase
6. Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3′-kinase and formation of a p130(Cas). Crk complex
7. Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involving human melanoma cell attachment to vitronectin, fibronectin, and von Willebrand factor
8. Interaction of circulating cell derived and plasma growth factors in stimulating cultured smooth muscle cell replication
9. 125FAK
10. Glycosylation of insulin like growth factor binding protein 3 (IGFBP-3) is not required for potentiation of IGF-I action: Evidence for processing of cell bound IGFBP-3
11. Requirement of the NPXY motif in the integrin β3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo
12. Insulin like growth factor binding protein-2 inhibits smooth muscle cell migration response to IGF-I
13. Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation
14. The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas and paxillin
15. Reduced cell motility and enhanced focal contact formation in cells from FAK-deficient mice
16. Protease resistant IGFBP-5 inhibits actions of IGF-I on porcine smooth muscle cells
17. Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the β1 integrin by means of its Arg-Gly-Asp sequence
18. Ligand occupancy of the αVβ3 integrin is necessary for smooth muscle cell to migrate in response to insulin-like growth factor I
19. Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion associated tyrosine kinase
20. Cell migration: A physically integrated molecular process
21. Outside-in integrin signal transduction
22. Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function
23. Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs
24. Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility
25. The pathogenesis of atherosclerosis: A perspective for the 1990s
26. Integrin cytoplasmic domains: Mediators of cytoskeletal linkages and extra-and intracellular initiated transmembrane signaling
27. SRC
28. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
29. Protein tyrosine phosphatase SHP-2 regulates cell spreading, migration and focal adhesion
30. Blocking ligand occupancy of the αVβ3 integrin inhibits IGF-I signaling in vascular smooth muscle cells