Angiotensin II-augmented migration of VSMCs towards PDGF-BB involves Pyk2 and ERK 1/2 activation

Basic Research in Cardiology

Volumn 97, Issue 4, 2002, Pages 334-342

  Blaschke, Florian ^a   Stawowy, Philipp ^a   Kappert, Kai ^a   Goetze, Stephan ^a   Kintscher, Ulrich ^a   Wollert Wulf, Brigitte ^a   Fleck, Eckart ^a   Graf, Kristof ^a  

^a DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

Integrins; Migration; Mitogen activated protein kinase; Pyk2; Vascular smooth muscle cell

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BETA3 INTEGRIN; BETA3 INTEGRIN ANTIBODY; BETA5 INTEGRIN; BETA5 INTEGRIN ANTIBODY; FOCAL ADHESION KINASE; INTEGRIN; LOSARTAN POTASSIUM; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PLATELET DERIVED GROWTH FACTOR BB; PROLINE TYROSINE KINASE 2; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; ANGIOGENIC FACTOR; ANGIOTENSIN II; FOCAL ADHESION KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; PLATELET DERIVED GROWTH FACTOR; PLATELET-DERIVED GROWTH FACTOR BB; PTK2B PROTEIN, RAT; VASOCONSTRICTOR AGENT;

ANIMAL CELL; ARTICLE; CELL LEVEL; CELL MEMBRANE; CELL MIGRATION; CHEMOTAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; CYTOSOL; DRUG ANTAGONISM; DRUG EXPOSURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HEART VENTRICLE REMODELING; HYPERTENSION; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; METABOLIC ACTIVATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CELL MOTION; CYTOLOGY; DRUG EFFECT; FLOW CYTOMETRY; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ANGIOGENESIS FACTOR; ANGIOTENSIN II; ANIMAL; CELL MOVEMENT; CELLS, CULTURED; FLOW CYTOMETRY; INTEGRINS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; P42 MAP KINASE; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-TYROSINE KINASE; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; VASOCONSTRICTOR AGENTS; ANGIOGENESIS INDUCING AGENTS; ANIMALS; FOCAL ADHESION KINASE 2; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTEIN-TYROSINE KINASES;

EID: 0035997542     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-002-0357-8     Document Type: Article

References (33)

1. Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall
2. Nitric oxide inhibits angiotensin II-induced migration of rat aortic smooth muscle cell. Role of cyclic-nucleotides and angiotensin1 receptors
3. Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors
4. Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor
5. Angiotensin II and coronary artery disease, congestive heart failure, and sudden cardiac death
6. Angiotensin II mediated signal transduction. Important role of tyrosine kinases
7. The role of tyrosine phosphorylation in angiotensin II-mediated intracellular signalling
8. Involvement of PYK2 in angiotensin II signaling of vascular smooth muscle cells
9. Angiotensin II stimulates tyrosine phosphorylation of the focal adhesion-associated protein paxillin in aortic smooth muscle cells
10. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor
11. Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II
12. Calcium- and protein kinase C-dependent activation of the tyrosine kinase PYK2 by angiotensin II in vascular smooth muscle
13. Mitogen-activated protein kinase activation is involved in platelet-derived growth factor-directed migration by vascular smooth muscle cells
14. Inhibition of MAP kinase blocks insulin-mediated DNA synthesis and transcriptional activation of c-fos by Elk-1 in vascular smooth muscle cells
15. Integrins and signal transduction pathways: The road taken
16. Cell adhesion: Old and new questions
17. Fibroblast growth factor-2 potentiates vascular smooth muscle cell migration to platelet-derived growth factor: Upregulation of alpha2beta1 integrin and disassembly of actin filaments
18. Angiotensin II and PDGF-BB stimulate beta(1)-integrin-mediated adhesion and spreading in human VSMCs
19. The smooth muscle cell in culture
20. Glucocorticoids and protein kinase C regulate neutral endopeptidase 24.11 in human vascular smooth muscle cells
21. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
22. Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on g protein-mediated activation of mitogen-activated protein kinases
23. Induction of interleukin-6 expression by angiotensin II in rat vascular smooth muscle cells
24. Platelet-derived growth factor induces interleukin-6 transcription in osteoblasts through the activator protein-1 complex and activating transcription factor-2
25. Integrins alphav-beta3 and alphavbeta5 mediate VSMC migration and are elevated during neointima formation in the rat aorta
26. Beta3-integrins rather than beta1-integrins dominate integrin-matrix interactions involved in post injury smooth muscle cell migration
27. Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src
28. Downregulation by antisense oligonucleotides establishes a role for the proline-rich tyrosine kinase PYK2 in angiotensin II-induced signaling in vascular smooth muscle
29. A role for PYK2 in regulation of ERK1/2 MAP kinases and PI3-kinase by ANG II in vascular smooth muscle
30. Central role of the MAPK pathway in ang II-mediated DNA synthesis and migration in rat vascular smooth muscle cells
31. Targeting of PYK2 to focal adhesions as a cellular mechanism for convergence between integrins and G protein-coupled receptor signaling cascades
32. Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration
33. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK-cell migration