Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

Molecular and Cellular Biology

Volumn 21, Issue 22, 2001, Pages 7641-7652

  Ruest, P J ^a   Shin, N Y ^a   Polte, T R ^a   Zhang, X ^a   Hanks, S K ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCKING PROTEIN; FOCAL ADHESION KINASE; INTEGRIN; ONCOPROTEIN; PROLINE; PROTEIN KINASE P60; PROTEIN P130; PROTEIN TYROSINE KINASE; TYROSINE;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL MOTILITY; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; CRK-ASSOCIATED SUBSTRATE PROTEIN; FOCAL ADHESION PROTEIN-TYROSINE KINASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEINS; RETINOBLASTOMA-LIKE PROTEIN P130; SRC HOMOLOGY DOMAINS; SRC-FAMILY KINASES; TYROSINE;

ANIMALIA;

EID: 0034769929     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.22.7641-7652.2001     Document Type: Article

References (67)

1. Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein
2. Matrix survival signaling: From fibronectin via focal adhesion kinase to c-Jun NH2-terminal kinase
3. cas
4. HEF1
5. Cas
6. CAS using a panel of monoclonal antibodies
7. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
8. BCAR1, a human homologue of the adapter protein p130Cas, and anti-estrogen resistance in breast cancer cells
9. The role of SRC-CAS interactions in cellular transformation: Ectopic expression of the carboxy terminus of CAS inhibits SRC-CAS interactions but has no effect on cellular transformation
10. cas-binding proteins and their role in cellular transformation
11. Regulation of c-Src activity and function by the adaptor CAS
12. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src-family kinases
13. Specificity in recognition of phosphopeptides by src-homology 2 domains
14. Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration
15. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells
16. Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix
17. The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway
18. cas; a novel mechanism of protein tyrosine phosphatase substrate recognition
19. Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G
20. Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase
21. Cas
22. Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase
23. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane
24. Cas
25. Cas, an assembling molecule of actin filaments, promotes cell movement, cell migration, and cell spreading in fibroblasts
26. Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn
27. Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases
28. Activation of Rac1 by a Crk SH3-binding protein, DOCK180
29. CAS/Crk coupling serves as a "molecular switch" for induction of cell migration
30. Src family kinases are required for integrin but not PDGFR signal transduction
31. Four proline-rich sequences in the guanine nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk
32. cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae
33. CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry
34. Interactions between two cytoskeleton-associated tyrosine kinases: Calcium-dependent tyrosine kinase and focal adhesion tyrosine kinase
35. Cas
36. Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand
37. Fyn and SHP2
38. A novel oncogene with structural similarity to phospholipase C
39. Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in B1 integrin-mediated signaling in lymphocytes
40. Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase
41. Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs
42. Cas-related proteins and a GTPase activating protein
43. Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle
44. Integrin signalling: A new Cas(t) of characters enters the stage
45. Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2
46. Adhesion-induced tyrosine phosphorylation of the p130 SRC substrate
47. Cas
48. Cas) are elevated in cytoskeletal-associated fractions following adhesion and Src transformation: Requirements for Src kinase activity and FAK proline-rich motifs
49. cas adapter protein and regulates cellular adhesion and spreading
50. Identification of a ten-amino acid proline-rich SH3 binding site
51. Phosphospecific antibodies reveal focal adhesion kinase activation loop phosphorylation in nascent and mature focal adhesions and requirement for the autophosphorylation site
52. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and c-Src in a tyrosine phosphorylation-dependent manner
53. Cas in fibroblasts
54. FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk
55. Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases
56. src
57. cas, and Nck adaptor proteins
58. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK-cell migration
59. Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase - A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates
60. C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins
61. The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin
62. Cas protein and primary breast cancer: Prognosis and response to tamoxifen treatment
63. Characterizatiion of the interaction of natural proline-rich peptides with five different SH3 domains
64. cas signaling complex formation upon integrin-mediated cell adhesion: A role for Src family kinases
65. CAS/Crk signalling mediates uptake of Yersinia into human epithelial cells
66. Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain
67. Focal adhesion kinase promotes phospholipase C-γ1 activity