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Volumn 19, Issue 6, 2007, Pages 443-456

Vascular Damaging Agents

Author keywords

Angiogenesis inhibitors; chemotherapy; combretastatin; radiobiology; radiotherapy; vascular disrupting agents

Indexed keywords

5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; ANGIOGENESIS INHIBITOR; ANGIOSTATIN; ARSENIC TRIOXIDE; AURISTATIN PE; AXITINIB; BEVACIZUMAB; BIBF 1120; CARBOPLATIN; COMBRETASTATIN A1 PHOSPHATE; COMBRETASTATIN A4 PHOSPHATE; ENDOSTATIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GLYCERYL TRINITRATE; N [2 [(4 HYDROXYPHENYL)AMINO] 3 PYRIDINYL] 4 METHOXYBENZENESULFONAMIDE; N ACETYLCOLCHINOL PHOSPHATE; NPI 2358; PACLITAXEL; PIPERAZINEDIONE; PROTEIN TYROSINE KINASE INHIBITOR; SERINE 2 METHOXY 5 [2 (3,4,5 TRIMETHOXYPHENYL)VINYL]ANILIDE; SORAFENIB; STEROID; SUNITINIB; THALIDOMIDE; THROMBOSPONDIN 1; UNCLASSIFIED DRUG; VANDETANIB; VASCULAR TARGETING AGENT; VATALANIB;

EID: 34347231300     PISSN: 09366555     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clon.2007.03.014     Document Type: Article
Times cited : (132)

References (198)
  • 1
    • 12244292196 scopus 로고    scopus 로고
    • Differentiation and definition of vascular-targeted therapies
    • Siemann D.W., Bibby M.C., Dark G.G., et al. Differentiation and definition of vascular-targeted therapies. Clin Cancer Res 11 (2005) 416-420
    • (2005) Clin Cancer Res , vol.11 , pp. 416-420
    • Siemann, D.W.1    Bibby, M.C.2    Dark, G.G.3
  • 2
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 6 (2000) 389-395
    • (2000) Nat Med , vol.6 , pp. 389-395
    • Carmeliet, P.1
  • 3
    • 0035352721 scopus 로고    scopus 로고
    • Angiogenesis: pathological, prognostic, and growth-factor pathways and their link to trial design and anticancer drugs
    • Fox S.B., Gasparini G., and Harris A.L. Angiogenesis: pathological, prognostic, and growth-factor pathways and their link to trial design and anticancer drugs. Lancet Oncol 2 (2001) 278-289
    • (2001) Lancet Oncol , vol.2 , pp. 278-289
    • Fox, S.B.1    Gasparini, G.2    Harris, A.L.3
  • 4
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat Med 9 (2003) 653-660
    • (2003) Nat Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 5
    • 85013312416 scopus 로고
    • Tumour angiogenesis: therapeutic implications
    • Folkman J. Tumour angiogenesis: therapeutic implications. N Engl J Med 285 (1971) 1182-1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 6
    • 0015008620 scopus 로고
    • Isolation of a tumor factor responsible for angiogenesis
    • Folkman J., Merler E., Abernathy C., and Williams G. Isolation of a tumor factor responsible for angiogenesis. J Exp Med 133 (1971) 275-288
    • (1971) J Exp Med , vol.133 , pp. 275-288
    • Folkman, J.1    Merler, E.2    Abernathy, C.3    Williams, G.4
  • 7
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger D.R., Galli S.J., Dvorak A.M., Perruzzi C.A., Harvey V.S., and Dvorak H.F. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219 (1983) 983-985
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 8
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung D.W., Cachianes G., Kuang W.J., Goeddel D.V., and Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246 (1989) 1306-1309
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 9
    • 0024816246 scopus 로고
    • Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells
    • Plouet J., Schilling J., and Gospodarowicz D. Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells. EMBO J 8 (1989) 3801-3806
    • (1989) EMBO J , vol.8 , pp. 3801-3806
    • Plouet, J.1    Schilling, J.2    Gospodarowicz, D.3
  • 10
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman J., and Klagsbrun M. Angiogenic factors. Science 235 (1987) 442-447
    • (1987) Science , vol.235 , pp. 442-447
    • Folkman, J.1    Klagsbrun, M.2
  • 11
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D., and Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86 (1996) 353-364
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 12
    • 0017842951 scopus 로고
    • Angiogenesis as a marker of preneoplastic lesions of the human breast
    • Brem S.S., Jensen H.M., and Gullino P.M. Angiogenesis as a marker of preneoplastic lesions of the human breast. Cancer 41 (1978) 239-244
    • (1978) Cancer , vol.41 , pp. 239-244
    • Brem, S.S.1    Jensen, H.M.2    Gullino, P.M.3
  • 13
    • 0029155712 scopus 로고
    • Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia
    • Guidi A.J., Abu-Jawdeh G., Berse B., et al. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia. J Natl Cancer Inst 87 (1995) 1237-1245
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1237-1245
    • Guidi, A.J.1    Abu-Jawdeh, G.2    Berse, B.3
  • 14
    • 0028910567 scopus 로고
    • Consequences of angiogenesis for tumor progression, metastasis and cancer therapy
    • Rak J.W., St Croix B.D., and Kerbel R.S. Consequences of angiogenesis for tumor progression, metastasis and cancer therapy. Anticancer Drugs 6 (1995) 3-18
    • (1995) Anticancer Drugs , vol.6 , pp. 3-18
    • Rak, J.W.1    St Croix, B.D.2    Kerbel, R.S.3
  • 15
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G., and Benjamin L.E. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3 (2003) 401-410
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 16
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin D.J., and Ellis L.M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23 (2005) 1011-1027
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 17
    • 0033119833 scopus 로고    scopus 로고
    • Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
    • Grunstein J., Roberts W.G., Mathieu-Costello O., Hanahan D., and Johnson R.S. Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function. Cancer Res 59 (1999) 1592-1598
    • (1999) Cancer Res , vol.59 , pp. 1592-1598
    • Grunstein, J.1    Roberts, W.G.2    Mathieu-Costello, O.3    Hanahan, D.4    Johnson, R.S.5
  • 18
    • 0033588842 scopus 로고    scopus 로고
    • New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
    • Holash J., Wiegand S.J., and Yancopoulos G.D. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 18 (1999) 5356-5362
    • (1999) Oncogene , vol.18 , pp. 5356-5362
    • Holash, J.1    Wiegand, S.J.2    Yancopoulos, G.D.3
  • 19
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe J.A., Jiang B.H., Iyer N.V., et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16 (1996) 4604-4613
    • (1996) Mol Cell Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3
  • 20
    • 0027960791 scopus 로고
    • Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression
    • Hlatky L., Tsionou C., Hahnfeldt P., and Coleman C.N. Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression. Cancer Res 54 (1994) 6083-6086
    • (1994) Cancer Res , vol.54 , pp. 6083-6086
    • Hlatky, L.1    Tsionou, C.2    Hahnfeldt, P.3    Coleman, C.N.4
  • 22
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell P.H., Wiesener M.S., Chang G.W., et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399 (1999) 271-275
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3
  • 24
    • 0033888525 scopus 로고    scopus 로고
    • Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia
    • Mandriota S.J., Pyke C., Di Sanza C., Quinodoz P., Pittet B., and Pepper M.S. Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia. Am J Pathol 156 (2000) 2077-2089
    • (2000) Am J Pathol , vol.156 , pp. 2077-2089
    • Mandriota, S.J.1    Pyke, C.2    Di Sanza, C.3    Quinodoz, P.4    Pittet, B.5    Pepper, M.S.6
  • 25
    • 33746467198 scopus 로고    scopus 로고
    • Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer
    • Gu J., Yamamoto H., Ogawa M., et al. Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer. Oncol Rep 15 (2006) 779-783
    • (2006) Oncol Rep , vol.15 , pp. 779-783
    • Gu, J.1    Yamamoto, H.2    Ogawa, M.3
  • 26
    • 0028786601 scopus 로고
    • A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • Melillo G., Musso T., Sica A., Taylor L.S., Cox G.W., and Varesio L. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med 182 (1995) 1683-1693
    • (1995) J Exp Med , vol.182 , pp. 1683-1693
    • Melillo, G.1    Musso, T.2    Sica, A.3    Taylor, L.S.4    Cox, G.W.5    Varesio, L.6
  • 27
    • 0032842837 scopus 로고    scopus 로고
    • Hypoxia induces pivotal tumor angiogenesis control factors including p53, vascular endothelial growth factor and the NFkappaB-dependent inducible nitric oxide synthase and cyclooxygenase-2
    • Chiarugi V., Magnelli L., Chiarugi A., and Gallo O. Hypoxia induces pivotal tumor angiogenesis control factors including p53, vascular endothelial growth factor and the NFkappaB-dependent inducible nitric oxide synthase and cyclooxygenase-2. J Cancer Res Clin Oncol 125 (1999) 525-528
    • (1999) J Cancer Res Clin Oncol , vol.125 , pp. 525-528
    • Chiarugi, V.1    Magnelli, L.2    Chiarugi, A.3    Gallo, O.4
  • 28
    • 0029070920 scopus 로고
    • Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells
    • Kuwabara K., Ogawa S., Matsumoto M., et al. Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells. Proc Natl Acad Sci USA 92 (1995) 4606-4610
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4606-4610
    • Kuwabara, K.1    Ogawa, S.2    Matsumoto, M.3
  • 29
    • 30944442620 scopus 로고    scopus 로고
    • Hypoxia inducible factor 1-alpha regulates of platelet derived growth factor-B in human glioblastoma cells
    • Yoshida D., Kim K., Noha M., and Teramoto A. Hypoxia inducible factor 1-alpha regulates of platelet derived growth factor-B in human glioblastoma cells. J Neurooncol 76 (2006) 13-21
    • (2006) J Neurooncol , vol.76 , pp. 13-21
    • Yoshida, D.1    Kim, K.2    Noha, M.3    Teramoto, A.4
  • 30
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber T.G., Osmanian C., Jacks T., et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379 (1996) 88-91
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3
  • 31
    • 18144364375 scopus 로고    scopus 로고
    • The role of p53 in hypoxia-induced apoptosis
    • Hammond E.M., and Giaccia A.J. The role of p53 in hypoxia-induced apoptosis. Biochem Biophys Res Commun 331 (2005) 718-725
    • (2005) Biochem Biophys Res Commun , vol.331 , pp. 718-725
    • Hammond, E.M.1    Giaccia, A.J.2
  • 32
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • Jain R.K. Molecular regulation of vessel maturation. Nat Med 9 (2003) 685-693
    • (2003) Nat Med , vol.9 , pp. 685-693
    • Jain, R.K.1
  • 33
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature 386 (1997) 671-674
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 34
    • 33845707705 scopus 로고    scopus 로고
    • VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization
    • Li B., Sharpe E.E., Maupin A.B., et al. VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization. Faseb J 20 (2006) 1495-1497
    • (2006) Faseb J , vol.20 , pp. 1495-1497
    • Li, B.1    Sharpe, E.E.2    Maupin, A.B.3
  • 35
    • 0033529618 scopus 로고    scopus 로고
    • Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    • Asahara T., Masuda H., Takahashi T., et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 85 (1999) 221-228
    • (1999) Circ Res , vol.85 , pp. 221-228
    • Asahara, T.1    Masuda, H.2    Takahashi, T.3
  • 36
    • 0038386470 scopus 로고    scopus 로고
    • Role of bone marrow-derived cells in tumor angiogenesis and treatment
    • Jain R.K., and Duda D.G. Role of bone marrow-derived cells in tumor angiogenesis and treatment. Cancer Cell 3 (2003) 515-516
    • (2003) Cancer Cell , vol.3 , pp. 515-516
    • Jain, R.K.1    Duda, D.G.2
  • 37
    • 33646395092 scopus 로고    scopus 로고
    • Circulating endothelial cells, endothelial progenitor cells, and endothelial microparticles in cancer
    • Goon P.K., Lip G.Y., Boos C.J., Stonelake P.S., and Blann A.D. Circulating endothelial cells, endothelial progenitor cells, and endothelial microparticles in cancer. Neoplasia 8 (2006) 79-88
    • (2006) Neoplasia , vol.8 , pp. 79-88
    • Goon, P.K.1    Lip, G.Y.2    Boos, C.J.3    Stonelake, P.S.4    Blann, A.D.5
  • 38
    • 0038644403 scopus 로고    scopus 로고
    • Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells
    • De Palma M., Venneri M.A., Roca C., and Naldini L. Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells. Nat Med 9 (2003) 789-795
    • (2003) Nat Med , vol.9 , pp. 789-795
    • De Palma, M.1    Venneri, M.A.2    Roca, C.3    Naldini, L.4
  • 39
    • 0034721785 scopus 로고    scopus 로고
    • Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation
    • Crosby J.R., Kaminski W.E., Schatteman G., et al. Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation. Circ Res 87 (2000) 728-730
    • (2000) Circ Res , vol.87 , pp. 728-730
    • Crosby, J.R.1    Kaminski, W.E.2    Schatteman, G.3
  • 40
    • 0035383784 scopus 로고    scopus 로고
    • Resting and activated endothelial cells are increased in the peripheral blood of cancer patients
    • Mancuso P., Burlini A., Pruneri G., Goldhirsch A., Martinelli G., and Bertolini F. Resting and activated endothelial cells are increased in the peripheral blood of cancer patients. Blood 97 (2001) 3658-3661
    • (2001) Blood , vol.97 , pp. 3658-3661
    • Mancuso, P.1    Burlini, A.2    Pruneri, G.3    Goldhirsch, A.4    Martinelli, G.5    Bertolini, F.6
  • 41
    • 0035360833 scopus 로고    scopus 로고
    • Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma
    • Monestiroli S., Mancuso P., Burlini A., et al. Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma. Cancer Res 61 (2001) 4341-4344
    • (2001) Cancer Res , vol.61 , pp. 4341-4344
    • Monestiroli, S.1    Mancuso, P.2    Burlini, A.3
  • 42
    • 0026089377 scopus 로고
    • Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions
    • Less J.R., Skalak T., Sevick E.M., and Jain R.K. Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions. Cancer Res 51 (1991) 265-273
    • (1991) Cancer Res , vol.51 , pp. 265-273
    • Less, J.R.1    Skalak, T.2    Sevick, E.M.3    Jain, R.K.4
  • 43
    • 0032952966 scopus 로고    scopus 로고
    • Evidence for characteristic vascular patterns in solid tumours: quantitative studies using corrosion casts
    • Konerding M.A., Malkusch W., Klapthor B., et al. Evidence for characteristic vascular patterns in solid tumours: quantitative studies using corrosion casts. Br J Cancer 80 (1999) 724-732
    • (1999) Br J Cancer , vol.80 , pp. 724-732
    • Konerding, M.A.1    Malkusch, W.2    Klapthor, B.3
  • 44
    • 0034161989 scopus 로고    scopus 로고
    • Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies
    • Eberhard A., Kahlert S., Goede V., Hemmerlein B., Plate K.H., and Augustin H.G. Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. Cancer Res 60 (2000) 1388-1393
    • (2000) Cancer Res , vol.60 , pp. 1388-1393
    • Eberhard, A.1    Kahlert, S.2    Goede, V.3    Hemmerlein, B.4    Plate, K.H.5    Augustin, H.G.6
  • 45
    • 0024411217 scopus 로고
    • Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure
    • Sevick E.M., and Jain R.K. Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure. Cancer Res 49 (1989) 3506-3512
    • (1989) Cancer Res , vol.49 , pp. 3506-3512
    • Sevick, E.M.1    Jain, R.K.2
  • 46
    • 0025122289 scopus 로고
    • The relationship between regional variations in blood flow and histology in a transplanted rat fibrosarcoma
    • Tozer G.M., Lewis S., Michalowski A., and Aber V. The relationship between regional variations in blood flow and histology in a transplanted rat fibrosarcoma. Br J Cancer 61 (1990) 250-257
    • (1990) Br J Cancer , vol.61 , pp. 250-257
    • Tozer, G.M.1    Lewis, S.2    Michalowski, A.3    Aber, V.4
  • 47
    • 0034321578 scopus 로고    scopus 로고
    • Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance
    • Vaupel P., and Hockel M. Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance. Int J Oncol 17 (2000) 869-879
    • (2000) Int J Oncol , vol.17 , pp. 869-879
    • Vaupel, P.1    Hockel, M.2
  • 48
    • 0025334830 scopus 로고
    • Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy
    • Boucher Y., Baxter L.T., and Jain R.K. Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy. Cancer Res 50 (1990) 4478-4484
    • (1990) Cancer Res , vol.50 , pp. 4478-4484
    • Boucher, Y.1    Baxter, L.T.2    Jain, R.K.3
  • 49
    • 0023788067 scopus 로고
    • Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules
    • Dvorak H.F., Nagy J.A., Dvorak J.T., and Dvorak A. Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am J Pathol 133 (1988) 95-109
    • (1988) Am J Pathol , vol.133 , pp. 95-109
    • Dvorak, H.F.1    Nagy, J.A.2    Dvorak, J.T.3    Dvorak, A.4
  • 50
    • 0033839080 scopus 로고    scopus 로고
    • Openings between defective endothelial cells explain tumor vessel leakiness
    • Hashizume H., Baluk P., Morikawa S., et al. Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol 156 (2000) 1363-1380
    • (2000) Am J Pathol , vol.156 , pp. 1363-1380
    • Hashizume, H.1    Baluk, P.2    Morikawa, S.3
  • 51
    • 0023481357 scopus 로고
    • Transport of molecules across tumor vasculature
    • Jain R.K. Transport of molecules across tumor vasculature. Cancer Metastasis Rev 6 (1987) 559-593
    • (1987) Cancer Metastasis Rev , vol.6 , pp. 559-593
    • Jain, R.K.1
  • 52
    • 0142151097 scopus 로고    scopus 로고
    • Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors
    • Baluk P., Morikawa S., Haskell A., Mancuso M., and McDonald D.M. Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors. Am J Pathol 163 (2003) 1801-1815
    • (2003) Am J Pathol , vol.163 , pp. 1801-1815
    • Baluk, P.1    Morikawa, S.2    Haskell, A.3    Mancuso, M.4    McDonald, D.M.5
  • 53
    • 0026786660 scopus 로고
    • Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse
    • Boucher Y., and Jain R.K. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. Cancer Res 52 (1992) 5110-5114
    • (1992) Cancer Res , vol.52 , pp. 5110-5114
    • Boucher, Y.1    Jain, R.K.2
  • 54
    • 0027537936 scopus 로고
    • Expression of alpha-smooth muscle actin in benign or malignant ovarian tumors
    • Kobayashi H., Tsuruchi N., Sugihara K., et al. Expression of alpha-smooth muscle actin in benign or malignant ovarian tumors. Gynecol Oncol 48 (1993) 308-313
    • (1993) Gynecol Oncol , vol.48 , pp. 308-313
    • Kobayashi, H.1    Tsuruchi, N.2    Sugihara, K.3
  • 55
    • 0025093973 scopus 로고
    • Vascular attack as a therapeutic strategy for cancer
    • Denekamp J. Vascular attack as a therapeutic strategy for cancer. Cancer Metastasis Rev 9 (1990) 267-282
    • (1990) Cancer Metastasis Rev , vol.9 , pp. 267-282
    • Denekamp, J.1
  • 56
    • 0027563591 scopus 로고
    • Review article: angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy
    • Denekamp J. Review article: angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy. Br J Radiol 66 (1993) 181-196
    • (1993) Br J Radiol , vol.66 , pp. 181-196
    • Denekamp, J.1
  • 57
    • 0035417875 scopus 로고    scopus 로고
    • Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability
    • Tozer G.M., Prise V.E., Wilson J., et al. Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. Cancer Res 61 (2001) 6413-6422
    • (2001) Cancer Res , vol.61 , pp. 6413-6422
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3
  • 58
    • 0028124643 scopus 로고
    • Correlation between immune and vascular activities of xanthenone acetic acid antitumor agents
    • Zwi L.J., Baguley B.C., Gavin J.B., and Wilson W.R. Correlation between immune and vascular activities of xanthenone acetic acid antitumor agents. Oncol Res 6 (1994) 79-85
    • (1994) Oncol Res , vol.6 , pp. 79-85
    • Zwi, L.J.1    Baguley, B.C.2    Gavin, J.B.3    Wilson, W.R.4
  • 59
    • 3142587028 scopus 로고    scopus 로고
    • Tumor microenvironmental physiology and its implications for radiation oncology
    • Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 14 (2004) 198-206
    • (2004) Semin Radiat Oncol , vol.14 , pp. 198-206
    • Vaupel, P.1
  • 60
    • 0025974326 scopus 로고
    • Keynote address: the influence of microenvironmental factors on the activity of radiation and drugs
    • Durand R.E. Keynote address: the influence of microenvironmental factors on the activity of radiation and drugs. Int J Radiat Oncol Biol Phys 20 (1991) 253-258
    • (1991) Int J Radiat Oncol Biol Phys , vol.20 , pp. 253-258
    • Durand, R.E.1
  • 61
    • 0027261178 scopus 로고
    • Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone
    • Okunieff P., Hoeckel M., Dunphy E.P., Schlenger K., Knoop C., and Vaupel P. Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone. Int J Radiat Oncol Biol Phys 26 (1993) 631-636
    • (1993) Int J Radiat Oncol Biol Phys , vol.26 , pp. 631-636
    • Okunieff, P.1    Hoeckel, M.2    Dunphy, E.P.3    Schlenger, K.4    Knoop, C.5    Vaupel, P.6
  • 62
    • 0032708195 scopus 로고    scopus 로고
    • Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome
    • Brizel D.M., Dodge R.K., Clough R.W., and Dewhirst M.W. Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother Oncol 53 (1999) 113-117
    • (1999) Radiother Oncol , vol.53 , pp. 113-117
    • Brizel, D.M.1    Dodge, R.K.2    Clough, R.W.3    Dewhirst, M.W.4
  • 63
    • 0029955072 scopus 로고    scopus 로고
    • Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
    • Nordsmark M., Overgaard M., and Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 41 (1996) 31-39
    • (1996) Radiother Oncol , vol.41 , pp. 31-39
    • Nordsmark, M.1    Overgaard, M.2    Overgaard, J.3
  • 65
    • 0010170555 scopus 로고
    • Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells
    • Young S.D., Marshall R.S., and Hill R.P. Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci USA 85 (1988) 9533-9537
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 9533-9537
    • Young, S.D.1    Marshall, R.S.2    Hill, R.P.3
  • 66
    • 0025025779 scopus 로고
    • Tumor progression: potential role of unstable genomic changes
    • Hill R.P. Tumor progression: potential role of unstable genomic changes. Cancer Metastasis Rev 9 (1990) 137-147
    • (1990) Cancer Metastasis Rev , vol.9 , pp. 137-147
    • Hill, R.P.1
  • 67
    • 0030067856 scopus 로고    scopus 로고
    • Hypoxic stress proteins: survival of the fittest
    • Giaccia A.J. Hypoxic stress proteins: survival of the fittest. Semin Radiat Oncol 6 (1996) 46-58
    • (1996) Semin Radiat Oncol , vol.6 , pp. 46-58
    • Giaccia, A.J.1
  • 68
    • 0030022252 scopus 로고    scopus 로고
    • Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
    • Brizel D., Scully S., Harrelson J., et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56 (1996) 941-943
    • (1996) Cancer Res , vol.56 , pp. 941-943
    • Brizel, D.1    Scully, S.2    Harrelson, J.3
  • 69
    • 14544305077 scopus 로고    scopus 로고
    • Combination of antiangiogenic therapy with other anticancer therapies: results, challenges, and open questions
    • Gasparini G., Longo R., Fanelli M., and Teicher B.A. Combination of antiangiogenic therapy with other anticancer therapies: results, challenges, and open questions. J Clin Oncol 23 (2005) 1295-1311
    • (2005) J Clin Oncol , vol.23 , pp. 1295-1311
    • Gasparini, G.1    Longo, R.2    Fanelli, M.3    Teicher, B.A.4
  • 70
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350 (2004) 2335-2342
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 71
    • 20644432867 scopus 로고    scopus 로고
    • Bevacizumab in combination with fluorouracil and leucovorin: an active regimen for first-line metastatic colorectal cancer
    • Hurwitz H.I., Fehrenbacher L., Hainsworth J.D., et al. Bevacizumab in combination with fluorouracil and leucovorin: an active regimen for first-line metastatic colorectal cancer. J Clin Oncol 23 (2005) 3502-3508
    • (2005) J Clin Oncol , vol.23 , pp. 3502-3508
    • Hurwitz, H.I.1    Fehrenbacher, L.2    Hainsworth, J.D.3
  • 72
    • 21244481589 scopus 로고    scopus 로고
    • High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: results from the Eastern Cooperative Oncology Group (ECOG) study E3200
    • Giantonio B.J., Catalano P.J., Meropol N.J., et al. High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: results from the Eastern Cooperative Oncology Group (ECOG) study E3200. J Clin Oncol (Meeting Abstracts) 23 (2005) 2
    • (2005) J Clin Oncol (Meeting Abstracts) , vol.23 , pp. 2
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 73
    • 33644870156 scopus 로고    scopus 로고
    • First-line treatment for advanced non-small-cell lung cancer
    • 1678-1680
    • Laskin J.J., and Sandler A.B. First-line treatment for advanced non-small-cell lung cancer. Oncology (Williston Park) 19 (2005) 1671-1676 1678-1680
    • (2005) Oncology (Williston Park) , vol.19 , pp. 1671-1676
    • Laskin, J.J.1    Sandler, A.B.2
  • 74
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N., and Kerbel R.S. Angiogenesis as a therapeutic target. Nature 438 (2005) 967-974
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 75
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: a VEGF blocker with potent antitumor effects
    • Holash J., Davis S., Papadopoulos N., et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 99 (2002) 11393-11398
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 76
    • 26444484355 scopus 로고    scopus 로고
    • Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model
    • Hu L., Hofmann J., Holash J., Yancopoulos G.D., Sood A.K., and Jaffe R.B. Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model. Clin Cancer Res 11 (2005) 6966-6971
    • (2005) Clin Cancer Res , vol.11 , pp. 6966-6971
    • Hu, L.1    Hofmann, J.2    Holash, J.3    Yancopoulos, G.D.4    Sood, A.K.5    Jaffe, R.B.6
  • 77
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer R.J., Michaelson M.D., Redman B.G., et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 24 (2006) 16-24
    • (2006) J Clin Oncol , vol.24 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3
  • 78
    • 33646432734 scopus 로고    scopus 로고
    • Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate
    • Prenen H., Cools J., Mentens N., et al. Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate. Clin Cancer Res 12 (2006) 2622-2627
    • (2006) Clin Cancer Res , vol.12 , pp. 2622-2627
    • Prenen, H.1    Cools, J.2    Mentens, N.3
  • 79
    • 33744984843 scopus 로고    scopus 로고
    • Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
    • Ratain M.J., Eisen T., Stadler W.M., et al. Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 24 (2006) 2505-2512
    • (2006) J Clin Oncol , vol.24 , pp. 2505-2512
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3
  • 80
    • 21244488907 scopus 로고    scopus 로고
    • ZD6474-clinical experience to date
    • Heymach J.V. ZD6474-clinical experience to date. Br J Cancer 92 Suppl. 1 (2005) S14-S20
    • (2005) Br J Cancer , vol.92 , Issue.SUPPL. 1
    • Heymach, J.V.1
  • 81
    • 21844464600 scopus 로고    scopus 로고
    • Vatalanib (PTK787/ZK 222584) in combination with FOLFOX4 versus FOLFOX4 alone as first-line treatment for colorectal cancer: preliminary results from the CONFIRM-1 trial
    • Tyagi P. Vatalanib (PTK787/ZK 222584) in combination with FOLFOX4 versus FOLFOX4 alone as first-line treatment for colorectal cancer: preliminary results from the CONFIRM-1 trial. Clin Colorectal Cancer 5 (2005) 24-26
    • (2005) Clin Colorectal Cancer , vol.5 , pp. 24-26
    • Tyagi, P.1
  • 82
    • 33747197773 scopus 로고    scopus 로고
    • New treatment approaches in metastatic renal cell carcinoma
    • Mancuso A., and Sternberg C.N. New treatment approaches in metastatic renal cell carcinoma. Curr Opin Urol 16 (2006) 337-341
    • (2006) Curr Opin Urol , vol.16 , pp. 337-341
    • Mancuso, A.1    Sternberg, C.N.2
  • 83
    • 33845315778 scopus 로고    scopus 로고
    • A phase I study of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) given continuously to patients with advanced solid tumours, incorporating dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)
    • Lee C.P., Taylor N.J., Attard G., et al. A phase I study of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) given continuously to patients with advanced solid tumours, incorporating dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). J Clin Oncol (Meeting Abstracts) 24 (2006) 3015
    • (2006) J Clin Oncol (Meeting Abstracts) , vol.24 , pp. 3015
    • Lee, C.P.1    Taylor, N.J.2    Attard, G.3
  • 84
    • 20444491613 scopus 로고    scopus 로고
    • Drug insight: thalidomide as a treatment for multiple myeloma
    • Kumar S., and Anderson K.C. Drug insight: thalidomide as a treatment for multiple myeloma. Nat Clin Pract Oncol 2 (2005) 262-270
    • (2005) Nat Clin Pract Oncol , vol.2 , pp. 262-270
    • Kumar, S.1    Anderson, K.C.2
  • 85
    • 33847400589 scopus 로고    scopus 로고
    • [Randomized phase II trial on escalated doses of Rh-endostatin (YH-16) for advanced non-small cell lung cancer]
    • Yang L., Wang J.W., Sun Y., et al. [Randomized phase II trial on escalated doses of Rh-endostatin (YH-16) for advanced non-small cell lung cancer]. Zhonghua Zhong Liu Za Zhi 28 (2006) 138-141
    • (2006) Zhonghua Zhong Liu Za Zhi , vol.28 , pp. 138-141
    • Yang, L.1    Wang, J.W.2    Sun, Y.3
  • 86
    • 33745141942 scopus 로고    scopus 로고
    • Angiogenesis and cancer: a cross-talk between basic science and clinical trials (the "do ut des" paradigm)
    • de Castro Junior G., Puglisi F., de Azambuja E., El Saghir N.S., and Awada A. Angiogenesis and cancer: a cross-talk between basic science and clinical trials (the "do ut des" paradigm). Crit Rev Oncol/Hematol 59 (2006) 40-50
    • (2006) Crit Rev Oncol/Hematol , vol.59 , pp. 40-50
    • de Castro Junior, G.1    Puglisi, F.2    de Azambuja, E.3    El Saghir, N.S.4    Awada, A.5
  • 87
    • 0842311621 scopus 로고    scopus 로고
    • Vascular targeting agents as cancer therapeutics
    • Thorpe P.E. Vascular targeting agents as cancer therapeutics. Clin Cancer Res 10 (2004) 415-427
    • (2004) Clin Cancer Res , vol.10 , pp. 415-427
    • Thorpe, P.E.1
  • 88
    • 0037125028 scopus 로고    scopus 로고
    • Induction of endothelial cell apoptosis by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid
    • Ching L.M., Cao Z., Kieda C., Zwain S., Jameson M.B., and Baguley B.C. Induction of endothelial cell apoptosis by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid. Br J Cancer 86 (2002) 1937-1942
    • (2002) Br J Cancer , vol.86 , pp. 1937-1942
    • Ching, L.M.1    Cao, Z.2    Kieda, C.3    Zwain, S.4    Jameson, M.B.5    Baguley, B.C.6
  • 89
    • 0027173672 scopus 로고
    • Vinca alkaloids: anti-vascular effects in a murine tumour
    • Hill S.A., Lonergan S.J., Denekamp J., and Chaplin D.J. Vinca alkaloids: anti-vascular effects in a murine tumour. Eur J Cancer 29A (1993) 1320-1324
    • (1993) Eur J Cancer , vol.29 A , pp. 1320-1324
    • Hill, S.A.1    Lonergan, S.J.2    Denekamp, J.3    Chaplin, D.J.4
  • 90
    • 0025793698 scopus 로고
    • Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism
    • Baguley B.C., Holdaway K.H., Thomsen L.L., Zhuang L., and Zwi L. Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism. Eur J Cancer 27 (1991) 482-487
    • (1991) Eur J Cancer , vol.27 , pp. 482-487
    • Baguley, B.C.1    Holdaway, K.H.2    Thomsen, L.L.3    Zhuang, L.4    Zwi, L.5
  • 91
    • 0035064594 scopus 로고    scopus 로고
    • Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo
    • Galbraith S.M., Chaplin D.J., Lee F., et al. Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo. Anticancer Res 21 (2001) 93-102
    • (2001) Anticancer Res , vol.21 , pp. 93-102
    • Galbraith, S.M.1    Chaplin, D.J.2    Lee, F.3
  • 92
    • 0038576231 scopus 로고    scopus 로고
    • 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study
    • Rustin G.J., Bradley C., Galbraith S., et al. 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study. Br J Cancer 88 (2003) 1160-1167
    • (2003) Br J Cancer , vol.88 , pp. 1160-1167
    • Rustin, G.J.1    Bradley, C.2    Galbraith, S.3
  • 93
    • 0038575250 scopus 로고    scopus 로고
    • Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent
    • Jameson M.B., Thompson P.I., Baguley B.C., et al. Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent. Br J Cancer 88 (2003) 1844-1850
    • (2003) Br J Cancer , vol.88 , pp. 1844-1850
    • Jameson, M.B.1    Thompson, P.I.2    Baguley, B.C.3
  • 94
    • 0037106501 scopus 로고    scopus 로고
    • Effects of 5,6-dimethylxanthenone-4-acetic acid on human tumor microcirculation assessed by dynamic contrast-enhanced magnetic resonance imaging
    • Galbraith S.M., Rustin G.J.S., Lodge M.A., et al. Effects of 5,6-dimethylxanthenone-4-acetic acid on human tumor microcirculation assessed by dynamic contrast-enhanced magnetic resonance imaging. J Clin Oncol 20 (2002) 3826-3840
    • (2002) J Clin Oncol , vol.20 , pp. 3826-3840
    • Galbraith, S.M.1    Rustin, G.J.S.2    Lodge, M.A.3
  • 95
    • 0033119771 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues
    • Tozer G.M., Prise V.E., Wilson J., et al. Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues. Cancer Res 59 (1999) 1626-1634
    • (1999) Cancer Res , vol.59 , pp. 1626-1634
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3
  • 96
    • 0037096814 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer
    • Dowlati A., Robertson K., Cooney M., et al. A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer. Cancer Res 62 (2002) 3408-3416
    • (2002) Cancer Res , vol.62 , pp. 3408-3416
    • Dowlati, A.1    Robertson, K.2    Cooney, M.3
  • 97
    • 0642307227 scopus 로고    scopus 로고
    • Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow
    • Stevenson J.P., Rosen M., Sun W., et al. Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow. J Clin Oncol 21 (2003) 4428-4438
    • (2003) J Clin Oncol , vol.21 , pp. 4428-4438
    • Stevenson, J.P.1    Rosen, M.2    Sun, W.3
  • 98
    • 0042386700 scopus 로고    scopus 로고
    • Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results
    • Rustin G.J., Galbraith S.M., Anderson H., et al. Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results. J Clin Oncol 21 (2003) 2815-2822
    • (2003) J Clin Oncol , vol.21 , pp. 2815-2822
    • Rustin, G.J.1    Galbraith, S.M.2    Anderson, H.3
  • 99
    • 0042386691 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate has tumour anti-vascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging
    • Galbraith S.M., Maxwell R.J., Lodge M.A., et al. Combretastatin A4 phosphate has tumour anti-vascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging. J Clin Oncol 21 (2003) 2831-2842
    • (2003) J Clin Oncol , vol.21 , pp. 2831-2842
    • Galbraith, S.M.1    Maxwell, R.J.2    Lodge, M.A.3
  • 100
    • 0042887593 scopus 로고    scopus 로고
    • Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate
    • Anderson H.L., Yap J.T., Miller M.P., Robbins A., Jones T., and Price P.M. Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate. J Clin Oncol 21 (2003) 2823-2830
    • (2003) J Clin Oncol , vol.21 , pp. 2823-2830
    • Anderson, H.L.1    Yap, J.T.2    Miller, M.P.3    Robbins, A.4    Jones, T.5    Price, P.M.6
  • 101
    • 33645732100 scopus 로고    scopus 로고
    • Phase I clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumors
    • Beerepoot L.V., Radema S.A., Witteveen E.O., et al. Phase I clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumors. J Clin Oncol 24 (2006) 1491-1498
    • (2006) J Clin Oncol , vol.24 , pp. 1491-1498
    • Beerepoot, L.V.1    Radema, S.A.2    Witteveen, E.O.3
  • 102
    • 19344377818 scopus 로고    scopus 로고
    • A phase I dose escalation trial of ZD6126, a novel vascular targeting agent, in patients with cancer refractory to other treatments
    • (abstract 36)
    • LoRusso P., Gadgeel S., Wozniak A., et al. A phase I dose escalation trial of ZD6126, a novel vascular targeting agent, in patients with cancer refractory to other treatments. Proc AACR-NCI-EORTC (2001) (abstract 36)
    • (2001) Proc AACR-NCI-EORTC
    • LoRusso, P.1    Gadgeel, S.2    Wozniak, A.3
  • 103
    • 0012692946 scopus 로고    scopus 로고
    • A dose escalation study of the novel vascular targeting agent ZD6126 in patients with solid tumours
    • (abstract 438)
    • Gadgeel S., LoRusso P., Wozniak A., and Wheeler C. A dose escalation study of the novel vascular targeting agent ZD6126 in patients with solid tumours. Proc Am Soc Clin Oncol 21 (2002) (abstract 438)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Gadgeel, S.1    LoRusso, P.2    Wozniak, A.3    Wheeler, C.4
  • 104
    • 0013405842 scopus 로고    scopus 로고
    • MRI evaluation of the effects of the vascular targeting agent ZD6126 on tumor vasculature
    • (abstract 440)
    • DelProposto Z., LoRusso P., Latif Z., et al. MRI evaluation of the effects of the vascular targeting agent ZD6126 on tumor vasculature. Proc Am Soc Clin Oncol 21 (2002) (abstract 440)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • DelProposto, Z.1    LoRusso, P.2    Latif, Z.3
  • 105
    • 0242329757 scopus 로고    scopus 로고
    • Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE8062) induces tumour blood flow stasis
    • Hori K., and Saito S. Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE8062) induces tumour blood flow stasis. Br J Cancer 89 (2003) 1334-1344
    • (2003) Br J Cancer , vol.89 , pp. 1334-1344
    • Hori, K.1    Saito, S.2
  • 106
    • 33750569421 scopus 로고    scopus 로고
    • A pharmacokinetic and DCE-MRI-dynamic phase I study of the antivascular combretastatin analogue AVE8062A administered every 3 weeks
    • (abstract 5827)
    • Sessa C., Lo Russo P., Tolcher A., et al. A pharmacokinetic and DCE-MRI-dynamic phase I study of the antivascular combretastatin analogue AVE8062A administered every 3 weeks. Proc Am Assoc Cancer Res 46 (2005) (abstract 5827)
    • (2005) Proc Am Assoc Cancer Res , vol.46
    • Sessa, C.1    Lo Russo, P.2    Tolcher, A.3
  • 107
    • 0036324914 scopus 로고    scopus 로고
    • Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503
    • Hill S.A., Tozer G.M., Pettit G.R., and Chaplin D.J. Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503. Anticancer Res 22 (2002) 1453-1458
    • (2002) Anticancer Res , vol.22 , pp. 1453-1458
    • Hill, S.A.1    Tozer, G.M.2    Pettit, G.R.3    Chaplin, D.J.4
  • 108
    • 1642283508 scopus 로고    scopus 로고
    • Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate
    • Kirwan I.G., Loadman P.M., Swaine D.J., et al. Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate. Clin Cancer Res 10 (2004) 1446-1453
    • (2004) Clin Cancer Res , vol.10 , pp. 1446-1453
    • Kirwan, I.G.1    Loadman, P.M.2    Swaine, D.J.3
  • 109
    • 33646741205 scopus 로고    scopus 로고
    • The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: results of a phase 1 study
    • Hande K.R., Hagey A., Berlin J., et al. The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: results of a phase 1 study. Clin Cancer Res 12 (2006) 2834-2840
    • (2006) Clin Cancer Res , vol.12 , pp. 2834-2840
    • Hande, K.R.1    Hagey, A.2    Berlin, J.3
  • 110
    • 33748372759 scopus 로고    scopus 로고
    • A phase 1 study of ABT-751, an orally bioavailable tubulin inhibitor, administered daily for 7 days every 21 days in pediatric patients with solid tumors
    • Fox E., Maris J.M., Widemann B.C., et al. A phase 1 study of ABT-751, an orally bioavailable tubulin inhibitor, administered daily for 7 days every 21 days in pediatric patients with solid tumors. Clin Cancer Res 12 (2006) 4882-4887
    • (2006) Clin Cancer Res , vol.12 , pp. 4882-4887
    • Fox, E.1    Maris, J.M.2    Widemann, B.C.3
  • 111
    • 25144483821 scopus 로고    scopus 로고
    • Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies
    • Yee K.W., Hagey A., Verstovsek S., et al. Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies. Clin Cancer Res 11 (2005) 6615-6624
    • (2005) Clin Cancer Res , vol.11 , pp. 6615-6624
    • Yee, K.W.1    Hagey, A.2    Verstovsek, S.3
  • 112
    • 0018425119 scopus 로고
    • Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity
    • Steel G.G., and Peckham M.J. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int J Radiat Oncol Biol Phys 5 (1979) 85-91
    • (1979) Int J Radiat Oncol Biol Phys , vol.5 , pp. 85-91
    • Steel, G.G.1    Peckham, M.J.2
  • 113
    • 0036779867 scopus 로고    scopus 로고
    • The vascular response of tumor and normal tissues in the rat to the vascular targeting agent, combretastatin A-4-phosphate, at clinically relevant doses
    • Prise V.E., Honess D.J., Stratford M.R., Wilson J., and Tozer G.M. The vascular response of tumor and normal tissues in the rat to the vascular targeting agent, combretastatin A-4-phosphate, at clinically relevant doses. Int J Oncol 21 (2002) 717-726
    • (2002) Int J Oncol , vol.21 , pp. 717-726
    • Prise, V.E.1    Honess, D.J.2    Stratford, M.R.3    Wilson, J.4    Tozer, G.M.5
  • 114
    • 0037222218 scopus 로고    scopus 로고
    • Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
    • Siim B.G., Lee A.E., Shalal-Zwain S., Pruijn F.B., McKeage M.J., and Wilson W.R. Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Cancer Chemother Pharmacol 51 (2003) 43-52
    • (2003) Cancer Chemother Pharmacol , vol.51 , pp. 43-52
    • Siim, B.G.1    Lee, A.E.2    Shalal-Zwain, S.3    Pruijn, F.B.4    McKeage, M.J.5    Wilson, W.R.6
  • 115
    • 0034472914 scopus 로고    scopus 로고
    • Combretastatins novel vascular targeting drugs for improving anti-cancer therapy. Combretastatins and conventional therapy
    • Horsman M.R., Murata R., Breidahl T., et al. Combretastatins novel vascular targeting drugs for improving anti-cancer therapy. Combretastatins and conventional therapy. Adv Exp Med Biol 476 (2000) 311-323
    • (2000) Adv Exp Med Biol , vol.476 , pp. 311-323
    • Horsman, M.R.1    Murata, R.2    Breidahl, T.3
  • 116
    • 0035233996 scopus 로고    scopus 로고
    • Combretastatin A-4 and doxorubicin combination treatment is effective in a preclinical model of human medullary thyroid carcinoma
    • Nelkin B.D., and Ball D.W. Combretastatin A-4 and doxorubicin combination treatment is effective in a preclinical model of human medullary thyroid carcinoma. Oncol Rep 8 (2001) 157-160
    • (2001) Oncol Rep , vol.8 , pp. 157-160
    • Nelkin, B.D.1    Ball, D.W.2
  • 117
    • 0036215178 scopus 로고    scopus 로고
    • Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma
    • Li L., Rojiani A.M., and Siemann D.W. Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma. Acta Oncol 41 (2002) 91-97
    • (2002) Acta Oncol , vol.41 , pp. 91-97
    • Li, L.1    Rojiani, A.M.2    Siemann, D.W.3
  • 118
    • 0037562506 scopus 로고    scopus 로고
    • Combretastatin A-1 phosphate potentiates the antitumour activity of cisplatin in a murine adenocarcinoma model
    • Shnyder S.D., Cooper P.A., Pettit G.R., and Lippert III J.W. Combretastatin A-1 phosphate potentiates the antitumour activity of cisplatin in a murine adenocarcinoma model. Anticancer Res 23 (2003) 1619-1623
    • (2003) Anticancer Res , vol.23 , pp. 1619-1623
    • Shnyder, S.D.1    Cooper, P.A.2    Pettit, G.R.3    Lippert III, J.W.4
  • 119
    • 0036278972 scopus 로고    scopus 로고
    • Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models
    • Blakey D.C., Westwood F.R., Walker M., et al. Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models. Clin Cancer Res 8 (2002) 1974-1983
    • (2002) Clin Cancer Res , vol.8 , pp. 1974-1983
    • Blakey, D.C.1    Westwood, F.R.2    Walker, M.3
  • 120
    • 9344239900 scopus 로고    scopus 로고
    • Sensitization of tumor-associated endothelial cell apoptosis by the novel vascular-targeting agent ZD6126 in combination with cisplatin
    • Goto H., Yano S., Matsumori Y., Ogawa H., Blakey D.C., and Sone S. Sensitization of tumor-associated endothelial cell apoptosis by the novel vascular-targeting agent ZD6126 in combination with cisplatin. Clin Cancer Res 10 (2004) 7671-7676
    • (2004) Clin Cancer Res , vol.10 , pp. 7671-7676
    • Goto, H.1    Yano, S.2    Matsumori, Y.3    Ogawa, H.4    Blakey, D.C.5    Sone, S.6
  • 121
    • 0036891109 scopus 로고    scopus 로고
    • Antitumor efficacy of conventional anticancer drugs is enhanced by the vascular targeting agent ZD6126
    • Siemann D.W., and Rojiani A.M. Antitumor efficacy of conventional anticancer drugs is enhanced by the vascular targeting agent ZD6126. Int J Radiat Oncol Biol Phys 54 (2002) 1512-1517
    • (2002) Int J Radiat Oncol Biol Phys , vol.54 , pp. 1512-1517
    • Siemann, D.W.1    Rojiani, A.M.2
  • 122
    • 0038297388 scopus 로고    scopus 로고
    • Combination effect of AC-7700, a novel combretastatin A-4 derivative, and cisplatin against murine and human tumors in vivo
    • Morinaga Y., Suga Y., Ehara S., Harada K., Nihei Y., and Suzuki M. Combination effect of AC-7700, a novel combretastatin A-4 derivative, and cisplatin against murine and human tumors in vivo. Cancer Sci 94 (2003) 200-204
    • (2003) Cancer Sci , vol.94 , pp. 200-204
    • Morinaga, Y.1    Suga, Y.2    Ehara, S.3    Harada, K.4    Nihei, Y.5    Suzuki, M.6
  • 123
    • 0031742231 scopus 로고    scopus 로고
    • Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: effects on radiation therapy
    • Li L., Rojiani A., and Siemann D.W. Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: effects on radiation therapy. Int J Radiat Oncol Biol Phys 42 (1998) 899-903
    • (1998) Int J Radiat Oncol Biol Phys , vol.42 , pp. 899-903
    • Li, L.1    Rojiani, A.2    Siemann, D.W.3
  • 124
    • 0035889331 scopus 로고    scopus 로고
    • Combretastatin A-4 disodium phosphate: a vascular targeting agent that improves the anti-tumor effects of hyperthermia, radiation, and mild thermoradiotherapy
    • Murata R., Overgaard J., and Horsman M.R. Combretastatin A-4 disodium phosphate: a vascular targeting agent that improves the anti-tumor effects of hyperthermia, radiation, and mild thermoradiotherapy. Int J Radiat Oncol Biol Phys 51 (2001) 1018-1024
    • (2001) Int J Radiat Oncol Biol Phys , vol.51 , pp. 1018-1024
    • Murata, R.1    Overgaard, J.2    Horsman, M.R.3
  • 125
    • 0034962379 scopus 로고    scopus 로고
    • Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumors
    • Murata R., Siemann D.W., Overgaard J., and Horsman M.R. Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumors. Radiother Oncol 60 (2001) 155-161
    • (2001) Radiother Oncol , vol.60 , pp. 155-161
    • Murata, R.1    Siemann, D.W.2    Overgaard, J.3    Horsman, M.R.4
  • 126
    • 0036569804 scopus 로고    scopus 로고
    • Enhancement of radiation therapy by the novel vascular targeting agent ZD6126
    • Siemann D.W., and Rojiani A.M. Enhancement of radiation therapy by the novel vascular targeting agent ZD6126. Int J Radiat Oncol Biol Phys 53 (2002) 164-171
    • (2002) Int J Radiat Oncol Biol Phys , vol.53 , pp. 164-171
    • Siemann, D.W.1    Rojiani, A.M.2
  • 127
    • 0031775298 scopus 로고    scopus 로고
    • Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid
    • Wilson W.R., Li A.E., Cowan D.S., and Siim B.G. Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid. Int J Radiat Oncol Biol Phys 42 (1998) 905-908
    • (1998) Int J Radiat Oncol Biol Phys , vol.42 , pp. 905-908
    • Wilson, W.R.1    Li, A.E.2    Cowan, D.S.3    Siim, B.G.4
  • 128
    • 0142155561 scopus 로고    scopus 로고
    • Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response
    • Horsman M.R., and Murata R. Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response. Int J Radiat Oncol Biol Phys 57 (2003) 1047-1055
    • (2003) Int J Radiat Oncol Biol Phys , vol.57 , pp. 1047-1055
    • Horsman, M.R.1    Murata, R.2
  • 129
    • 0034923996 scopus 로고    scopus 로고
    • Improving local tumor control by combining vascular targeting drugs, mild hyperthermia and radiation
    • Horsman M.R., Murata R., and Overgaard J. Improving local tumor control by combining vascular targeting drugs, mild hyperthermia and radiation. Acta Oncol 40 (2001) 497-503
    • (2001) Acta Oncol , vol.40 , pp. 497-503
    • Horsman, M.R.1    Murata, R.2    Overgaard, J.3
  • 130
    • 20344394640 scopus 로고    scopus 로고
    • The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large, advanced tumors
    • Siemann D.W., and Rojiani A.M. The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large, advanced tumors. Int J Radiat Oncol Biol Phys 62 (2005) 846-853
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , pp. 846-853
    • Siemann, D.W.1    Rojiani, A.M.2
  • 131
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang J.C., Haworth L., Sherry R.M., et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 349 (2003) 427-434
    • (2003) N Engl J Med , vol.349 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 132
    • 0842304140 scopus 로고    scopus 로고
    • Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis
    • Huang J., Soffer S.Z., Kim E.S., et al. Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis. Mol Cancer Res 2 (2004) 36-42
    • (2004) Mol Cancer Res , vol.2 , pp. 36-42
    • Huang, J.1    Soffer, S.Z.2    Kim, E.S.3
  • 133
    • 33746731749 scopus 로고    scopus 로고
    • Antiangiogenic and radiotherapy for cancer treatment
    • Kobayashi H., and Lin P.C. Antiangiogenic and radiotherapy for cancer treatment. Histol Histopathol 21 (2006) 1125-1134
    • (2006) Histol Histopathol , vol.21 , pp. 1125-1134
    • Kobayashi, H.1    Lin, P.C.2
  • 134
    • 16844371587 scopus 로고    scopus 로고
    • The tumor bed effect: increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene products
    • Rofstad E.K., Mathiesen B., Henriksen K., Kindem K., and Galappathi K. The tumor bed effect: increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene products. Cancer Res 65 (2005) 2387-2396
    • (2005) Cancer Res , vol.65 , pp. 2387-2396
    • Rofstad, E.K.1    Mathiesen, B.2    Henriksen, K.3    Kindem, K.4    Galappathi, K.5
  • 135
    • 0021178225 scopus 로고
    • Irradiation induces release of von Willebrand protein from endothelial cells in culture
    • Sporn L.A., Rubin P., Marder V.J., and Wagner D.D. Irradiation induces release of von Willebrand protein from endothelial cells in culture. Blood 64 (1984) 567-570
    • (1984) Blood , vol.64 , pp. 567-570
    • Sporn, L.A.1    Rubin, P.2    Marder, V.J.3    Wagner, D.D.4
  • 136
    • 0021955682 scopus 로고
    • Acute radiation effects on the content and release of plasminogen activator activity in cultured aortic endothelial cells
    • Ts'ao C., and Ward W.F. Acute radiation effects on the content and release of plasminogen activator activity in cultured aortic endothelial cells. Radiat Res 101 (1985) 394-401
    • (1985) Radiat Res , vol.101 , pp. 394-401
    • Ts'ao, C.1    Ward, W.F.2
  • 137
    • 0033564974 scopus 로고    scopus 로고
    • Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation
    • Gorski D.H., Beckett M.A., Jaskowiak N.T., et al. Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res 59 (1999) 3374-3378
    • (1999) Cancer Res , vol.59 , pp. 3374-3378
    • Gorski, D.H.1    Beckett, M.A.2    Jaskowiak, N.T.3
  • 138
    • 0036371621 scopus 로고    scopus 로고
    • Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance
    • Gupta V.K., Jaskowiak N.T., Beckett M.A., et al. Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer J 8 (2002) 47-54
    • (2002) Cancer J , vol.8 , pp. 47-54
    • Gupta, V.K.1    Jaskowiak, N.T.2    Beckett, M.A.3
  • 139
    • 0038756364 scopus 로고    scopus 로고
    • SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro
    • Abdollahi A., Lipson K.E., Han X., et al. SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro. Cancer Res 63 (2003) 3755-3763
    • (2003) Cancer Res , vol.63 , pp. 3755-3763
    • Abdollahi, A.1    Lipson, K.E.2    Han, X.3
  • 140
    • 0025739765 scopus 로고
    • Autocrine effects of fibroblast growth factor in repair of radiation damage in endothelial cells
    • Haimovitz-Friedman A., Vlodavsky I., Chaudhuri A., Witte L., and Fuks Z. Autocrine effects of fibroblast growth factor in repair of radiation damage in endothelial cells. Cancer Res 51 (1991) 2552-2558
    • (1991) Cancer Res , vol.51 , pp. 2552-2558
    • Haimovitz-Friedman, A.1    Vlodavsky, I.2    Chaudhuri, A.3    Witte, L.4    Fuks, Z.5
  • 141
    • 0028238298 scopus 로고
    • Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo
    • Fuks Z., Persaud R.S., Alfieri A., et al. Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo. Cancer Res 54 (1994) 2582-2590
    • (1994) Cancer Res , vol.54 , pp. 2582-2590
    • Fuks, Z.1    Persaud, R.S.2    Alfieri, A.3
  • 142
    • 0036244229 scopus 로고    scopus 로고
    • Angiogenesis and fibroblast proliferation precede formation of recurrent tumors after radiation therapy in nude mice
    • Hast J., Schiffer I.B., Neugebauer B., et al. Angiogenesis and fibroblast proliferation precede formation of recurrent tumors after radiation therapy in nude mice. Anticancer Res 22 (2002) 677-688
    • (2002) Anticancer Res , vol.22 , pp. 677-688
    • Hast, J.1    Schiffer, I.B.2    Neugebauer, B.3
  • 143
    • 31144449264 scopus 로고    scopus 로고
    • Ionizing radiation inhibits tumor neovascularization by inducing ineffective angiogenesis
    • Tsai J.H., Makonnen S., Feldman M., Sehgal C.M., Maity A., and Lee W.M. Ionizing radiation inhibits tumor neovascularization by inducing ineffective angiogenesis. Cancer Biol Ther 4 (2005) 1395-1400
    • (2005) Cancer Biol Ther , vol.4 , pp. 1395-1400
    • Tsai, J.H.1    Makonnen, S.2    Feldman, M.3    Sehgal, C.M.4    Maity, A.5    Lee, W.M.6
  • 145
    • 0034655168 scopus 로고    scopus 로고
    • Irradiation of a primary tumor, unlike surgical removal, enhances angiogenesis suppression at a distal site: potential role of host-tumor interaction
    • Hartford A.C., Gohongi T., Fukumura D., and Jain R.K. Irradiation of a primary tumor, unlike surgical removal, enhances angiogenesis suppression at a distal site: potential role of host-tumor interaction. Cancer Res 60 (2000) 2128-2131
    • (2000) Cancer Res , vol.60 , pp. 2128-2131
    • Hartford, A.C.1    Gohongi, T.2    Fukumura, D.3    Jain, R.K.4
  • 146
    • 0942268140 scopus 로고    scopus 로고
    • Thrombospondin-1 treatment prevents growth of dormant lung micrometastases after surgical resection and curative radiation therapy of the primary tumor in human melanoma xenografts
    • Rofstad E.K., Galappathi K., and Mathiesen B. Thrombospondin-1 treatment prevents growth of dormant lung micrometastases after surgical resection and curative radiation therapy of the primary tumor in human melanoma xenografts. Int J Radiat Oncol Biol Phys 58 (2004) 493-499
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 493-499
    • Rofstad, E.K.1    Galappathi, K.2    Mathiesen, B.3
  • 147
    • 0035555569 scopus 로고    scopus 로고
    • Squamous cell head and neck cancer: evidence of angiogenic regeneration during radiotherapy
    • Koukourakis M.I., Giatromanolaki A., Sivridis E., et al. Squamous cell head and neck cancer: evidence of angiogenic regeneration during radiotherapy. Anticancer Res 21 (2001) 4301-4309
    • (2001) Anticancer Res , vol.21 , pp. 4301-4309
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3
  • 148
    • 0033952360 scopus 로고    scopus 로고
    • Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy
    • Koukourakis M.I., Giatromanolaki A., Fountzilas G., Sivridis E., Gatter K.C., and Harris A.L. Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy. Clin Cancer Res 6 (2000) 381-389
    • (2000) Clin Cancer Res , vol.6 , pp. 381-389
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Fountzilas, G.3    Sivridis, E.4    Gatter, K.C.5    Harris, A.L.6
  • 149
    • 0038626211 scopus 로고    scopus 로고
    • Tumor response to radiotherapy regulated by endothelial cell apoptosis
    • Garcia-Barros M., Paris F., Cordon-Cardo C., et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 300 (2003) 1155-1159
    • (2003) Science , vol.300 , pp. 1155-1159
    • Garcia-Barros, M.1    Paris, F.2    Cordon-Cardo, C.3
  • 150
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel R.S., and Kamen B.A. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 4 (2004) 423-436
    • (2004) Nat Rev Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 151
    • 0027019408 scopus 로고
    • Peripheral blood stem cell mobilization by chemotherapy with and without recombinant human granulocyte colony-stimulating factor
    • Schwartzberg L.S., Birch R., Hazelton B., et al. Peripheral blood stem cell mobilization by chemotherapy with and without recombinant human granulocyte colony-stimulating factor. J Hematother 1 (1992) 317-327
    • (1992) J Hematother , vol.1 , pp. 317-327
    • Schwartzberg, L.S.1    Birch, R.2    Hazelton, B.3
  • 152
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T., Butterfield C.E., Kraling B.M., et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 60 (2000) 1878-1886
    • (2000) Cancer Res , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3
  • 153
    • 0041589524 scopus 로고    scopus 로고
    • Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells
    • Bertolini F., Paul S., Mancuso P., et al. Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells. Cancer Res 63 (2003) 4342-4346
    • (2003) Cancer Res , vol.63 , pp. 4342-4346
    • Bertolini, F.1    Paul, S.2    Mancuso, P.3
  • 154
    • 33344459620 scopus 로고    scopus 로고
    • Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer
    • Furstenberger G., von Moos R., Lucas R., et al. Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer. Br J Cancer 94 (2006) 524-531
    • (2006) Br J Cancer , vol.94 , pp. 524-531
    • Furstenberger, G.1    von Moos, R.2    Lucas, R.3
  • 155
    • 28044436491 scopus 로고    scopus 로고
    • Anti-angiogenic treatment of breast cancer using metronomic low-dose chemotherapy
    • Munoz R., Shaked Y., Bertolini F., Emmenegger U., Man S., and Kerbel R.S. Anti-angiogenic treatment of breast cancer using metronomic low-dose chemotherapy. Breast 14 (2005) 466-479
    • (2005) Breast , vol.14 , pp. 466-479
    • Munoz, R.1    Shaked, Y.2    Bertolini, F.3    Emmenegger, U.4    Man, S.5    Kerbel, R.S.6
  • 157
    • 0038176480 scopus 로고    scopus 로고
    • Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction
    • Wachsberger P., Burd R., and Dicker A.P. Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction. Clin Cancer Res 9 (2003) 1957-1971
    • (2003) Clin Cancer Res , vol.9 , pp. 1957-1971
    • Wachsberger, P.1    Burd, R.2    Dicker, A.P.3
  • 158
    • 0034759198 scopus 로고    scopus 로고
    • Improved tumor response by combining radiation and the vascular-damaging drug 5,6-dimethylxanthenone-4-acetic acid
    • Murata R., Siemann D.W., Overgaard J., and Horsman M.R. Improved tumor response by combining radiation and the vascular-damaging drug 5,6-dimethylxanthenone-4-acetic acid. Radiat Res 156 (2001) 503-509
    • (2001) Radiat Res , vol.156 , pp. 503-509
    • Murata, R.1    Siemann, D.W.2    Overgaard, J.3    Horsman, M.R.4
  • 159
    • 12244296444 scopus 로고    scopus 로고
    • Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma
    • Wachsberger P.R., Burd R., Marero N., et al. Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma. Clin Cancer Res 11 (2005) 835-842
    • (2005) Clin Cancer Res , vol.11 , pp. 835-842
    • Wachsberger, P.R.1    Burd, R.2    Marero, N.3
  • 160
    • 0036568457 scopus 로고    scopus 로고
    • Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy
    • Siemann D.W., Mercer E., Lepler S., and Rojiani A.M. Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy. Int J Cancer 99 (2002) 1-6
    • (2002) Int J Cancer , vol.99 , pp. 1-6
    • Siemann, D.W.1    Mercer, E.2    Lepler, S.3    Rojiani, A.M.4
  • 161
    • 20044395276 scopus 로고    scopus 로고
    • Phase I trial of combretastatin a-4 phosphate with carboplatin
    • Bilenker J.H., Flaherty K.T., Rosen M., et al. Phase I trial of combretastatin a-4 phosphate with carboplatin. Clin Cancer Res 11 (2005) 1527-1533
    • (2005) Clin Cancer Res , vol.11 , pp. 1527-1533
    • Bilenker, J.H.1    Flaherty, K.T.2    Rosen, M.3
  • 162
    • 0035874889 scopus 로고    scopus 로고
    • Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin A-4 3-O-phosphate
    • Pedley R., Hill S., Boxer G., et al. Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin A-4 3-O-phosphate. Cancer Res 61 (2001) 4716-4722
    • (2001) Cancer Res , vol.61 , pp. 4716-4722
    • Pedley, R.1    Hill, S.2    Boxer, G.3
  • 163
    • 33749005405 scopus 로고    scopus 로고
    • Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors
    • Shaked Y., Ciarrocchi A., Franco M., et al. Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 313 (2006) 1785-1787
    • (2006) Science , vol.313 , pp. 1785-1787
    • Shaked, Y.1    Ciarrocchi, A.2    Franco, M.3
  • 164
    • 7444259131 scopus 로고    scopus 로고
    • Efficacy of combined antiangiogenic and vascular disrupting agents in treatment of solid tumors
    • Siemann D.W., and Shi W. Efficacy of combined antiangiogenic and vascular disrupting agents in treatment of solid tumors. Int J Radiat Oncol Biol Phys 60 (2004) 1233-1240
    • (2004) Int J Radiat Oncol Biol Phys , vol.60 , pp. 1233-1240
    • Siemann, D.W.1    Shi, W.2
  • 165
    • 34247254358 scopus 로고    scopus 로고
    • AS1404-202 Study Group Investigators. Phase II study of DMXAA combined with carboplatin and paclitaxel in recurrent ovarian cancer
    • Gabra H. AS1404-202 Study Group Investigators. Phase II study of DMXAA combined with carboplatin and paclitaxel in recurrent ovarian cancer. ASCO Meeting Abstracts 24 (2006) 5032
    • (2006) ASCO Meeting Abstracts , vol.24 , pp. 5032
    • Gabra, H.1
  • 166
    • 34247266033 scopus 로고    scopus 로고
    • AS1404-201 Study Group Investigators. Phase Ib/II study of DMXAA combined with carboplatin and paclitaxel in non-small cell lung cancer (NSCLC)
    • McKeage M. AS1404-201 Study Group Investigators. Phase Ib/II study of DMXAA combined with carboplatin and paclitaxel in non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 24 (2006) 7102
    • (2006) ASCO Meeting Abstracts , vol.24 , pp. 7102
    • McKeage, M.1
  • 167
    • 33745898122 scopus 로고    scopus 로고
    • A dose escalation study combining combretastatin A-4 phosphate (CA4P) with carboplatin or paclitaxel in patients with advanced cancer
    • Rustin G.J.S., Nathan P.D., Boxall J., et al. A dose escalation study combining combretastatin A-4 phosphate (CA4P) with carboplatin or paclitaxel in patients with advanced cancer. Clin Cancer Res 11 (2005) 8968
    • (2005) Clin Cancer Res , vol.11 , pp. 8968
    • Rustin, G.J.S.1    Nathan, P.D.2    Boxall, J.3
  • 168
    • 33745143121 scopus 로고    scopus 로고
    • Phase Ib trial of combretastatin A4 phosphate (CA4P) in combination with radiotherapy (RT): initial clinical results
    • Ng Q.S., Carnell D., Milner J., Meer K., Saunders M.I., and Hoskin P.J. Phase Ib trial of combretastatin A4 phosphate (CA4P) in combination with radiotherapy (RT): initial clinical results. J Clin Oncol (Meeting Abstracts) 23 (2005) 3117
    • (2005) J Clin Oncol (Meeting Abstracts) , vol.23 , pp. 3117
    • Ng, Q.S.1    Carnell, D.2    Milner, J.3    Meer, K.4    Saunders, M.I.5    Hoskin, P.J.6
  • 169
    • 33745976468 scopus 로고    scopus 로고
    • Current status of angiogenesis inhibitors combined with radiation therapy
    • Nieder C., Wiedenmann N., Andratschke N., and Molls M. Current status of angiogenesis inhibitors combined with radiation therapy. Cancer Treat Rev 32 (2006) 348-364
    • (2006) Cancer Treat Rev , vol.32 , pp. 348-364
    • Nieder, C.1    Wiedenmann, N.2    Andratschke, N.3    Molls, M.4
  • 170
    • 29244454573 scopus 로고    scopus 로고
    • Radiation combined with antiangiogenic and antivascular agents
    • O'Reilly M.S. Radiation combined with antiangiogenic and antivascular agents. Semin Radiat Oncol 16 (2006) 45-50
    • (2006) Semin Radiat Oncol , vol.16 , pp. 45-50
    • O'Reilly, M.S.1
  • 171
    • 0029069833 scopus 로고
    • Influence of an anti-angiogenic treatment on 9L gliosarcoma: oxygenation and response to cytotoxic therapy
    • Teicher B.A., Holden S.A., Ara G., et al. Influence of an anti-angiogenic treatment on 9L gliosarcoma: oxygenation and response to cytotoxic therapy. Int J Cancer 61 (1995) 732-737
    • (1995) Int J Cancer , vol.61 , pp. 732-737
    • Teicher, B.A.1    Holden, S.A.2    Ara, G.3
  • 172
    • 0029971486 scopus 로고    scopus 로고
    • Comparison of several antiangiogenic regimens alone and with cytotoxic therapies in the Lewis lung carcinoma
    • Teicher B.A., Holden S.A., Ara G., Korbut T., and Menon K. Comparison of several antiangiogenic regimens alone and with cytotoxic therapies in the Lewis lung carcinoma. Cancer Chemother Pharmacol 38 (1996) 169-177
    • (1996) Cancer Chemother Pharmacol , vol.38 , pp. 169-177
    • Teicher, B.A.1    Holden, S.A.2    Ara, G.3    Korbut, T.4    Menon, K.5
  • 173
    • 0030971274 scopus 로고    scopus 로고
    • An antiangiogenic agent (TNP-470) inhibited reoxygenation during fractionated radiotherapy of murine mammary carcinoma
    • Murata R., Nishimura Y., and Hiraoka M. An antiangiogenic agent (TNP-470) inhibited reoxygenation during fractionated radiotherapy of murine mammary carcinoma. Int J Radiat Oncol Biol Phys 37 (1997) 1107-1113
    • (1997) Int J Radiat Oncol Biol Phys , vol.37 , pp. 1107-1113
    • Murata, R.1    Nishimura, Y.2    Hiraoka, M.3
  • 174
    • 0034306974 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions
    • Lee C.G., Heijn M., di Tomaso E., et al. Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res 60 (2000) 5565-5570
    • (2000) Cancer Res , vol.60 , pp. 5565-5570
    • Lee, C.G.1    Heijn, M.2    di Tomaso, E.3
  • 175
    • 19944426756 scopus 로고    scopus 로고
    • Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment
    • Ansiaux R., Baudelet C., Jordan B.F., et al. Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment. Clin Cancer Res 11 (2005) 743-750
    • (2005) Clin Cancer Res , vol.11 , pp. 743-750
    • Ansiaux, R.1    Baudelet, C.2    Jordan, B.F.3
  • 176
    • 0041672462 scopus 로고    scopus 로고
    • Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts
    • Rofstad E.K., Henriksen K., Galappathi K., and Mathiesen B. Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts. Cancer Res 63 (2003) 4055-4061
    • (2003) Cancer Res , vol.63 , pp. 4055-4061
    • Rofstad, E.K.1    Henriksen, K.2    Galappathi, K.3    Mathiesen, B.4
  • 177
    • 0142217882 scopus 로고    scopus 로고
    • Disparate effects of endostatin on tumor vascular perfusion and hypoxia in two murine mammary carcinomas
    • Fenton B.M., Paoni S.F., Grimwood B.G., and Ding I. Disparate effects of endostatin on tumor vascular perfusion and hypoxia in two murine mammary carcinomas. Int J Radiat Oncol Biol Phys 57 (2003) 1038-1046
    • (2003) Int J Radiat Oncol Biol Phys , vol.57 , pp. 1038-1046
    • Fenton, B.M.1    Paoni, S.F.2    Grimwood, B.G.3    Ding, I.4
  • 178
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307 (2005) 58-62
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 179
    • 27544495515 scopus 로고    scopus 로고
    • Rapid vessel regression, protease inhibition, and stromal normalization upon short-term vascular endothelial growth factor receptor 2 inhibition in skin carcinoma heterotransplants
    • Miller D.W., Vosseler S., Mirancea N., et al. Rapid vessel regression, protease inhibition, and stromal normalization upon short-term vascular endothelial growth factor receptor 2 inhibition in skin carcinoma heterotransplants. Am J Pathol 167 (2005) 1389-1403
    • (2005) Am J Pathol , vol.167 , pp. 1389-1403
    • Miller, D.W.1    Vosseler, S.2    Mirancea, N.3
  • 180
    • 13944260479 scopus 로고    scopus 로고
    • Angiogenesis inhibition by vascular endothelial growth factor receptor-2 blockade reduces stromal matrix metalloproteinase expression, normalizes stromal tissue, and reverts epithelial tumor phenotype in surface heterotransplants
    • Vosseler S., Mirancea N., Bohlen P., Mueller M.M., and Fusenig N.E. Angiogenesis inhibition by vascular endothelial growth factor receptor-2 blockade reduces stromal matrix metalloproteinase expression, normalizes stromal tissue, and reverts epithelial tumor phenotype in surface heterotransplants. Cancer Res 65 (2005) 1294-1305
    • (2005) Cancer Res , vol.65 , pp. 1294-1305
    • Vosseler, S.1    Mirancea, N.2    Bohlen, P.3    Mueller, M.M.4    Fusenig, N.E.5
  • 181
    • 19944422751 scopus 로고    scopus 로고
    • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    • Winkler F., Kozin S.V., Tong R.T., et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 6 (2004) 553-563
    • (2004) Cancer Cell , vol.6 , pp. 553-563
    • Winkler, F.1    Kozin, S.V.2    Tong, R.T.3
  • 182
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong R.T., Boucher Y., Kozin S.V., Winkler F., Hicklin D.J., and Jain R.K. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 64 (2004) 3731-3736
    • (2004) Cancer Res , vol.64 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 183
    • 0034099423 scopus 로고    scopus 로고
    • Therapeutic synergy of TNP-470 and ionizing radiation: effects on tumor growth, vessel morphology, and angiogenesis in human glioblastoma multiforme xenografts
    • Lund E.L., Bastholm L., and Kristjansen P.E. Therapeutic synergy of TNP-470 and ionizing radiation: effects on tumor growth, vessel morphology, and angiogenesis in human glioblastoma multiforme xenografts. Clin Cancer Res 6 (2000) 971-978
    • (2000) Clin Cancer Res , vol.6 , pp. 971-978
    • Lund, E.L.1    Bastholm, L.2    Kristjansen, P.E.3
  • 184
    • 13044292648 scopus 로고    scopus 로고
    • Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules
    • Netti P.A., Hamberg L.M., Babich J.W., et al. Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules. PNAS 96 (1999) 3137-3142
    • (1999) PNAS , vol.96 , pp. 3137-3142
    • Netti, P.A.1    Hamberg, L.M.2    Babich, J.W.3
  • 185
    • 20944448672 scopus 로고    scopus 로고
    • Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy
    • Huber P.E., Bischof M., Jenne J., et al. Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy. Cancer Res 65 (2005) 3643-3655
    • (2005) Cancer Res , vol.65 , pp. 3643-3655
    • Huber, P.E.1    Bischof, M.2    Jenne, J.3
  • 186
    • 22744435494 scopus 로고    scopus 로고
    • Phase I study of neoadjuvant bevacizumab, 5-fluorouracil, and radiation therapy followed by surgery for patients with primary rectal cancer
    • Willett C.G., Chung D., Sahani D., et al. Phase I study of neoadjuvant bevacizumab, 5-fluorouracil, and radiation therapy followed by surgery for patients with primary rectal cancer. J Clin Oncol (Meeting Abstracts) 22 (2004) 3589
    • (2004) J Clin Oncol (Meeting Abstracts) , vol.22 , pp. 3589
    • Willett, C.G.1    Chung, D.2    Sahani, D.3
  • 187
    • 33644968548 scopus 로고    scopus 로고
    • Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer
    • Crane C.H., Ellis L.M., Abbruzzese J.L., et al. Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer. J Clin Oncol 24 (2006) 1145-1151
    • (2006) J Clin Oncol , vol.24 , pp. 1145-1151
    • Crane, C.H.1    Ellis, L.M.2    Abbruzzese, J.L.3
  • 188
    • 0021198831 scopus 로고
    • In situ radiation response and oxygen enhancement ratio of KHT sarcoma cells in various phases of the cell cycle
    • Siemann D.W., and Keng P.C. In situ radiation response and oxygen enhancement ratio of KHT sarcoma cells in various phases of the cell cycle. Br J Radiol 57 (1984) 823-827
    • (1984) Br J Radiol , vol.57 , pp. 823-827
    • Siemann, D.W.1    Keng, P.C.2
  • 190
    • 0033844886 scopus 로고    scopus 로고
    • Combretastatin A-4 prodrug: a potent inhibitor of malignant hemangioendothelioma cell proliferation
    • Bohle A.S., Leuschner I., Kalthoff H., and Henne-Bruns D. Combretastatin A-4 prodrug: a potent inhibitor of malignant hemangioendothelioma cell proliferation. Int J Cancer 87 (2000) 838-843
    • (2000) Int J Cancer , vol.87 , pp. 838-843
    • Bohle, A.S.1    Leuschner, I.2    Kalthoff, H.3    Henne-Bruns, D.4
  • 191
    • 0035129337 scopus 로고    scopus 로고
    • Evaluation of combretastatin A-4 prodrug in a non-Hodgkin's lymphoma xenograft model: preclinical efficacy
    • Nabha S.M., Mohammad R.M., Wall N.R., et al. Evaluation of combretastatin A-4 prodrug in a non-Hodgkin's lymphoma xenograft model: preclinical efficacy. Anticancer Drugs 12 (2001) 57-63
    • (2001) Anticancer Drugs , vol.12 , pp. 57-63
    • Nabha, S.M.1    Mohammad, R.M.2    Wall, N.R.3
  • 192
    • 33646348698 scopus 로고    scopus 로고
    • Antimitotic sulfonamides inhibit microtubule assembly dynamics and cancer cell proliferation
    • Mohan R., Banerjee M., Ray A., et al. Antimitotic sulfonamides inhibit microtubule assembly dynamics and cancer cell proliferation. Biochemistry 45 (2006) 5440-5449
    • (2006) Biochemistry , vol.45 , pp. 5440-5449
    • Mohan, R.1    Banerjee, M.2    Ray, A.3
  • 193
  • 194
    • 33745728147 scopus 로고    scopus 로고
    • YC-1 induces S cell cycle arrest and apoptosis by activating checkpoint kinases
    • Yeo E.J., Ryu J.H., Chun Y.S., et al. YC-1 induces S cell cycle arrest and apoptosis by activating checkpoint kinases. Cancer Res 66 (2006) 6345-6352
    • (2006) Cancer Res , vol.66 , pp. 6345-6352
    • Yeo, E.J.1    Ryu, J.H.2    Chun, Y.S.3
  • 195
    • 20444492764 scopus 로고    scopus 로고
    • Mechanisms of disease: radiosensitization by epidermal growth factor receptor inhibitors
    • Sartor C.I. Mechanisms of disease: radiosensitization by epidermal growth factor receptor inhibitors. Nat Clin Pract Oncol 1 (2004) 80-87
    • (2004) Nat Clin Pract Oncol , vol.1 , pp. 80-87
    • Sartor, C.I.1
  • 196
    • 18144401256 scopus 로고    scopus 로고
    • Both antiangiogenesis- and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584
    • Liu Y., Poon R.T., Li Q., Kok T.W., Lau C., and Fan S.T. Both antiangiogenesis- and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584. Cancer Res 65 (2005) 3691-3699
    • (2005) Cancer Res , vol.65 , pp. 3691-3699
    • Liu, Y.1    Poon, R.T.2    Li, Q.3    Kok, T.W.4    Lau, C.5    Fan, S.T.6
  • 197
    • 0036681995 scopus 로고    scopus 로고
    • Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa)
    • Huang S.M., Li J., Armstrong E.A., and Harari P.M. Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa). Cancer Res 62 (2002) 4300-4306
    • (2002) Cancer Res , vol.62 , pp. 4300-4306
    • Huang, S.M.1    Li, J.2    Armstrong, E.A.3    Harari, P.M.4
  • 198
    • 0034612236 scopus 로고    scopus 로고
    • Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1
    • Zhang Y., Griffith E.C., Sage J., Jacks T., and Liu J.O. Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1. Proc Natl Acad Sci USA 97 (2000) 6427-6432
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6427-6432
    • Zhang, Y.1    Griffith, E.C.2    Sage, J.3    Jacks, T.4    Liu, J.O.5


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