메뉴 건너뛰기




Volumn 5, Issue 1, 2005, Pages 24-26

Vatalanib (PTK787/ZK 222584) in combination with FOLFOX4 versus FOLFOX4 alone as first-line treatment for colorectal cancer: Preliminary results from the CONFIRM-1 trial

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PLACEBO; PROTEIN TYROSINE KINASE INHIBITOR; VANDETANIB; VATALANIB; ANTINEOPLASTIC AGENT; FOLFOX PROTOCOL; PHTHALAZINE DERIVATIVE; PLATINUM COMPLEX; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE;

EID: 21844464600     PISSN: 15330028     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1533-0028(11)70162-1     Document Type: Article
Times cited : (38)

References (13)
  • 1
    • 0015311426 scopus 로고
    • Anti-angiogenesis: New concept for therapy of solid tumors
    • Folkman J. Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg 1972; 175:409-416.
    • (1972) Ann Surg , vol.175 , pp. 409-416
    • Folkman, J.1
  • 2
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 3
    • 0032807992 scopus 로고    scopus 로고
    • Prognostic and predictive value of intratumoral microvessels density in operable non-small-cell lung cancer
    • Dazzi C, Cariello A, Maioli P, et al. Prognostic and predictive value of intratumoral microvessels density in operable non-small-cell lung cancer. Lung Cancer 1999; 24:81-88.
    • (1999) Lung Cancer , vol.24 , pp. 81-88
    • Dazzi, C.1    Cariello, A.2    Maioli, P.3
  • 4
    • 1842415455 scopus 로고    scopus 로고
    • Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer
    • Takahashi Y, Tucker SL, Kitadai Y, et al. Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer. Arch Surg 1997; 132:541-546.
    • (1997) Arch Surg , vol.132 , pp. 541-546
    • Takahashi, Y.1    Tucker, S.L.2    Kitadai, Y.3
  • 5
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim KJ, Li B, Winer J, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993; 362:841-844.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3
  • 6
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350:2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 7
    • 0034282515 scopus 로고    scopus 로고
    • Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model
    • Drevs J, Hofmann I, Hugenschmidt H, et al. Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model. Cancer Res 2000; 60:4819-4824.
    • (2000) Cancer Res , vol.60 , pp. 4819-4824
    • Drevs, J.1    Hofmann, I.2    Hugenschmidt, H.3
  • 8
    • 0347615101 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PM787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: Results from two phase I studies
    • Morgan B, Thomas AL, Drevs J, et al. Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PM787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: results from two phase I studies. J Clin Oncol 2003; 21:3955-3964.
    • (2003) J Clin Oncol , vol.21 , pp. 3955-3964
    • Morgan, B.1    Thomas, A.L.2    Drevs, J.3
  • 9
    • 0347615100 scopus 로고    scopus 로고
    • Preliminary phase I results of the oral, once-daily angiogenesis inhibitor PTK787/ZK 222584 (PTK/ZK) in combination with chemotherapy for the treatment of metastatic colorectal cancer
    • (Abstract #297)
    • Trarbach T, Thomas AL, Bartel C, et al. preliminary phase I results of the oral, once-daily angiogenesis inhibitor PTK787/ZK 222584 (PTK/ZK) in combination with chemotherapy for the treatment of metastatic colorectal cancer. Eur J Cancer 2003; 1 (suppl 5):S91 (Abstract #297).
    • (2003) Eur J Cancer , vol.1 , Issue.SUPPL. 5
    • Trarbach, T.1    Thomas, A.L.2    Bartel, C.3
  • 10
    • 7444222477 scopus 로고    scopus 로고
    • Expanded phase I/II study of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with FOLFOX-4 as first-line treatment for patients with metastatic colorectal cancer
    • (Abstract #3556)
    • Steward WP, Thomas A, Morgan B, et al. Expanded phase I/II study of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with FOLFOX-4 as first-line treatment for patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol 2004; 23:259 (Abstract #3556).
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 259
    • Steward, W.P.1    Thomas, A.2    Morgan, B.3
  • 11
    • 85030601148 scopus 로고    scopus 로고
    • First-line treatment of metastatic colorectal cancer with oxaliplatin /5-FU/leucovorin plus PTK787/ZK 222584 or placebo
    • Available at: Accessed March 31
    • First-line treatment of metastatic colorectal cancer with oxaliplatin/ 5-FU/leucovorin plus PTK787/ZK 222584 or placebo. Available at: http://www.clinicaltrials.gov/ct/show/NCT00056459?order=1. Accessed March 31, 2005.
    • (2005)
  • 12
    • 85030599566 scopus 로고    scopus 로고
    • Treatment of patients with previously treated metastatic colorectal cancer with oxaliplatin/5FU/LV and PTK787 or placebo
    • Available at: Accessed March 31
    • Treatment of patients with previously treated metastatic colorectal cancer with oxaliplatin/5FU/LV and PTK787 or placebo. Available at: http://www.clinicaltrials.gov/ct/show/NCT00056446?order=1. Accessed March 31, 2005.
    • (2005)
  • 13
    • 85030609319 scopus 로고    scopus 로고
    • PTK/ZK CONFIRM 1 phase III study shows positive drug effects in metastatic colorectal cancer-filing now anticipated for early 2007
    • [press release]. Berlin: Schering Group; March 21
    • PTK/ZK CONFIRM 1 phase III study shows positive drug effects in metastatic colorectal cancer-filing now anticipated for early 2007 [press release]. Berlin: Schering Group; March 21, 2005.
    • (2005)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.