Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

Nature Medicine

Volumn 9, Issue 6, 2003, Pages 789-795

  De Palma, Michele ^a   Venneri, Mary Anna ^a   Roca, Cristina ^a   Naldini, Luigi ^a,b  

^a UNIVERSITY OF TURIN   (Italy)

^b SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LENTIVIRUS VECTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CANCER; CANCER GENETICS; CELL TYPE; CONTROLLED STUDY; DNA MODIFICATION; DRUG TARGETING; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MALE; MARKER GENE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; STEM CELL; SUICIDE GENE; TEK GENE; TIE2 GENE; VASCULAR ENDOTHELIUM; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BIOLOGICAL MARKERS; BONE MARROW TRANSPLANTATION; FEMALE; GENE TARGETING; GENE THERAPY; GENES, REPORTER; GENETIC VECTORS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; MALE; MICE; MICE, INBRED STRAINS; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; PHENOTYPE; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TIE-2; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED;

ANIMALIA; LENTIVIRUS;

EID: 0038644403     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm871     Document Type: Article

References (25)

1. Folkman, J., Hahnfeldt, P. & Hlatky, L. Cancer: looking outside the genome. Nat. Rev. Mol. Cell Biol. 1, 76-79 (2000).
2. Carmeliet, P. & Jain, R.K. Angiogenesis in cancer and other diseases. Nature 407, 249-257 (2000).
3. Coussens, L.M. & Werb, Z. Inflammation and cancer. Nature 420, 860-867 (2002).
4. Mantovani, A., Sozzani, S., Locati, M., Allavena, P. & Sica, A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23, 549-555 (2002).
5. Rafii, S., Lyden, D., Benezra, R., Hattori, K. & Heissig, B. Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? Nat. Rev. Cancer 2, 826-835 (2002).
6. Jones, N., Iljin, K., Dumont, D.J. & Alitalo, K. Tie receptors: new modulators of angiogenic and lymphangiogenic responses. Nat. Rev. Mol. Cell Biol. 2, 257-267 (2001).
7. Schlaeger, T.M. et al. Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice. Proc. Natl. Acad. Sci. USA 94, 3058-3063 (1997).
8. Follenzi, A., Ailles, L.E., Bakovic, S., Geuna, M. & Naldini, L. Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat. Genet. 25, 217-222 (2000).
9. Follenzi, A., Sabatino, G., Lombardo, A., Boccaccio, C. & Naldini, L. Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors. Hum. Gene Ther. 13, 243-260 (2002).
10. Motoike, T. et al. Universal GFP reporter for the study of vascular development. Genesis 28, 75-81 (2000).
11. Okabe, M., Ikawa, M., Kominami, K., Nakanishi, T. & Nishimune, Y. 'Green mice' as a source of ubiquitous green cells. FEBS Lett. 407, 313-319 (1997).
12. Asahara, T. et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ. Res. 85, 221-228 (1999).
13. Reyes, M. et al. Origin of endothelial progenitors in human postnatal bone marrow. J. Clin. Invest 109, 337-346 (2002).
14. Lyden, D. et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat. Med. 7, 1194-1201 (2001).
15. Davidoff, A.M. et al. Bone marrow-derived cells contribute to tumor neovasculature and, when modified to express an angiogenesis inhibitor, can restrict tumor growth in mice. Clin. Cancer Res. 7, 2870-2879 (2001).
16. Takakura, N. et al. Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. Immunity 9, 677-686 (1998).
17. Takakura, N. et al. A role for hematopoietic stem cells in promoting angiogenesis. Cell 102, 199-209 (2000).
18. Peters, K.G. et al. Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis. Br. J. Cancer 77, 51-56 (1998).
19. Holash, J. et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284, 1994-1998 (1999).
20. Tanaka, S. et al. Tie2 vascular endothelial receptor expression and function in hepatocellular carcinoma. Hepatology 35, 861-867 (2002).
21. Coussens, L.M., Tinkle, C.L., Hanahan, D. & Werb, Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103, 481-490 (2000).
22. Luttun, A. et al. Revascularization of ischemic tissues by PIGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. 8, 831-840 (2002).
23. Sawano, A. et al. Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans. Blood 97, 785-791 (2001).
24. Rafii, S. Circulating endothelial precursors: mystery, reality, and promise. J. Clin. Invest. 105, 17-19 (2000).
25. Bonini, C. et al. HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 276, 1719-1724 (1997).