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Volumn 26, Issue 3, 2007, Pages 93-110

Clinicopathological features of medulloblastoma: An overview with an emphasis on molecular biology

Author keywords

Cerebellum; Embryonal brain tumor; Medulloblastoma

Indexed keywords

CARBOPLATIN; CISPLATIN; CYCLOPAMINE; CYCLOPHOSPHAMIDE; CYTARABINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ETOPOSIDE; IFOSFAMIDE; LOMUSTINE; MANNITOL; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 1; NOTCH2 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PREDNISONE; PROCARBAZINE; PROTEIN MDM2; S6 KINASE; SCATTER FACTOR RECEPTOR; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR OTX2; VINCRISTINE;

EID: 34249276339     PISSN: 07225091     EISSN: None     Source Type: Journal    
DOI: 10.5414/npp26093     Document Type: Review
Times cited : (2)

References (124)
  • 1
    • 0036245047 scopus 로고    scopus 로고
    • MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group
    • Aldosari N, Bigner SH, Burger PC, Becker L, Kepner JL, Friedman HS, McLendon RE. MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group. Arch Pathol Lab Med. 2002; 126: 540-544.
    • (2002) Arch Pathol Lab Med , vol.126 , pp. 540-544
    • Aldosari, N.1    Bigner, S.H.2    Burger, P.C.3    Becker, L.4    Kepner, J.L.5    Friedman, H.S.6    McLendon, R.E.7
  • 2
    • 0027621275 scopus 로고
    • The clinical and radiological evaluation of primary brain tumors in children, Part I: Clinical evaluation
    • Allen ED, Byrd SE, Darling CF, Tomita T, Wilczynski MA. The clinical and radiological evaluation of primary brain tumors in children, Part I: Clinical evaluation. J Natl Med Assoc. 1993; 85: 445-451.
    • (1993) J Natl Med Assoc , vol.85 , pp. 445-451
    • Allen, E.D.1    Byrd, S.E.2    Darling, C.F.3    Tomita, T.4    Wilczynski, M.A.5
  • 4
    • 0032970323 scopus 로고    scopus 로고
    • Comparative genomic hybridization detects many recurrent imbalances in central nervous system primitive neuroectodermal tumours in children
    • Avet-Loiseau H, Venuat AM, Terrier-Lacombe MJ, Lellouch-Tubiana A, Zerah M, Vassal G. Comparative genomic hybridization detects many recurrent imbalances in central nervous system primitive neuroectodermal tumours in children. Br J Cancer. 1999; 79: 1843-1847.
    • (1999) Br J Cancer , vol.79 , pp. 1843-1847
    • Avet-Loiseau, H.1    Venuat, A.M.2    Terrier-Lacombe, M.J.3    Lellouch-Tubiana, A.4    Zerah, M.5    Vassal, G.6
  • 5
    • 0025891733 scopus 로고
    • N-myc and c-myc oncogenes amplification in medulloblastomas. Evidence of particularly aggressive behavior of a tumor with c-myc amplification
    • Badiali M, Pession A, Basso G, Andreini L, Rigobello L, Galassi E, Giangaspero F. N-myc and c-myc oncogenes amplification in medulloblastomas. Evidence of particularly aggressive behavior of a tumor with c-myc amplification. Tumori. 1991; 77: 118-121.
    • (1991) Tumori , vol.77 , pp. 118-121
    • Badiali, M.1    Pession, A.2    Basso, G.3    Andreini, L.4    Rigobello, L.5    Galassi, E.6    Giangaspero, F.7
  • 6
    • 0001587471 scopus 로고
    • Medulloblastoma cerebelli: A common type of midcerebellar glioma of childhood
    • Bailey P, Cushing H. Medulloblastoma cerebelli: a common type of midcerebellar glioma of childhood. Arch Neurol Psychiatry. 1925; 14: 192-223.
    • (1925) Arch Neurol Psychiatry , vol.14 , pp. 192-223
    • Bailey, P.1    Cushing, H.2
  • 7
    • 0033860991 scopus 로고    scopus 로고
    • Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping
    • Bayani J, Zielenska M, Marrano P, Kwan Ng Y, Taylor MD, Jay V, Rutka JT, Squire JA. Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping. J Neurosurg. 2000; 93: 437-448.
    • (2000) J Neurosurg , vol.93 , pp. 437-448
    • Bayani, J.1    Zielenska, M.2    Marrano, P.3    Kwan, N.Y.4    Taylor, M.D.5    Jay, V.6    Rutka, J.T.7    Squire, J.A.8
  • 9
    • 13444249487 scopus 로고    scopus 로고
    • Genomic amplification of Orthodenticle homolog 2 (OTX2) in medulloblastomas
    • Boon K, Eberhart C, Riggins G. Genomic amplification of Orthodenticle homolog 2 (OTX2) in medulloblastomas. Cancer Res. 2005; 65: 703-707.
    • (2005) Cancer Res , vol.65 , pp. 703-707
    • Boon, K.1    Eberhart, C.2    Riggins, G.3
  • 10
    • 0344873115 scopus 로고    scopus 로고
    • Comparison of medulloblastoma and normal neural transcriptomes identifies a restricted set of activated genes
    • Boon K, Edwards J, Siu I, Olschner D, Eberhart C, Marra M, Strausberg R, Riggins G. Comparison of medulloblastoma and normal neural transcriptomes identifies a restricted set of activated genes. Oncogene. 2003; 22: 7687-7694.
    • (2003) Oncogene , vol.22 , pp. 7687-7694
    • Boon, K.1    Edwards, J.2    Siu, I.3    Olschner, D.4    Eberhart, C.5    Marra, M.6    Strausberg, R.7    Riggins, G.8
  • 11
    • 33645094926 scopus 로고    scopus 로고
    • N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma
    • Browd SR, Kenney AM, Gottfried ON, Yoon JW, Walterhouse D, Pedone CA, Fults DW. N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma. Cancer Res. 2006; 66: 2666-2672.
    • (2006) Cancer Res , vol.66 , pp. 2666-2672
    • Browd, S.R.1    Kenney, A.M.2    Gottfried, O.N.3    Yoon, J.W.4    Walterhouse, D.5    Pedone, C.A.6    Fults, D.W.7
  • 13
    • 0036617113 scopus 로고    scopus 로고
    • Brief report: Transient mutism following posterior fossa surgery studied by single photon emission computed tomography (SPECT)
    • Clerico A, Sordi A, Ragni G, Festa A, Cappelli C, Maini CL. Brief report: transient mutism following posterior fossa surgery studied by single photon emission computed tomography (SPECT). Med Pediatr Oncol. 2002; 38: 445-448.
    • (2002) Med Pediatr Oncol , vol.38 , pp. 445-448
    • Clerico, A.1    Sordi, A.2    Ragni, G.3    Festa, A.4    Cappelli, C.5    Maini, C.L.6
  • 14
    • 0024998205 scopus 로고
    • Deletion mapping of the medulloblastoma locus on chromosome 17p
    • Cogen PH, Daneshvar L, Metzger AK, Edwards MS. Deletion mapping of the medulloblastoma locus on chromosome 17p. Genomics. 1990; 8: 279-285.
    • (1990) Genomics , vol.8 , pp. 279-285
    • Cogen, P.H.1    Daneshvar, L.2    Metzger, A.K.3    Edwards, M.S.4
  • 15
    • 0142153787 scopus 로고    scopus 로고
    • The hedgehog signaling network
    • Cohen MM Jr. The hedgehog signaling network. Am J Med Genet A. 2003; 123: 5-28.
    • (2003) Am J Med Genet A , vol.123 , pp. 5-28
    • Cohen Jr., M.M.1
  • 16
    • 0032486433 scopus 로고    scopus 로고
    • Teratogen-mediated inhibition of target tissue response to Shh signaling
    • Cooper MK, Porter JA, Young KE, Beachy PA. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science. 1998; 280: 1603-1607.
    • (1998) Science , vol.280 , pp. 1603-1607
    • Cooper, M.K.1    Porter, J.A.2    Young, K.E.3    Beachy, P.A.4
  • 17
    • 0032796826 scopus 로고    scopus 로고
    • Sonic hedgehog regulates the growth and patterning of the cerebellum
    • Dahmane N, Ruiz I Altaba A. Sonic hedgehog regulates the growth and patterning of the cerebellum. Development. 1999; 126: 3089-3100.
    • (1999) Development , vol.126 , pp. 3089-3100
    • Dahmane, N.1    Ruiz, I.2    Altaba, A.3
  • 18
    • 33645035911 scopus 로고    scopus 로고
    • de Haas T, Oussoren E, Grajkowska W, Perek-Polnik M, Popovic M, Zadravec- Zaletel L, Perera M, Corte G, Wirths O, van Sluis P, Pietsch T, Troost D, Baas F, Versteeg R, Kool M. OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas. J Neuropathol Exp Neurol. 2006; 65: 176-186.
    • de Haas T, Oussoren E, Grajkowska W, Perek-Polnik M, Popovic M, Zadravec- Zaletel L, Perera M, Corte G, Wirths O, van Sluis P, Pietsch T, Troost D, Baas F, Versteeg R, Kool M. OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas. J Neuropathol Exp Neurol. 2006; 65: 176-186.
  • 19
    • 0022337690 scopus 로고
    • Myelography for staging medulloblastoma
    • Deutsch M, Laurent JP, Cohen ME. Myelography for staging medulloblastoma. Cancer. 1985; 56: 1763-1766.
    • (1985) Cancer , vol.56 , pp. 1763-1766
    • Deutsch, M.1    Laurent, J.P.2    Cohen, M.E.3
  • 21
    • 0025673558 scopus 로고
    • Cerebellar mutism after posterior fossa surgery
    • Dietze DD Jr, Mickle JP. Cerebellar mutism after posterior fossa surgery. Pediatr Neurosurg. 1990; 16: 25-31.
    • (1990) Pediatr Neurosurg , vol.16 , pp. 25-31
    • Dietze Jr, D.D.1    Mickle, J.P.2
  • 22
    • 2642541662 scopus 로고    scopus 로고
    • Mouse models of childhood cancer of the nervous system
    • Dyer MA. Mouse models of childhood cancer of the nervous system. J Clin Pathol. 2004; 57: 561-576.
    • (2004) J Clin Pathol , vol.57 , pp. 561-576
    • MA, D.1
  • 23
    • 0037223273 scopus 로고    scopus 로고
    • Medulloblastoma in mice lacking p53 and PARP: All roads lead to Gli
    • Eberhart CG. Medulloblastoma in mice lacking p53 and PARP: all roads lead to Gli. Am J Pathol. 2003; 162: 7-10.
    • (2003) Am J Pathol , vol.162 , pp. 7-10
    • CG, E.1
  • 26
    • 0036132648 scopus 로고    scopus 로고
    • Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas
    • Eberhart CG, Kratz JE, Schuster A, Goldthwaite P, Cohen KJ, Perlman EJ, Burger PC. Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas. Brain Pathol. 2002; 12: 36-44.
    • (2002) Brain Pathol , vol.12 , pp. 36-44
    • Eberhart, C.G.1    Kratz, J.E.2    Schuster, A.3    Goldthwaite, P.4    Cohen, K.J.5    Perlman, E.J.6    Burger, P.C.7
  • 28
    • 32944461274 scopus 로고    scopus 로고
    • β-Catenin status predicts a favorable outcome in childhood medulloblastoma: The United Kingdom Children's Cancer Study Group Brain Tumour Committee
    • Ellison DW, Onilude OE, Lindsey JC, Lusher ME, Weston CL, Taylor RE, Pearson AD, Clifford SC. β-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee. J Clin Oncol. 2005; 23: 7951-7957.
    • (2005) J Clin Oncol , vol.23 , pp. 7951-7957
    • Ellison, D.W.1    Onilude, O.E.2    Lindsey, J.C.3    Lusher, M.E.4    Weston, C.L.5    Taylor, R.E.6    Pearson, A.D.7    Clifford, S.C.8
  • 29
    • 0036664066 scopus 로고    scopus 로고
    • Single photon emission tomography following posterior fossa surgery in patients with and without mutism
    • Ersahin Y, Yararbas U, Duman Y, Mutluer S. Single photon emission tomography following posterior fossa surgery in patients with and without mutism. Childs Nerv Syst. 2002; 18: 318-325.
    • (2002) Childs Nerv Syst , vol.18 , pp. 318-325
    • Ersahin, Y.1    Yararbas, U.2    Duman, Y.3    Mutluer, S.4
  • 32
    • 0036293474 scopus 로고    scopus 로고
    • Radiotherapy for medulloblastoma in children: A perspective on current international clinical research efforts
    • Freeman CR, Taylor RE, Kortmann RD, Carrie C. Radiotherapy for medulloblastoma in children: a perspective on current international clinical research efforts. Med Pediatr Oncol. 2002; 39: 99-108.
    • (2002) Med Pediatr Oncol , vol.39 , pp. 99-108
    • Freeman, C.R.1    Taylor, R.E.2    Kortmann, R.D.3    Carrie, C.4
  • 33
    • 0028029456 scopus 로고
    • Chromosome analysis of brain tumors in childhood
    • Fujii Y, Hongo T, Hayashi Y. Chromosome analysis of brain tumors in childhood. Genes Chromosomes Cancer. 1994; 11: 205-215.
    • (1994) Genes Chromosomes Cancer , vol.11 , pp. 205-215
    • Fujii, Y.1    Hongo, T.2    Hayashi, Y.3
  • 34
    • 33749044182 scopus 로고    scopus 로고
    • Gajjar A, Chintagumpala M, Ashley D, Kellie S, Kun LE, Merchant TE, Woo S, Wheeler G, Ahem V, Krasin MJ, Fouladi M, Broniscer A, Krance R, Hale GA, Stewart CF, Dauser R, Sanford RA, Fuller C, Lau C, Boyett JM, Wallace D, Gilbertson RJ. Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. Lancet Oncol. 2006; 7: 813-820.
    • Gajjar A, Chintagumpala M, Ashley D, Kellie S, Kun LE, Merchant TE, Woo S, Wheeler G, Ahem V, Krasin MJ, Fouladi M, Broniscer A, Krance R, Hale GA, Stewart CF, Dauser R, Sanford RA, Fuller C, Lau C, Boyett JM, Wallace D, Gilbertson RJ. Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. Lancet Oncol. 2006; 7: 813-820.
  • 35
    • 1842614251 scopus 로고    scopus 로고
    • Gajjar A, Hernan R, Kocak M, Fuller C, Lee Y, McKinnon PJ, Wallace D, Lau C, Chintagumpala M, Ashley DM, Kellie SJ, Kun L, Gilbertson RJ. Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma. J Clin Oncol. 2004; 22: 984-993. Epub 2004 Feb 2017.
    • Gajjar A, Hernan R, Kocak M, Fuller C, Lee Y, McKinnon PJ, Wallace D, Lau C, Chintagumpala M, Ashley DM, Kellie SJ, Kun L, Gilbertson RJ. Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma. J Clin Oncol. 2004; 22: 984-993. Epub 2004 Feb 2017.
  • 40
    • 0242361321 scopus 로고    scopus 로고
    • PDGFRB is overexpressed in metastatic medulloblastoma
    • Gilbertson RJ, Clifford SC. PDGFRB is overexpressed in metastatic medulloblastoma. Nat Genet. 2003; 35: 197-198.
    • (2003) Nat Genet , vol.35 , pp. 197-198
    • Gilbertson, R.J.1    Clifford, S.C.2
  • 43
    • 0031874838 scopus 로고    scopus 로고
    • Giordana MT, Migheli A, Pavanelli E. Isochromosome 17q is a constant finding in medulloblastoma. An interphase cytogenetic study on tissue sections. Neuropathol Appi Neurobiol. 1998; 24: 233-238.
    • Giordana MT, Migheli A, Pavanelli E. Isochromosome 17q is a constant finding in medulloblastoma. An interphase cytogenetic study on tissue sections. Neuropathol Appi Neurobiol. 1998; 24: 233-238.
  • 44
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • Goodrich LV, Milenkovic L, Higgins KM, Scott MP. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science. 1997; 277: 1109-1113.
    • (1997) Science , vol.277 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 45
    • 33747339465 scopus 로고    scopus 로고
    • Wnt signaling: Multiple pathways, multiple receptors, and multiple transcription factors
    • Epub Jun 22
    • Gordon MD, Nusse R. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem. 2006; 281: 22429-22433. Epub 2006 Jun 22.
    • (2006) J Biol Chem. 2006 , vol.281 , pp. 22429-22433
    • Gordon, M.D.1    Nusse, R.2
  • 46
    • 0033843435 scopus 로고    scopus 로고
    • Neurotrophin receptor TrkC predicts good clinical outcome in medulloblastoma and other primitive neuroectodermal brain rumors
    • Grotzer MA, Janss AJ, Phillips PC, Trojanowski JQ. Neurotrophin receptor TrkC predicts good clinical outcome in medulloblastoma and other primitive neuroectodermal brain rumors. Klin Padiatr. 2000; 212: 196-199.
    • (2000) Klin Padiatr , vol.212 , pp. 196-199
    • Grotzer, M.A.1    Janss, A.J.2    Phillips, P.C.3    Trojanowski, J.Q.4
  • 48
    • 0031904140 scopus 로고    scopus 로고
    • Turcot's syndrome presenting with medulloblastoma and familiar adenomatous polyposis: A case report and review of the literature
    • Hamada H, Kurimoto M, Endo S, Ogiichi T, Akai T, Takaku A. Turcot's syndrome presenting with medulloblastoma and familiar adenomatous polyposis: a case report and review of the literature. Acta Neurochir (Wien). 1998; 140: 631-632.
    • (1998) Acta Neurochir (Wien) , vol.140 , pp. 631-632
    • Hamada, H.1    Kurimoto, M.2    Endo, S.3    Ogiichi, T.4    Akai, T.5    Takaku, A.6
  • 52
    • 0029004938 scopus 로고
    • Detection of cerebrospinal fluid metastasis: CT myelography or MR?
    • Heinz R, Wiener D, Friedman H, Tien R. Detection of cerebrospinal fluid metastasis: CT myelography or MR? Am J Neuroradiol. 1995; 16: 1147-1151.
    • (1995) Am J Neuroradiol , vol.16 , pp. 1147-1151
    • Heinz, R.1    Wiener, D.2    Friedman, H.3    Tien, R.4
  • 54
    • 0037224320 scopus 로고    scopus 로고
    • Hernan R, Fasheh R, Calabrese C, Frank AJ, Maclean KH, Allard D, Barraclough R, Gilbertson RJ. ERBB2 upregulates S100A4 and several other prometastatic genes in medulloblastoma. Cancer Res. 2003; 63: 140-148.
    • Hernan R, Fasheh R, Calabrese C, Frank AJ, Maclean KH, Allard D, Barraclough R, Gilbertson RJ. ERBB2 upregulates S100A4 and several other prometastatic genes in medulloblastoma. Cancer Res. 2003; 63: 140-148.
  • 55
    • 24944535651 scopus 로고    scopus 로고
    • Identification of a novel homozygous deletion region at 6q23.1 in medulloblastomas using high-resolution array comparative genomic hybridization analysis
    • Hui AB, Takano H, Lo KW, Kuo WL, Lam CN, Tong CY, Chang Q, Gray JW, Ng HK. Identification of a novel homozygous deletion region at 6q23.1 in medulloblastomas using high-resolution array comparative genomic hybridization analysis. Clin Cancer Res. 2005; 11: 4707-4716.
    • (2005) Clin Cancer Res , vol.11 , pp. 4707-4716
    • Hui, A.B.1    Takano, H.2    Lo, K.W.3    Kuo, W.L.4    Lam, C.N.5    Tong, C.Y.6    Chang, Q.7    Gray, J.W.8    Ng, H.K.9
  • 57
    • 29644446889 scopus 로고    scopus 로고
    • The therapy of infantile malignant brain tumors: Current status?
    • Kalifa C, Grill J. The therapy of infantile malignant brain tumors: current status? J Neurooncol. 2005; 75: 279-285.
    • (2005) J Neurooncol , vol.75 , pp. 279-285
    • Kalifa, C.1    Grill, J.2
  • 58
    • 32444449871 scopus 로고    scopus 로고
    • Kasper M, Regi G, Frischauf AM, Aberger F. GLI transcription factors: mediators of oncogenic Hedgehog signalling. Eur J Cancer. 2006; 42: 437-445. Epub 2006 Jan 2010.
    • Kasper M, Regi G, Frischauf AM, Aberger F. GLI transcription factors: mediators of oncogenic Hedgehog signalling. Eur J Cancer. 2006; 42: 437-445. Epub 2006 Jan 2010.
  • 59
    • 0037209055 scopus 로고    scopus 로고
    • On the neuronal/neuroblastic nature of medulloblastomas; a tribute to Pio de Rio Hortega an Moises Polak
    • Katsetos C, Del Valle L, Legido A, de Chadarevian J, Perentes E, Mork S. On the neuronal/neuroblastic nature of medulloblastomas; a tribute to Pio de Rio Hortega an Moises Polak. Acta Neuropathol. 2003; 105: 1-13.
    • (2003) Acta Neuropathol , vol.105 , pp. 1-13
    • Katsetos, C.1    Del Valle, L.2    Legido, A.3    de Chadarevian, J.4    Perentes, E.5    Mork, S.6
  • 61
    • 0018232837 scopus 로고
    • Cyclopamine and related steroidal alkaloid teratogens: Their occurrence, structural relationship, and biologic effects
    • Keeler RF. Cyclopamine and related steroidal alkaloid teratogens: their occurrence, structural relationship, and biologic effects. Lipids. 1978; 13: 708-715.
    • (1978) Lipids , vol.13 , pp. 708-715
    • RF, K.1
  • 62
    • 0037232580 scopus 로고    scopus 로고
    • Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
    • Kenney AM, Cole MD, Rowitch DH. Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development. 2003; 130: 15-28.
    • (2003) Development , vol.130 , pp. 15-28
    • Kenney, A.M.1    Cole, M.D.2    Rowitch, D.H.3
  • 63
    • 1642474000 scopus 로고    scopus 로고
    • Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development. 2004; 131: 217-228
    • Dec
    • Kenney AM, Widlund HR, Rowitch DH. Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development. 2004; 131: 217-228. Epub 2003 Dec 2003.
    • (2003) Epub 2003
    • Kenney, A.M.1    Widlund, H.R.2    Rowitch, D.H.3
  • 65
    • 33645211987 scopus 로고    scopus 로고
    • Neural precursor cycling at sonic speed: N-myc pedals, gsk-3 brakes. Cell Cycle. 2006; 5: 47-52
    • Jan
    • Knoepfler PS, Kenney AM. Neural precursor cycling at sonic speed: n-myc pedals, gsk-3 brakes. Cell Cycle. 2006; 5: 47-52. Epub 2006 Jan 2001.
    • (2001) Epub 2006
    • Knoepfler, P.S.1    Kenney, A.M.2
  • 66
    • 0020701570 scopus 로고
    • Medulloblastoma. The identification of prognostic subgroups and implications for multimodality management
    • Kopelson G, Linggood R, Kleinman GM. Medulloblastoma. The identification of prognostic subgroups and implications for multimodality management. Cancer. 1983; 51: 312-319.
    • (1983) Cancer , vol.51 , pp. 312-319
    • Kopelson, G.1    Linggood, R.2    Kleinman, G.M.3
  • 67
    • 0032667681 scopus 로고    scopus 로고
    • Prognostic value of tumor-associated antigens immunoreactivity and apoptosis in medulloblastomas. An analysis of 73 cases
    • Korshunov A, Golanov A, Ozerov S, Sycheva R. Prognostic value of tumor-associated antigens immunoreactivity and apoptosis in medulloblastomas. An analysis of 73 cases. Brain Tumor Pathol. 1999; 16: 37-44.
    • (1999) Brain Tumor Pathol , vol.16 , pp. 37-44
    • Korshunov, A.1    Golanov, A.2    Ozerov, S.3    Sycheva, R.4
  • 68
    • 0029852316 scopus 로고    scopus 로고
    • Ventriculo-peritoneal shunt requirement in children with posterior fossa tumours: An 11-year audit
    • Kumar V, Phipps K, Harkness W, Hayward RD. Ventriculo-peritoneal shunt requirement in children with posterior fossa tumours: an 11-year audit. Br J Neurosurg. 1996; 10: 467-470.
    • (1996) Br J Neurosurg , vol.10 , pp. 467-470
    • Kumar, V.1    Phipps, K.2    Harkness, W.3    Hayward, R.D.4
  • 69
    • 0037112505 scopus 로고    scopus 로고
    • DNA ligase IV suppresses medulloblastoma formation
    • Lee Y, McKinnon PJ. DNA ligase IV suppresses medulloblastoma formation. Cancer Res. 2002; 62: 6395-6399.
    • (2002) Cancer Res , vol.62 , pp. 6395-6399
    • Lee, Y.1    McKinnon, P.J.2
  • 70
    • 2942530769 scopus 로고    scopus 로고
    • Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum
    • Lewis PM, Gritli-Linde A, Smeyne R, Kottmann A, Mc-Mahon AP. Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol. 2004; 270: 393-410.
    • (2004) Dev Biol , vol.270 , pp. 393-410
    • Lewis, P.M.1    Gritli-Linde, A.2    Smeyne, R.3    Kottmann, A.4    Mc-Mahon, A.P.5
  • 72
    • 0034656212 scopus 로고    scopus 로고
    • Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
    • Marino S, Vooijs M, van Der Gulden H, Jankers J, Berns A. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 2000; 14: 994-1004.
    • (2000) Genes Dev , vol.14 , pp. 994-1004
    • Marino, S.1    Vooijs, M.2    van Der Gulden, H.3    Jankers, J.4    Berns, A.5
  • 73
    • 12444311694 scopus 로고    scopus 로고
    • Chemoradiotherapy for brain tumors: Current status and perspectives
    • Matsutani M. Chemoradiotherapy for brain tumors: current status and perspectives. Int J Clin Oncol. 2004; 9: 471-474.
    • (2004) Int J Clin Oncol , vol.9 , pp. 471-474
    • Matsutani, M.1
  • 74
    • 33746750132 scopus 로고    scopus 로고
    • High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumors
    • McCabe MG, Ichimura K, Liu L, Plant K, Backlund LM, Pearson DM, Collins VP. High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumors. J Neuropathol Exp Neurol. 2006; 65: 549-561.
    • (2006) J Neuropathol Exp Neurol , vol.65 , pp. 549-561
    • McCabe, M.G.1    Ichimura, K.2    Liu, L.3    Plant, K.4    Backlund, L.M.5    Pearson, D.M.6    Collins, V.P.7
  • 75
    • 0036329571 scopus 로고    scopus 로고
    • Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor: A SEER update
    • McNeil DE, Cote RT, Clegg L, Rorke LB. Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor: A SEER update. Med Pediatr Oncol. 2002; 39: 190-194.
    • (2002) Med Pediatr Oncol , vol.39 , pp. 190-194
    • McNeil, D.E.1    Cote, R.T.2    Clegg, L.3    Rorke, L.B.4
  • 76
    • 0036333208 scopus 로고    scopus 로고
    • A mitogen gradient of dorsal midline Wnts organizes growth in the CNS
    • Megason SG, McMahon AP. A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development. 2002; 129: 2087-2098.
    • (2002) Development , vol.129 , pp. 2087-2098
    • Megason, S.G.1    McMahon, A.P.2
  • 78
    • 0033620978 scopus 로고    scopus 로고
    • Michiels EM, Oussoren E, Van Groenigen M, Pauws E, Bossuyt PM, Voute PA, Baas F. Genes differentially expressed in medulloblastoma and fetal brain. Physiol Genomics. 1999; 1: 83-91.
    • Michiels EM, Oussoren E, Van Groenigen M, Pauws E, Bossuyt PM, Voute PA, Baas F. Genes differentially expressed in medulloblastoma and fetal brain. Physiol Genomics. 1999; 1: 83-91.
  • 81
    • 2342533921 scopus 로고    scopus 로고
    • Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival
    • Neben K, Korshunov A, Benner A, Wrobel G Hahn M, Kokocinski F, Golanov A, Joos S, Lichter P. Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival. Cancer Res. 2004; 64: 3103-3111.
    • (2004) Cancer Res , vol.64 , pp. 3103-3111
    • Neben, K.1    Korshunov, A.2    Benner, A.3    Wrobel, G.4    Hahn, M.5    Kokocinski, F.6    Golanov, A.7    Joos, S.8    Lichter, P.9
  • 83
    • 0032980271 scopus 로고    scopus 로고
    • Childhood medulloblastoma: Progress and future challenges
    • Packer RJ. Childhood medulloblastoma: progress and future challenges. Brain Dev. 1999; 21: 75-81.
    • (1999) Brain Dev , vol.21 , pp. 75-81
    • RJ, P.1
  • 86
    • 0020533529 scopus 로고
    • Medulloblastoma: Clinical presentation and management. Experience at the hospital for sick children, toronto, 1950-1980
    • Park TS, Hoffman HJ, Hendrick EB, Humphreys RP, Becker LE. Medulloblastoma: clinical presentation and management. Experience at the hospital for sick children, toronto, 1950-1980. J Neurosurg. 1983; 58: 543-552.
    • (1983) J Neurosurg , vol.58 , pp. 543-552
    • Park, T.S.1    Hoffman, H.J.2    Hendrick, E.B.3    Humphreys, R.P.4    Becker, L.E.5
  • 87
    • 0034084768 scopus 로고    scopus 로고
    • Roles of Wnt proteins in neural development and maintenance
    • Patapoutian A, Reichardt LF. Roles of Wnt proteins in neural development and maintenance. Curr Opin Neurobiol. 2000; 10: 392-399.
    • (2000) Curr Opin Neurobiol , vol.10 , pp. 392-399
    • Patapoutian, A.1    Reichardt, L.F.2
  • 92
    • 0019456516 scopus 로고
    • Hydrocephalus and infratentorial tumors. Incidence, clinical picture, and treatment
    • Raimondi AJ, Tomita T. Hydrocephalus and infratentorial tumors. Incidence, clinical picture, and treatment. J Neurosurg. 1981; 55: 174-182.
    • (1981) J Neurosurg , vol.55 , pp. 174-182
    • Raimondi, A.J.1    Tomita, T.2
  • 94
    • 0033849398 scopus 로고    scopus 로고
    • Multiple genomic alterations including N-myc amplification in a primary large cell medulloblastoma
    • Reardon DA, Jenkins JJ, Sublett JE, Burger PC, Kun LK. Multiple genomic alterations including N-myc amplification in a primary large cell medulloblastoma. Pediatr Neurosurg. 2000; 32: 187-191.
    • (2000) Pediatr Neurosurg , vol.32 , pp. 187-191
    • Reardon, D.A.1    Jenkins, J.J.2    Sublett, J.E.3    Burger, P.C.4    Kun, L.K.5
  • 96
    • 0032080853 scopus 로고    scopus 로고
    • Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
    • Reifenberger J, Wolter M, Weber RG, Megahed M, Ruzicka T, Lichter P, Reifenberger G. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res. 1998; 58: 1798-1803.
    • (1998) Cancer Res , vol.58 , pp. 1798-1803
    • Reifenberger, J.1    Wolter, M.2    Weber, R.G.3    Megahed, M.4    Ruzicka, T.5    Lichter, P.6    Reifenberger, G.7
  • 97
    • 0034842285 scopus 로고    scopus 로고
    • Epidemiology of central nervous system tumors in childhood and adolescence based on the new WHO classification
    • Rickert CH, Paulus W. Epidemiology of central nervous system tumors in childhood and adolescence based on the new WHO classification. Childs Nerv Syst. 2001; 77: 502-511.
    • (2001) Childs Nerv Syst , vol.77 , pp. 502-511
    • Rickert, C.H.1    Paulus, W.2
  • 99
    • 0036644901 scopus 로고    scopus 로고
    • Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma
    • Rood BR, Zhang H, Weitman DM, Cogen PH. Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma. Cancer Res. 2002; 62: 3794-3797.
    • (2002) Cancer Res , vol.62 , pp. 3794-3797
    • Rood, B.R.1    Zhang, H.2    Weitman, D.M.3    Cogen, P.H.4
  • 101
    • 33747165307 scopus 로고    scopus 로고
    • Current treatment approaches to early childhood medulloblastoma
    • Rutkowski S. Current treatment approaches to early childhood medulloblastoma. Expert Rev Neurother. 2006; 6: 1211-1221.
    • (2006) Expert Rev Neurother , vol.6 , pp. 1211-1221
    • Rutkowski, S.1
  • 102
    • 33847695354 scopus 로고    scopus 로고
    • β-catenin function is required for cerebellar morphogenesis
    • Schuller U, Rowitch DH. β-catenin function is required for cerebellar morphogenesis. Brain Res. 2006; 1140: 161-169.
    • (2006) Brain Res , vol.1140 , pp. 161-169
    • Schuller, U.1    Rowitch, D.H.2
  • 103
    • 0032898184 scopus 로고    scopus 로고
    • Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32
    • Smyth I, Narang MA,, Evans T, Heimann C, Nakamura Y, Chenevix-Trench G, Pietsch T, Wicking C, Wainwright BJ. Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32. Hum Mol Genet. 1999; 8: 291-297.
    • (1999) Hum Mol Genet , vol.8 , pp. 291-297
    • Smyth, I.1    Narang, M.A.2    Evans, T.3    Heimann, C.4    Nakamura, Y.5    Chenevix-Trench, G.6    Pietsch, T.7    Wicking, C.8    Wainwright, B.J.9
  • 105
    • 34249328132 scopus 로고    scopus 로고
    • High-dose chemotherapy and autologous stem cell rescue in children with newly diagnosed high-risk or relapsed medulloblastoma or supratentorial primitive neuroectodermal tumor
    • Sung KW, Yoo KH, Cho EJ, Koo HH, Lim DH, Shin HJ, Ahn SD, Ra YS, Choi ES, Ghim TT. High-dose chemotherapy and autologous stem cell rescue in children with newly diagnosed high-risk or relapsed medulloblastoma or supratentorial primitive neuroectodermal tumor. Pediatr Blood Cancer. 2006; 25: 25.
    • (2006) Pediatr Blood Cancer , vol.25 , pp. 25
    • Sung, K.W.1    Yoo, K.H.2    Cho, E.J.3    Koo, H.H.4    Lim, D.H.5    Shin, H.J.6    Ahn, S.D.7    Ra, Y.S.8    Choi, E.S.9    Ghim, T.T.10
  • 109
    • 33646362581 scopus 로고    scopus 로고
    • Thompson MC, Fuller C, Hogg TL, Dalton J, Finkelstein D, Lau CC, Chintagumpala M, Adesina A, Ashley DM, Kellie SJ, Taylor MD, Curran T, Gajjar A, Gilbertson RJ. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol. 2006; 24: 1924-1931. Epub 2006 Mar 1927.
    • Thompson MC, Fuller C, Hogg TL, Dalton J, Finkelstein D, Lau CC, Chintagumpala M, Adesina A, Ashley DM, Kellie SJ, Taylor MD, Curran T, Gajjar A, Gilbertson RJ. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol. 2006; 24: 1924-1931. Epub 2006 Mar 1927.
  • 111
    • 0942290729 scopus 로고    scopus 로고
    • Detection of oncogene amplifications in medulloblastomas by comparative genomic hybridization and array-based comparative genomic hybridization
    • Tong CY, Hui AB, Yin XL, Pang JC, Zhu XL, Poon WS, Ng HK. Detection of oncogene amplifications in medulloblastomas by comparative genomic hybridization and array-based comparative genomic hybridization. J Neurosurg. 2004; 100: 187-193.
    • (2004) J Neurosurg , vol.100 , pp. 187-193
    • Tong, C.Y.1    Hui, A.B.2    Yin, X.L.3    Pang, J.C.4    Zhu, X.L.5    Poon, W.S.6    Ng, H.K.7
  • 112
    • 0037219382 scopus 로고    scopus 로고
    • Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice
    • Tong WM, Ohgaki H, Huang H, Granier C, Kleihues P, Wang ZQ. Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice. Am J Pathol. 2003; 162: 343-352.
    • (2003) Am J Pathol , vol.162 , pp. 343-352
    • Tong, W.M.1    Ohgaki, H.2    Huang, H.3    Granier, C.4    Kleihues, P.5    Wang, Z.Q.6
  • 115
    • 0031880374 scopus 로고    scopus 로고
    • The anatomy of the cerebellum
    • Voogd J, Glickstein M. The anatomy of the cerebellum. Trends Neurosci. 1998; 21: 370-375.
    • (1998) Trends Neurosci , vol.21 , pp. 370-375
    • Voogd, J.1    Glickstein, M.2
  • 117
    • 0035409307 scopus 로고    scopus 로고
    • Genetic regulation of cerebellar development
    • Wang VY, Zoqhbi HY. Genetic regulation of cerebellar development. Nat Rev Neurosci. 2001; 2: 484-491.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 484-491
    • Wang, V.Y.1    Zoqhbi, H.Y.2
  • 118
    • 0034927062 scopus 로고    scopus 로고
    • The developmental biology of brain tumors
    • Wechsler-Reya R, Scott MP. The developmental biology of brain tumors. Annu. Rev. Neurosci. 2001; 24: 385-428.
    • (2001) Annu. Rev. Neurosci , vol.24 , pp. 385-428
    • Wechsler-Reya, R.1    Scott, M.P.2
  • 119
    • 0035863498 scopus 로고    scopus 로고
    • Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
    • Wetmore C, Eberhart DE, Curran T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res. 2001; 61: 513-516.
    • (2001) Cancer Res , vol.61 , pp. 513-516
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3
  • 120
    • 0035253120 scopus 로고    scopus 로고
    • The rhombic lip and early cerebellar development
    • Wingate RJ. The rhombic lip and early cerebellar development. Curr Opin Neurobiol. 2001; 11: 82-88.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 82-88
    • RJ, W.1
  • 121
    • 0036616280 scopus 로고    scopus 로고
    • Cytodifferentiation of Bergmann glia and its relationship with Purkinje cells
    • Yamada K, Watanabe M. Cytodifferentiation of Bergmann glia and its relationship with Purkinje cells. Anat Sci Int. 2002; 77: 94-108.
    • (2002) Anat Sci Int , vol.77 , pp. 94-108
    • Yamada, K.1    Watanabe, M.2


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