OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas

Journal of Neuropathology and Experimental Neurology

Volumn 65, Issue 2, 2006, Pages 176-186

  De Haas, Talitha ^a   Oussoren, Esmeralda ^a   Grajkowska, Wieslawa ^b   Perek Polnik, Marta ^f   Popovic, Mara ^c,d   Zadravec Zaletel, Lorna ^c   Perera, Marzia ^c,d   Corte, Giorgio ^d   Wirths, Oliver ^e   Van Sluis, Peter ^a   Pietsch, Torsten ^e   Troost, Dirk ^a   Baas, Frank ^a   Versteeg, Rogier ^a   Kool, Marcel ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b CHILDREN'S MEMORIAL HEALTH INSTITUTE   (Poland)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

^d UNIVERSITY OF GENOA   (Italy)

^e UNIVERSITY OF BONN   (Germany)

^f NONE

Author keywords

Brain tumor; Cerebellum; Medulloblastoma; OTX1; OTX2; P75NTR

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR OTX; TRANSCRIPTION FACTOR OTX1; TRANSCRIPTION FACTOR OTX2; UNCLASSIFIED DRUG; OTX1 PROTEIN, HUMAN; OTX2 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AGED; ARTICLE; CEREBELLUM VERMIS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FETUS; GENE AMPLIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; MEDULLOBLASTOMA; NEWBORN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TUMOR CLASSIFICATION; AGE; CEREBELLUM; CLASSIFICATION; FEMALE; GENETICS; GROWTH, DEVELOPMENT AND AGING; HISTOLOGY; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESCHOOL CHILD;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CEREBELLUM; CHILD; CHILD, PRESCHOOL; FEMALE; FETUS; HUMANS; INFANT; INFANT, NEWBORN; MALE; MEDULLOBLASTOMA; MIDDLE AGED; OTX TRANSCRIPTION FACTORS; RNA, MESSENGER;

EID: 33645035911     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.jnen.0000199576.70923.8a     Document Type: Article

References (30)

1. Kleihues P, Louis D, Scheithauer B, et al. The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 2002;61:215-25
2. Roberts RO, Lynch CF, Jones MP, et al. Medulloblastoma: A population-based study of 532 cases. J Neuropathol Exp Neurol 1991;50:134-44
3. Michiels EM, Oussoren E, van Groenigen M, et al. Genes differentially expressed in medulloblastoma and fetal brain. Physiol Genomics 1999;1:83-91
4. Simeone A, Puelles E, Acampora D. The Otx family. Curr Opin Genet Dev 2002;12:409-15
5. Boon K, Eberhart C, Riggins G. Genomic amplification of Orthodenticle homolog 2 (OTX2) in medulloblastomas. Cancer Res 2005;65:703-7
6. Di C, Liao S, Adamson DC, et al. Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans-retinoic acid. Cancer Res 2005;65:719-24
7. Katsetos C, Burger P. Medulloblastoma. Semin Diagn Pathol 1994;11:85-97
8. Katsetos C, Del Valle L, Legido A, et al. On the neuronal/neuroblastic nature of medulloblastomas: A tribute to Pio de Rio Hortega and Moises Polak. Acta Neuropathol 2003;105:1-13
9. Rorke LB. The cerebellar medulloblastoma and its relationship to primitive neuroectodermal tumors. J Neuropathol Exp Neurol 1983;42:1-15
10. Stevenson L, Echlin F. Nature and origin of some tumors of the cerebellum. Arch Neurol Psychiatry 1934;31:93-109
11. Yokota N, Aruga J, Takai S, et al. Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma. Cancer Res 1996;56:377-83
12. Katsetos CD, Herman MM, Krishna L, et al. Calbindin-D28k in subsets of medulloblastomas and in the human medulloblastoma cell line D283 Med. Arch Pathol Lab Med 1995;119:734-43
13. Buhren J, Christoph A, Buslei R, et al. Expression of the neurotrophin receptor p75NTR in medulloblastomas is correlated with distinct histological and clinical features: Evidence for a medulloblastoma subtype derived from the external granule cell layer. J Neuropathol Exp Neurol 2000;59:229-40
14. Salsano E, Pollo B, Eoli M, et al. Expression of MATH1, a marker of cerebellar granule cell progenitors, identifies different medulloblastoma sub-types. Neurosci Lett 2004;370:180-85
15. Church GM, Gilbert W. Genomic sequencing. Proc Natl Acad Sci U S A 1984;81:1991-95
16. Gherzi R, Briata P, Boncinelli E, et al. The human homeodomain protein OTX2 binds to the human tenascin-C promoter and trans-represses its activity in transfected cells. DNA Cell Biol 1997;16:559-67
17. Boon K, Osorio EC, Greenhut SF, et al. An anatomy of normal and malignant gene expression. Proc Natl Acad Sci U S A 2002;99:11287-92
18. Boon K, Edwards J, Siu I, et al. Comparison of medulloblastoma and normal neural transcriptomes identifies a restricted set of activated genes. Oncogene 2003;22:7687-94
19. Frantz GD, Weimann JM, Levin ME, et al. Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum. J Neurosci 1994;14:5725-40
20. Yokota N, Mainprize TG, Taylor MD, et al. Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization. Oncogene 2004;23:3444-53
21. Sarkar C, Pramanik P, Karak AK, et al. Are childhood and adult medulloblastomas different? A comparative study of clinicopathological features, proliferation index and apoptotic index. J Neurooncol 2002;59:49-61
22. Kortmann R, Brandes A. Current and future strategies in the management of medulloblastoma in adults. Forum (Genova) 2003;13:99-110
23. Ildan F, Cetinalp E, Bagdatoglu H, et al. Cerebellar medulloblastomas in adults. Neurosurg Rev 1994;17:205-9
24. Bourgouin PM, Tampieri D, Grahovac SZ, et al. CT and MR imaging findings in adults with cerebellar medulloblastoma: Comparison with findings in children. AJR Am J Roentgenol 1992;159:609-12
25. Acampora D, Avantaggiato V, Tuorto F, et al. Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation. Development 1998;125:5091-5104
26. Acampora D, Gulisano M, Simeone A. Otx genes and the genetic control of brain morphogenesis. Mol Cell Neurosci 1999;13:1-8
27. Mallamaci A, Di Blas E, Briata P, et al. OTX2 homeoprotein in the developing central nervous system and migratory cells of the olfactory area. Mech Dev 1996;58:165-78
28. Sotelo C. Cellular and genetic regulation of the development of the cerebellar system. Prog Neurobiol 2004;72:295-339
29. Katsetos CD, Frankfurter A, Christakos S, et al. Differential localization of class III, beta-tubulin isotype and calbindin-D28k defines distinct neuronal types in the developing human cerebellar cortex. J Neuropathol Exp Neurol 1993;52:655-66
30. Wang Y, Christakos S. Retinoic acid regulates the expression of the calcium binding protein, calbindin-D28K. Mol Endocrinol 1995;9:1510-21