메뉴 건너뛰기




Volumn 23, Issue 34, 2005, Pages 8853-8862

Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CYCLIN DEPENDENT KINASE 6; LOMUSTINE; PROTEIN PPM1D; TUMOR MARKER; TUMOR PROTEIN; UNCLASSIFIED DRUG; VINCRISTINE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2C;

EID: 31544450175     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2005.02.8589     Document Type: Article
Times cited : (198)

References (69)
  • 1
    • 0035041023 scopus 로고    scopus 로고
    • Brain and other central nervous system tumors: Rates, trends, and epidemiology
    • Gurney JG, Kadan-Lottick N: Brain and other central nervous system tumors: Rates, trends, and epidemiology. Curr Opin Oncol 13: 160-166, 2001
    • (2001) Curr Opin Oncol , vol.13 , pp. 160-166
    • Gurney, J.G.1    Kadan-Lottick, N.2
  • 2
    • 1842509920 scopus 로고    scopus 로고
    • Biologic risk stratification of medulloblastoma: The real time is now
    • Fisher PG, Burger PC, Eberhart CG: Biologic risk stratification of medulloblastoma: The real time is now. J Clin Oncol 22:971-974, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 971-974
    • Fisher, P.G.1    Burger, P.C.2    Eberhart, C.G.3
  • 3
    • 0037080303 scopus 로고    scopus 로고
    • Histopathologic grading of medulloblastomas: A Pediatric Oncology Group study
    • Eberhart CG, Kepner JL, Goldthwaite PT, et al: Histopathologic grading of medulloblastomas: A Pediatric Oncology Group study. Cancer 94:552-560, 2002
    • (2002) Cancer , vol.94 , pp. 552-560
    • Eberhart, C.G.1    Kepner, J.L.2    Goldthwaite, P.T.3
  • 4
    • 0032728334 scopus 로고    scopus 로고
    • Medulloblastoma with extensive nodularity: A variant with favorable prognosis
    • Giangaspero F, Perilongo G, Fondelli MP, et al: Medulloblastoma with extensive nodularity: A variant with favorable prognosis. J Neurosurg 91:971-977, 1999
    • (1999) J Neurosurg , vol.91 , pp. 971-977
    • Giangaspero, F.1    Perilongo, G.2    Fondelli, M.P.3
  • 5
    • 0026663357 scopus 로고
    • Large-cell medulloblastomas: A distinct variant with highly aggressive behavior
    • Giangaspero F, Rigobello L, Badiali M, et al: Large-cell medulloblastomas: A distinct variant with highly aggressive behavior. Am J Surg Pathol 16:687-693, 1992
    • (1992) Am J Surg Pathol , vol.16 , pp. 687-693
    • Giangaspero, F.1    Rigobello, L.2    Badiali, M.3
  • 6
    • 0033791188 scopus 로고    scopus 로고
    • Large cell/anaplastic medulloblastomas: A Pediatric Oncology Group Study
    • Brown HG, Kepner JL, Perlman EJ, et al: "Large cell/anaplastic" medulloblastomas: A Pediatric Oncology Group Study. J Neuropathol Exp Neurol 59:857-865, 2000
    • (2000) J Neuropathol Exp Neurol , vol.59 , pp. 857-865
    • Brown, H.G.1    Kepner, J.L.2    Perlman, E.J.3
  • 7
    • 0033050817 scopus 로고    scopus 로고
    • Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: Conclusions from the Children's Cancer Group 921 randomized phase III study
    • Zeltzer PM, Boyett JM, Finlay JL, et al: Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: Conclusions from the Children's Cancer Group 921 randomized phase III study. J Clin Oncol 17:832-845, 1999
    • (1999) J Clin Oncol , vol.17 , pp. 832-845
    • Zeltzer, P.M.1    Boyett, J.M.2    Finlay, J.L.3
  • 8
    • 0036204622 scopus 로고    scopus 로고
    • Paediatric embryonic brain tumours: Biological and clinical relevance of molecular genetic abnormalities
    • Gilbertson R: Paediatric embryonic brain tumours: Biological and clinical relevance of molecular genetic abnormalities. Eur J Cancer 38:675-685, 2002
    • (2002) Eur J Cancer , vol.38 , pp. 675-685
    • Gilbertson, R.1
  • 9
    • 0041307002 scopus 로고    scopus 로고
    • Analysis of gene expression in the normal and malignant cerebellum
    • Wechsler-Reya RJ: Analysis of gene expression in the normal and malignant cerebellum. Recent Prog Horm Res 58:227-248, 2003
    • (2003) Recent Prog Horm Res , vol.58 , pp. 227-248
    • Wechsler-Reya, R.J.1
  • 10
    • 0033860991 scopus 로고    scopus 로고
    • Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping
    • Bayani J, Zielenska M, Marrano P, et al: Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping. J Neurosurg 93:437-448, 2000
    • (2000) J Neurosurg , vol.93 , pp. 437-448
    • Bayani, J.1    Zielenska, M.2    Marrano, P.3
  • 11
    • 27644512310 scopus 로고    scopus 로고
    • Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients
    • Pan E, Pellarin M, Holmes E, et al: Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients. Clin Cancer Res 11:4733-4740, 2005
    • (2005) Clin Cancer Res , vol.11 , pp. 4733-4740
    • Pan, E.1    Pellarin, M.2    Holmes, E.3
  • 12
    • 0032987525 scopus 로고    scopus 로고
    • Comparative genomic hybridization and histological variation in primitive neuroectodermal tumours
    • Nicholson JC, Ross FM, Kohler JA, et al: Comparative genomic hybridization and histological variation in primitive neuroectodermal tumours. Br J Cancer 80:1322-1331, 1999
    • (1999) Br J Cancer , vol.80 , pp. 1322-1331
    • Nicholson, J.C.1    Ross, F.M.2    Kohler, J.A.3
  • 13
    • 0030776230 scopus 로고    scopus 로고
    • Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization
    • Reardon DA, Michalkiewicz E, Boyett JM, et al: Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization. Cancer Res 57:4042-4047, 1997
    • (1997) Cancer Res , vol.57 , pp. 4042-4047
    • Reardon, D.A.1    Michalkiewicz, E.2    Boyett, J.M.3
  • 14
    • 0032970323 scopus 로고    scopus 로고
    • Comparative genomic hybridization detects many recurrent imbalances in central nervous system primitive neuroectodermal tumours in children
    • Avet-Loiseau H, Venuat AM, Terrier-Lacombe MJ, et al: Comparative genomic hybridization detects many recurrent imbalances in central nervous system primitive neuroectodermal tumours in children. Br J Cancer 79:1843-1847, 1999
    • (1999) Br J Cancer , vol.79 , pp. 1843-1847
    • Avet-Loiseau, H.1    Venuat, A.M.2    Terrier-Lacombe, M.J.3
  • 15
    • 0029900741 scopus 로고    scopus 로고
    • Mapping of chromosomal gains and losses in primitive neuroectodermal tumors by comparative genomic hybridization
    • Schutz BR, Scheurlen W, Krauss J, et al: Mapping of chromosomal gains and losses in primitive neuroectodermal tumors by comparative genomic hybridization. Genes Chromosomes Cancer 16:196-203, 1996
    • (1996) Genes Chromosomes Cancer , vol.16 , pp. 196-203
    • Schutz, B.R.1    Scheurlen, W.2    Krauss, J.3
  • 16
    • 0034541832 scopus 로고    scopus 로고
    • Comparative genomic hybridization of medulloblastomas and clinical relevance: Eleven new cases and a review of the literature
    • Gilhuis HJ, Anderl KL, Boerman RH, et al: Comparative genomic hybridization of medulloblastomas and clinical relevance: Eleven new cases and a review of the literature. Clin Neurol Neurosurg 102:203-209, 2000
    • (2000) Clin Neurol Neurosurg , vol.102 , pp. 203-209
    • Gilhuis, H.J.1    Anderl, K.L.2    Boerman, R.H.3
  • 17
    • 0036132648 scopus 로고    scopus 로고
    • Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas
    • Eberhart CG, Kratz JE, Schuster A, et al: Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas. Brain Pathol 12:36-44, 2002
    • (2002) Brain Pathol , vol.12 , pp. 36-44
    • Eberhart, C.G.1    Kratz, J.E.2    Schuster, A.3
  • 18
    • 24944535651 scopus 로고    scopus 로고
    • Identification of a novel homozygous deletion region at 6q23.1 in medulloblastomas using high-resolution array comparative genomic hybridization analysis
    • Hui AB, Takano H, Lo KW, et al: Identification of a novel homozygous deletion region at 6q23.1 in medulloblastomas using high-resolution array comparative genomic hybridization analysis. Clin Cancer Res 11:4707-4716, 2005
    • (2005) Clin Cancer Res , vol.11 , pp. 4707-4716
    • Hui, A.B.1    Takano, H.2    Lo, K.W.3
  • 19
    • 4143081483 scopus 로고    scopus 로고
    • Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients
    • Lamont JM, McManamy CS, Pearson AD, et al: Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients. Clin Cancer Res 10:5482-5493, 2004
    • (2004) Clin Cancer Res , vol.10 , pp. 5482-5493
    • Lamont, J.M.1    McManamy, C.S.2    Pearson, A.D.3
  • 20
    • 0033785455 scopus 로고    scopus 로고
    • Comparative genomic hybridization: Uses and limitations
    • Lichter P, Joos S, Bentz M, et al: Comparative genomic hybridization: Uses and limitations. Semin Hematol 37:348-357, 2000
    • (2000) Semin Hematol , vol.37 , pp. 348-357
    • Lichter, P.1    Joos, S.2    Bentz, M.3
  • 21
    • 0030701970 scopus 로고    scopus 로고
    • Matrix-based comparative genomic hybridization: Biochips to screen for genomic imbalances
    • Solinas-Toldo S, Lampel S, Stilgenbauer S, et al: Matrix-based comparative genomic hybridization: Biochips to screen for genomic imbalances. Genes Chromosomes Cancer 20:399-407, 1997
    • (1997) Genes Chromosomes Cancer , vol.20 , pp. 399-407
    • Solinas-Toldo, S.1    Lampel, S.2    Stilgenbauer, S.3
  • 22
    • 17344371740 scopus 로고    scopus 로고
    • High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays
    • Pinkel D, Segraves R, Sudar D, et al: High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat Genet 20:207-211, 1998
    • (1998) Nat Genet , vol.20 , pp. 207-211
    • Pinkel, D.1    Segraves, R.2    Sudar, D.3
  • 23
    • 10744225365 scopus 로고    scopus 로고
    • Automated array-based genomic profiling in chronic lymphocytic leukemia: Development of a clinical tool and discovery of recurrent genomic alterations
    • Schwaenen C, Nessling M, Wessendorf S, et al: Automated array-based genomic profiling in chronic lymphocytic leukemia: Development of a clinical tool and discovery of recurrent genomic alterations. Proc Natl Acad Sci U S A 101:1039-1044, 2004
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 1039-1044
    • Schwaenen, C.1    Nessling, M.2    Wessendorf, S.3
  • 24
    • 19444377455 scopus 로고    scopus 로고
    • Detection of chromosomal imbalances in retinoblastoma by matrix-based comparative genomic hybridization
    • Zielinski B, Gratias S, Toedt G, et al: Detection of chromosomal imbalances in retinoblastoma by matrix-based comparative genomic hybridization. Genes Chromosomes Cancer 43:294-301, 2005
    • (2005) Genes Chromosomes Cancer , vol.43 , pp. 294-301
    • Zielinski, B.1    Gratias, S.2    Toedt, G.3
  • 26
    • 0342614892 scopus 로고    scopus 로고
    • Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: Results of the German prospective randomized trial HIT '91
    • Kortmann RD, Kuhl J, Timmermann B, et al: Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: Results of the German prospective randomized trial HIT '91. Int J Radiat Oncol Biol Phys 46:269-279, 2000
    • (2000) Int J Radiat Oncol Biol Phys , vol.46 , pp. 269-279
    • Kortmann, R.D.1    Kuhl, J.2    Timmermann, B.3
  • 27
    • 0022712686 scopus 로고
    • Censoring distributions as a measure of follow-up in survival analysis
    • Korn EL: Censoring distributions as a measure of follow-up in survival analysis. Stat Med 5:255-260, 1986
    • (1986) Stat Med , vol.5 , pp. 255-260
    • Korn, E.L.1
  • 28
    • 0037376804 scopus 로고    scopus 로고
    • DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones
    • Fiegler H, Carr P, Douglas EJ, et al: DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. Genes Chromosomes Cancer 36:361-374, 2003
    • (2003) Genes Chromosomes Cancer , vol.36 , pp. 361-374
    • Fiegler, H.1    Carr, P.2    Douglas, E.J.3
  • 29
    • 0033851883 scopus 로고    scopus 로고
    • An optimized set of human telomere clones for studying telomere integrity and architecture
    • Knight SJ, Lese CM, Precht KS, et al: An optimized set of human telomere clones for studying telomere integrity and architecture. Am J Hum Genet 67:320-332, 2000
    • (2000) Am J Hum Genet , vol.67 , pp. 320-332
    • Knight, S.J.1    Lese, C.M.2    Precht, K.S.3
  • 30
    • 0037444269 scopus 로고    scopus 로고
    • Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinoma
    • Freier K, Joos S, Flechtenmacher C, et al: Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinoma. Cancer Res 63:1179-1182, 2003
    • (2003) Cancer Res , vol.63 , pp. 1179-1182
    • Freier, K.1    Joos, S.2    Flechtenmacher, C.3
  • 31
    • 0023064191 scopus 로고
    • Genomic organization of alpha satellite DNA on human chromosome 7: Evidence for two distinct alphoid domains on a single chromosome
    • Waye JS, England SB, Willard HF: Genomic organization of alpha satellite DNA on human chromosome 7: Evidence for two distinct alphoid domains on a single chromosome. Mol Cell Biol 7:349-356, 1987
    • (1987) Mol Cell Biol , vol.7 , pp. 349-356
    • Waye, J.S.1    England, S.B.2    Willard, H.F.3
  • 32
    • 0033557839 scopus 로고    scopus 로고
    • Survey of gene amplifications during prostate cancer progression by higb-throughout fluorescence in situ hybridization on tissue microarrays
    • Bubendorf L, Kononen J, Koivisto P, et al: Survey of gene amplifications during prostate cancer progression by higb-throughout fluorescence in situ hybridization on tissue microarrays. Cancer Res 59:803-806, 1999
    • (1999) Cancer Res , vol.59 , pp. 803-806
    • Bubendorf, L.1    Kononen, J.2    Koivisto, P.3
  • 33
    • 0023692635 scopus 로고
    • Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries
    • Lichter P, Cremer T, Borden J, et al: Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries. Hum Genet 80:224-234, 1988
    • (1988) Hum Genet , vol.80 , pp. 224-234
    • Lichter, P.1    Cremer, T.2    Borden, J.3
  • 34
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45, 2001
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 35
    • 0035034745 scopus 로고    scopus 로고
    • Using full probability models to compute probabilities of actual interest to decision makers
    • Harrell FE Jr, Shih YC: Using full probability models to compute probabilities of actual interest to decision makers. Int J Technol Assess Health Care 17:17-26, 2001
    • (2001) Int J Technol Assess Health Care , vol.17 , pp. 17-26
    • Harrell Jr, F.E.1    Shih, Y.C.2
  • 36
  • 37
    • 0038244014 scopus 로고    scopus 로고
    • HTERT gene amplification and increased mRNA expression in central nervous system embryonal tumors
    • Fan X, Wang Y, Kratz J, et al: HTERT gene amplification and increased mRNA expression in central nervous system embryonal tumors. Am J Pathol 162:1763-1769, 2003
    • (2003) Am J Pathol , vol.162 , pp. 1763-1769
    • Fan, X.1    Wang, Y.2    Kratz, J.3
  • 38
    • 0028172248 scopus 로고
    • p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma
    • Adesina AM, Nalbantoglu J, Cavenee WK: p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma. Cancer Res 54:5649-5651, 1994
    • (1994) Cancer Res , vol.54 , pp. 5649-5651
    • Adesina, A.M.1    Nalbantoglu, J.2    Cavenee, W.K.3
  • 39
    • 0026634161 scopus 로고
    • Evidence for a 17p tumor related locus distinct from p53 in pediatric primitive neuroectodermal tumors
    • Biegel JA, Burk CD, Barr FG, et al: Evidence for a 17p tumor related locus distinct from p53 in pediatric primitive neuroectodermal tumors. Cancer Res 52:3391-3395, 1992
    • (1992) Cancer Res , vol.52 , pp. 3391-3395
    • Biegel, J.A.1    Burk, C.D.2    Barr, F.G.3
  • 40
    • 3242722919 scopus 로고    scopus 로고
    • REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
    • Di Marcotullio L, Ferretti E, De Smaele E, et al: REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma. Proc Natl Acad Sci U S A 101:10833-10838, 2004
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10833-10838
    • Di Marcotullio, L.1    Ferretti, E.2    De Smaele, E.3
  • 41
    • 0029893043 scopus 로고    scopus 로고
    • Molecular analysis of the lissencephaly gene 1 (LIS-1) in medulloblastomas
    • Koch A, Tonn J, Kraus JA, et al: Molecular analysis of the lissencephaly gene 1 (LIS-1) in medulloblastomas. Neuropathol Appl Neurobiol 22:233-242, 1996
    • (1996) Neuropathol Appl Neurobiol , vol.22 , pp. 233-242
    • Koch, A.1    Tonn, J.2    Kraus, J.A.3
  • 42
    • 0028040905 scopus 로고
    • Physical mapping of chromosome 17p13.3 in the region of a putative tumor suppressor gene important in medulloblastoma
    • McDonald JD, Daneshvar L, Willert JR, et al: Physical mapping of chromosome 17p13.3 in the region of a putative tumor suppressor gene important in medulloblastoma. Genomics 23:229-232, 1994
    • (1994) Genomics , vol.23 , pp. 229-232
    • McDonald, J.D.1    Daneshvar, L.2    Willert, J.R.3
  • 43
    • 0027430022 scopus 로고
    • Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system
    • Ohgaki H, Eibl RH, Schwab M, et al: Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system. Mol Carcinog 8:74-80, 1993
    • (1993) Mol Carcinog , vol.8 , pp. 74-80
    • Ohgaki, H.1    Eibl, R.H.2    Schwab, M.3
  • 44
    • 0032431032 scopus 로고    scopus 로고
    • The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
    • Wu X, Senechal K, Neshat MS, et al: The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci U S A 95:15587-15591, 1998
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15587-15591
    • Wu, X.1    Senechal, K.2    Neshat, M.S.3
  • 45
    • 2342533921 scopus 로고    scopus 로고
    • Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival
    • Neben K, Korshunov A, Benner A, et al: Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival. Cancer Res 64:3103-3111, 2004
    • (2004) Cancer Res , vol.64 , pp. 3103-3111
    • Neben, K.1    Korshunov, A.2    Benner, A.3
  • 46
    • 0038132179 scopus 로고    scopus 로고
    • Transcriptional profiling of the Sonic hedgehog response: A critical role for N-myc in proliferation of neuronal precursors
    • Oliver TG, Grasfeder LL, Carroll AL, et al: Transcriptional profiling of the Sonic hedgehog response: A critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci U S A 100:7331-7336, 2003
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 7331-7336
    • Oliver, T.G.1    Grasfeder, L.L.2    Carroll, A.L.3
  • 47
    • 0037446975 scopus 로고    scopus 로고
    • PPM1D is a potential target for 17q gain in neuroblastoma
    • Saito-Ohara F, Imoto I, Inoue J, et al: PPM1D is a potential target for 17q gain in neuroblastoma. Cancer Res 63:1876-1883, 2003
    • (2003) Cancer Res , vol.63 , pp. 1876-1883
    • Saito-Ohara, F.1    Imoto, I.2    Inoue, J.3
  • 48
    • 18544385947 scopus 로고    scopus 로고
    • Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23
    • Li J, Yang Y, Peng Y, et al: Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat Genet 31:133-134, 2002
    • (2002) Nat Genet , vol.31 , pp. 133-134
    • Li, J.1    Yang, Y.2    Peng, Y.3
  • 49
    • 0037838822 scopus 로고    scopus 로고
    • Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets
    • Hirasawa A, Saito-Ohara F, Inoue J, et al: Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets. Clin Cancer Res 9:1995-2004, 2003
    • (2003) Clin Cancer Res , vol.9 , pp. 1995-2004
    • Hirasawa, A.1    Saito-Ohara, F.2    Inoue, J.3
  • 50
    • 0036613212 scopus 로고    scopus 로고
    • Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
    • Bulavin DV, Demidov ON, Saito S, et al: Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Nat Genet 31:210-215, 2002
    • (2002) Nat Genet , vol.31 , pp. 210-215
    • Bulavin, D.V.1    Demidov, O.N.2    Saito, S.3
  • 51
    • 1842483852 scopus 로고    scopus 로고
    • Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway
    • Bulavin DV, Phillips C, Nannenga B, et al: Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat Genet 36:343-350, 2004
    • (2004) Nat Genet , vol.36 , pp. 343-350
    • Bulavin, D.V.1    Phillips, C.2    Nannenga, B.3
  • 52
    • 0034383398 scopus 로고    scopus 로고
    • p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation
    • Takekawa M, Adachi M, Nakahata A, et al: p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation. Embo J 19:6517-6526, 2000
    • (2000) Embo J , vol.19 , pp. 6517-6526
    • Takekawa, M.1    Adachi, M.2    Nakahata, A.3
  • 53
    • 0035347120 scopus 로고    scopus 로고
    • Absence of germline and somatic p53 alterations in children with sporadic brain tumors
    • Portwine C, Chilton-MacNeill S, Brown C, et al: Absence of germline and somatic p53 alterations in children with sporadic brain tumors. J Neurooncol 52:227-235, 2001
    • (2001) J Neurooncol , vol.52 , pp. 227-235
    • Portwine, C.1    Chilton-MacNeill, S.2    Brown, C.3
  • 54
    • 23244460009 scopus 로고    scopus 로고
    • Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5
    • Moro T, Ogasawara T, Chikuda H, et al: Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5. J Cell Physiol 204:927-933, 2005
    • (2005) J Cell Physiol , vol.204 , pp. 927-933
    • Moro, T.1    Ogasawara, T.2    Chikuda, H.3
  • 55
    • 0031963715 scopus 로고    scopus 로고
    • Differential expression of cyclin-dependent kinase 6 in cortical thymocytes and T-cell lymphoblastic lymphoma/leukemia
    • Chilosi M, Doglioni C, Yan Z, et al: Differential expression of cyclin-dependent kinase 6 in cortical thymocytes and T-cell lymphoblastic lymphoma/leukemia. Am J Pathol 152:209-217, 1998
    • (1998) Am J Pathol , vol.152 , pp. 209-217
    • Chilosi, M.1    Doglioni, C.2    Yan, Z.3
  • 56
    • 0030982897 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA
    • Costello JF, Plass C, Arap W, et al: Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. Cancer Res 57:1250-1254, 1997
    • (1997) Cancer Res , vol.57 , pp. 1250-1254
    • Costello, J.F.1    Plass, C.2    Arap, W.3
  • 57
    • 0037075887 scopus 로고    scopus 로고
    • Cyclin D-dependent kinases, INK4 inhibitors and cancer
    • Ortega S, Malumbres M, Barbacid M: Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta 1602:73-87, 2002
    • (2002) Biochim Biophys Acta , vol.1602 , pp. 73-87
    • Ortega, S.1    Malumbres, M.2    Barbacid, M.3
  • 58
    • 0141482110 scopus 로고    scopus 로고
    • Hemangiosarcomas, medullobiastomas, and other tumors in Ink4c/p53-null mice
    • Zindy F, Nilsson LM, Nguyen L, et al: Hemangiosarcomas, medullobiastomas, and other tumors in Ink4c/p53-null mice. Cancer Res 63:5420-5427, 2003
    • (2003) Cancer Res , vol.63 , pp. 5420-5427
    • Zindy, F.1    Nilsson, L.M.2    Nguyen, L.3
  • 59
    • 0035863498 scopus 로고    scopus 로고
    • Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
    • Wetmore C, Eberhart DE, Curran T: Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 61:513-516, 2001
    • (2001) Cancer Res , vol.61 , pp. 513-516
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3
  • 60
    • 0034656212 scopus 로고    scopus 로고
    • Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
    • Marino S, Vooijs M, van Der Gulden H, et al: Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev 14:994-1004, 2000
    • (2000) Genes Dev , vol.14 , pp. 994-1004
    • Marino, S.1    Vooijs, M.2    van Der Gulden, H.3
  • 61
    • 2642541662 scopus 로고    scopus 로고
    • Mouse models of childhood cancer of the nervous system
    • Dyer MA: Mouse models of childhood cancer of the nervous system. J Clin Pathol 57:561-576, 2004
    • (2004) J Clin Pathol , vol.57 , pp. 561-576
    • Dyer, M.A.1
  • 62
    • 0842265003 scopus 로고    scopus 로고
    • Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a)
    • Faast R, White J, Cartwright P, et al: Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a). Oncogene 23:491-502, 2004
    • (2004) Oncogene , vol.23 , pp. 491-502
    • Faast, R.1    White, J.2    Cartwright, P.3
  • 63
    • 0038375546 scopus 로고    scopus 로고
    • CDK6 blocks differentiation: Coupling cell proliferation to the block to differentiation in leukemic cells
    • Matushansky I, Radparvar F, Skoultchi AI: CDK6 blocks differentiation: Coupling cell proliferation to the block to differentiation in leukemic cells. Oncogene 22:4143-4149, 2003
    • (2003) Oncogene , vol.22 , pp. 4143-4149
    • Matushansky, I.1    Radparvar, F.2    Skoultchi, A.I.3
  • 64
    • 2442681686 scopus 로고    scopus 로고
    • Histopathological and molecular prognostic markers in medulloblastoma: C-myc, N-myc, TrkC, and anaplasia
    • Eberhart CG, Kratz J, Wang Y, et al: Histopathological and molecular prognostic markers in medulloblastoma: C-myc, N-myc, TrkC, and anaplasia. J Neuropathol Exp Neurol 63:441449, 2004
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 441449
    • Eberhart, C.G.1    Kratz, J.2    Wang, Y.3
  • 65
    • 1842614251 scopus 로고    scopus 로고
    • Clinical, histopathologic, and molecular markers of prognosis: Toward a new disease risk stratification system for medulloblastoma
    • Gajjar A, Hernan R, Kocak M, et al: Clinical, histopathologic, and molecular markers of prognosis: Toward a new disease risk stratification system for medulloblastoma. J Clin Oncol 22:984-993, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 984-993
    • Gajjar, A.1    Hernan, R.2    Kocak, M.3
  • 66
    • 0034890563 scopus 로고    scopus 로고
    • MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma
    • Grotzer MA, Hogarty MD, Janss AJ, et al: MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma. Clin Cancer Res 7:2425-2433, 2001
    • (2001) Clin Cancer Res , vol.7 , pp. 2425-2433
    • Grotzer, M.A.1    Hogarty, M.D.2    Janss, A.J.3
  • 67
    • 0242361321 scopus 로고    scopus 로고
    • PDGFRB is overexpressed in metastatic medulloblastoma
    • Gilbertson RJ, Clifford SC: PDGFRB is overexpressed in metastatic medulloblastoma. Nat Genet 35:197-198, 2003
    • (2003) Nat Genet , vol.35 , pp. 197-198
    • Gilbertson, R.J.1    Clifford, S.C.2
  • 68
    • 0034794796 scopus 로고    scopus 로고
    • Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease
    • MacDonald TJ, Brown KM, LaFleur B, et al: Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nat Genet 29:143-152, 2001
    • (2001) Nat Genet , vol.29 , pp. 143-152
    • MacDonald, T.J.1    Brown, K.M.2    LaFleur, B.3
  • 69
    • 9444228344 scopus 로고    scopus 로고
    • Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts
    • Fry DW, Harvey PJ, Keller PR, et al: Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther 3:1427-1438, 2004
    • (2004) Mol Cancer Ther , vol.3 , pp. 1427-1438
    • Fry, D.W.1    Harvey, P.J.2    Keller, P.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.