Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping

Journal of Neurosurgery

Volumn 93, Issue 3, 2000, Pages 437-448

  Bayani, J ^a   Zielenska, M ^a   Marrano, P ^a   Yim Kwan Ng, ^a   Taylor, M D ^a   Jay, V ^a   Rutka, J T ^a   Squire, J A ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Brain neoplasm; Chromosome; Fluorescence in situ hybridization; Molecular genetics; Primitive neuroectodermal tumor

Indexed keywords

ARTICLE; CHILD; CHROMOSOME 10; CHROMOSOME 13; CHROMOSOME 14; CHROMOSOME 17; CHROMOSOME 18; CHROMOSOME 22; CHROMOSOME 3; CHROMOSOME 6; CHROMOSOME 7; CHROMOSOME LOSS; CHROMOSOME REARRANGEMENT; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; HUMAN; HUMAN TISSUE; INFANT; KARYOTYPING; MEDULLOBLASTOMA; NEUROECTODERM TUMOR; PRIORITY JOURNAL;

EID: 0033860991     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.2000.93.3.0437     Document Type: Article

References (56)

1. p53 Gene mutation and mdm2 gene amplification are uncommon in medulloblastoma
2. Microsatellite analysis of loss of heterozygosity on chromosomes 9q, 11p and 17p in medulloblastomas
3. Comparative genomic hybridization detects many recurrent imbalances in central nervous system primitive neuroectodermal tumours in children
4. Prognostic implications of chromosome 17p deletions in human medulloblastomas
5. Sequential G-ganding, SKY and FISH provide a refined identification of translocation breakpoints and complex chromosomal rearrangements
6. Application of a simplified comparative genomic hybridization technique to screen for gene amplification in pediatric solid tumors
7. Cytogenetic analysis of 120 primary pediatric brain tumors and literature review
8. Cytogenetics and molecular genetics of childhood brain tumors
9. Evidence for a 17p tumor related locus distinct from p53 in pediatric primitive neuroectodermal tumors
10. Isochromosome 17q demonstrated by interphase fluorescence in situ hybridization in primitive neuroectodermal tumors of the central nervous system
11. Isochromosome 17q in primitive neuroectodermal tumors of the central nervous system
12. Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts
13. Cytogenetics of human brain tumors
14. Structural chromosomal abnormalities in human medulloblastoma
15. Cytogenetics and molecular genetics of malignant gliomas and medulloblastoma
16. Assessment of MYCN amplification in neuroblastoma biopsies by differential polymerase chain reaction
17. Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome
18. A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
19. DCC expression is altered by multiple mechanisms in brain tumours
20. Numerical chromosomal changes in DNA hypodiploid solid tumors: Restricted loss and gain of certain chromosomes
21. Increased karyotype precision using fluorescence in situ hybridization and spectral karyotyping in patients with myeloid malignancies
22. Chromosome abnormalities in pediatric brain tumors
23. Identification of de novo chromosomal markers and derivatives by spectral karyotyping
24. Loss of genetic information in central nervous system tumors common to children and young adults
25. Molecular and cytogenetic analysis of a cerebellar primitive neuroectodermal tumor with prominent neuronal differentiation: Detection of MYCN amplification by differential polymerase chain reaction and Southern blot analysis
26. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors
27. Prognostic significance of age, MYCN oncogene amplification, tumor cell ploidy, and histology in 110 infants with stage D(S) neuroblastoma: The pediatric oncology group experience - A pediatric oncology group study
28. The new WHO classification of brain tumours
29. Detection of MYCN gene amplification and deletions of chromosome 1p in neuroblastoma by in situ hybridization using routine histologic sections
30. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
31. Neuron-associated class III beta-tubulin isotype, retinal S-antigen, synaptophysin, and glial fibrillary acidic protein in human medulloblastomas: A clinicopathological analysis of 36 cases
32. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours
33. Comparative genomic hybridization and histological variation in primitive neuroectodermal tumours
34. Characterization of 5q deletions by subtelomeric probes and spectral karyotyping
35. Genetic alterations in pediatric medulloblastomas detected by comparative genomic hybridization
36. p53 Mutations in non-astrocytic human brain tumors
37. Chemotherapy for medulloblastoma/primitive neuroectodermal tumors of the posterior fossa
38. Application of comparative genomic hybridization, spectral karyotyping, and microarray analysis in the identification of subtype-specific patterns of genomic changes in rhabdomyosarcoma
39. Reduction to homozygosity and gene amplification in central nervous system primitive neuroectodermal tumors of childhood
40. Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization
41. Images in neuroscience. Spectral karyotyping analysis in diagnostic cytogenetics
42. Hemangioendothelioma of bone in a patient with a constitutional supernumerary marker
43. Comparative genomic hybridization in patients with supratentorial and infratentorial primitive neuroectodermal tumors
44. High-resolution deletion mapping of chromosome arm 17p in childhood primitive neuroectodermal tumors reveals a common chromosomal disruption within the Smith-Magenis region, an unstable region in chromosome band 17p11.2
45. Multicolor spectral karyotyping of human chromosomes
46. Spectral karyotyping refines cytogenetic diagnostics of constitutional chromosomal abnormalities
47. Mapping of chromosomal gains and losses in primitive neuroectodermal tumors by comparative genomic hybridization
48. Transcription mapping in a medulloblastoma breakpoint interval and Smith-Magenis syndrome candidate region: Identification of 53 transcriptional units and new candidate genes
49. Analysis of chromosome 22q as an aid to the diagnosis of rhabdoid tumor. A case report
50. Karyotyping human chromosomes by combinatorial multi-fluor FISH
51. Identification of MYCN copy number heterogeneity by direct FISH analysis of neuroblastoma preparations
52. Loss of heterozygosity on 6q, 16q, and 17p in human central nervous system primitive neuroectodermal tumors
53. Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts
54. Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping
55. Molecular characterization of a genetically unstable region containing the SMS critical area and a breakpoint cluster for human PNETs