Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and Anaplasia

Journal of Neuropathology and Experimental Neurology

Volumn 63, Issue 5, 2004, Pages 441-449

  Eberhart, Charles G ^a,b   Kratz, John ^a   Wang, Yunyue ^a   Summers, Krista ^a   Stearns, Duncan ^a   Cohen, Kenneth ^c   Dang, Chi V ^a   Burger, Peter C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

^c NONE

Author keywords

Anaplasia; c myc; Medulloblastoma; N myc; Prognosis; TrkC

Indexed keywords

BETA CATENIN; MESSENGER RNA; MOLECULAR MARKER; MYC PROTEIN; NEUROTROPHIN 3 RECEPTOR; PROTEIN C MYB; PROTEIN MXI1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ADOLESCENT; ADULT; ANAPLASTIC CARCINOMA; ARTICLE; CANCER SURVIVAL; CELL NUCLEUS; CHILD; FEMALE; GENE MUTATION; HISTOPATHOLOGY; HUMAN; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; MALE; MEDULLOBLASTOMA; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SURVIVAL RATE; SURVIVAL TIME; UNITED STATES;

EID: 2442681686     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/63.5.441     Document Type: Article

References (34)

1. Gilhuis HJ, Anderl KL, Boerman RH, et al. Comparative genomic hybridization of medulloblastomas and clinical relevance: Eleven new cases and a review of the literature. Clin Neurol Neurosurg 2001;102:203-9
2. Schutz BR, Scheurlen W, Krauss J, et al. Mapping of chromosomal gains and losses in primitive neuroectodermal tumors by comparative genomic hybridization. Genes Chromosomes Cancer 1996;16:196-203
3. Fruhwald MC, O'Dorisio MS, Rush LJ, et al. Gene amplification in PNETs/medulloblastomas: Mapping of a novel amplified gene within the MYCN amplicon. J Med Genet 2000;37:501-9
4. Kleihues P, Cavenee W. Tumors of the nervous system. Lyon, France: IARC Press, 2000
5. Jay V, Squire J, Bayani J, et al. Oncogene amplification in medulloblastoma: Analysis of a case by comparative genomic hybridization and fluorescence in situ hybridization. Pathology 1999;31:337-44
6. Brown HG, Kepner JL, Perlman EJ, et al. "Large cell/ anaplastic" medulloblastomas: A Pediatric Oncology Group study. J Neuropathol Exp Neurol 2000;59:857-65
7. Giangaspero F, Rigobello L, Badiali M, et al. Large-cell medulloblastomas. A distinct variant with highly aggressive behavior. Am J Surg Pathol 1992;16:687-93
8. Aldosari N, Bigner SH, Burger PC, et al. MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group. Arch Pathol Lab Med 2002;126:540-44
9. Herms J, Neidt I, Luscher B, et al. C-MYC expression in medulloblastoma and its prognostic value. Int J Cancer 2000;89:395-402
10. Grotzer MA, Hogarty MD, Janss AJ, et al. MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma. Clin Cancer Res 2001;7:2425-33
11. Pomeroy SL, Tamayo P, Gaasenbeek M, et al. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 2002;415:436-42
12. Oliver TG, Grasfeder LL, Carroll AL, et al. Transcriptional profiling of the Sonic hedgehog response: A critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci USA 2003;100:7331-36
13. Eberhart CG, Kepner JL, Goldthwaite PT, et al. Histopathologic grading of medulloblastomas: A Pediatric Oncology Group study. Cancer 2002;94:552-60
14. Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 1998;4:844-47
15. Iacobuzio-Donahue CA, Ryu B, Hruban RH, et al. Exploring the host desmoplastic response to pancreatic carcinoma: Gene expression of stromal and neoplastic cells at the site of primary invasion. Am J Pathol 2002;160:91-99
16. Eagle LR, Yin X, Brothman AR, et al. Mutation of the MXI1 gene in prostate cancer. Nat Genet 1995;9:249-55
17. Eberhart CG, Kratz JE, Schuster A, et al. Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas. Brain Pathol 2002;12:36-44
18. Aldosari N, Bigner SH, Burger PC, et al. MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group. Arch Pathol Lab Med 2002;126:540-44
19. Michaelson JS, Leder P. Beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland. Oncogene 2001;20:5093-99
20. Ishigaki K, Namba H, Nakashima M, et al. Aberrant localization of beta-catenin correlates with overexpression of its target gene in human papillary thyroid cancer. J Clin Endocrinol Metab 2002;87:3433-40
21. He TC, Sparks AB, Rago C, et al. Identification of c-MYC as a target of the APC pathway. Science 1998;281:1509-12
22. Dang CV, Resar LM, Emison E, et al. Function of the c-Myc oncogenic transcription factor. Exp Cell Res 1999;253:63-77
23. Schreiber-Agus N, Meng Y, Hoang T, et al. Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth. Nature 1998;393:483-87
24. Leonard JR, Cai DX, Rivet DJ, et al. Large cell/anaplastic medulloblastomas and medullomyoblastomas: Clinicopathological and genetic features. J Neurosurg 2001;95:82-88
25. McManamy CS, Lamont JM, Taylor RE, et al. Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas. J Neuropathol Exp Neurol 2003;62:627-32
26. Segal RA, Goumnerova LC, Kwon YK, et al. Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma. Proc Natl Acad Sci USA 1994;91:12867-71
27. Grotzer MA, Janss AJ, Phillips PC, et al. Neurotrophin receptor TrkC predicts good clinical outcome in medulloblastoma and other primitive neuroectodermal brain tumors. Klin Padiatr 2000;212:196-99
28. Malynn BA, de Alboran IM, O'Hagan RC, et al. N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev 2000;14:1390-99
29. Tomlinson FH, Jenkins RB, Scheithauer BW, et al. Aggressive medulloblastoma with high-level N-myc amplification. Mayo Clin Proc 1994;69:359-65
30. Reardon DA, Jenkins JJ, Sublett JE, et al. Multiple genomic alterations including N-myc amplification in a primary large cell medulloblastoma. Pediatr Neurosurg 2000;32:187-91
31. Eberhart CG, Kaufman WE, Tihan T, et al. Apoptosis, neuronal maturation, and neurotrophin expression within medulloblastoma nodules. J Neuropathol Exp Neurol 2001;60:462-69
32. Giangaspero F, Perilongo G, Fondelli MP, et al. Medulloblastoma with extensive nodularity: A variant with favorable prognosis. J Neurosurg 1999;91:971-77
33. Pietsch T, Waha A, Koch A, et al. Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res 1997;57:2085-88
34. Siu IM, Lal A, Blankenship JR, et al. c-Myc promoter activation in medulloblastoma. Cancer Res 2003;63:4773-76