Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages

Nature Immunology

Volumn 8, Issue 6, 2007, Pages 610-618

  Pathak, Sushil Kumar ^a   Basu, Sanchita ^a   Basu, Kunal Kumar ^a   Banerjee, Anirban ^a   Pathak, Shresh ^a   Bhattacharyya, Asima ^a,c   Kaisho, Tsuneyasu ^b   Kundu, Manikuntala ^a   Basu, Joyoti ^a  

^a BOSE INSTITUTE   (India)

^b RIKEN Center for Integrative Medical Sciences   (Japan)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EARLY SECRETORY ANTIGENIC TARGET 6; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE B; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CELL LINE; ENZYME ACTIVATION; HUMANS; INTERFERON REGULATORY FACTORS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-12 SUBUNIT P40; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYCOBACTERIUM TUBERCULOSIS; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TIME FACTORS; TOLL-LIKE RECEPTOR 2;

EID: 34249012130     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1468     Document Type: Article

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